Published in J Biol Chem on October 26, 2005
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Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
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A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1. Clin Sci (Lond) (2004) 1.56
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A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet (2013) 1.50
Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice. Cardiovasc Res (2005) 1.49
The natural cardioprotective particle HDL modulates connexin43 gap junction channels. Cardiovasc Res (2011) 1.43
Eligibility to treatment and economic effect of the implementation of the new U.S. or European Society of Hypertension/European Society of Cardiology hypertension guidelines. J Hypertens (2015) 1.40
Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism. J Biol Chem (2001) 1.39
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Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project). Am J Cardiol (2005) 1.32
Dose-dependent positive association between cigarette smoking, abdominal obesity and body fat: cross-sectional data from a population-based survey. BMC Public Health (2011) 1.32
Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position - 107, implicating the Sp1 transcription factor. Biochem J (2003) 1.30
The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC Psychiatry (2009) 1.29
Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes (2008) 1.27
Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme. Am J Pathol (2003) 1.27
Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene. PLoS Genet (2010) 1.25
Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Circulation (2003) 1.22
Prevalence, awareness, treatment and control of high blood pressure in a Swiss city general population: the CoLaus study. Eur J Cardiovasc Prev Rehabil (2009) 1.22
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop. Diabetes (2009) 1.20
Geriatric depression and vascular diseases: what are the links? J Affect Disord (2004) 1.20
Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes (2008) 1.17
ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. EMBO J (2006) 1.16
Alcohol drinking and cardiovascular risk in a population with high mean alcohol consumption. Am J Cardiol (2008) 1.12
Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. Atherosclerosis (2006) 1.12
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. PLoS One (2011) 1.11
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr (2013) 1.08
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Insulin-secreting beta-cell dysfunction induced by human lipoproteins. J Biol Chem (2003) 1.08
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Prevalence of obesity and abdominal obesity in the Lausanne population. BMC Public Health (2008) 1.05
An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. Metabolism (2004) 1.05
An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension. Cardiovasc Res (2010) 1.05
Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis. Cell Signal (2002) 1.05
Glucose metabolism in cancer cells. Curr Opin Clin Nutr Metab Care (2010) 1.04
Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. Arterioscler Thromb Vasc Biol (2003) 1.04
Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study). Clin Endocrinol (Oxf) (2013) 1.03
Glucose represses connexin36 in insulin-secreting cells. J Cell Sci (2005) 1.03
Caspase-3 protects stressed organs against cell death. Mol Cell Biol (2012) 1.03
Methods for testing association between uncertain genotypes and quantitative traits. Biostatistics (2010) 1.02
When are pro-inflammatory cytokines SAFE in heart failure? Eur Heart J (2011) 1.02
Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. Cardiovasc Res (2009) 1.00
Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers. Alcohol Clin Exp Res (2002) 1.00
The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1. J Biol Chem (2004) 1.00
Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. J Lipid Res (2005) 1.00
HDL-associated paraoxonase-1 can redistribute to cell membranes and influence sensitivity to oxidative stress. Free Radic Biol Med (2010) 1.00
The Lausanne cohort Lc65+: a population-based prospective study of the manifestations, determinants and outcomes of frailty. BMC Geriatr (2008) 0.99
Prevalence and factors associated with difficulty and intention to quit smoking in Switzerland. BMC Public Health (2011) 0.99
The RasGAP N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B activation. J Biol Chem (2002) 0.99
Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines. J Biol Chem (2003) 0.98
Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res (2010) 0.98
Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol (2004) 0.97
Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1. PLoS One (2011) 0.97
Assessment of the capacity to consent to treatment in patients admitted to acute medical wards. BMC Med Ethics (2009) 0.96
Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I. J Lipid Res (2005) 0.96
HDL oxidation compromises its influence on paraoxonase-1 secretion and its capacity to modulate enzyme activity. Arterioscler Thromb Vasc Biol (2007) 0.94
Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease. J Am Coll Cardiol (2006) 0.94
Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS One (2012) 0.94
HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking. Diabetes (2012) 0.93
Association between variants of the leptin receptor gene (LEPR) and overweight: a systematic review and an analysis of the CoLaus study. PLoS One (2011) 0.92
ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells. J Biol Chem (2007) 0.92
Complexin I regulates glucose-induced secretion in pancreatic beta-cells. J Cell Sci (2004) 0.92
Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations. Eur J Epidemiol (2012) 0.92
Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments. J Biol Chem (2002) 0.92
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells. J Cell Sci (2003) 0.92
Risk of falls and major bleeds in patients on oral anticoagulation therapy. Am J Med (2012) 0.92
A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells. Oncogene (2004) 0.92
Predictive accuracy and usefulness of calibration of the ESC SCORE in Switzerland. Eur J Cardiovasc Prev Rehabil (2008) 0.91
Distribution of plasma levels of adiponectin and leptin in an adult Caucasian population. Clin Endocrinol (Oxf) (2009) 0.91
Pharmacogenetic interaction between paraoxonase-1 gene promoter polymorphism C-107T and statin. Pharmacogenet Genomics (2007) 0.91
Small, dense lipoprotein particles and reduced paraoxonase-1 in patients with the metabolic syndrome. J Clin Endocrinol Metab (2005) 0.91
HDL subfraction distribution of paraoxonase-1 and its relevance to enzyme activity and resistance to oxidative stress. J Lipid Res (2008) 0.91
Not all inflammatory markers are linked to kidney function: results from a population-based study. Am J Nephrol (2012) 0.91
The inter-rater reliability of the Pulmonary Embolism Severity Index. Thromb Haemost (2010) 0.90
Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study. BMC Public Health (2011) 0.90