Centrosome amplification, chromosome instability and cancer development.

The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88

Centrosome amplification can initiate tumorigenesis in flies. Cell (2008) 4.62

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36

Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data. BMC Bioinformatics (2007) 1.75

Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell Cycle (2012) 1.71

Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication. BMC Mol Biol (2007) 1.64

Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3. Hum Mol Genet (2009) 1.61

CENPA overexpression promotes genome instability in pRb-depleted human cells. Mol Cancer (2009) 1.31

Centrioles: active players or passengers during mitosis? Cell Mol Life Sci (2010) 1.31

Single-walled carbon nanotube-induced mitotic disruption. Mutat Res (2011) 1.26

MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene. Oncogene (2007) 1.24

Loss of polycystin-1 causes centrosome amplification and genomic instability. Hum Mol Genet (2008) 1.20

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20

P53, cyclin-dependent kinase and abnormal amplification of centrosomes. Biochim Biophys Acta (2008) 1.19

Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy. Cell Death Differ (2012) 1.17

Studying chromosome instability in the mouse. Biochim Biophys Acta (2008) 1.17

Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells. Oncogene (2008) 1.16

RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation. BMC Cell Biol (2009) 1.15

The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene (2010) 1.15

Aneuploidy and tumorigenesis. Semin Cell Dev Biol (2011) 1.15

Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle (2008) 1.14

Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol (2009) 1.12

Error-prone polyploid mitosis during normal Drosophila development. Genes Dev (2010) 1.12

Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Hum Mol Genet (2010) 1.11

Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst (2008) 1.09

RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Mol Cell Biol (2007) 1.07

Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. Blood (2010) 1.06

The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication. J Cell Sci (2010) 1.05

Proliferation defects and genome instability in cells lacking Cul4A. Oncogene (2009) 1.05

SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer (2006) 1.03

Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable. Oncogene (2009) 1.03

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells. Mol Biol Cell (2008) 1.00

Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer. Cancer Res (2007) 1.00

A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability. Front Oncol (2013) 1.00

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99

Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis. Mol Biol Cell (2009) 0.98

Suppression of centrosome duplication and amplification by deacetylases. Cell Cycle (2012) 0.98

Laser microsurgery in the GFP era: a cell biologist's perspective. Methods Cell Biol (2007) 0.98

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer (2007) 0.97

Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase. J Biol Chem (2012) 0.97

Neoplastic transformation of human bronchial cells by lead chromate particles. Am J Respir Cell Mol Biol (2007) 0.96

Epstein-Barr virus DNase (BGLF5) induces genomic instability in human epithelial cells. Nucleic Acids Res (2009) 0.96

Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells. Br J Cancer (2008) 0.95

Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci U S A (2012) 0.94

Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PLoS One (2014) 0.94

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther (2008) 0.93

Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation. Cell Cycle (2013) 0.93

Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblasts. Chem Res Toxicol (2010) 0.92

The centrosome and cell proliferation. Cell Div (2006) 0.91

The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification. Cell Div (2011) 0.90

Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell Cycle (2012) 0.90

Impaired p53 function leads to centrosome amplification, acquired ERalpha phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts. Oncogene (2008) 0.90

Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. Cancer Metastasis Rev (2010) 0.90

RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication. Oncogene (2006) 0.90

Centrosome and retroviruses: the dangerous liaisons. Retrovirology (2007) 0.90

Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. Mol Biol Cell (2009) 0.89

Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma. PLoS One (2013) 0.88

Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene (2011) 0.88

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach. Cell Death Dis (2012) 0.88

The fate of chrysotile-induced multipolar mitosis and aneuploid population in cultured lung cancer cells. PLoS One (2011) 0.88

Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells. Cell Death Dis (2014) 0.87

Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model. PLoS One (2013) 0.86

CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma. Mod Pathol (2016) 0.86

Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors. PLoS One (2013) 0.86

Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis. BMC Cancer (2008) 0.85

Centrosome dynamics as a source of chromosomal instability. Trends Cell Biol (2014) 0.84

Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells. Cell Div (2012) 0.83

Epstein-Barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles. J Virol (2007) 0.83

E2F activators signal and maintain centrosome amplification in breast cancer cells. Mol Cell Biol (2014) 0.83

KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries. J Ovarian Res (2014) 0.82

Steroidogenic factor 1 (NR5A1) maintains centrosome homeostasis in steroidogenic cells by restricting centrosomal DNA-dependent protein kinase activation. Mol Cell Biol (2012) 0.82

Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts. BMC Genomics (2009) 0.82

The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability. Mol Cell Biol (2009) 0.82

Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci U S A (2015) 0.82

The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest. Mol Cancer (2009) 0.82

A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts. Cell Death Dis (2010) 0.82

Genomic instability and copy-number heterogeneity of chromosome 19q, including the kallikrein locus, in ovarian carcinomas. Mol Oncol (2010) 0.82

HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model". J Cancer Sci (2015) 0.81

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells. PLoS One (2010) 0.81

RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication. Oncogene (2010) 0.81

HTLV-1 Tax: centrosome amplification and cancer. Retrovirology (2006) 0.81

Role of NEK2A in human cancer and its therapeutic potentials. Biomed Res Int (2015) 0.81

Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis. Cell Cycle (2014) 0.81

MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach. Virchows Arch (2007) 0.80

Reduced expression of mir15a in the blood of patients with oral squamous cell carcinoma is associated with tumor staging. Exp Ther Med (2010) 0.80

Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression. Am J Pathol (2013) 0.80

Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun (2015) 0.79

Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes. Oxid Med Cell Longev (2012) 0.79

Mechanisms of metal-induced centrosome amplification. Biochem Soc Trans (2010) 0.78

Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification. Cell Cycle (2015) 0.78

Aneuploidy as an early mechanistic event in metal carcinogenesis. Biochem Soc Trans (2010) 0.78

Chloroquine alleviates etoposide-induced centrosome amplification by inhibiting CDK2 in adrenocortical tumor cells. Oncogenesis (2015) 0.78

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol (2017) 0.77

Genotoxic, Cytotoxic, Antigenotoxic, and Anticytotoxic Effects of Sulfonamide Chalcone Using the Ames Test and the Mouse Bone Marrow Micronucleus Test. PLoS One (2015) 0.77

AP4 is required for mitogen- and c-MYC-induced cell cycle progression. Oncotarget (2014) 0.77

CENP-W plays a role in maintaining bipolar spindle structure. PLoS One (2014) 0.77

Unbalanced replication as a major source of genetic instability in cancer cells. Am J Blood Res (2012) 0.77

Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy. Chem Res Toxicol (2010) 0.77

Transcriptome analysis of neoplastic hemocytes in soft-shell clams Mya arenaria: Focus on cell cycle molecular mechanism. Results Immunol (2013) 0.77

DNA demethylation caused by 5-Aza-2'-deoxycytidine induces mitotic alterations and aneuploidy. Oncotarget (2016) 0.76