Published in J Biol Chem on January 18, 2012
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CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia (2013) 1.76
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The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal. Hum Mol Genet (2013) 1.07
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Nuclear transport factors: global regulation of mitosis. Curr Opin Cell Biol (2015) 0.81
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds. BMC Cancer (2015) 0.79
BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Cell Cycle (2014) 0.77
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Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst) (2015) 0.76
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Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway. Cancer Biol Ther (2016) 0.75
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Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst) (2010) 2.51
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol (2004) 2.46
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Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol (2002) 1.95
Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. Nat Cell Biol (2004) 1.91
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Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity. Mol Biol Cell (2003) 1.57
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene (2003) 1.43
BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. J Biol Chem (2002) 1.43
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. J Biol Chem (2004) 1.39
RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol Biol Cell (2003) 1.35
Identification of a functional nuclear export sequence in BRCA1. J Biol Chem (2000) 1.33
Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol (2005) 1.33
Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. Exp Cell Res (2004) 1.29
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Mol Biol Cell (2005) 1.28
Identification of a gamma-tubulin-binding domain in BRCA1. Cancer Res (2001) 1.26
Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol (2003) 1.24
Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton (2003) 1.23
Subcellular localization of the BRCA1 gene product in mitotic cells. Genes Chromosomes Cancer (2002) 1.22
BRCA1 regulates gamma-tubulin binding to centrosomes. Cancer Biol Ther (2007) 1.15
Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function. Cancer Res (2006) 1.13
Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS Lett (2005) 1.12
The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci. J Biol Chem (2004) 1.11
Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. Mol Biol Cell (2004) 1.09
Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice. Mutat Res (2001) 1.09
Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res (2007) 1.07
The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes. Environ Mol Mutagen (2009) 1.06
BRCA1 associates with processive RNA polymerase II. J Biol Chem (2003) 1.05
Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking. Bioessays (2005) 1.05
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. Biochem Biophys Res Commun (2007) 1.01
BRCA1 phosphorylation: biological consequences. Cancer Biol Ther (2006) 1.00
Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. Oncogene (2004) 0.98
Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding. Proc Natl Acad Sci U S A (2010) 0.93
Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1. Cell Cycle (2005) 0.91
Centriole separation in DNA damage-induced centrosome amplification. Environ Mol Mutagen (2009) 0.89
Nuclear targeting and cell cycle regulatory function of human BARD1. J Biol Chem (2005) 0.87
Ubiquitin and SUMO signalling in DNA repair. Biochem Soc Trans (2010) 0.87
Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cell Signal (2007) 0.86
Association of loss of BRCA1 expression with centrosome aberration in human breast cancer. J Cancer Res Clin Oncol (2008) 0.84
A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin. Biochem Biophys Res Commun (2009) 0.84
A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2. Oncogene (2007) 0.83
Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation. Cell Signal (2011) 0.82
Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage. Cell Signal (2009) 0.81
Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Exp Cell Res (2003) 1.91
Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells. Am J Pathol (2009) 1.75
Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants? Breast Cancer Res (2007) 1.61
IQGAP1 regulation and roles in cancer. Cell Signal (2009) 1.58
BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. J Biol Chem (2002) 1.43
Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. Exp Cell Res (2004) 1.29
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention. Exp Cell Res (2004) 1.12
The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci. J Biol Chem (2004) 1.11
APC shuttling to the membrane, nucleus and beyond. Trends Cell Biol (2008) 1.08
Protein trafficking in response to DNA damage. Cell Signal (2007) 1.06
Redefining the subcellular location and transport of APC: new insights using a panel of antibodies. EMBO Rep (2005) 1.04
IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. J Biol Chem (2007) 1.01
Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. Oncogene (2004) 0.98
Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem (2006) 0.96
IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int J Biochem Cell Biol (2010) 0.95
Wnt signaling from membrane to nucleus: β-catenin caught in a loop. Int J Biochem Cell Biol (2012) 0.95
An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays. Assay Drug Dev Technol (2007) 0.95
Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants. Cancer Res (2007) 0.95
Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways. Exp Cell Res (2003) 0.94
Retracted Specific armadillo repeat sequences facilitate β-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2/Nup358. J Biol Chem (2011) 0.94
A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci. Cell Signal (2009) 0.91
APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria. IUBMB Life (2011) 0.90
Regulation of beta-catenin trafficking to the membrane in living cells. Cell Signal (2008) 0.89
BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis. J Biol Chem (2007) 0.89
Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. J Biol Chem (2007) 0.87
Nuclear targeting and cell cycle regulatory function of human BARD1. J Biol Chem (2005) 0.87
Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit. J Biol Chem (2010) 0.86
Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cell Signal (2007) 0.86
Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. Int J Biochem Cell Biol (2011) 0.84
Regulation of β-catenin nuclear dynamics by GSK-3β involves a LEF-1 positive feedback loop. Traffic (2011) 0.84
Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci. Radiother Oncol (2012) 0.82
Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation. Cell Signal (2011) 0.82
Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage. Cell Signal (2009) 0.81
Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress. Biochim Biophys Acta (2013) 0.80
BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters. Cancer Lett (2008) 0.80
The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. Int J Biochem Cell Biol (2012) 0.79
The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci. Traffic (2012) 0.77
Detection of cytoplasmic and nuclear localization of adenomatous polyposis coli (APC) protein in cells. Methods Mol Biol (2008) 0.76
Wnt signaling proteins associate with the nuclear pore complex: implications for cancer. Adv Exp Med Biol (2014) 0.75
Cryptic mitochondrial targeting signals in human ARF: clues to controlling cancer? Cell Cycle (2010) 0.75
Specific Armadillo repeat sequences facilitate β-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2/Nup358. J Biol Chem (2016) 0.75
A two-step fluorescence-activated cell sorting approach to isolate genetically modified mammalian cells with isopropyl-beta-D-thiogalactoside (IPTG)-inducible gene expression. Cytometry A (2012) 0.75
Methods to measure nuclear export of beta-catenin using fixed and live cell assays. Methods Mol Biol (2010) 0.75