Aneuploidy and tumorigenesis.

Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 1.51

A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. Dev Cell (2014) 1.30

SCF ubiquitin ligases in the maintenance of genome stability. Trends Biochem Sci (2011) 1.21

Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy. Cell Div (2011) 1.12

p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology (2013) 1.05

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol (2012) 1.00

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99

Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells. Cell Cycle (2014) 0.92

Characterization of chromosome stability in diploid, polyploid and hybrid yeast cells. PLoS One (2013) 0.91

Hepatocytes polyploidization and cell cycle control in liver physiopathology. Int J Hepatol (2012) 0.91

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. Oncotarget (2015) 0.90

Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proc Natl Acad Sci U S A (2013) 0.89

STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments. J Cell Sci (2014) 0.85

Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents. Front Genet (2013) 0.81

Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut. Nat Commun (2015) 0.79

Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev (2016) 0.79

Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments. Nucleic Acids Res (2016) 0.78

Phospho-Bcl-xL(Ser62) influences spindle assembly and chromosome segregation during mitosis. Cell Cycle (2014) 0.78

Re-evaluate the effect of hyperbaric oxygen therapy in cancer - a preclinical therapeutic small animal model study. PLoS One (2012) 0.78

Mitotic Kinases and p53 Signaling. Biochem Res Int (2012) 0.78

Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization. J Biol Chem (2014) 0.78

RanGTP aids anaphase entry through Ubr5-mediated protein turnover. J Cell Biol (2015) 0.78

Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes. Oncotarget (2016) 0.77

Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells. World J Gastroenterol (2014) 0.76

MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1. J Cell Biol (2016) 0.75

EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell Cycle (2015) 0.75

DNA ploidy and S-phase fraction analysis in peritoneal carcinomatosis from ovarian cancer: correlation with clinical pathological factors and response to chemotherapy. Onco Targets Ther (2017) 0.75

Feedback control of mitosis in budding yeast. Cell (1991) 12.39

Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20

A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45

Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science (2007) 7.69

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature (1999) 7.21

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet (2004) 6.85

Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell (2006) 6.46

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43

Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell (2006) 6.37

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature (2001) 6.36

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell (2006) 5.88

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell (2000) 5.69

Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell (2002) 5.36

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science (2008) 5.36

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J Cell Biol (1996) 5.24

ATM activation by oxidative stress. Science (2010) 5.22

Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell (2000) 5.10

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol (2001) 5.09

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell (2000) 4.91

The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature (2004) 4.60

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet (2004) 4.58

Chromosomal cohesin forms a ring. Cell (2003) 4.38

Dual inhibition of sister chromatid separation at metaphase. Cell (2001) 4.23

Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr Biol (2006) 3.96

Kinetochore microtubule dynamics and the metaphase-anaphase transition. J Cell Biol (1995) 3.86

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev (2008) 3.79

Identification of aneuploidy-tolerating mutations. Cell (2010) 3.73

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol (2005) 3.72

The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65

Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol (2001) 3.63

Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell (2004) 3.51

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol (2003) 3.40

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol (2010) 3.28

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell (2008) 3.26

Centrosome amplification, chromosome instability and cancer development. Cancer Lett (2005) 3.24

Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res (1997) 3.17

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. J Cell Biol (1996) 2.98

Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol (2009) 2.83

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res (2004) 2.79

Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev (2002) 2.77

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol (2007) 2.69

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet (1998) 2.50

Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci (2008) 2.41

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J Cell Biol (1999) 2.41

BUBR1 deficiency results in abnormal megakaryopoiesis. Blood (2003) 2.31

Constitutional aneuploidy in the normal human brain. J Neurosci (2005) 2.28

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol (2006) 2.24

Regulation of sister chromatid cohesion between chromosome arms. Curr Biol (2004) 2.16

Mitotic checkpoints: from yeast to cancer. Curr Opin Genet Dev (2001) 2.13

sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell (2008) 2.12

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A (2009) 2.04

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Nat Cell Biol (1999) 2.03

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98

Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res (2007) 1.96

Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell (2003) 1.78

Isochromosomes in neoplasia. Genes Chromosomes Cancer (1994) 1.64

Aneuploid neurons are functionally active and integrated into brain circuitry. Proc Natl Acad Sci U S A (2005) 1.53

Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A (2005) 1.52

Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51

Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle (2003) 1.49

The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study. J Histochem Cytochem (2005) 1.42

Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil Cytoskeleton (2000) 1.25

Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J Neurosci (2003) 1.24

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res (2009) 1.23

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut (2008) 1.21

Centrosome abnormalities, genomic instability and carcinogenic progression. Biochim Biophys Acta (2001) 1.19

Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation. J Pathol (2003) 1.16

Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer. Cancer Genet Cytogenet (2007) 1.08

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells. IUBMB Life (2004) 1.07

Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update. Endocr Relat Cancer (2008) 1.05

Individual adult human neurons display aneuploidy: detection by fluorescence in situ hybridization and single neuron PCR. Cell Cycle (2005) 0.92

The dynamics of cancer chromosomes and genomes. Cytogenet Genome Res (2007) 0.90

The clinicopathological significance of BUBR1 overexpression in hepatocellular carcinoma. J Clin Pathol (2009) 0.89

Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas. Cell Oncol (2008) 0.89

Adult murine neurons: their chromatin and chromosome changes and failure to support embryonic development as revealed by nuclear transfer. Cytogenet Genome Res (2002) 0.87

BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival. Head Neck (2010) 0.84

Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res (2013) 6.89

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49

Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66

The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol (2008) 2.53

GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol (2008) 2.45

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98

Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J (2005) 1.97

Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod (2012) 1.88

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol (2006) 1.81

Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest (2014) 1.71

The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One (2010) 1.67

DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci U S A (2005) 1.57

Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51

Dynamic gene expression during the onset of myoblast differentiation in vitro. Genomics (2003) 1.36

The function of APC/CCdh1 in cell cycle and beyond. Cell Div (2009) 1.35

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol (2007) 1.32

Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell (2005) 1.21

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med (2014) 1.18

BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet (2010) 1.18

The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression. Mol Cell Biol (2007) 1.17

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest (2014) 1.03

Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol Cell Biol (2011) 1.00

The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest (2004) 1.00

Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol (2010) 1.00

A transgenic approach for RNA interference-based genetic screening in mice. Proc Natl Acad Sci U S A (2006) 0.99

DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem (2011) 0.97

Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol (2008) 0.95

Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res (2008) 0.89

Transgenic RNA interference in mice. Physiology (Bethesda) (2007) 0.88

The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression. Cell Cycle (2011) 0.88

Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. Mol Cell Biol (2009) 0.88

Production of a mouse line with a conditional Crim1 mutant allele. Genesis (2012) 0.82

Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81

Overexpression of CXC chemokine ligand 14 exacerbates collagen-induced arthritis. J Immunol (2010) 0.81

Cdc14b: a new player in aging. Aging (Albany NY) (2011) 0.78

Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. Proc Natl Acad Sci U S A (2014) 0.76

A phosphatase turns aggressive: the oncogenicity of Cdc14B. Cell Cycle (2011) 0.75

Spindle assembly checkpoint, aneuploidy and tumorigenesis. Cell Cycle (2009) 0.75

Seminars in Cell & Developmental Biology. Anaphase promoting complex, control of mitosis, and beyond & micronutrient and mineral supply in developmental biology. Editorial. Semin Cell Dev Biol (2011) 0.75