Published in Am J Physiol Lung Cell Mol Physiol on October 28, 2005
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med (2009) 1.61
Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem (2010) 1.36
Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease. Oxid Med Cell Longev (2013) 1.34
Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. Antioxid Redox Signal (2008) 1.31
Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter. Am J Physiol Lung Cell Mol Physiol (2007) 1.22
Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis (2008) 1.09
Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis. Am J Respir Cell Mol Biol (2012) 1.06
Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease. Pediatr Nephrol (2009) 1.06
Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix. Am J Respir Cell Mol Biol (2006) 0.98
A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration. Am J Physiol Lung Cell Mol Physiol (2007) 0.96
Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease. Neurobiol Aging (2009) 0.95
Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radic Biol Med (2012) 0.94
Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins. Am J Physiol Lung Cell Mol Physiol (2009) 0.90
Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice. Inhal Toxicol (2011) 0.86
The complex regulation of TGF-β in cardiovascular disease. Vasc Health Risk Manag (2012) 0.86
Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox Biol (2015) 0.83
Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. J Alzheimers Dis (2011) 0.83
Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma. Am J Physiol Lung Cell Mol Physiol (2015) 0.76
Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med (2006) 9.17
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell (2005) 5.90
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev (2008) 3.46
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A (2004) 3.07
Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med (2007) 2.86
Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J (2009) 2.48
Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol (2009) 1.69
Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Biochem Biophys Res Commun (2005) 1.58
Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly. J Cell Biol (2003) 1.54
Cellular response to hypoxia involves signaling via Smad proteins. Blood (2002) 1.45
Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo. Kidney Int (2004) 1.44
Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats. J Appl Physiol (1985) (2012) 1.41
Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci (2003) 1.39
Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem (2004) 1.38
Glutathione metabolism during aging and in Alzheimer disease. Ann N Y Acad Sci (2004) 1.36
Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem (2010) 1.36
Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation. J Biol Chem (2002) 1.36
Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study. Arthritis Rheum (2007) 1.35
Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. Am J Pathol (2004) 1.33
The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex. J Biol Chem (2004) 1.29
Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys (2004) 1.29
Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation. J Biol Chem (2010) 1.25
Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. J Biol Chem (2004) 1.24
Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal. Free Radic Biol Med (2005) 1.24
Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms. Matrix Biol (2012) 1.23
The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem (2002) 1.23
Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics. FASEB J (2004) 1.22
Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter. Am J Physiol Lung Cell Mol Physiol (2007) 1.22
A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Pathol (2007) 1.20
Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications. Am J Physiol Lung Cell Mol Physiol (2010) 1.18
Glutathione regulates transforming growth factor-beta-stimulated collagen production in fibroblasts. Am J Physiol Lung Cell Mol Physiol (2003) 1.17
The N-terminus of thrombospondin: the domain stands apart. Int J Biochem Cell Biol (2004) 1.16
Antioxidant-mediated augmentation of ozone-induced membrane oxidation. Free Radic Biol Med (2005) 1.15
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys (2004) 1.14
The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation. Am J Physiol Lung Cell Mol Physiol (2007) 1.13
Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J Biol Chem (2004) 1.10
Mechanisms and modification of chlorine-induced lung injury in animals. Proc Am Thorac Soc (2010) 1.09
Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice. Am J Respir Cell Mol Biol (2010) 1.09
Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. Toxicol Sci (2012) 1.08
Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells. J Biol Chem (2002) 1.08
Quinones and glutathione metabolism. Methods Enzymol (2004) 1.07
Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am J Pathol (2011) 1.06
Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol (2010) 1.06
Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling. Am J Respir Cell Mol Biol (2010) 1.06
Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis. Am J Respir Cell Mol Biol (2012) 1.06
Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation. Am J Respir Cell Mol Biol (2011) 1.05
4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways. Free Radic Biol Med (2005) 1.05
Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J (2008) 1.05
Regulation of endothelial cell function BY FAK and PYK2. Front Biosci (2004) 1.05
4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. Am J Respir Cell Mol Biol (2005) 1.03
Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. J Biol Chem (2009) 1.02
Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity. Diabetes (2003) 1.00
Influence of epithelial lining fluid lipids on NO(2)-induced membrane oxidation and nitration. Free Radic Biol Med (2003) 0.99
Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I. Exp Cell Res (2006) 0.99
Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow diet. Circulation (2004) 0.98
gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells. Free Radic Biol Med (2005) 0.98
The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia. Microvasc Res (2008) 0.96
Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation. J Biol Chem (2004) 0.96
Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin. Am J Pathol (2008) 0.95
Structural insight into the role of thrombospondin-1 binding to calreticulin in calreticulin-induced focal adhesion disassembly. Biochemistry (2010) 0.95
Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Radic Biol Med (2012) 0.94
Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radic Biol Med (2012) 0.94
Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix. J Biol Chem (2009) 0.94
Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. Biochem J (2010) 0.92
MCP-1 stimulates MMP-9 expression via ERK 1/2 and p38 MAPK signaling pathways in human aortic smooth muscle cells. Cell Physiol Biochem (2014) 0.89
Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation. Biochem Biophys Res Commun (2012) 0.89
Gender differences in glutathione metabolism in Alzheimer's disease. J Neurosci Res (2005) 0.88
Calreticulin regulates transforming growth factor-β-stimulated extracellular matrix production. J Biol Chem (2013) 0.88
Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition. PLoS Pathog (2010) 0.87
A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. Environ Mol Mutagen (2003) 0.87
Site-specific dynamics of CD11b+ and CD103+ dendritic cell accumulations following ozone exposure. Am J Physiol Lung Cell Mol Physiol (2012) 0.87
Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis. J Vasc Res (2009) 0.87
Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair. Oral Biosci Med (2005) 0.86
Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice. Inhal Toxicol (2011) 0.86
Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. Am J Physiol Lung Cell Mol Physiol (2010) 0.85
Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1. Cancer Res (2009) 0.85
Innate immune response to LPS in airway epithelium is dependent on chronological age and antecedent exposures. Am J Respir Cell Mol Biol (2013) 0.85
CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells. Biol Pharm Bull (2009) 0.84
The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling. Am J Pathol (2010) 0.84
Exposing animals to oxidant gases: nose only vs. whole body. Proc Am Thorac Soc (2010) 0.84
Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding. Biochemistry (2011) 0.84
Molecular insight into the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactions. Biochemistry (2014) 0.83
Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression. J Cell Physiol (2006) 0.83
Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitro. Am J Physiol Lung Cell Mol Physiol (2004) 0.83
Amino acids induce indicators of response to injury in glomerular mesangial cells. Am J Physiol Renal Physiol (2003) 0.83
Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. J Alzheimers Dis (2011) 0.83
CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury. J Lipid Res (2013) 0.82
Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques. Toxicol Pathol (2007) 0.81
Panel discussion review: session four--assessing biological plausibility of epidemiological findings in air pollution research. J Expo Sci Environ Epidemiol (2007) 0.79
Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation. Am J Physiol Lung Cell Mol Physiol (2011) 0.79
Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys. Am J Physiol Lung Cell Mol Physiol (2010) 0.78
Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells. Am J Physiol Cell Physiol (2010) 0.78
Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications. Free Radic Biol Med (2012) 0.78
Branch-based model for the diameters of the pulmonary airways: accounting for departures from self-consistency and registration errors. Anat Rec (Hoboken) (2012) 0.78
Hyperglycemic arterial disturbed flow niche as an in vitro model of atherosclerosis. Anal Chem (2014) 0.78
Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats. J Aerosol Med Pulm Drug Deliv (2012) 0.77
On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics? Nitric Oxide (2009) 0.77