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1
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Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.
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Cell
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2005
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5.90
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2
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LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
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Physiol Rev
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2008
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3.46
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3
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Calreticulin: non-endoplasmic reticulum functions in physiology and disease.
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FASEB J
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2009
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2.48
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4
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Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions.
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Biochem Biophys Res Commun
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2005
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1.58
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5
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Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly.
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J Cell Biol
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2003
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1.54
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6
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Cellular response to hypoxia involves signaling via Smad proteins.
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Blood
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2002
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1.45
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7
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Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo.
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Kidney Int
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2004
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1.44
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8
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Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration.
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J Cell Sci
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2003
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1.39
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9
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Molecular interactions that confer latency to transforming growth factor-beta.
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J Biol Chem
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2004
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1.38
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10
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Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation.
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J Biol Chem
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2002
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1.36
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11
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Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli.
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Am J Pathol
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2004
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1.33
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12
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The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex.
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J Biol Chem
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2004
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1.29
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13
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Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.
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J Biol Chem
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2010
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1.25
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14
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Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2.
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J Biol Chem
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2004
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1.24
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15
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The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.
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J Biol Chem
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2002
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1.23
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16
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Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms.
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Matrix Biol
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2012
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1.23
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17
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Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics.
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FASEB J
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2004
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1.22
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18
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A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.
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Am J Pathol
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2007
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1.20
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19
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The N-terminus of thrombospondin: the domain stands apart.
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Int J Biochem Cell Biol
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2004
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1.16
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20
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The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.
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Am J Physiol Lung Cell Mol Physiol
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2007
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1.13
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21
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Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.
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J Biol Chem
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2004
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1.10
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22
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Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells.
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J Biol Chem
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2002
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1.08
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23
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Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy.
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Am J Pathol
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2011
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1.06
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24
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Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.
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FASEB J
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2008
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1.05
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25
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Regulation of endothelial cell function BY FAK and PYK2.
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Front Biosci
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2004
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1.05
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26
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Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation.
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J Biol Chem
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2009
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1.02
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27
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Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity.
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Diabetes
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2003
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1.00
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28
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Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I.
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Exp Cell Res
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2006
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0.99
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29
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The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia.
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Microvasc Res
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2008
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0.96
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30
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Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen.
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Am J Physiol Lung Cell Mol Physiol
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2005
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0.96
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31
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Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation.
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J Biol Chem
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2004
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0.96
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32
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Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.
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Am J Pathol
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2008
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0.95
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33
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Structural insight into the role of thrombospondin-1 binding to calreticulin in calreticulin-induced focal adhesion disassembly.
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Biochemistry
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2010
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0.95
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34
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Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix.
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J Biol Chem
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2009
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0.94
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35
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Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.
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Biochem J
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2010
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0.92
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36
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Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation.
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Biochem Biophys Res Commun
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2012
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0.89
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37
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Calreticulin regulates transforming growth factor-β-stimulated extracellular matrix production.
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J Biol Chem
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2013
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0.88
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38
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Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition.
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PLoS Pathog
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2010
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0.87
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39
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Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis.
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J Vasc Res
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2009
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0.87
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40
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Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair.
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Oral Biosci Med
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2005
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0.86
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41
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Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.
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Cancer Res
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2009
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0.85
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42
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The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling.
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Am J Pathol
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2010
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0.84
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43
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Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding.
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Biochemistry
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2011
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0.84
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44
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Molecular insight into the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactions.
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Biochemistry
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2014
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0.83
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45
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Amino acids induce indicators of response to injury in glomerular mesangial cells.
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Am J Physiol Renal Physiol
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2003
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0.83
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46
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CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury.
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J Lipid Res
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2013
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0.82
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47
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Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation.
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Am J Physiol Lung Cell Mol Physiol
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2011
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0.79
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48
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Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells.
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Am J Physiol Cell Physiol
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2010
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0.78
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49
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Hyperglycemic arterial disturbed flow niche as an in vitro model of atherosclerosis.
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Anal Chem
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2014
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0.78
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50
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Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation.
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J Vasc Res
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2016
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0.76
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