Published in Cell on October 21, 2005
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C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol (2008) 1.59
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity (2015) 1.56
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Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol (2009) 1.39
Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther (2011) 1.39
Danger signalling during cancer cell death: origins, plasticity and regulation. Cell Death Differ (2013) 1.39
Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci U S A (2011) 1.38
Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal (2008) 1.38
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med (2013) 1.36
Interactions of tumor cells with dendritic cells: balancing immunity and tolerance. Cell Death Differ (2007) 1.35
Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A (2011) 1.35
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Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells Mol Dis (2010) 1.31
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Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol (2016) 1.26
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Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler Thromb Vasc Biol (2010) 1.23
Calreticulin in the immune system: ins and outs. Trends Immunol (2012) 1.23
Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis. Cell Death Differ (2010) 1.22
State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 1.21
Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol (2008) 1.20
Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration. Front Pharmacol (2012) 1.20
Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia. Cell Death Dis (2010) 1.18
NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem (2008) 1.16
CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease. ISRN Hematol (2013) 1.16
Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Cell Death Differ (2013) 1.13
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Calreticulin enhances porcine wound repair by diverse biological effects. Am J Pathol (2008) 1.10
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The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J Leukoc Biol (2008) 1.10
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Immunosurveillance and immunotherapy of tumors by innate immune cells. Curr Opin Immunol (2015) 1.10
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci (2009) 1.09
Ageing is associated with diminished apoptotic cell clearance in vivo. Clin Exp Immunol (2008) 1.09
Dying cell clearance and its impact on the outcome of tumor radiotherapy. Front Oncol (2012) 1.08
Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A (2015) 1.08
Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet (2009) 1.07
Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells. J Immunol (2011) 1.07
Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis. J Immunol (2014) 1.06
CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest. Br J Pharmacol (2012) 1.06
Cancer and innate immune system interactions: translational potentials for cancer immunotherapy. J Immunother (2012) 1.05
Prognostic effect of calreticulin mutations in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation. Leukemia (2014) 1.05
Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J (2008) 1.05
Eat-me signals: keys to molecular phagocyte biology and "appetite" control. J Cell Physiol (2012) 1.04
Electrochemotherapy with bleomycin induces hallmarks of immunogenic cell death in murine colon cancer cells. Oncoimmunology (2014) 1.04
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest (2002) 5.55
Resolution of lung inflammation by CD44. Science (2002) 4.09
By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell (2003) 3.65
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Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest (2006) 2.93
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Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem (2006) 2.47
Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol (2002) 2.43
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood (2006) 2.41
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Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem (2004) 2.30
Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest (2002) 2.19
Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood (2004) 2.17
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The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. PLoS One (2012) 2.05
Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood (2008) 2.02
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med (2011) 1.95
Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med (2011) 1.92
Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol (2005) 1.86
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem (2001) 1.86
Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol (2003) 1.82
Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland. Biol Reprod (2007) 1.81
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med (2012) 1.81
Calreticulin signaling in health and disease. Int J Biochem Cell Biol (2012) 1.81
A detailed evaluation of acute respiratory decline in patients with fibrotic lung disease: aetiology and outcomes. Respirology (2010) 1.80
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Recognition ligands on apoptotic cells: a perspective. J Leukoc Biol (2006) 1.78
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol (2005) 1.77
Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum. Int J Biochem Cell Biol (2005) 1.77
Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J (2004) 1.74
The final step in programmed cell death: phagocytes carry apoptotic cells to the grave. Essays Biochem (2003) 1.70
Caregiver negative affect is a primary determinant of caregiver report of pediatric asthma quality of life. Ann Allergy Asthma Immunol (2002) 1.67
Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A (2006) 1.64
ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol (2006) 1.63
Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Mol Cell (2004) 1.62
Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol (2006) 1.62
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc Natl Acad Sci U S A (2007) 1.58
Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Biochem Biophys Res Commun (2005) 1.58
Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. Am J Respir Cell Mol Biol (2002) 1.57
Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood (2005) 1.55
Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity (2012) 1.55
Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J (2004) 1.54
Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly. J Cell Biol (2003) 1.54
IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol (2011) 1.54
Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity (2002) 1.54
Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem (2002) 1.53
Calcium-binding proteins and calcium-release channels in human maturing oocytes, pronuclear zygotes and early preimplantation embryos. Hum Reprod (2002) 1.52
Neutrophil clearance: when the party is over, clean-up begins. Trends Immunol (2011) 1.47
Cellular response to hypoxia involves signaling via Smad proteins. Blood (2002) 1.45
Endoplasmic reticulum quality control and apoptosis. Acta Biochim Pol (2005) 1.45
Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo. Kidney Int (2004) 1.44
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood (2006) 1.44
Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. Mol Phylogenet Evol (2005) 1.44
Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med (2011) 1.43
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathog (2007) 1.41
Modulation of macrophage efferocytosis in inflammation. Front Immunol (2011) 1.40
Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci (2003) 1.39
Clinical problem-solving. The missing piece. N Engl J Med (2006) 1.38
Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem (2004) 1.38
Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. J Clin Invest (2007) 1.38
The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood (2006) 1.37
Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation. J Biol Chem (2002) 1.36
SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol (2011) 1.35
Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. Am J Pathol (2004) 1.33
Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol (2008) 1.32
Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57. Int Rev Cytol (2005) 1.32
Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med (2009) 1.31
Calcium signalling: past, present and future. Cell Calcium (2005) 1.31
The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex. J Biol Chem (2004) 1.29
Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am J Respir Crit Care Med (2008) 1.28
Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol (2008) 1.26
Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation. J Biol Chem (2010) 1.25
Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A (2011) 1.25
Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-beta activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2. J Biol Chem (2004) 1.24