Published in Curr Opin Struct Biol on November 02, 2005
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex. EMBO Rep (2007) 2.01
Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A (2006) 1.80
Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry (2008) 1.68
Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol Microbiol (2010) 1.58
Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol (2009) 1.29
Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genet Biol (2010) 1.28
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
Epigenetics in atherosclerosis and inflammation. J Cell Mol Med (2010) 1.21
The activity of HDAC8 depends on local and distal sequences of its peptide substrates. Biochemistry (2008) 1.14
Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations. J Am Chem Soc (2008) 1.14
Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One (2010) 1.06
Transcriptional regulation of neuronal differentiation: the epigenetic layer of complexity. Biochim Biophys Acta (2008) 0.98
Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer. Cell Cycle (2011) 0.95
HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases. Chonnam Med J (2016) 0.93
The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer (2013) 0.92
Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate. Bioorg Med Chem Lett (2011) 0.91
Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. Anal Biochem (2010) 0.90
General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry (2016) 0.82
Prospects for the development of epigenetic drugs for CNS conditions. Nat Rev Drug Discov (2015) 0.82
Folate deficiency affects histone methylation. Med Hypotheses (2016) 0.78
The HIRA complex that deposits the histone H3.3 is conserved in Arabidopsis and facilitates transcriptional dynamics. Biol Open (2014) 0.77
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature (2008) 2.83
The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Nat Struct Biol (2002) 2.56
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol (2008) 1.89
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell (2011) 1.86
Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. Mol Cell (2007) 1.77
Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol (2008) 1.72
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci U S A (2003) 1.68
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor. J Biol Chem (2005) 1.61
Structure of the p53 core domain dimer bound to DNA. J Biol Chem (2006) 1.60
Structure and autoregulation of the yeast Hst2 homolog of Sir2. Nat Struct Biol (2003) 1.59
Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol (2006) 1.58
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide. Structure (2003) 1.55
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. Structure (2008) 1.55
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev (2007) 1.49
Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Mol Cell (2003) 1.47
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc Natl Acad Sci U S A (2004) 1.45
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc Natl Acad Sci U S A (2006) 1.44
A mechanism-based inactivator for histone demethylase LSD1. J Am Chem Soc (2006) 1.43
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. Cell Rep (2013) 1.43
Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem (2007) 1.40
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli. J Mol Biol (2004) 1.31
MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J (2011) 1.29
Structure of Vps75 and implications for histone chaperone function. Proc Natl Acad Sci U S A (2008) 1.27
14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation. Mol Cell Biol (2008) 1.27
Structural basis for sirtuin function: what we know and what we don't. Biochim Biophys Acta (2009) 1.26
Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. Biochem Pharmacol (2010) 1.24
Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol (2008) 1.23
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A (2002) 1.22
Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. J Am Chem Soc (2008) 1.21
Structural basis for dimerization in DNA recognition by Gal4. Structure (2008) 1.16
Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat Struct Mol Biol (2013) 1.16
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J Am Chem Soc (2010) 1.15
Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA binding. J Biol Chem (2003) 1.14
Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. Biochemistry (2008) 1.14
Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep (2006) 1.12
Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. Blood (2010) 1.11
Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J Am Chem Soc (2011) 1.11
Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. Biochemistry (2003) 1.11
Structure of a ternary Naa50p (NAT5/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation. J Biol Chem (2011) 1.11
SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity. J Biol Chem (2011) 1.09
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem (2013) 1.09
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. ACS Chem Biol (2008) 1.09
Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family. Structure (2006) 1.07
Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. Structure (2011) 1.07
Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1. J Virol (2005) 1.06
The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. J Biol Chem (2007) 1.05
Identification of host-chromosome binding sites and candidate gene targets for Kaposi's sarcoma-associated herpesvirus LANA. J Virol (2012) 1.05
Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry (2007) 1.05
Structural basis for sirtuin activity and inhibition. J Biol Chem (2012) 1.04
Acridine derivatives activate p53 and induce tumor cell death through Bax. Cancer Biol Ther (2005) 1.02
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol (2011) 1.00
Histone acetyltransferases: Rising ancient counterparts to protein kinases. Biopolymers (2013) 0.98
Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A (2012) 0.98
Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme. J Mol Biol (2007) 0.97
The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry (2009) 0.97
Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA. PLoS Pathog (2013) 0.95
Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor. J Biol Chem (2005) 0.93
Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chem Biol (2014) 0.92
The microtubule-associated tau protein has intrinsic acetyltransferase activity. Nat Struct Mol Biol (2013) 0.91
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem (2013) 0.91
Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. Structure (2006) 0.90
When viral oncoprotein meets tumor suppressor: a structural view. Genes Dev (2006) 0.90
The art of filling protein pockets efficiently with octahedral metal complexes. Angew Chem Int Ed Engl (2012) 0.90
Ankyrin for methylated lysines. Nat Struct Mol Biol (2008) 0.90
Structure and mechanism of non-histone protein acetyltransferase enzymes. FEBS J (2013) 0.90
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry (2012) 0.89
Structure and biochemical characterization of protein acetyltransferase from Sulfolobus solfataricus. J Biol Chem (2009) 0.88
Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. J Med Chem (2009) 0.87
Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity. J Biol Chem (2002) 0.86
The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain. J Mol Biol (2007) 0.86
Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics. J Proteomics (2012) 0.86
Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins. Chem Biol (2012) 0.86
Identification of a novel family of BRAF(V600E) inhibitors. J Med Chem (2012) 0.85
High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. Acta Crystallogr D Biol Crystallogr (2006) 0.85
Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog. Proc Natl Acad Sci U S A (2013) 0.85
Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem Biol (2014) 0.84
Different regions of the HPV-E7 and Ad-E1A viral oncoproteins bind competitively but through distinct mechanisms to the CH1 transactivation domain of p300. Biochemistry (2012) 0.81
Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem (2009) 0.79
Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization. Org Biomol Chem (2012) 0.78
Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases. PLoS One (2012) 0.78
Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues. Biochemistry (2014) 0.78
Co-expression of proteins in E. coli using dual expression vectors. Methods Mol Biol (2003) 0.78
Biochemistry. Red wine, toast of the town (again). Science (2013) 0.78
Insights into structure and function of GCN5/PCAF and yEsa 1 histone acetyltransferase domains:. Methods Enzymol (2003) 0.77
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction. J Phys Chem B (2014) 0.77
Development of organometallic S6K1 inhibitors. J Med Chem (2014) 0.76
Anticipating drug resistance in the MAP kinase pathway. Pigment Cell Melanoma Res (2009) 0.76
Crystallization of macromolecules. Curr Protoc Protein Sci (2004) 0.75
Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAF(V600E) inhibitors. Bioorg Med Chem Lett (2013) 0.75
Crystallization of macromolecules. Curr Protoc Protein Sci (2011) 0.75