Published in Structure on July 01, 2008
Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79
A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding. Cell (2010) 2.00
Structural basis for cooperative RNA binding and export complex assembly by HIV Rev. Nat Struct Mol Biol (2010) 1.57
Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae. Mol Biol Cell (2011) 1.21
Massively parallel single-amino-acid mutagenesis. Nat Methods (2015) 1.14
Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Proc Natl Acad Sci U S A (2012) 0.93
In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity. Sci Rep (2016) 0.91
Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator. J Biol Chem (2011) 0.88
Guiding lights: recent developments in optogenetic control of biochemical signals. Pflugers Arch (2013) 0.86
Locally, meiotic double-strand breaks targeted by Gal4BD-Spo11 occur at discrete sites with a sequence preference. Mol Cell Biol (2009) 0.86
Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol (2017) 0.81
Distance and helical phase dependence of synergistic transcription activation in cis-regulatory module. PLoS One (2012) 0.80
Monitoring molecular-specific pharmacodynamics of rapamycin in vivo with inducible Gal4->Fluc transgenic reporter mice. Mol Cancer Ther (2010) 0.76
A virtual pebble game to ensemble average graph rigidity. Algorithms Mol Biol (2015) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65
Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys J (2000) 21.93
LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng (1995) 19.22
Deletion analysis of GAL4 defines two transcriptional activating segments. Cell (1987) 14.13
Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01
A new class of yeast transcriptional activators. Cell (1987) 9.53
Calculation of hydrodynamic properties of globular proteins from their atomic-level structure. Biophys J (2000) 7.40
A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. Microbiol Rev (1987) 7.00
Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science (1986) 6.79
DNA recognition by GAL4: structure of a protein-DNA complex. Nature (1992) 5.60
An amino-terminal fragment of GAL4 binds DNA as a dimer. J Mol Biol (1989) 3.65
Regulation of the galactose pathway in Saccharomyces cerevisiae: induction of uridyl transferase mRNA and dependency on GAL4 gene function. Proc Natl Acad Sci U S A (1978) 3.49
Genetic co-regulation of galactose and melibiose utilization in Saccharomyces. J Bacteriol (1976) 2.92
Contact with a component of the polymerase II holoenzyme suffices for gene activation. Cell (1995) 2.85
Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol (1997) 2.40
GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators. Cell (1990) 2.26
Gene activation by recruitment of the RNA polymerase II holoenzyme. Genes Dev (1996) 1.90
Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae. Nature (1992) 1.79
Crystal structure of a PPR1-DNA complex: DNA recognition by proteins containing a Zn2Cys6 binuclear cluster. Genes Dev (1994) 1.62
DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA. Mol Cell Biol (1996) 1.54
Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein. Nat Struct Biol (1999) 1.51
Hydration from hydrodynamics. General considerations and applications of bead modelling to globular proteins. Biophys Chem (2001) 1.37
Toxicity of 2-deoxygalactose to Saccharomyces cerevisiae cells constitutively synthesizing galactose-metabolizing enzymes. Mol Cell Biol (1984) 1.32
Crystal structure of a PUT3-DNA complex reveals a novel mechanism for DNA recognition by a protein containing a Zn2Cys6 binuclear cluster. Nat Struct Biol (1997) 1.30
A genetic switch in a bacterial virus. Sci Am (1982) 1.28
Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme. Mol Cell (1998) 1.04
Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain. Genes Dev (2001) 0.96
Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. Structure (2006) 0.90
Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation. Nat Struct Biol (1999) 0.89
Modulation of DNA-binding domains for sequence-specific DNA recognition. Gene (2003) 0.87
Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation. Nucleic Acids Res (2000) 0.78
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (2013) 6.43
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
Forced unfolding of proteins within cells. Science (2007) 3.95
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci (2008) 3.86
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics (2007) 3.53
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature (2008) 2.83
HUPO Plasma Proteome Project specimen collection and handling: towards the standardization of parameters for plasma proteome samples. Proteomics (2005) 2.71
Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study. Nat Biotechnol (2006) 2.66
The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Nat Struct Biol (2002) 2.56
A chromatin remodelling complex that loads cohesin onto human chromosomes. Nature (2002) 2.53
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Altered functional connectivity and small-world in mesial temporal lobe epilepsy. PLoS One (2010) 2.37
Structural and functional effects of hereditary hemolytic anemia-associated point mutations in the alpha spectrin tetramer site. Blood (2008) 2.12
Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma. Proteomics (2005) 2.02
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat Struct Mol Biol (2008) 1.89
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell (2011) 1.86
Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation. Mol Cell (2012) 1.85
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. Mol Cell (2007) 1.77
Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol (2008) 1.72
Cooperativity in forced unfolding of tandem spectrin repeats. Biophys J (2003) 1.70
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci U S A (2003) 1.68
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67
A novel four-dimensional strategy combining protein and peptide separation methods enables detection of low-abundance proteins in human plasma and serum proteomes. Proteomics (2005) 1.62
Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp (2010) 1.62
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor. J Biol Chem (2005) 1.61
Structure of the p53 core domain dimer bound to DNA. J Biol Chem (2006) 1.60
Structure and autoregulation of the yeast Hst2 homolog of Sir2. Nat Struct Biol (2003) 1.59
Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol (2006) 1.58
Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance. Structure (2012) 1.56
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide. Structure (2003) 1.55
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. Structure (2008) 1.55
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol Cell (2005) 1.51
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev (2007) 1.49
Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase. Mol Cell (2003) 1.47
Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains. Biophys J (2003) 1.46
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc Natl Acad Sci U S A (2004) 1.45
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc Natl Acad Sci U S A (2006) 1.44
A mechanism-based inactivator for histone demethylase LSD1. J Am Chem Soc (2006) 1.43
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. Cell Rep (2013) 1.43
The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation. Blood (2013) 1.43
Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem (2007) 1.40
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity. Biochem J (2009) 1.32
Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Escherichia coli. J Mol Biol (2004) 1.31
Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun (2013) 1.29
MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J (2011) 1.29
Structure of Vps75 and implications for histone chaperone function. Proc Natl Acad Sci U S A (2008) 1.27
14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation. Mol Cell Biol (2008) 1.27
Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell. Cell (2012) 1.26
Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection. Blood (2003) 1.26
Structural basis for sirtuin function: what we know and what we don't. Biochim Biophys Acta (2009) 1.26
Comparison of extensive protein fractionation and repetitive LC-MS/MS analyses on depth of analysis for complex proteomes. J Proteome Res (2010) 1.25
Structure and activity of enzymes that remove histone modifications. Curr Opin Struct Biol (2005) 1.24
Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. Biochem Pharmacol (2010) 1.24
Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol (2008) 1.23
Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood (2006) 1.22
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A (2002) 1.22
Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. J Am Chem Soc (2008) 1.21
Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci (2010) 1.21
Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1. J Biol Chem (2008) 1.18
Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A (2012) 1.18
Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci (2007) 1.17
Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci (2011) 1.17
Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics (2009) 1.17
Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci (2007) 1.16
Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat Struct Mol Biol (2013) 1.16
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J Am Chem Soc (2010) 1.15
Structure of a Sir2 substrate, Alba, reveals a mechanism for deacetylation-induced enhancement of DNA binding. J Biol Chem (2003) 1.14
Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J (2013) 1.14
Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. Biochemistry (2008) 1.14
Systematic discovery of ectopic pregnancy serum biomarkers using 3-D protein profiling coupled with label-free quantitation. J Proteome Res (2011) 1.14
Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep (2006) 1.12
Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol (2004) 1.12
Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer. BMC Syst Biol (2013) 1.12
Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding. J Biol Chem (2004) 1.11
Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. Blood (2010) 1.11
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A (2012) 1.11
Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem (2007) 1.11
Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities. J Biol Chem (2010) 1.11
Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates. Biochemistry (2003) 1.11