Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 1410764)

Published in Breast Cancer Res on September 30, 2005

Authors

Paige J Baugher1, Lakshmi Krishnamoorthy, Janet E Price, Surangani F Dharmawardhane

Author Affiliations

1: Molecular Cell and Developmental Biology Section and The Institute for Cellular and Molecular Biology, The University of Texas at Austin, University Station, Austin, TX 78712, USA. p.baugher@mail.utexas.edu

Articles citing this

Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer. J Proteome Res (2010) 1.75

Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61

p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48

Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res (2009) 1.39

RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis. Mol Cancer Ther (2013) 1.21

Gbetagamma signaling promotes breast cancer cell migration and invasion. J Pharmacol Exp Ther (2010) 1.18

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem (2012) 1.17

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol (2014) 1.15

Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling. J Biol Chem (2009) 1.09

Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia (2007) 1.07

Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. J Biol Chem (2009) 1.06

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion. Biochem Pharmacol (2013) 0.97

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer. Endocr Relat Cancer (2011) 0.95

The tumor suppressor role of miR-124 in osteosarcoma. PLoS One (2014) 0.95

Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. J Biol Chem (2010) 0.94

The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. Transl Oncol (2014) 0.94

ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration. Clin Exp Metastasis (2010) 0.91

Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation. PLoS Genet (2006) 0.90

Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment? Curr Drug Targets (2010) 0.87

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Mol Med (2007) 0.87

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity. Int J Cancer (2009) 0.87

RAC3 is a pro-migratory co-activator of ERα. Oncogene (2011) 0.86

Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines. BMC Cancer (2013) 0.83

Phosphorylation of Cdc42 effector protein-4 (CEP4) by protein kinase C promotes motility of human breast cells. J Biol Chem (2014) 0.82

A computer-assisted 3D model for analyzing the aggregation of tumorigenic cells reveals specialized behaviors and unique cell types that facilitate aggregate coalescence. PLoS One (2015) 0.82

Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS One (2015) 0.81

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One (2015) 0.77

Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2015) 0.77

Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adh Migr (2015) 0.76

Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility. Soft Matter (2014) 0.76

Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells. Mol Biol Cell (2017) 0.75

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther (2017) 0.75

Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44. PLoS One (2017) 0.75

Rac1 is a potential target to circumvent radioresistance. J Thorac Dis (2016) 0.75

Association of RAC1 Gene Polymorphisms with Primary End-Stage Renal Disease in Chinese Renal Recipients. PLoS One (2016) 0.75

Mediated coalescence: a possible mechanism for tumor cellular heterogeneity. Am J Cancer Res (2015) 0.75

Articles cited by this

Cell migration: integrating signals from front to back. Science (2003) 29.13

Rho and Rac take center stage. Cell (2004) 10.64

Integrin signalling during tumour progression. Nat Rev Mol Cell Biol (2004) 6.53

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80

Rho GTPases and cell migration. J Cell Sci (2001) 5.66

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol (1998) 4.22

The interplay between Src and integrins in normal and tumor biology. Oncogene (2004) 3.37

Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta (2004) 2.98

Rho GTPases: signaling, migration, and invasion. Exp Cell Res (2000) 2.82

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell (1996) 2.39

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38

Rho GTPases in transformation and metastasis. Adv Cancer Res (2002) 2.07

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci U S A (2000) 1.97

Characterization of RAC3, a novel member of the Rho family. J Biol Chem (1997) 1.82

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol (2002) 1.72

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem (1992) 1.69

Regulation of WASP/WAVE proteins: making a long story short. J Cell Biol (2004) 1.50

Increased levels of alpha6 integrins are associated with the metastatic phenotype of human breast cancer cells. Clin Exp Metastasis (1999) 1.47

Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med (2001) 1.46

Altered Rho GTPase signaling pathways in breast cancer cells. Breast Cancer Res Treat (2004) 1.41

Lamellipodia in invasion. Semin Cancer Biol (2001) 1.40

Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Semin Cancer Biol (2001) 1.30

Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci (2003) 1.19

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci (2004) 1.14

N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. J Cell Sci (2002) 1.14

Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors. J Cancer Res Clin Oncol (2001) 1.04

Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target. Carcinogenesis (2004) 1.01

Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid. Biochem Biophys Res Commun (2000) 0.96

Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions. Cells Tissues Organs (2003) 0.94

Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancers. Breast Cancer Res (2003) 0.85

Measurement of protein tyrosine phosphorylation in cell adhesion. Methods Mol Biol (2005) 0.80

Articles by these authors

Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res (2005) 2.46

Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy. Mol Cancer Ther (2003) 2.08

Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo. J Clin Oncol (2004) 1.84

The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat (2004) 1.69

CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer. Clin Cancer Res (2005) 1.66

Breast cancer metastasis: challenges and opportunities. Cancer Res (2009) 1.63

CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res (2005) 1.54

Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice. Clin Exp Metastasis (2004) 1.53

Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res (2011) 1.35

Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem (2009) 1.32

alphaB-crystallin as a marker of lymph node involvement in breast carcinoma. Cancer (2004) 1.20

Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease. Cancer Res (2005) 1.20

Chemokine receptor CXCR4 expression in breast cancer as a potential predictive marker of isolated tumor cells in bone marrow. Clin Exp Metastasis (2005) 1.18

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res (2008) 1.14

Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice. Cancer Res (2003) 1.13

Podocalyxin expression in malignant astrocytic tumors. Biochem Biophys Res Commun (2008) 1.10

The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model. BMC Cancer (2012) 1.08

Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia (2007) 1.07

Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice. Clin Cancer Res (2005) 1.05

Activation of notch signaling in a xenograft model of brain metastasis. Clin Cancer Res (2008) 1.02

Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol (2008) 1.01

Characterization of anti-podoplanin monoclonal antibodies: critical epitopes for neutralizing the interaction between podoplanin and CLEC-2. Hybridoma (Larchmt) (2008) 1.01

Phosphorylation of galectin-3 contributes to malignant transformation of human epithelial cells via modulation of unique sets of genes. Cancer Res (2005) 0.97

Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to taxol-induced apoptosis in vitro and in vivo. Neoplasia (2009) 0.95

Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model. Breast J (2009) 0.91

Different signalling pathways regulate VEGF and IL-8 expression in breast cancer: implications for therapy. Eur J Cancer (2004) 0.90

Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar. Am J Pathol (2011) 0.88

Differential expression of MHC class II molecules in highly metastatic breast cancer cells is mediated by the regulation of the CIITA transcription Implication of CIITA in tumor and metastasis development. Int J Biochem Cell Biol (2005) 0.87

Aberrant promoter methylation of the RASSF1A and APC genes in epithelial ovarian carcinoma development. Cell Oncol (Dordr) (2012) 0.87

Selection of more aggressive variants of the gI101A human breast cancer cell line: a model for analyzing the metastatic phenotype of breast cancer. Clin Exp Metastasis (2003) 0.86

Altered expression of β-catenin, E-cadherin, and E-cadherin promoter methylation in epithelial ovarian carcinoma. Tumour Biol (2013) 0.85

Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model. J Urol (2002) 0.83

Renal cell carcinoma bone metastasis: epidermal growth factor receptor targeting. Clin Orthop Relat Res (2003) 0.82

Prime-boost vaccination with plasmid and adenovirus gene vaccines control HER2/neu+ metastatic breast cancer in mice. Breast Cancer Res (2005) 0.81

Epigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinoma. Tumour Biol (2014) 0.80

Clinical outcome of adjuvant endocrine treatment according to Her-2/neu status in breast cancer. Indian J Med Res (2011) 0.79

Evaluation of immunohistochemistry and enzyme linked immunosorbent assay for HER-2/neu expression in breast carcinoma. Indian J Clin Biochem (2008) 0.79

Correlation study of Carcino Embryonic Antigen & Cancer Antigen 15.3 in pretreated female breast cancer patients. Indian J Clin Biochem (2007) 0.79

Association of methylenetetrahydrofolate reductase gene polymorphisms & colorectal cancer in India. Indian J Med Res (2010) 0.78

BRCA1 promoter hypermethylation and protein expression in ovarian carcinoma--an Indian study. Tumour Biol (2014) 0.78

Clinical utility of serum human epidermal receptor-2/neu detection in breast cancer patients. Indian J Med Res (2007) 0.77

Near real-time in vivo confocal imaging of mouse mammary tumors. Front Biosci (2002) 0.77

Effect of Vitamin B(12) and Folate on Homocysteine levels in colorectal cancer. Indian J Clin Biochem (2008) 0.77

Biomarkers for breast cancer: the search continues. Cancer Biol Ther (2010) 0.77

Clinically relevant metastatic breast cancer models to study chemosensitivity. Methods Mol Med (2005) 0.76

Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia. Indian J Pediatr (2008) 0.76

Association between plasma homocysteine and riboflavin status in Acute Lymphoblastic Leukemia in children. Indian J Clin Biochem (2009) 0.75

Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold. Ann Biomed Eng (2011) 0.75

Therapeutic intervention with breast cancer metastasis. Crit Rev Eukaryot Gene Expr (2002) 0.75