Gbetagamma signaling promotes breast cancer cell migration and invasion.

Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Oncogene (2012) 1.69

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem (2012) 1.17

Targeting G protein coupled receptor-related pathways as emerging molecular therapies. Saudi Pharm J (2013) 1.06

Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Mol Pharmacol (2011) 1.04

NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest (2013) 0.99

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J Cell Biol (2012) 0.99

A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer. J Biol Chem (2011) 0.98

CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model. PLoS One (2012) 0.98

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion. Biochem Pharmacol (2013) 0.97

Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling. J Am Soc Nephrol (2013) 0.97

Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene (2014) 0.95

The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. J Biol Chem (2011) 0.91

Phosphoinositide 3-kinase gamma regulates airway smooth muscle contraction by modulating calcium oscillations. J Pharmacol Exp Ther (2010) 0.91

RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer. Oncogenesis (2013) 0.87

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics. Trends Pharmacol Sci (2013) 0.87

Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3). J Biol Chem (2014) 0.86

Inhibition of the ethanol-induced potentiation of α1 glycine receptor by a small peptide that interferes with Gβγ binding. J Biol Chem (2012) 0.84

A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis. J Biol Chem (2014) 0.84

Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion. Oncotarget (2016) 0.84

The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. Cell Adh Migr (2012) 0.82

Direct-reversible binding of small molecules to G protein βγ subunits. Biochim Biophys Acta (2011) 0.82

Gβγ subunits inhibit Epac-induced melanoma cell migration. BMC Cancer (2011) 0.80

A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell (2014) 0.77

Distinct pathways of ERK1/2 activation by hydroxy-carboxylic acid receptor-1. PLoS One (2014) 0.77

Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma. Oncogene (2015) 0.76

PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway. Cell Signal (2015) 0.75

GPCR Signaling Mediates Tumor Metastasis via PI3Kβ. Cancer Res (2016) 0.75

CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer. Mol Cancer Ther (2015) 0.75

Cellular Contraction Can Drive Rapid Epithelial Flows. Biophys J (2017) 0.75

Cancer statistics, 2008. CA Cancer J Clin (2008) 86.74

G proteins: transducers of receptor-generated signals. Annu Rev Biochem (1987) 27.41

G-protein-coupled receptors and cancer. Nat Rev Cancer (2007) 6.80

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood (2005) 5.21

Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol (2004) 4.96

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell (2005) 3.92

Regulation of cancer cell motility through actin reorganization. Cancer Sci (2005) 3.87

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell (2002) 3.80

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell (2003) 3.66

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett (2002) 3.56

Differential targeting of Gbetagamma-subunit signaling with small molecules. Science (2006) 2.96

Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene (2001) 2.77

RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (1997) 2.43

Functions of CXCL12 and CXCR4 in breast cancer. Cancer Lett (2005) 2.11

G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci (2008) 2.05

Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci U S A (1997) 1.99

Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol Pharmacol (2007) 1.98

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem (1995) 1.85

The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat Protoc (2007) 1.82

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene (2009) 1.76

Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE (2000) 1.68

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54

Regulation of nuclear factor kappaB activation by G-protein-coupled receptors. J Leukoc Biol (2001) 1.50

Lamellipodia in invasion. Semin Cancer Biol (2001) 1.40

Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res (2009) 1.39

Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proc Natl Acad Sci U S A (1997) 1.38

G proteins in cancer: the prostate cancer paradigm. Sci STKE (2004) 1.37

Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration. J Neurosci (2005) 1.31

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer Res (2005) 1.30

Galphai is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem (1999) 1.26

Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukoc Biol (2007) 1.17

P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res (2007) 1.17

Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. J Biol Chem (2003) 1.11

The active role of beta gamma in signal transduction. Curr Opin Cell Biol (1994) 1.05

Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex. Cancer Res (2006) 1.03

Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. J Biol Chem (2001) 1.03

Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol Pharmacol (2007) 0.94

Suppression of cellular invasion by activated G-protein subunits Galphao, Galphai1, Galphai2, and Galphai3 and sequestration of Gbetagamma. Mol Pharmacol (2001) 0.81

Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation. Peptides (2004) 0.77

The status of the world's land and marine mammals: diversity, threat, and knowledge. Science (2008) 8.03

The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti. PLoS Pathog (2010) 3.59

Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem (2003) 2.15

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology (2006) 2.01

Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host. BMC Genomics (2008) 1.84

A DNAbeta associated with Tomato yellow leaf curl China virus is required for symptom induction. J Virol (2004) 1.79

Characterization of DNAbeta associated with begomoviruses in China and evidence for co-evolution with their cognate viral DNA-A. J Gen Virol (2003) 1.79

Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling. Mol Endocrinol (2010) 1.77

Vitronectin: growth factor complexes hold potential as a wound therapy approach. J Invest Dermatol (2008) 1.71

Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. J Biol Chem (2011) 1.52

Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol (2011) 1.50

Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res (2009) 1.39

Diet-induced obesity and hepatic steatosis in L-Fabp / mice is abrogated with SF, but not PUFA, feeding and attenuated after cholesterol supplementation. Am J Physiol Gastrointest Liver Physiol (2007) 1.34

Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology (2008) 1.32

Suppression of methylation-mediated transcriptional gene silencing by βC1-SAHH protein interaction during geminivirus-betasatellite infection. PLoS Pathog (2011) 1.30

A prospective phase II study of L-asparaginase- CHOP plus radiation in newly diagnosed extranodal NK/T-cell lymphoma, nasal type. J Hematol Oncol (2013) 1.20

The role of voltage-gated potassium channels in the regulation of mouse uterine contractility. Reprod Biol Endocrinol (2007) 1.13

Tobacco curly shoot virus DNAbeta Is Not Necessary for Infection but Intensifies Symptoms in a Host-Dependent Manner. Phytopathology (2005) 1.13

L-asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type. Ann Hematol (2008) 1.09

Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing. BMC Genomics (2014) 1.09

Performance of shear wave elastography for differentiation of benign and malignant solid breast masses. PLoS One (2013) 1.05

Characterization of small interfering RNAs derived from the geminivirus/betasatellite complex using deep sequencing. PLoS One (2011) 1.04

Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth. J Biol Chem (2010) 1.03

Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J Lipid Res (2008) 1.03

Response of the mosquito protein interaction network to dengue infection. BMC Genomics (2010) 1.02

Biliary ascariasis in a bile duct stones-removed female patient. World J Gastroenterol (2013) 1.01

Automated modular synthesis of aptamer-drug conjugates for targeted drug delivery. J Am Chem Soc (2014) 1.00

Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts. Liver Transpl (2011) 1.00

Monoclonal antibody-based serological methods for detection of Cucumber green mottle mosaic virus. Virol J (2011) 0.99

Efficient virus-induced gene silencing in plants using a modified geminivirus DNA1 component. Plant Biotechnol J (2009) 0.98

Root and shoot traits responses to phosphorus deficiency and QTL analysis at seedling stage using introgression lines of rice. J Genet Genomics (2009) 0.98

Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol Endocrinol (2005) 0.98

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion. Biochem Pharmacol (2013) 0.97

Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice. Mol Cell Biochem (2008) 0.96

Comprehensive analysis of host gene expression in Autographa californica nucleopolyhedrovirus-infected Spodoptera frugiperda cells. Virology (2011) 0.96

Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release. Eur J Appl Physiol (2009) 0.94

Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol Pharmacol (2007) 0.94

An association between immunosenescence and CD4(+)CD25(+) regulatory T cells: a systematic review. Biomed Environ Sci (2010) 0.93

Molecular characterization of two distinct begomoviruses from Papaya in China. Virus Genes (2004) 0.92

Intermittent high altitude hypoxia inhibits opening of mitochondrial permeability transition pores against reperfusion injury. J Mol Cell Cardiol (2005) 0.92

[An analysis of hepatitis B virus infection rate in 405 cases of non-Hodgkin lymphoma]. Zhonghua Xue Ye Xue Za Zhi (2011) 0.92

Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. Cancer Res (2007) 0.92

Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia. PLoS One (2012) 0.91

Phosphoinositide 3-kinase gamma regulates airway smooth muscle contraction by modulating calcium oscillations. J Pharmacol Exp Ther (2010) 0.91

Association between proton pump inhibitor use and anemia: a retrospective cohort study. Dig Dis Sci (2011) 0.91

Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth. Int J Cancer (2011) 0.91

Do self-report and medical record comorbidity data predict longitudinal functional capacity and quality of life health outcomes similarly? BMC Health Serv Res (2012) 0.90

Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? PLoS Negl Trop Dis (2013) 0.90

Primary malignant melanoma of the lung in the elderly: case report and literature review. Chin Med J (Engl) (2010) 0.90

Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. J Lipid Res (2012) 0.89

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor. J Biol Chem (2005) 0.89

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis. J Lipid Res (2012) 0.89

ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res (2008) 0.88

Changes of regulatory T cells and FoxP3 gene expression in the aging process and its relationship with lung tumors in humans and mice. Chin Med J (Engl) (2012) 0.88

Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells. Free Radic Biol Med (2012) 0.88

Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation. Breast Cancer Res (2014) 0.87

DHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation. FEBS Lett (2010) 0.87

Tonic inhibitory role for cAMP in alpha(1a)-adrenergic receptor coupling to extracellular signal-regulated kinases 1/2. J Pharmacol Exp Ther (2002) 0.87

Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness. J Allergy Clin Immunol (2012) 0.87

A tomato glutaredoxin gene SlGRX1 regulates plant responses to oxidative, drought and salt stresses. Planta (2010) 0.87

Novel mutations found in mitochondrial diabetes in Chinese Han population. Diabetes Res Clin Pract (2006) 0.87

Psychological and biological correlates of fatigue after mild-to-moderate traumatic brain injury. West J Nurs Res (2009) 0.87

PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients. Acta Pharmacol Sin (2013) 0.86

Low-income African American and non-Hispanic White mothers' self-efficacy, "picky eater" perception, and toddler fruit and vegetable consumption. Public Health Nurs (2010) 0.86

Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect of L-asparaginase based regimen, and prognostic factors. Hematol Oncol (2006) 0.86

Rapid genotyping of APOA5 -1131T>C polymorphism using high resolution melting analysis with unlabeled probes. Gene (2012) 0.86

Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. Fitoterapia (2011) 0.86

Bradykinin-related peptides and tryptophyllins in the skin secretions of the most primitive extant frog, Ascaphus truei. Gen Comp Endocrinol (2005) 0.86

Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain. J Nutr (2004) 0.85

Anti-tumor activity of CrTX in human lung adenocarcinoma cell line A549. Acta Pharmacol Sin (2011) 0.85

Blood pressure changes after intravenous fosphenytoin and levetiracetam in patients with acute cerebral symptoms. Epilepsy Res (2009) 0.85

Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection. J Nutr (2010) 0.84

Tomato yellow leaf curl Thailand virus-[Y72] from Yunnan is a monopartite begomovirus associated with DNAbeta. Virus Genes (2009) 0.84

Secondary central nervous system involvement in 599 patients with diffuse large B-cell lymphoma: are there any changes in the rituximab era? Int J Hematol (2013) 0.84

Pentobarbital anesthesia alters neural responses in the precedence effect. Neurosci Lett (2011) 0.84

Effect of pirfenidone against vanadate-induced kidney fibrosis in rats. Biochem Pharmacol (2002) 0.84

Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration. Biopharm Drug Dispos (2002) 0.84

Corridor connecting giant panda habitats from north to south in the Min Mountains, Sichuan, China. Integr Zool (2006) 0.84

Genome-wide association studies-derived susceptibility loci in type 2 diabetes: confirmation in a Chinese population. Clin Invest Med (2012) 0.84