Published in J Neurosci on November 09, 2005
Modulation of striatal projection systems by dopamine. Annu Rev Neurosci (2011) 4.84
Striatal plasticity and basal ganglia circuit function. Neuron (2008) 3.89
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci (2006) 3.00
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron (2008) 2.94
Endocannabinoid signaling and long-term synaptic plasticity. Annu Rev Physiol (2009) 2.35
Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum. Neuropharmacology (2010) 2.14
Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. Eur J Neurosci (2009) 1.88
Endocannabinoid signaling is critical for habit formation. Front Integr Neurosci (2007) 1.81
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron (2007) 1.81
Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci (2010) 1.81
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS One (2007) 1.67
Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection. Curr Opin Neurobiol (2009) 1.58
Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One (2007) 1.41
FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nat Neurosci (2008) 1.36
Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. Proc Natl Acad Sci U S A (2006) 1.35
Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal. J Neurosci (2011) 1.28
Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci (2010) 1.28
RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits. Neuron (2012) 1.28
Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. J Physiol (2010) 1.27
Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin. Proc Natl Acad Sci U S A (2008) 1.27
Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load. J Physiol (2007) 1.27
Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci (2012) 1.25
Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. Proc Natl Acad Sci U S A (2007) 1.25
Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex. J Neurosci (2010) 1.24
Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus. Proc Natl Acad Sci U S A (2008) 1.13
Molecular substrates of action control in cortico-striatal circuits. Prog Neurobiol (2011) 1.12
Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci (2009) 1.11
D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. J Neurosci (2008) 1.09
Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. Neuropsychopharmacology (2010) 1.06
Looking for the role of cannabinoid receptor heteromers in striatal function. Neuropharmacology (2008) 1.06
Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice. J Physiol (2006) 1.04
Centrality of striatal cholinergic transmission in Basal Ganglia function. Front Neuroanat (2011) 1.04
The role of dopamine in modulating the structure and function of striatal circuits. Prog Brain Res (2010) 1.04
Serotonin induces long-term depression at corticostriatal synapses. J Neurosci (2011) 1.04
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology (2007) 1.03
Dopaminergic modulation of striatal neurons, circuits, and assemblies. Neuroscience (2011) 1.03
Acute and chronic effects of ethanol on learning-related synaptic plasticity. Alcohol (2013) 1.03
Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. J Neurosci (2011) 1.02
Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning. Learn Mem (2011) 1.01
Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility. Front Neurosci (2013) 0.99
AMPA receptor-dependent H2O2 generation in striatal medium spiny neurons but not dopamine axons: one source of a retrograde signal that can inhibit dopamine release. J Neurophysiol (2008) 0.99
Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus. Proc Natl Acad Sci U S A (2008) 0.98
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. Proc Natl Acad Sci U S A (2014) 0.98
High on habits. Front Neurosci (2008) 0.97
Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine? Neuroscience (2013) 0.96
Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum. J Physiol (2012) 0.96
mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation. J Neurosci (2010) 0.96
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance. Nat Neurosci (2012) 0.96
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. Neuropharmacology (2011) 0.94
Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light. Front Behav Neurosci (2011) 0.94
Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons. J Physiol (2010) 0.93
The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci (2010) 0.93
Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. J Physiol (2012) 0.92
Striatal action-learning based on dopamine concentration. Exp Brain Res (2009) 0.92
Endocannabinoids in synaptic plasticity and neuroprotection. Neuroscientist (2014) 0.92
Neuromodulatory control of striatal plasticity and behavior. Curr Opin Neurobiol (2011) 0.91
Presynaptic long-term plasticity. Front Synaptic Neurosci (2013) 0.91
In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci (2008) 0.90
The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. Neuroscience (2011) 0.90
Sensitivity to theta-burst timing permits LTP in dorsal striatal adult brain slice. J Neurophysiol (2013) 0.89
Metaplasticity of hypothalamic synapses following in vivo challenge. Neuron (2009) 0.89
Regulation of dendritic calcium release in striatal spiny projection neurons. J Neurophysiol (2013) 0.89
Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2. Neurochem Int (2008) 0.88
Endocannabinoid-dependent plasticity at spinal nociceptor synapses. J Physiol (2012) 0.88
Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models. Neurobiol Dis (2014) 0.88
Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum. Cell Rep (2014) 0.87
Developmental alterations of DHPG-induced long-term depression of corticostriatal synaptic transmission: switch from NMDA receptor-dependent towards CB1 receptor-dependent plasticity. Pflugers Arch (2009) 0.87
CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. Nat Neurosci (2013) 0.86
Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology (2007) 0.86
Endocannabinoid-dopamine interactions in striatal synaptic plasticity. Front Pharmacol (2012) 0.85
Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels. Neurochem Int (2007) 0.84
Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models. Eur J Neurosci (2012) 0.84
From real-world events to psychosis: the emerging neuropharmacology of delusions. Schizophr Bull (2009) 0.84
Dopaminergic modulation of corticostriatal responses in medium spiny projection neurons from direct and indirect pathways. Front Syst Neurosci (2011) 0.83
Dopamine Release and Uptake Impairments and Behavioral Alterations Observed in Mice that Model Fragile X Mental Retardation Syndrome. ACS Chem Neurosci (2010) 0.82
New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons. Eur J Neurosci (2012) 0.82
mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion. PLoS One (2013) 0.82
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity. Mol Pharmacol (2015) 0.81
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Pharmacol Res (2010) 0.81
Frequency selectivity and dopamine-dependence of plasticity at glutamatergic synapses in the subthalamic nucleus. Neuroscience (2011) 0.81
A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS One (2012) 0.81
Endocannabinoids in striatal plasticity. Parkinsonism Relat Disord (2012) 0.80
Prenatal ethanol exposure alters synaptic plasticity in the dorsolateral striatum of rat offspring via changing the reactivity of dopamine receptor. PLoS One (2012) 0.79
Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning. J Neurophysiol (2010) 0.79
Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection. Mol Neurodegener (2015) 0.79
Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases. Front Cell Neurosci (2015) 0.79
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses. Hippocampus (2014) 0.78
Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons. J Neurosci (2014) 0.78
Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS Comput Biol (2013) 0.78
The Basal Ganglia as a Substrate for the Multiple Actions of Amphetamines. Basal Ganglia (2011) 0.78
The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. Neuropharmacology (2014) 0.78
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest (2017) 0.78
A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology (2012) 0.78
Cellular signal mechanisms of reward-related plasticity in the hippocampus. Neural Plast (2012) 0.78
Induction of cannabinoid- and N-methyl-D-aspartate receptor-mediated long-term depression in the nucleus accumbens and dorsolateral striatum is region and age dependent. Int J Neuropsychopharmacol (2015) 0.77
Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses. Cell Rep (2015) 0.77
Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat. Neuroscience (2012) 0.77
Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice. Brain Res (2013) 0.76
The 5-HT1A-receptor agonist flibanserin reduces drug-induced dyskinesia in RGS9-deficient mice. J Neural Transm (Vienna) (2012) 0.76
Cannabinoid type 1 receptors transiently silence glutamatergic nerve terminals of cultured cerebellar granule cells. PLoS One (2014) 0.76
AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci (2002) 13.09
Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci (2006) 12.37
Synaptic scaling mediated by glial TNF-alpha. Nature (2006) 6.76
Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron (2003) 6.19
Synaptic plasticity and addiction. Nat Rev Neurosci (2007) 6.08
Input-specific control of reward and aversion in the ventral tegmental area. Nature (2012) 4.60
Control of synaptic strength by glial TNFalpha. Science (2002) 4.46
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models. Nature (2007) 4.36
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron (2011) 3.93
Striatal plasticity and basal ganglia circuit function. Neuron (2008) 3.89
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron (2011) 3.89
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome. Nat Neurosci (2007) 3.74
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat Neurosci (2004) 3.64
Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci (2005) 3.38
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology (2007) 3.10
Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron (2004) 3.09
Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron (2008) 3.07
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci (2010) 3.02
CREB modulates excitability of nucleus accumbens neurons. Nat Neurosci (2006) 2.95
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci (2004) 2.73
Beta-catenin is critical for dendritic morphogenesis. Nat Neurosci (2003) 2.70
Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. Nature (2012) 2.61
A developmental switch in the signaling cascades for LTP induction. Nat Neurosci (2003) 2.61
Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. J Neurosci (2004) 2.59
Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature (2013) 2.55
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature (2013) 2.55
Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens. Nat Neurosci (2010) 2.40
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function. Neuron (2006) 2.25
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron (2008) 2.15
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron (2008) 2.15
Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci (2008) 2.15
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology (2006) 2.10
Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proc Natl Acad Sci U S A (2007) 2.03
Generation of silent synapses by acute in vivo expression of CaMKIV and CREB. Neuron (2005) 1.86
A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors. Nat Neurosci (2009) 1.80
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron (2004) 1.74
Postsynaptic complexin controls AMPA receptor exocytosis during LTP. Neuron (2012) 1.74
Comprehensive qPCR profiling of gene expression in single neuronal cells. Nat Protoc (2011) 1.73
Neuronal pentraxins mediate synaptic refinement in the developing visual system. J Neurosci (2006) 1.71
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell (2013) 1.70
Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology (2013) 1.67
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harb Perspect Biol (2012) 1.67
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A (2011) 1.63
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci (2006) 1.61
Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat Neurosci (2005) 1.59
∆FosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc Natl Acad Sci U S A (2013) 1.46
The addicted brain. Sci Am (2004) 1.42
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo. Proc Natl Acad Sci U S A (2011) 1.39
Synaptic plasticity in the mesolimbic dopamine system. Philos Trans R Soc Lond B Biol Sci (2003) 1.36
Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther (2009) 1.34
Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci (2010) 1.34
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proc Natl Acad Sci U S A (2012) 1.33
LTP requires a unique postsynaptic SNARE fusion machinery. Neuron (2013) 1.33
Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release. Neuron (2013) 1.32
Mechanisms for synapse specificity during striatal long-term depression. J Neurosci (2007) 1.31
Differential roles for NSF and GRIP/ABP in AMPA receptor cycling. Proc Natl Acad Sci U S A (2002) 1.28
RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. Proc Natl Acad Sci U S A (2008) 1.28
Understanding synapses: past, present, and future. Neuron (2008) 1.25
CREB modulates the functional output of nucleus accumbens neurons: a critical role of N-methyl-D-aspartate glutamate receptor (NMDAR) receptors. J Biol Chem (2007) 1.21
Transsynaptic signaling by postsynaptic synapse-associated protein 97. J Neurosci (2006) 1.20
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci U S A (2003) 1.19
Cocaine-induced plasticity of intrinsic membrane properties in prefrontal cortex pyramidal neurons: adaptations in potassium currents. J Neurosci (2005) 1.18
The best of times, the worst of times for psychiatric disease. Nat Neurosci (2012) 1.18
A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression. Nat Neurosci (2010) 1.17
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol (2011) 1.16
Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc Natl Acad Sci U S A (2008) 1.14
Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron (2009) 1.13
Integrating synaptic plasticity and striatal circuit function in addiction. Curr Opin Neurobiol (2011) 1.08
Substrate localization creates specificity in calcium/calmodulin-dependent protein kinase II signaling at synapses. J Biol Chem (2006) 1.08
Multiple functions for the cadherin/catenin complex during neuronal development. Neuropharmacology (2004) 1.05
Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine. J Neurosci (2002) 1.02
Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease. PLoS One (2012) 1.02
A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice. J Neurosci (2012) 1.01
Functional engraftment of the medial ganglionic eminence cells in experimental stroke model. Cell Transplant (2009) 0.98
Interactions between drebrin and Ras regulate dendritic spine plasticity. Eur J Neurosci (2008) 0.98
Ionotropic NMDA receptor signaling is required for the induction of long-term depression in the mouse hippocampal CA1 region. J Neurosci (2014) 0.97
N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Eur J Neurosci (2009) 0.94
Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. J Neurophysiol (2008) 0.93
Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus. Brain Res (2011) 0.91
Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron (2013) 0.91
Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice. Proc Natl Acad Sci U S A (2013) 0.89
A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors. J Biol Chem (2002) 0.84
GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling. Neuron (2005) 0.84
LTP: AMPA receptors trading places. Nat Neurosci (2006) 0.83
Alzheimer's disease: Recollection of lost memories. Nature (2011) 0.79
Mechanisms underlying dedepression of synaptic NMDA receptors in the hippocampus. J Neurophysiol (2007) 0.77
QnAs with Robert C. Malenka. Proc Natl Acad Sci U S A (2011) 0.75