Published in J Neurosci on June 29, 2011
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science (2013) 2.21
Learning From Animal Models of Obsessive-Compulsive Disorder. Biol Psychiatry (2015) 2.07
Endocannabinoid signaling and synaptic function. Neuron (2012) 1.90
Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci (2011) 1.02
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun (2016) 0.97
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism. Neurosci Biobehav Rev (2014) 0.94
Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Biol Psychiatry (2013) 0.94
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One (2012) 0.91
A selective review of glutamate pharmacological therapy in obsessive-compulsive and related disorders. Psychol Res Behav Manag (2015) 0.89
Utilizing GCaMP transgenic mice to monitor endogenous Gq/11-coupled receptors. Front Pharmacol (2015) 0.83
Neuroligin 1 modulates striatal glutamatergic neurotransmission in a pathway and NMDAR subunit-specific manner. Front Synaptic Neurosci (2015) 0.82
Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci (2016) 0.80
Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol Autism (2014) 0.78
Changes in sensitivity of reward and motor behavior to dopaminergic, glutamatergic, and cholinergic drugs in a mouse model of fragile X syndrome. PLoS One (2013) 0.78
Contrasting actions of group I metabotropic glutamate receptors in distinct mouse striatal neurones. J Physiol (2014) 0.78
Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior. Neuroscience (2015) 0.76
Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models. Neurobiol Dis (2016) 0.75
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. Biol Psychiatry (2016) 0.75
Impaired Ethanol-Induced Sensitization and Decreased Cannabinoid Receptor-1 in a Model of Posttraumatic Stress Disorder. PLoS One (2016) 0.75
Hunger and Satiety Gauge Reward Sensitivity. Front Endocrinol (Lausanne) (2017) 0.75
Gene expression profiling predicts pathways and genes associated with Parkinson's disease. Neurol Sci (2015) 0.75
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature (2003) 16.48
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet (2006) 11.14
The mGluR theory of fragile X mental retardation. Trends Neurosci (2004) 8.88
PDZ domain proteins of synapses. Nat Rev Neurosci (2004) 8.14
Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A (2002) 6.45
Endocannabinoid-mediated control of synaptic transmission. Physiol Rev (2009) 5.56
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci U S A (1999) 5.11
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature (2007) 4.59
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models. Nature (2007) 4.36
Endocannabinoid signaling in the brain. Science (2002) 4.28
Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron (2001) 3.91
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron (1999) 3.68
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron (2006) 3.58
Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science (1997) 3.16
Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron (2001) 2.94
GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J Cell Biol (1997) 2.92
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther (2004) 2.83
Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. J Neurosci (2008) 2.50
Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Neuron (2007) 2.50
Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus. J Neurosci (2001) 2.48
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J Med Chem (2004) 2.46
Endocannabinoid signaling and long-term synaptic plasticity. Annu Rev Physiol (2009) 2.35
Dichotomous anatomical properties of adult striatal medium spiny neurons. J Neurosci (2008) 2.29
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature (2001) 2.28
Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation. Neuron (2009) 2.27
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol Chem (1997) 2.23
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum. J Neurosci (2005) 2.18
Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons. J Neurosci (2003) 2.14
Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum. Neuropharmacology (2010) 2.14
Laminar organization of the NMDA receptor complex within the postsynaptic density. J Neurosci (2001) 2.13
Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. Eur J Neurosci (2009) 1.88
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem (2008) 1.87
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron (2007) 1.81
Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci (2004) 1.74
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr Biol (2003) 1.66
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol Pharmacol (2007) 1.63
A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accumbens. J Neurosci (2004) 1.57
A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses. J Neurosci (2004) 1.53
Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons. Eur J Neurosci (2008) 1.49
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nat Neurosci (2010) 1.48
Decreased probability of neurotransmitter release underlies striatal long-term depression and postnatal development of corticostriatal synapses. Proc Natl Acad Sci U S A (1997) 1.48
Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochem Biophys Res Commun (1999) 1.46
Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation. Eur J Neurosci (2002) 1.44
Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. J Neurosci (2007) 1.42
The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. Chem Phys Lipids (2000) 1.36
Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J Neurosci (2005) 1.35
Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. Proc Natl Acad Sci U S A (2006) 1.35
Mechanisms for synapse specificity during striatal long-term depression. J Neurosci (2007) 1.31
Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. J Comp Neurol (2004) 1.25
Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. Proc Natl Acad Sci U S A (2007) 1.25
Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci (2010) 1.24
Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. J Neurophysiol (2001) 1.21
Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3. J Neurophysiol (1995) 1.19
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors. Proc Natl Acad Sci U S A (2007) 1.19
Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. Neuropsychopharmacology (2010) 1.14
Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus. Proc Natl Acad Sci U S A (2008) 1.13
Characterization of a range of fura dyes with two-photon excitation. Biophys J (2004) 1.12
Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90. J Neurosci (1997) 1.06
The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. J Biol Chem (2005) 1.05
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. J Neurosci (2010) 1.04
Post-receptor mechanisms underlying striatal long-term depression. J Neurosci (1994) 1.03
Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA. Brain Res Mol Brain Res (2004) 1.01
Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses. Ann N Y Acad Sci (1999) 0.99
Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. Eur J Neurosci (2003) 0.97
Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. J Mol Neurosci (2007) 0.91
Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum. Neurosci Res (2006) 0.91
Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments. Genes Cells (2000) 0.90
Imaging action potentials with calcium indicators. Cold Spring Harb Protoc (2009) 0.83
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature (2002) 11.85
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
A transcription activator-like effector toolbox for genome engineering. Nat Protoc (2012) 6.81
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature (2011) 5.62
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature (2007) 4.59
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci (2006) 3.95
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18
Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol (2005) 2.61
Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature (2003) 2.51
Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. J Neurosci (2008) 2.50
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science (2013) 2.21
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron (2011) 2.14
Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol (2008) 2.12
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nat Neurosci (2003) 2.03
The primordial, blue-cone color system of the mouse retina. J Neurosci (2005) 1.94
Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci (2010) 1.87
Generation of silent synapses by acute in vivo expression of CaMKIV and CREB. Neuron (2005) 1.86
Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion. Nat Neurosci (2003) 1.77
Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nat Neurosci (2011) 1.74
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem (2007) 1.70
Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon. Neuron (2006) 1.63
Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation. Pain (2006) 1.61
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci (2010) 1.50
Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice. Nat Neurosci (2008) 1.43
The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia. J Neurosci (2006) 1.42
Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron (2009) 1.42
Imaging neural activity using Thy1-GCaMP transgenic mice. Neuron (2012) 1.40
Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron (2009) 1.31
Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron (2004) 1.28
PSD93 regulates synaptic stability at neuronal cholinergic synapses. J Neurosci (2004) 1.26
Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell Rep (2012) 1.25
Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. J Comp Neurol (2004) 1.25
Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. Brain Cell Biol (2008) 1.21
ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains. J Neurosci (2013) 1.20
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology (2012) 1.17
An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons. Front Syst Neurosci (2011) 1.15
Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics. Methods Mol Biol (2014) 1.14
Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders. Annu Rev Neurosci (2012) 1.13
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology (2002) 1.13
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J Clin Invest (2015) 1.09
Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics. Curr Opin Neurobiol (2011) 1.07
3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse. Hippocampus (2008) 1.06
Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors. J Biol Chem (2005) 1.05
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. Genome Biol (2014) 1.04
Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J Cell Biol (2007) 1.04
Cellular and synaptic network defects in autism. Curr Opin Neurobiol (2012) 1.02
Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci (2011) 1.02
Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice. J Neurosci (2012) 1.02
Labeling neurons in vivo for morphological and functional studies. Curr Opin Neurobiol (2004) 1.02
Next-generation transgenic mice for optogenetic analysis of neural circuits. Front Neural Circuits (2013) 1.01
Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res (2013) 1.00
Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. Brain Cell Biol (2008) 0.99
Cortical control of affective networks. J Neurosci (2013) 0.97
Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum. Proc Natl Acad Sci U S A (2009) 0.96
Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder. Curr Chem Genomics (2008) 0.95
Fluorescent labeling of newborn dentate granule cells in GAD67-GFP transgenic mice: a genetic tool for the study of adult neurogenesis. PLoS One (2010) 0.95
Optical inhibition of motor nerve and muscle activity in vivo. Muscle Nerve (2013) 0.94
Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol (2005) 0.93
Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity. Mol Pain (2009) 0.91
Presynaptic long-term plasticity. Front Synaptic Neurosci (2013) 0.91
MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. J Neurosci (2014) 0.88
Facial nerve monitoring parameters as a predictor of postoperative facial nerve outcomes after vestibular schwannoma resection. Otol Neurotol (2005) 0.88
Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution. Sci Rep (2012) 0.88
Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. J Neurosci (2010) 0.87
Confocal Analysis of Cholinergic and Dopaminergic Inputs onto Pyramidal Cells in the Prefrontal Cortex of Rodents. Front Neuroanat (2010) 0.87
In vivo imaging of juxtaglomerular neuron turnover in the mouse olfactory bulb. Proc Natl Acad Sci U S A (2006) 0.87
LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2. Mol Cell Neurosci (2005) 0.87
Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone. Cell Res (2010) 0.87
Imaging synaptic inhibition with the genetically encoded chloride indicator Clomeleon. Cold Spring Harb Protoc (2011) 0.86
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry (2011) 0.84
Munc13-1 is required for presynaptic long-term potentiation. J Neurosci (2011) 0.83
Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures. Nat Commun (2016) 0.80
SnapShot: Autism and the synapse. Cell (2011) 0.79
The accessory posterolateral nerve: an immunohistological analysis. Am J Rhinol Allergy (2012) 0.78
Association of rhinosinusitis with nasopharyngeal carcinoma: a population-based study. Laryngoscope (2014) 0.78
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest (2017) 0.78
Complete deletion of all alpha-dystrobrevin isoforms does not reveal new neuromuscular junction phenotype. Gene Expr (2007) 0.77
A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities. PLoS One (2013) 0.77
Spotlight on movement disorders: What optogenetics has to offer. Mov Disord (2015) 0.77
Bactericidal thurincin H causes unique morphological changes in Bacillus cereus F4552 without affecting membrane permeability. FEMS Microbiol Lett (2014) 0.76
Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice. Biol Psychiatry Cogn Neurosci Neuroimaging (2016) 0.76
Neuroscience: When lights take the circuits out. Nature (2011) 0.75
Unfolding neurodevelopmental disorders: found in translation. Nat Med (2011) 0.75
Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci (2017) 0.75
[One-stage surgical treatment of congenital blepharophimosis syndrome]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2007) 0.75
[An experimental study on chemically induced animal model of goat cleft palate in uterus]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2011) 0.75
[Application of facial tissue expander fibrous envelope for tension reduction]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2012) 0.75
[Animal model of goat cleft palate made by uterine cavitary operations]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2010) 0.75
[Adhesive deformity from the upper eyelid fold formation and its treatment]. Zhonghua Zheng Xing Wai Ke Za Zhi (2002) 0.75
[Effect of in-utero surgical repair at different stages on mid-facial development of goats with cleft palate]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2011) 0.75
Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci (2017) 0.75
Reduction of patulin in apple cider by UV radiation. J Food Prot (2010) 0.75
Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci (2017) 0.75