Nonhomologous end joining in yeast.

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80

Mechanisms of change in gene copy number. Nat Rev Genet (2009) 9.01

DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28

One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome. Proc Natl Acad Sci U S A (2008) 2.82

Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks. EMBO J (2006) 2.62

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J (2008) 2.21

Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics (2007) 2.19

Mating-type genes and MAT switching in Saccharomyces cerevisiae. Genetics (2012) 1.96

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO J (2010) 1.92

Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation. Mol Cell (2012) 1.85

DNA end resection--unraveling the tail. DNA Repair (Amst) (2011) 1.82

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J (2007) 1.80

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev (2008) 1.80

Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol Cell Biol (2006) 1.71

Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol (2006) 1.71

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast. Proc Natl Acad Sci U S A (2010) 1.61

Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end. Genetics (2012) 1.56

Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics (2008) 1.55

The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep (2008) 1.54

Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex. Mol Cell Biol (2009) 1.47

Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Genetics (2006) 1.47

Retracted Rtt107 phosphorylation promotes localisation to DNA double-stranded breaks (DSBs) and recombinational repair between sister chromatids. PLoS One (2011) 1.45

Akt: a double-edged sword in cell proliferation and genome stability. J Oncol (2012) 1.44

The unnamed complex: what do we know about Smc5-Smc6? Chromosome Res (2009) 1.39

Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics (2006) 1.33

Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4. DNA Repair (Amst) (2007) 1.29

Alternative endings. Proc Natl Acad Sci U S A (2008) 1.27

Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair. Philos Trans R Soc Lond B Biol Sci (2011) 1.27

Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora. Proc Natl Acad Sci U S A (2006) 1.23

Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage. DNA Repair (Amst) (2009) 1.23

The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation. Mol Cell Biol (2012) 1.22

Mechanisms and regulation of DNA end resection. EMBO J (2010) 1.22

Deletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biology. PLoS One (2012) 1.20

Multiple-pathway analysis of double-strand break repair mutations in Drosophila. PLoS Genet (2007) 1.20

High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events. Genetics (2012) 1.19

Comparison of responses to double-strand breaks between Escherichia coli and Bacillus subtilis reveals different requirements for SOS induction. J Bacteriol (2008) 1.17

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends. PLoS Genet (2009) 1.15

A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics (2007) 1.15

Identification of a second DNA binding site in the human Rad52 protein. J Biol Chem (2008) 1.13

Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans. Subcell Biochem (2010) 1.13

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics (2008) 1.12

Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair. Biochemistry (2011) 1.10

Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks. DNA Repair (Amst) (2009) 1.09

Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell (2012) 1.08

Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication. PLoS Genet (2010) 1.07

Ku heterodimer-independent end joining in Trypanosoma brucei cell extracts relies upon sequence microhomology. Eukaryot Cell (2007) 1.06

Chromatin dynamics during repair of chromosomal DNA double-strand breaks. Epigenomics (2009) 1.05

MRN and the race to the break. Chromosoma (2009) 1.04

DNA repair and genome maintenance in Bacillus subtilis. Microbiol Mol Biol Rev (2012) 1.03

Promiscuous mismatch extension by human DNA polymerase lambda. Nucleic Acids Res (2006) 1.03

Multiplicity of DNA end resection machineries in chromosome break repair. Genes Dev (2009) 1.03

DNA polymerase delta in DNA replication and genome maintenance. Environ Mol Mutagen (2012) 1.02

Microhomology directs diverse DNA break repair pathways and chromosomal translocations. PLoS Genet (2012) 1.02

Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 1.01

Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1. Genetics (2008) 1.00

DNA double-strand break processing: the beginning of the end. Genes Dev (2008) 0.99

Amplification of a Zygosaccharomyces bailii DNA segment in wine yeast genomes by extrachromosomal circular DNA formation. PLoS One (2011) 0.99

Mismatch tolerance by DNA polymerase Pol4 in the course of nonhomologous end joining in Saccharomyces cerevisiae. Genetics (2006) 0.97

DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum. Microbiol Mol Biol Rev (2014) 0.96

Evidence that base stacking potential in annealed 3' overhangs determines polymerase utilization in yeast nonhomologous end joining. DNA Repair (Amst) (2007) 0.95

Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucleic Acids Res (2008) 0.95

Molecular characterization of KU70 and KU80 homologues and exploitation of a KU70-deficient mutant for improving gene deletion frequency in Rhodosporidium toruloides. BMC Microbiol (2014) 0.94

Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. Mol Cell Biol (2011) 0.93

Telomerase- and Rad52-independent immortalization of budding yeast by an inherited-long-telomere pathway of telomeric repeat amplification. Mol Cell Biol (2008) 0.93

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proc Natl Acad Sci U S A (2013) 0.93

Recombinational DNA repair in a cellular context: a search for the homology search. Nat Rev Microbiol (2009) 0.93

Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4. PLoS Genet (2014) 0.93

Characterization of T-DNA insertion patterns in the genome of rice blast fungus Magnaporthe oryzae. Curr Genet (2007) 0.93

Dicentric breakage at telomere fusions. Genes Dev (2010) 0.92

Yeast Tdp1 regulates the fidelity of nonhomologous end joining. Proc Natl Acad Sci U S A (2010) 0.92

Increased homologous integration frequency in Yarrowia lipolytica strains defective in non-homologous end-joining. Curr Genet (2013) 0.89

Rad52 function prevents chromosome loss and truncation in Candida albicans. Mol Microbiol (2011) 0.89

Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection. J Biol Chem (2015) 0.89

End-processing during non-homologous end-joining: a role for exonuclease 1. Nucleic Acids Res (2010) 0.88

Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Mol Cell Proteomics (2011) 0.88

Transposition of the Tourist-MITE mPing in yeast: an assay that retains key features of catalysis by the class 2 PIF/Harbinger superfamily. Mob DNA (2010) 0.88

The DNA end-binding protein Ku regulates silencing at the internal HML and HMR loci in Saccharomyces cerevisiae. Genetics (2008) 0.87

The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactis. Genetics (2007) 0.87

Knockout of the DNA ligase IV homolog gene in the sphingoid base producing yeast Pichia ciferrii significantly increases gene targeting efficiency. Curr Genet (2009) 0.86

Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function. J Biol Chem (2008) 0.85

In Saccharomyces cerevisiae, yKu and subtelomeric core X sequences repress homologous recombination near telomeres as part of the same pathway. Genetics (2009) 0.85

Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism. Proc Natl Acad Sci U S A (2009) 0.85

Synthetic viability genomic screening defines Sae2 function in DNA repair. EMBO J (2015) 0.85

Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol (2017) 0.85

Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity. PLoS Genet (2013) 0.84

Molecular basis for DNA double-strand break annealing and primer extension by an NHEJ DNA polymerase. Cell Rep (2013) 0.84

Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe. Genetics (2006) 0.84

Stripped-down DNA repair in a highly reduced parasite. BMC Mol Biol (2007) 0.84

Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repair. PLoS One (2013) 0.84

Inhibition of proteasomal degradation of rpn4 impairs nonhomologous end-joining repair of DNA double-strand breaks. PLoS One (2010) 0.83

Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability. Cancer Sci (2014) 0.83

The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep (2013) 0.82

Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae. DNA Repair (Amst) (2010) 0.82

Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae. Genetics (2011) 0.82

Small ubiquitin-like modifier (SUMO) isoforms and conjugation-independent function in DNA double-strand break repair pathways. J Biol Chem (2014) 0.82

To trim or not to trim: progression and control of DSB end resection. Cell Cycle (2013) 0.82

Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms. Expert Opin Drug Discov (2009) 0.82

Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci (2009) 0.82

Timing is everything: cell cycle control of Rad52. Cell Div (2010) 0.81

A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair. Nucleic Acids Res (2009) 0.81

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol (2003) 4.81

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc Natl Acad Sci U S A (2002) 2.50

Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science (2004) 2.04

Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy. Am J Hum Genet (2010) 1.96

Accessibility of home blood pressure monitors for blind and visually impaired people. J Diabetes Sci Technol (2007) 1.91

Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination. Genetics (2002) 1.85

Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58

DNA joint dependence of pol X family polymerase action in nonhomologous end joining. J Biol Chem (2005) 1.55

Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics (2008) 1.55

Rejoining of DNA double-strand breaks as a function of overhang length. Mol Cell Biol (2005) 1.52

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J Biol Chem (2006) 1.50

Targeting PARP in Prostate Cancer: Novelty, Pitfalls, and Promise. Oncology (Williston Park) (2016) 1.40

Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4. DNA Repair (Amst) (2007) 1.29

Replication stress and mechanisms of CNV formation. Curr Opin Genet Dev (2012) 1.23

Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing. Genetics (2010) 1.23

SnapShot: Nonhomologous DNA end joining (NHEJ). Cell (2010) 1.21

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response. Proc Natl Acad Sci U S A (2013) 1.19

Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining. Mol Cell Biol (2005) 1.18

Hydroxyurea induces de novo copy number variants in human cells. Proc Natl Acad Sci U S A (2011) 1.17

A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with Charcot-Marie-Tooth disease type 2N (CMT2N). Hum Mutat (2011) 1.14

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics (2008) 1.12

Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogens. PLoS Genet (2013) 1.09

De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining. PLoS Genet (2012) 1.07

Mycobacteriophage exploit NHEJ to facilitate genome circularization. Mol Cell (2006) 1.07

Non-homologous end-joining: bacteria join the chromosome breakdance. Trends Biochem Sci (2003) 1.05

Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. Mol Cell Biol (2010) 1.03

Genome-wide transcriptional effects of the anti-cancer agent camptothecin. PLoS One (2013) 1.00

Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2013) 0.99

Identification of DNA 3'-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis. Biochemistry (2004) 0.99

Increased recombination between active tRNA genes. DNA Cell Biol (2006) 0.98

The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions. J Biol Chem (2003) 0.97

New insights into NHEJ repair processes in prokaryotes. Cell Cycle (2005) 0.96

Evidence that base stacking potential in annealed 3' overhangs determines polymerase utilization in yeast nonhomologous end joining. DNA Repair (Amst) (2007) 0.95

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing. Genetics (2011) 0.95

ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. Cancer Res (2014) 0.90

Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair. DNA Repair (Amst) (2010) 0.90

The PHOA and PHOB cyclin-dependent kinases perform an essential function in Aspergillus nidulans. Genetics (2003) 0.87

Histidine kinase two-component response regulator proteins regulate reproductive development, virulence, and stress responses of the fungal cereal pathogens Cochliobolus heterostrophus and Gibberella zeae. Eukaryot Cell (2010) 0.87

Hydrophobin genes of the entomopathogenic fungus, Metarhizium brunneum, are differentially expressed and corresponding mutants are decreased in virulence. Curr Genet (2012) 0.86

Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity. PLoS Genet (2013) 0.84

Cochliobolus heterostrophus Llm1 - a Lae1-like methyltransferase regulates T-toxin production, virulence, and development. Fungal Genet Biol (2012) 0.81

Harnessing genomics to identify environmental determinants of heritable disease. Mutat Res (2012) 0.81

Copy number variants are produced in response to low-dose ionizing radiation in cultured cells. Environ Mol Mutagen (2013) 0.81

Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae. Genetics (2005) 0.78

Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding. DNA Repair (Amst) (2014) 0.76

Restricting the ligation step of non-homologous end-joining. DNA Repair (Amst) (2007) 0.76

Breaking news on fragile sites in cancer. Cancer Cell (2013) 0.75

Efficient gene knockout in the maize pathogen Setosphaeria turcica using Agrobacterium tumefaciens-mediated transformation. Phytopathology (2013) 0.75

Figuring algorithm for high-gradient mirrors with axis-symmetrical removal function. Appl Opt (2010) 0.75

Standardization of functional reporter and antibiotic resistance cassettes to facilitate the genetic engineering of filamentous fungi. ACS Synth Biol (2014) 0.75

Influence of source characteristics, chemicals, and flocculation on chemically enhanced primary treatment. Water Environ Res (2008) 0.75