Published in Ultrasound Med Biol on November 01, 2005
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A (2006) 3.70
Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev (2008) 2.80
Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res (2012) 2.60
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol (2008) 2.17
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound Med Biol (2008) 2.03
Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo. IEEE Trans Biomed Eng (2009) 1.97
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PLoS One (2008) 1.95
In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol (2010) 1.94
Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology (2014) 1.68
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. Radiology (2012) 1.64
Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. Ultrasound Med Biol (2007) 1.63
Ultrasound for drug and gene delivery to the brain. Adv Drug Deliv Rev (2008) 1.58
High intensity focused ultrasound in clinical tumor ablation. World J Clin Oncol (2011) 1.55
Magnetic resonance-guided focused ultrasound surgery: Part 2: A review of current and future applications. Neurosurgery (2012) 1.53
Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and definity microbubbles: a short-term study. Ultrasound Med Biol (2010) 1.51
Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Ultrasonics (2008) 1.42
An MRI-compatible system for focused ultrasound experiments in small animal models. Med Phys (2009) 1.36
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. PLoS One (2011) 1.35
Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system. Adv Drug Deliv Rev (2014) 1.34
The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice. J Acoust Soc Am (2011) 1.31
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol (2012) 1.29
The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound. J Control Release (2012) 1.23
Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. Exp Neurol (2013) 1.19
Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles. Ultrasound Med Biol (2010) 1.18
Ultrasound-mediated blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model. J Control Release (2012) 1.18
Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation. Biochem Biophys Res Commun (2007) 1.18
Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubbles. Phys Med Biol (2012) 1.13
Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound. Magn Reson Med (2010) 1.13
Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and blood-brain barriers improve outcomes in a rat glioma model. J Control Release (2013) 1.12
Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment. Neuro Oncol (2010) 1.11
Optimization of the ultrasound-induced blood-brain barrier opening. Theranostics (2012) 1.08
MR-guided focused ultrasound surgery, present and future. Med Phys (2013) 1.03
Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical study. PLoS One (2013) 1.03
Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound. Ultrasound Med Biol (2010) 1.02
High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke. PLoS One (2012) 1.01
The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure. J Cereb Blood Flow Metab (2014) 0.99
Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS. Adv Drug Deliv Rev (2016) 0.98
Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening. Mol Ther Nucleic Acids (2013) 0.95
Drug delivery systems, CNS protection, and the blood brain barrier. Biomed Res Int (2014) 0.95
Noninvasive and targeted drug delivery to the brain using focused ultrasound. ACS Chem Neurosci (2013) 0.95
Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine (2012) 0.94
Clot retraction affects the extent of ultrasound-enhanced thrombolysis in an ex vivo porcine thrombosis model. Ultrasound Med Biol (2013) 0.94
Ultrasound-mediated drug delivery for cardiovascular disease. Expert Opin Drug Deliv (2013) 0.93
Ultrasound enhanced drug delivery to the brain and central nervous system. Int J Hyperthermia (2012) 0.93
Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy. J Control Release (2013) 0.92
Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurg Focus (2012) 0.91
Ultrasound-induced blood-brain barrier opening. Curr Pharm Biotechnol (2012) 0.90
Site-specific opening of the blood-brain barrier. J Biophotonics (2010) 0.90
Investigation of cellular and molecular responses to pulsed focused ultrasound in a mouse model. PLoS One (2011) 0.88
Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study. J Control Release (2015) 0.88
Reorganization of gap junctions after focused ultrasound blood-brain barrier opening in the rat brain. J Cereb Blood Flow Metab (2010) 0.88
Transcranial MRI-Guided Focused Ultrasound: A Review of the Technologic and Neurologic Applications. AJR Am J Roentgenol (2015) 0.88
Magnetic resonance-guided focused ultrasound: a new technology for clinical neurosciences. Neurol Clin (2013) 0.87
Trans-cranial opening of the blood-brain barrier in targeted regions using a stereotaxic brain atlas and focused ultrasound energy. J Ther Ultrasound (2014) 0.87
Targeted drug delivery across the blood-brain barrier using ultrasound technique. Ther Deliv (2010) 0.87
Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: evaluation during tumor progression in a rat glioma model. Phys Med Biol (2015) 0.86
Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert Opin Drug Deliv (2013) 0.85
Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects. Chem Rev (2015) 0.85
Focused ultrasound-mediated drug delivery through the blood-brain barrier. Expert Rev Neurother (2015) 0.84
Effects of the microbubble shell physicochemical properties on ultrasound-mediated drug delivery to the brain. J Control Release (2015) 0.84
A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery. PLoS One (2014) 0.84
Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound. J Control Release (2015) 0.84
Therapeutic strategies to improve drug delivery across the blood-brain barrier. Neurosurg Focus (2015) 0.83
Breast tumor response to ultrasound mediated excitation of microbubbles and radiation therapy in vivo. Oncoscience (2016) 0.80
In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with focused ultrasound: a magnetic resonance imaging study. J Cereb Blood Flow Metab (2009) 0.79
Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound. Neuropharmacology (2016) 0.79
Pharmacodynamic and therapeutic investigation of focused ultrasound-induced blood-brain barrier opening for enhanced temozolomide delivery in glioma treatment. PLoS One (2014) 0.79
Drug and gene delivery across the blood-brain barrier with focused ultrasound. J Control Release (2015) 0.79
Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation. Proc Natl Acad Sci U S A (2016) 0.79
Focused ultrasound-mediated drug delivery to pancreatic cancer in a mouse model. J Ther Ultrasound (2013) 0.78
Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI. J Vis Exp (2012) 0.77
Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation. Oncotarget (2015) 0.77
Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles. Pharmaceutics (2015) 0.77
Short-time focused ultrasound hyperthermia enhances liposomal doxorubicin delivery and antitumor efficacy for brain metastasis of breast cancer. Int J Nanomedicine (2014) 0.77
Safety Validation of Repeated Blood-Brain Barrier Disruption Using Focused Ultrasound. Ultrasound Med Biol (2015) 0.77
Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography. Biomed Opt Express (2014) 0.77
Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer. Ther Deliv (2015) 0.76
Longitudinal Motor and Behavioral Assessment of Blood-Brain Barrier Opening with Transcranial Focused Ultrasound. Ultrasound Med Biol (2016) 0.76
Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. Theranostics (2017) 0.75
Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model. Radiology (2016) 0.75
MRI-Guided Focused Ultrasound as a New Method of Drug Delivery. J Drug Deliv (2013) 0.75
MR-Guided Delivery of Hydrophilic Molecular Imaging Agents Across the Blood-Brain Barrier Through Focused Ultrasound. Mol Imaging Biol (2017) 0.75
Unilateral Opening of Rat Blood-Brain Barrier Assisted by Diagnostic Ultrasound Targeted Microbubbles Destruction. Biomed Res Int (2016) 0.75
Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption. J Control Release (2016) 0.75
Efficient Enhancement of Blood-Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT). Theranostics (2017) 0.75
Treatment of Movement Disorders With Focused Ultrasound. J Cent Nerv Syst Dis (2017) 0.75
Statistical validation of image segmentation quality based on a spatial overlap index. Acad Radiol (2004) 5.74
A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res (2005) 4.34
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A (2006) 3.70
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer (2007) 3.21
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage (2005) 3.17
Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery (2010) 3.15
MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology (2003) 3.07
The human emotional brain without sleep--a prefrontal amygdala disconnect. Curr Biol (2007) 3.01
Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. Am J Psychiatry (2002) 2.84
Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biol Psychiatry (2003) 2.78
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol (2004) 2.76
Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol (2007) 2.66
Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res (2012) 2.60
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg (2006) 2.58
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. Ultrasound Med Biol (2008) 2.47
Spatial normalization of diffusion tensor MRI using multiple channels. Neuroimage (2003) 2.39
MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol (2013) 2.37
Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme. PLoS One (2011) 2.35
A deficit in the ability to form new human memories without sleep. Nat Neurosci (2007) 2.32
Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun (2005) 2.28
Robust nonrigid registration to capture brain shift from intraoperative MRI. IEEE Trans Med Imaging (2005) 2.21
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol (2008) 2.17
500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls. Magn Reson Med (2004) 2.13
White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. Neuroimage (2004) 2.09
Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound Med Biol (2003) 2.07
Serial registration of intraoperative MR images of the brain. Med Image Anal (2002) 2.03
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound Med Biol (2008) 2.03
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PLoS One (2010) 2.03
Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance. Cancer (2005) 1.97
Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci U S A (2013) 1.95
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PLoS One (2008) 1.95
Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry (2003) 1.94
High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy. AJNR Am J Neuroradiol (2002) 1.93
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols. Radiology (2007) 1.90
Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation. Radiology (2006) 1.89
Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry (2003) 1.75
Localized harmonic motion imaging: theory, simulations and experiments. Ultrasound Med Biol (2003) 1.74
MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder. Am J Psychiatry (2002) 1.72
Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology (2006) 1.71
Magnetic resonance image-guided focused ultrasound surgery. Cancer J (2002) 1.70
Focused ultrasound modulates region-specific brain activity. Neuroimage (2011) 1.68
Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology (2014) 1.68
Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder. Biol Psychiatry (2004) 1.66
Modulation of cerebellar activities by acupuncture stimulation: evidence from fMRI study. Neuroimage (2004) 1.64
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. Radiology (2012) 1.64
Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. Am J Psychiatry (2004) 1.64
Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. Ultrasound Med Biol (2007) 1.63
Functional MRI for neurofeedback: feasibility study on a hand motor task. Neuroreport (2002) 1.63
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J Cereb Blood Flow Metab (2006) 1.60
Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Eur J Radiol (2006) 1.60
Overview of therapeutic ultrasound applications and safety considerations. J Ultrasound Med (2012) 1.54
Diffusion tensor imaging and its application to neuropsychiatric disorders. Harv Rev Psychiatry (2002) 1.54
Renal ultrafiltration changes induced by focused US. Radiology (2009) 1.54
The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). Ultrasound Med Biol (2003) 1.53
Magnetic resonance-guided focused ultrasound surgery: Part 2: A review of current and future applications. Neurosurgery (2012) 1.53
MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magn Reson Imaging Clin N Am (2005) 1.52
Focused ultrasound surgery in oncology: overview and principles. Radiology (2011) 1.51
Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. Ultrasound Med Biol (2006) 1.49
MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain. Magn Reson Med (2004) 1.47
Brain-computer interface using fMRI: spatial navigation by thoughts. Neuroreport (2004) 1.46
Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring. PLoS One (2012) 1.46
Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Ultrasonics (2008) 1.42
Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics. Radiology (2006) 1.42
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success. Radiology (2008) 1.37
The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model. Phys Med Biol (2010) 1.37
Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis-related changes. J Magn Reson Imaging (2005) 1.37
An MRI-compatible system for focused ultrasound experiments in small animal models. Med Phys (2009) 1.36
Quantitative MR imaging assessment of prostate gland deformation before and during MR imaging-guided brachytherapy. Acad Radiol (2002) 1.35
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. PLoS One (2011) 1.35
Capturing intraoperative deformations: research experience at Brigham and Women's Hospital. Med Image Anal (2004) 1.35
Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity. BMC Neurosci (2011) 1.34
Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia. Arch Gen Psychiatry (2002) 1.33
Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia. Arch Gen Psychiatry (2003) 1.33
Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging study. Arch Gen Psychiatry (2002) 1.29
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol (2012) 1.29
MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals. Neurology (2003) 1.29
A numerical study of transcranial focused ultrasound beam propagation at low frequency. Phys Med Biol (2005) 1.27
Biexponential diffusion tensor analysis of human brain diffusion data. Magn Reson Med (2004) 1.26
The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound. J Control Release (2012) 1.23