Published in Protein Pept Lett on November 01, 2005
The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. PLoS One (2011) 1.14
Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit. Biochemistry (2010) 0.91
Structure and dynamics of an imidazoline nitroxide side chain with strongly hindered internal motion in proteins. J Magn Reson (2013) 0.84
The biology and future prospects of antivirulence therapies. Nat Rev Microbiol (2008) 3.83
Essential role for the second extracellular loop in C5a receptor activation. Nat Struct Mol Biol (2005) 2.71
A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol (2009) 2.29
A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech (2011) 1.92
Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell (2013) 1.69
C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J Biol Chem (2003) 1.44
A Drosophila model of high sugar diet-induced cardiomyopathy. PLoS Genet (2013) 1.28
Modeling the possible conformations of the extracellular loops in G-protein-coupled receptors. Proteins (2010) 1.27
Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop. J Biol Chem (2006) 1.00
Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator. Chem Biol Drug Des (2012) 0.98
Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech (2013) 0.98
Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic (2002) 0.98
C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J Biol Chem (2003) 0.98
Modeling flexible loops in the dark-adapted and activated states of rhodopsin, a prototypical G-protein-coupled receptor. Biophys J (2005) 0.97
Development of small molecules designed to modulate protein-protein interactions. J Comput Aided Mol Des (2006) 0.97
Protein recognition motifs: design of peptidomimetics of helix surfaces. Biopolymers (2007) 0.95
Prognostic factors in patients with well-differentiated thyroid cancer presenting with pulmonary metastasis. Cancer Biother Radiopharm (2008) 0.95
Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem (2013) 0.93
Conformational manifold of alpha-aminoisobutyric acid (Aib) containing alanine-based tripeptides in aqueous solution explored by vibrational spectroscopy, electronic circular dichroism spectroscopy, and molecular dynamics simulations. J Am Chem Soc (2007) 0.92
Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit. Biochemistry (2010) 0.91
Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling. J Biol Chem (2008) 0.91
Virtual screening for lead discovery. Methods Mol Biol (2011) 0.91
Impact of cis-proline analogs on peptide conformation. Biopolymers (2006) 0.91
A virtual library of constrained cyclic tetrapeptides that mimics all four side-chain orientations for over half the reverse turns in the protein data bank. J Comput Aided Mol Des (2008) 0.90
Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor. Biochemistry (2008) 0.89
Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation. Cell Cycle (2007) 0.89
Relative strength of cation-pi vs salt-bridge interactions: the Gtalpha(340-350) peptide/rhodopsin system. J Am Chem Soc (2006) 0.88
Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region. J Biol Chem (2010) 0.87
PHOENIX: a scoring function for affinity prediction derived using high-resolution crystal structures and calorimetry measurements. J Chem Inf Model (2011) 0.87
G-protein alpha and beta-gamma subunits interact with conformationally distinct signaling states of rhodopsin. Vision Res (2006) 0.86
Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye. Proc Natl Acad Sci U S A (2007) 0.85
Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem (2008) 0.85
Insight into the binding mode for cyclopentapeptide antagonists of the CXCR4 receptor. Chem Biol Drug Des (2006) 0.85
Three-dimensional model for meta-II rhodopsin, an activated G-protein-coupled receptor. Biochemistry (2003) 0.85
Design, synthesis, and metal binding of novel Pseudo- oligopeptides containing two phosphinic acid groups. Biopolymers (2008) 0.85
Motion of carboxyl terminus of Galpha is restricted upon G protein activation. A solution NMR study using semisynthetic Galpha subunits. J Biol Chem (2005) 0.84
Interactions between conserved residues in transmembrane helices 2 and 7 during angiotensin AT1 receptor activation. Chem Biol Drug Des (2006) 0.84
Conformationally restricted TRH analogues: constraining the pyroglutamate region. Bioorg Med Chem (2002) 0.84
Hydroxamate-based iron chelators: combinatorial syntheses of desferrioxamine B analogues and evaluation of binding affinities. J Comb Chem (2004) 0.83
Modeling of the complex between transducin and photoactivated rhodopsin, a prototypical G-protein-coupled receptor. Biochemistry (2007) 0.82
Frizzled receptors signal through G proteins. Cell Signal (2013) 0.82
Molecular dynamics of β-hairpin models of epigenetic recognition motifs. J Am Chem Soc (2012) 0.82
Privileged scaffolds targeting reverse-turn and helix recognition. Expert Opin Ther Targets (2008) 0.82
Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study. Proteins (2011) 0.82
Engineering cyclic tetrapeptides containing chimeric amino acids as preferred reverse-turn scaffolds. J Med Chem (2006) 0.81
Do benzodiazepines mimic reverse-turn structures? J Comput Aided Mol Des (2006) 0.81
A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues. J Biol Chem (2006) 0.81
Synthesis of the phenylpyridal scaffold as a helical peptide mimetic. Chemistry (2010) 0.81
Histone deacetylase inhibitors: structure-based modeling and isoform-selectivity prediction. J Chem Inf Model (2012) 0.81
Drug-like leads for steric discrimination between substrate and inhibitors of human acetylcholinesterase. Chem Biol Drug Des (2011) 0.81
Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking. J Biol Chem (2006) 0.80
Alternate binding mode of C-terminal phenethylamine analogs of G(t)alpha(340-350) to photoactivated rhodopsin. Chem Biol Drug Des (2006) 0.80
Difference between restoring and predicting 3D structures of the loops in G-protein-coupled receptors by molecular modeling. Proc Natl Acad Sci U S A (2011) 0.80
A comprehensive structure-function map of the intracellular surface of the human C5a receptor. II. Elucidation of G protein specificity determinants. J Biol Chem (2006) 0.80
A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genomics (2013) 0.80
Novel trihydroxamate-containing peptides: design, synthesis, and metal coordination. Biopolymers (2006) 0.80
SKATE: a docking program that decouples systematic sampling from scoring. J Comput Chem (2010) 0.80
ProVal: a protein-scoring function for the selection of native and near-native folds. Proteins (2004) 0.79
A second look at mini-protein stability: analysis of FSD-1 using circular dichroism, differential scanning calorimetry, and simulations. Biophys J (2009) 0.79
Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors. Chem Biol Drug Des (2010) 0.79
Conformational templates for rational drug design: flexibility of cyclo(D-Pro1-Ala2-Ala3-Ala4-Ala5) in DMSO solution. J Med Chem (2007) 0.79
Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor. Proteins (2010) 0.79
Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors. Chem Biol Drug Des (2007) 0.79
Using ligand-based virtual screening to allosterically stabilize the activated state of a GPCR. Chem Biol Drug Des (2010) 0.78
Peptide-bond modification for metal coordination: peptides containing two hydroxamate groups. Biopolymers (2003) 0.78
Design, synthesis and QSAR studies on N-aryl heteroarylisopropanolamines, a new class of non-peptidic HIV-1 protease inhibitors. Bioorg Med Chem (2002) 0.78
3D modeling of the activated states of constitutively active mutants of rhodopsin. Biochem Biophys Res Commun (2006) 0.78
Structural models for the complex of chemotaxis inhibitory protein of Staphylococcus aureus with the C5a receptor. Biochem Biophys Res Commun (2009) 0.78
E2F8 is a nonreceptor activator of heterotrimeric G proteins. J Mol Signal (2007) 0.77
Conformational movement of F251 contributes to the molecular mechanism of constitutive activation in the C5a receptor. Chem Biol Drug Des (2008) 0.77
Defining the interface between the C-terminal fragment of alpha-transducin and photoactivated rhodopsin. Biophys J (2007) 0.77
Impact of azaproline on Peptide conformation. J Org Chem (2004) 0.77
Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents. Bioorg Med Chem Lett (2003) 0.77
Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence. FEBS J (2009) 0.77
Comprehensive model of wild-type and mutant HIV-1 reverse transciptases. J Comput Aided Mol Des (2012) 0.76
A minimalistic 3D pharmacophore model for cyclopentapeptide CXCR4 antagonists. Biopolymers (2006) 0.76
Comparison of the retinitis pigmentosa mutations in rhodopsin with a functional map of the C5a receptor. Vision Res (2006) 0.76
Impact of azaproline on amide cis-trans isomerism: conformational analyses and NMR studies of model peptides including TRH analogues. J Am Chem Soc (2003) 0.76
Thyroid cancer: what to do after fine needle aspiration. Mo Med (2011) 0.76
Engineering metal complexes of chiral pentaazacrowns as privileged reverse-turn scaffolds. Chem Biol Drug Des (2007) 0.76
Helix stability of oligoglycine, oligoalanine, and oligo-β-alanine dodecamers reflected by hydrogen-bond persistence. Proteins (2014) 0.76
c[D-pro-Pro-D-pro-N-methyl-Ala] adopts a rigid conformation that serves as a scaffold to mimic reverse-turns. Biopolymers (2008) 0.75
Metal complexes of chiral pentaazacrowns as conformational templates for beta-turn recognition. J Comput Aided Mol Des (2003) 0.75
Validated ligand mapping of ACE active site. J Comput Aided Mol Des (2005) 0.75
Computational modeling of constitutively active mutants of GPCRs C5a receptor. Methods Enzymol (2010) 0.75