Published in J Mol Signal on March 30, 2007
E2f8 mediates tumor suppression in postnatal liver development. J Clin Invest (2016) 0.77
E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. J Cancer (2017) 0.75
Mitogen-activated protein kinase pathways. Curr Opin Cell Biol (1997) 9.10
Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol (2002) 7.64
The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev (2000) 5.93
G protein pathways. Science (2002) 5.29
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu Rev Biochem (2001) 3.86
G-protein signaling through tubby proteins. Science (2001) 3.59
GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci (1997) 3.50
Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev (1999) 2.73
Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. J Biol Chem (2002) 2.46
Bioactive lysophospholipids and their G protein-coupled receptors. Exp Cell Res (1999) 2.17
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J (2003) 2.14
E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene (1998) 2.12
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell (2004) 2.09
Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. Nat Biotechnol (1999) 2.09
Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2003) 2.04
Receptor-independent activators of heterotrimeric G-protein signaling pathways. J Biol Chem (1999) 2.00
In vivo association of E2F and DP family proteins. Mol Cell Biol (1995) 1.99
Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem (2005) 1.95
G0 is a major growth cone protein subject to regulation by GAP-43. Nature (1990) 1.72
Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell (1995) 1.71
E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. Oncogene (2005) 1.69
Functional properties of a Drosophila homolog of the E2F1 gene. Mol Cell Biol (1994) 1.67
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res (2005) 1.61
E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains. Oncogene (2004) 1.44
Development of C5a receptor antagonists. Differential loss of functional responses. J Immunol (1994) 1.39
AGS proteins: receptor-independent activators of G-protein signaling. Trends Pharmacol Sci (2005) 1.34
Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8. Curr Biol (2004) 1.33
RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell (2004) 1.27
E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form. J Biol Chem (2002) 1.26
Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein alpha-subunit chimeras. Yeast (2000) 1.24
Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration. J Biol Chem (2000) 1.24
Heterotrimeric G proteins: new tricks for an old dog. Cell (2004) 1.23
Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43. EMBO J (1992) 1.13
C5a receptor activation. Genetic identification of critical residues in four transmembrane helices. J Biol Chem (1999) 1.10
Functional analysis of heterologous GPCR signalling pathways in yeast. Trends Biotechnol (2005) 0.98
Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic (2002) 0.98
GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (1993) 0.96
An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism. J Biol Chem (1991) 0.93
Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. J Biol Chem (2002) 0.90
An amino-terminal domain of the growth-associated protein GAP-43 mediates its effects on filopodial formation and cell spreading. J Cell Sci (1994) 0.89
Essential role for the second extracellular loop in C5a receptor activation. Nat Struct Mol Biol (2005) 2.71
A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech (2011) 1.92
Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell (2013) 1.69
C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J Biol Chem (2003) 1.44
A Drosophila model of high sugar diet-induced cardiomyopathy. PLoS Genet (2013) 1.28
Modeling the possible conformations of the extracellular loops in G-protein-coupled receptors. Proteins (2010) 1.27
Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop. J Biol Chem (2006) 1.00
C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J Biol Chem (2003) 0.98
Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech (2013) 0.98
Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic (2002) 0.98
Prognostic factors in patients with well-differentiated thyroid cancer presenting with pulmonary metastasis. Cancer Biother Radiopharm (2008) 0.95
Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem (2013) 0.93
Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit. Biochemistry (2010) 0.91
Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling. J Biol Chem (2008) 0.91
Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor. Biochemistry (2008) 0.89
Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation. Cell Cycle (2007) 0.89
Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region. J Biol Chem (2010) 0.87
Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye. Proc Natl Acad Sci U S A (2007) 0.85
Motion of carboxyl terminus of Galpha is restricted upon G protein activation. A solution NMR study using semisynthetic Galpha subunits. J Biol Chem (2005) 0.84
Frizzled receptors signal through G proteins. Cell Signal (2013) 0.82
Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study. Proteins (2011) 0.82
A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues. J Biol Chem (2006) 0.81
Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking. J Biol Chem (2006) 0.80
Difference between restoring and predicting 3D structures of the loops in G-protein-coupled receptors by molecular modeling. Proc Natl Acad Sci U S A (2011) 0.80
Expressed protein ligation to study protein interactions: semi-synthesis of the G-protein alpha subunit. Protein Pept Lett (2005) 0.80
A comprehensive structure-function map of the intracellular surface of the human C5a receptor. II. Elucidation of G protein specificity determinants. J Biol Chem (2006) 0.80
A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genomics (2013) 0.80
Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor. Proteins (2010) 0.79
Structural models for the complex of chemotaxis inhibitory protein of Staphylococcus aureus with the C5a receptor. Biochem Biophys Res Commun (2009) 0.78
Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence. FEBS J (2009) 0.77
Conformational movement of F251 contributes to the molecular mechanism of constitutive activation in the C5a receptor. Chem Biol Drug Des (2008) 0.77
Comparison of the retinitis pigmentosa mutations in rhodopsin with a functional map of the C5a receptor. Vision Res (2006) 0.76
Thyroid cancer: what to do after fine needle aspiration. Mo Med (2011) 0.76
Computational modeling of constitutively active mutants of GPCRs C5a receptor. Methods Enzymol (2010) 0.75