Published in PLoS Biol on December 06, 2011
A high-coverage genome sequence from an archaic Denisovan individual. Science (2012) 7.89
Human-specific transcriptional networks in the brain. Neuron (2012) 2.80
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci (2012) 2.52
Comparative studies of gene expression and the evolution of gene regulation. Nat Rev Genet (2012) 1.79
MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
Cortical evolution: judge the brain by its cover. Neuron (2013) 1.54
An overview of microRNAs. Adv Drug Deliv Rev (2015) 1.48
Identification of differentially expressed microRNAs across the developing human brain. Mol Psychiatry (2013) 1.30
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res (2012) 1.27
Comparative primate genomics: emerging patterns of genome content and dynamics. Nat Rev Genet (2014) 1.23
The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression. PLoS One (2013) 1.22
Human brain evolution: transcripts, metabolites and their regulators. Nat Rev Neurosci (2013) 1.16
The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical neurons. J Neurosci (2013) 1.14
Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration. Front Neurosci (2012) 1.09
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol (2012) 1.08
Evolution of the human-specific microRNA miR-941. Nat Commun (2012) 1.06
Evolutionary biology for the 21st century. PLoS Biol (2013) 1.01
Systematic reviews of animal models: methodology versus epistemology. Int J Med Sci (2013) 1.01
Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain. EMBO J (2012) 0.97
Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers. PLoS One (2015) 0.96
Transcription factors are targeted by differentially expressed miRNAs in primates. Genome Biol Evol (2012) 0.93
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System. Neuron (2016) 0.93
Comparative analysis of human and mouse expression data illuminates tissue-specific evolutionary patterns of miRNAs. Nucleic Acids Res (2012) 0.92
Nonhuman primate models in the genomic era: a paradigm shift. ILAR J (2013) 0.89
Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species. BMC Genomics (2013) 0.87
Identification of a core miRNA-pathway regulatory network in glioma by therapeutically targeting miR-181d, miR-21, miR-23b, β-Catenin, CBP, and STAT3. PLoS One (2014) 0.87
An emerging role for microRNAs in sexually dimorphic neurobiological systems. Pflugers Arch (2013) 0.86
Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees. Genome Biol Evol (2015) 0.85
Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of systemic sclerosis and Sjögren's syndrome. Autoimmun Rev (2013) 0.84
Genetics of gene expression in CNS. Int Rev Neurobiol (2014) 0.84
Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression. Schizophr Bull (2013) 0.84
The evolution of Homo sapiens denisova and Homo sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain. BMC Genomics (2015) 0.84
Variations in the non-coding transcriptome as a driver of inter-strain divergence and physiological adaptation in bacteria. Sci Rep (2015) 0.83
BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation. Front Cell Neurosci (2014) 0.83
Steroids as external temporal codes act via microRNAs and cooperate with cytokines in differential neurogenesis. Fly (Austin) (2013) 0.82
Loss of functional Dicer in mouse radial glia cell-autonomously prolongs cortical neurogenesis. Dev Biol (2013) 0.81
Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. PLoS Biol (2016) 0.81
MicroRNAs in opioid addiction: elucidating evolution. Front Genet (2012) 0.81
Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs. Cereb Cortex (2014) 0.80
Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains. J Child Neurol (2015) 0.80
Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain. Front Neurosci (2016) 0.80
Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with Distal Enhancers and Noncoding RNAs. Genome Biol Evol (2015) 0.79
CNVs-microRNAs interactions demonstrate unique characteristics in the human genome. An interspecies in silico analysis. PLoS One (2013) 0.79
Host gene constraints and genomic context impact the expression and evolution of human microRNAs. Nat Commun (2016) 0.78
Refinement of neuronal synchronization with gamma oscillations in the medial prefrontal cortex after adolescence. PLoS One (2013) 0.78
Extensive ceRNA-ceRNA interaction networks mediated by miRNAs regulate development in multiple rhesus tissues. Nucleic Acids Res (2016) 0.77
A Consensus Network of Gene Regulatory Factors in the Human Frontal Lobe. Front Genet (2016) 0.77
Changes in snoRNA and snRNA Abundance in the Human, Chimpanzee, Macaque, and Mouse Brain. Genome Biol Evol (2016) 0.76
Functional genomics of human brain development and implications for autism spectrum disorders. Transl Psychiatry (2015) 0.76
Evolution of human longevity uncoupled from caloric restriction mechanisms. PLoS One (2014) 0.76
Phenotypic variation in infants, not adults, reflects genotypic variation among chimpanzees and bonobos. PLoS One (2014) 0.76
miR-204 downregulates EphB2 in aging mouse hippocampal neurons. Aging Cell (2016) 0.75
microRNAs and the adolescent brain: Filling the knowledge gap. Neurosci Biobehav Rev (2016) 0.75
Nr3C1-Bhlhb2 Axis Dysregulation Is Involved in the Development of Attention Deficit Hyperactivity. Mol Neurobiol (2016) 0.75
Layer cake: the first bite at gene expression diversity in the human brain. Genome Biol (2012) 0.75
Genetics of Cerebellar and Neocortical Expansion in Anthropoid Primates: A Comparative Approach. Brain Behav Evol (2017) 0.75
Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. Sci Rep (2017) 0.75
Evolution of the Human Nervous System Function, Structure, and Development. Cell (2017) 0.75
Evolutionary comparisons of miRNA regulation system in six model organisms. Genetica (2014) 0.75
Noncoding RNAs in neurodegeneration. Nat Rev Neurosci (2017) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
BLAT--the BLAST-like alignment tool. Genome Res (2002) 126.78
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol (2010) 75.21
KEGG for linking genomes to life and the environment. Nucleic Acids Res (2007) 49.37
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
Initial sequence of the chimpanzee genome and comparison with the human genome. Nature (2005) 25.67
Evolution at two levels in humans and chimpanzees. Science (1975) 21.07
Ensembl 2007. Nucleic Acids Res (2006) 20.10
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27
A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol (2011) 16.53
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
MATCH: A tool for searching transcription factor binding sites in DNA sequences. Nucleic Acids Res (2003) 11.82
A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19
Intra- and interspecific variation in primate gene expression patterns. Science (2002) 7.92
Diversity of microRNAs in human and chimpanzee brain. Nat Genet (2006) 6.57
Evolutionary changes in cis and trans gene regulation. Nature (2004) 6.24
Analysis of chemical modification of RNA from formalin-fixed samples and optimization of molecular biology applications for such samples. Nucleic Acids Res (1999) 5.69
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science (2005) 5.68
Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron (2009) 5.46
Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci U S A (2003) 4.69
A neutral model of transcriptome evolution. PLoS Biol (2004) 3.44
Regulatory changes underlying expression differences within and between Drosophila species. Nat Genet (2008) 3.24
Gene expression divergence recapitulates the developmental hourglass model. Nature (2010) 3.20
Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron (2008) 3.14
The emergence of humans: the coevolution of intelligence and longevity with intergenerational transfers. Proc Natl Acad Sci U S A (2002) 2.99
optix drives the repeated convergent evolution of butterfly wing pattern mimicry. Science (2011) 2.99
Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc (2007) 2.80
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles. Proc Natl Acad Sci U S A (2004) 2.74
Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals. PLoS Genet (2011) 2.53
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res (2010) 2.44
Genetics and the making of Homo sapiens. Nature (2003) 2.20
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc Natl Acad Sci U S A (2010) 2.06
MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors. Brain Pathol (2008) 1.90
Ontogeny of the human central nervous system: what is happening when? Early Hum Dev (2005) 1.85
Morphological evolution caused by many subtle-effect substitutions in regulatory DNA. Nature (2011) 1.83
Transcriptional neoteny in the human brain. Proc Natl Acad Sci U S A (2009) 1.78
Transcriptional regulation of vertebrate axon guidance and synapse formation. Nat Rev Neurosci (2007) 1.69
Both noncoding and protein-coding RNAs contribute to gene expression evolution in the primate brain. Genome Biol Evol (2010) 1.45
Spatial organization of neurons in the frontal pole sets humans apart from great apes. Cereb Cortex (2010) 1.42
Accelerated recruitment of new brain development genes into the human genome. PLoS Biol (2011) 1.39
Rapid sequence and expression divergence suggest selection for novel function in primate-specific KRAB-ZNF genes. Mol Biol Evol (2010) 1.38
Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories. BMC Genomics (2008) 1.33
Evolution of gene sequence and gene expression are not correlated in yeast. Trends Genet (2008) 1.28
Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Mol Psychiatry (2009) 1.22
MicroRNAs in CNS injury: potential roles and therapeutic implications. Bioessays (2011) 1.05
Cytokine responses to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques. Learn Mem (2001) 0.99
Social cognition and the prefrontal cortex. Behav Cogn Neurosci Rev (2003) 0.86
Evolution of neuronal and endothelial transcriptomes in primates. Genome Biol Evol (2010) 0.85
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature (2010) 8.99
Sequencing and analysis of Neanderthal genomic DNA. Science (2006) 8.06
Intra- and interspecific variation in primate gene expression patterns. Science (2002) 7.92
A high-coverage genome sequence from an archaic Denisovan individual. Science (2012) 7.89
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol (2004) 7.36
Conservation and divergence of methylation patterning in plants and animals. Proc Natl Acad Sci U S A (2010) 7.30
Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med (2011) 7.16
The evolution of gene expression levels in mammalian organs. Nature (2011) 7.16
Human susceptibility and resistance to Norwalk virus infection. Nat Med (2003) 7.07
Cubic AgPb(m)SbTe(2+m): bulk thermoelectric materials with high figure of merit. Science (2004) 7.07
Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat Genet (2004) 6.99
A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell (2008) 6.98
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet (2011) 6.98
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
Altered histone acetylation is associated with age-dependent memory impairment in mice. Science (2010) 6.38
Analysis of one million base pairs of Neanderthal DNA. Nature (2006) 6.17
Patterns of damage in genomic DNA sequences from a Neandertal. Proc Natl Acad Sci U S A (2007) 6.12
Molecular evolution of FOXP2, a gene involved in speech and language. Nature (2002) 5.89
A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning. Nat Genet (2006) 5.81
Genomewide comparison of DNA sequences between humans and chimpanzees. Am J Hum Genet (2002) 5.80
Targeted retrieval and analysis of five Neandertal mtDNA genomes. Science (2009) 5.79
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science (2005) 5.68
A genome-wide comparison of recent chimpanzee and human segmental duplications. Nature (2005) 5.51
Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol (2011) 5.48
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38
Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med (2013) 5.38
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet (2007) 5.28
Relationship between nucleosome positioning and DNA methylation. Nature (2010) 5.27
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum (2005) 5.18
Pack-MULE transposable elements mediate gene evolution in plants. Nature (2004) 5.13
Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet (2005) 5.00
Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA (2003) 4.88
Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature (2011) 4.85
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Evidence for gradients of human genetic diversity within and among continents. Genome Res (2004) 4.70
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Early allelic selection in maize as revealed by ancient DNA. Science (2003) 4.38
Ligand configurational entropy and protein binding. Proc Natl Acad Sci U S A (2007) 4.33
From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing. Nucleic Acids Res (2007) 4.26
Transmit and receive transmission line arrays for 7 Tesla parallel imaging. Magn Reson Med (2005) 4.25
Fast mapping of short sequences with mismatches, insertions and deletions using index structures. PLoS Comput Biol (2009) 4.24
Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting. Am J Obstet Gynecol (2011) 4.18
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Norwalk virus binds to histo-blood group antigens present on gastroduodenal epithelial cells of secretor individuals. Gastroenterology (2002) 4.13
Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patterns. J Infect Dis (2003) 4.03
Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature (2012) 4.00
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature (2010) 3.90
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science (2006) 3.87
Accelerated evolution of conserved noncoding sequences in humans. Science (2006) 3.87
Estimating accuracy of RNA-Seq and microarrays with proteomics. BMC Genomics (2009) 3.87
Regional patterns of gene expression in human and chimpanzee brains. Genome Res (2004) 3.84
No evidence of Neandertal mtDNA contribution to early modern humans. PLoS Biol (2004) 3.81
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns. J Virol (2005) 3.74
Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae. Nature (2005) 3.74
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71
The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr Biol (2007) 3.70
Epidemiological evidence for the link between sleep duration and high blood pressure: a systematic review and meta-analysis. Sleep Med (2013) 3.68
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell (2009) 3.63
Structural basis for the recognition of blood group trisaccharides by norovirus. J Virol (2007) 3.58
A neutral explanation for the correlation of diversity with recombination rates in humans. Am J Hum Genet (2003) 3.57
Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab (2006) 3.57
Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J (2010) 3.55
Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. Am J Hum Genet (2011) 3.53
Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum Mutat (2007) 3.52
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45
A neutral model of transcriptome evolution. PLoS Biol (2004) 3.44
RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in arabidopsis. PLoS Genet (2006) 3.41
Genomic sequencing of Pleistocene cave bears. Science (2005) 3.40
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39
The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol (2007) 3.39
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Multiplexed DNA sequence capture of mitochondrial genomes using PCR products. PLoS One (2010) 3.35
E2-2 protein and Fuchs's corneal dystrophy. N Engl J Med (2010) 3.31
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28
Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27