Published in Genes Dev on December 01, 2005
TGFbeta in Cancer. Cell (2008) 17.44
SMAD proteins control DROSHA-mediated microRNA maturation. Nature (2008) 9.67
TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 8.08
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60
Non-Smad pathways in TGF-beta signaling. Cell Res (2009) 5.54
Framework for a protein ontology. BMC Bioinformatics (2007) 5.24
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30
Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93
Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis. Nat Genet (2011) 3.93
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell (2008) 3.87
Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 3.69
Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol (2007) 3.47
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci U S A (2006) 3.13
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell (2010) 3.12
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell (2008) 3.04
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol (2010) 3.00
Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum Mutat (2009) 2.81
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun (2012) 2.65
A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A (2006) 2.60
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell (2013) 2.58
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest (2007) 2.52
Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell (2014) 2.43
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41
Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech (2013) 2.40
Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut (2007) 2.35
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol (2008) 2.21
BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein. J Cell Biol (2006) 2.17
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev (2007) 2.14
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12
Nodal morphogens. Cold Spring Harb Perspect Biol (2009) 2.09
Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A (2010) 2.07
Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology (2008) 2.04
Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol (2010) 2.01
Human hepatic stem cell and maturational liver lineage biology. Hepatology (2011) 1.99
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood (2008) 1.95
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med (2012) 1.93
Phospho-control of TGF-beta superfamily signaling. Cell Res (2009) 1.91
Development of the endochondral skeleton. Cold Spring Harb Perspect Biol (2013) 1.89
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest (2008) 1.88
Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem (2008) 1.84
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol (2008) 1.77
TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol (2011) 1.75
Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system. Proc Natl Acad Sci U S A (2008) 1.75
Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. Oncogene (2013) 1.74
Conversion of mechanical force into TGF-β-mediated biochemical signals. Curr Biol (2011) 1.74
Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol (2007) 1.72
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One (2009) 1.72
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med (2009) 1.69
Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol (2011) 1.68
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol (2007) 1.68
GLI2-mediated melanoma invasion and metastasis. J Natl Cancer Inst (2010) 1.68
Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice. J Clin Invest (2009) 1.67
Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell (2009) 1.67
Transforming growth factor-β and the hallmarks of cancer. Cell Signal (2010) 1.66
MYC and Breast Cancer. Genes Cancer (2010) 1.66
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol (2007) 1.65
Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis. Cancer Res (2011) 1.62
β-Catenin is essential for Müllerian duct regression during male sexual differentiation. Development (2011) 1.62
The inner nuclear envelope as a transcription factor resting place. EMBO Rep (2007) 1.61
Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. Dev Dyn (2006) 1.61
Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons. J Neurosci (2009) 1.61
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn (2007) 1.61
The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment Cell Res (2006) 1.59
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell (2012) 1.58
Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs (2010) 1.57
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol (2006) 1.54
MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module. Blood (2013) 1.52
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc Natl Acad Sci U S A (2006) 1.52
High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE (2007) 1.51
A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol (2007) 1.51
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J (2007) 1.49
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology (2009) 1.47
Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res (2010) 1.47
Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts. Mol Vis (2012) 1.45
Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation. J Biol Chem (2009) 1.45
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. Dev Cell (2009) 1.45
Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. J Biol Chem (2007) 1.43
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP). J Bone Miner Metab (2008) 1.41
Regulation of Smad activities. Biochim Biophys Acta (2006) 1.41
Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum (2008) 1.41
TGF-β - an excellent servant but a bad master. J Transl Med (2012) 1.41
Sequence comparison by sequence harmony identifies subtype-specific functional sites. Nucleic Acids Res (2006) 1.40
Cerebellum development and medulloblastoma. Curr Top Dev Biol (2011) 1.40
Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant. PLoS One (2016) 1.39
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts. PLoS One (2017) 1.39
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell (2015) 1.38
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem (2010) 1.38
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38
Noncanonical TGF-β signaling during mammary tumorigenesis. J Mammary Gland Biol Neoplasia (2011) 1.38
The polycomb protein Pc2 is a SUMO E3. Cell (2003) 3.91
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res (2008) 3.70
TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma. Cancer Cell (2010) 3.69
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell (2009) 3.38
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell (2007) 3.27
A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A (2006) 2.60
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med (2012) 1.93
TGIF inhibits retinoid signaling. Mol Cell Biol (2006) 1.40
Circulating tumour cells and cell-free DNA as tools for managing breast cancer. Nat Rev Clin Oncol (2013) 1.33
Multiple activities contribute to Pc2 E3 function. EMBO J (2004) 1.19
Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development (2010) 1.12
Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway. PLoS Genet (2012) 1.10
TGF-beta signalling-related markers in cancer patients with bone metastasis. Biomarkers (2008) 1.09
A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity. PLoS One (2010) 1.04
Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer. Invest New Drugs (2014) 1.04
The Tgif2 gene contains a retained intron within the coding sequence. BMC Mol Biol (2006) 1.03
Functional analysis of mutations in TGIF associated with holoprosencephaly. Mol Genet Metab (2006) 1.02
Opposite Smad and chicken ovalbumin upstream promoter transcription factor inputs in the regulation of the collagen VII gene promoter by transforming growth factor-beta. J Biol Chem (2004) 0.99
Maternal Tgif is required for vascularization of the embryonic placenta. Dev Biol (2008) 0.98
Drosophila TGIF proteins are transcriptional activators. Mol Cell Biol (2003) 0.93
dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2. Genetics (2006) 0.92
Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. Mol Cell Biol (2011) 0.91
Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation. Cancer Discov (2013) 0.91
Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis. Exp Cell Res (2009) 0.90
Premature senescence and increased TGFβ signaling in the absence of Tgif1. PLoS One (2012) 0.88
Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells. Mol Cell Biol (2013) 0.87
The Runx3 distal transcript encodes an additional transcriptional activation domain. FEBS J (2007) 0.84
Tgif1 represses apolipoprotein gene expression in liver. J Cell Biochem (2010) 0.83
Inhibition of CtBP1 activity by Akt-mediated phosphorylation. J Mol Biol (2010) 0.82
New approach to cancer therapy based on a molecularly defined cancer classification. CA Cancer J Clin (2013) 0.82
An autoinhibitory effect of the homothorax domain of Meis2. FEBS J (2010) 0.80
A rapid strategy to detect the recombined allele in LSL-TβRICA transgenic mice. Genesis (2010) 0.79
TGFbeta and cancer initiating cells. Cell Cycle (2009) 0.79
The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila. PLoS One (2010) 0.79
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2. J Lipid Res (2014) 0.78
Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1. Oncotarget (2014) 0.76
Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells. J Med Chem (2012) 0.76
Circulating tumour cells in early breast cancer. Lancet Oncol (2012) 0.75
Interrogating open issues in cancer medicine with patient-derived xenografts. Nat Rev Cancer (2017) 0.75