Published in Proc Natl Acad Sci U S A on August 14, 2006
TGFbeta in Cancer. Cell (2008) 17.44
SMAD proteins control DROSHA-mediated microRNA maturation. Nature (2008) 9.67
TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 8.08
Non-Smad pathways in TGF-beta signaling. Cell Res (2009) 5.54
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30
FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol (2008) 3.70
Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell (2013) 3.49
C. elegans dauer formation and the molecular basis of plasticity. Genes Dev (2008) 3.20
Foxo transcription factors control regulatory T cell development and function. Immunity (2010) 3.17
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45
Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech (2013) 2.40
Notch tumor suppressor function. Oncogene (2008) 2.26
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer (2008) 1.78
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol (2008) 1.77
TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol (2011) 1.75
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging (Albany NY) (2011) 1.65
Codependent activators direct myoblast-specific MyoD transcription. Dev Cell (2008) 1.52
Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling. Oncogene (2011) 1.48
Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. J Biol Chem (2007) 1.43
Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol (2007) 1.36
Atrogin-1, MuRF-1, and sarcopenia. Endocrine (2012) 1.33
FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol (2009) 1.27
CXCR4 expression in prostate cancer progenitor cells. PLoS One (2012) 1.25
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J (2008) 1.24
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene (2013) 1.19
Targeting TGF-β signaling in cancer. Expert Opin Ther Targets (2013) 1.16
The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A (2008) 1.12
Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. Mol Cell Biol (2008) 1.12
The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. Crit Rev Eukaryot Gene Expr (2011) 1.11
PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet (2011) 1.10
Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res (2008) 1.09
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules. BMC Syst Biol (2009) 1.08
Attenuation of the transforming growth factor beta-signaling pathway in chronic venous ulcers. Mol Med (2010) 1.05
Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics (2010) 1.05
Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell (2014) 1.04
Genome-wide mechanisms of Smad binding. Oncogene (2012) 1.02
Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. Mol Biol Cell (2007) 0.99
Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. PLoS One (2015) 0.99
Resistance to transforming growth factor β-mediated tumor suppression in melanoma: are multiple mechanisms in place? Carcinogenesis (2010) 0.97
Roles of Smad3 in TGF-beta signaling during carcinogenesis. Crit Rev Eukaryot Gene Expr (2007) 0.96
Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads. FEBS Lett (2012) 0.95
Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev Cell (2013) 0.95
Forkhead BoxO transcription factors restrain exercise-induced angiogenesis. J Physiol (2014) 0.94
Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem (2011) 0.94
Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo. Mol Endocrinol (2013) 0.93
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells. Int J Cancer (2010) 0.93
OVOL guides the epithelial-hybrid-mesenchymal transition. Oncotarget (2015) 0.93
ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One (2011) 0.92
Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human. Fertil Steril (2012) 0.92
The molecular mechanisms of Foxp3 gene regulation. Semin Immunol (2011) 0.91
Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. J Immunol (2011) 0.90
Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK. J Biol Chem (2010) 0.89
Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS One (2010) 0.89
Cell density sensing alters TGF-β signaling in a cell-type-specific manner, independent from Hippo pathway activation. Dev Cell (2015) 0.88
FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. J Biol Chem (2009) 0.87
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β. J Biol Chem (2013) 0.87
Foxo1 regulates marginal zone B-cell development. Eur J Immunol (2010) 0.86
FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH. Mol Endocrinol (2013) 0.86
Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells. Exp Cell Res (2010) 0.86
microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS One (2013) 0.86
Various jobs of proteolytic enzymes in skeletal muscle during unloading: facts and speculations. J Biomed Biotechnol (2012) 0.85
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression. J Lipid Res (2008) 0.85
Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development (2013) 0.85
Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev (2013) 0.83
Causes and consequences of nuclear envelope alterations in tumour progression. Eur J Cell Biol (2016) 0.83
Comprehensive genomic profiling in diabetic nephropathy reveals the predominance of proinflammatory pathways. Physiol Genomics (2013) 0.82
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts. Cell Rep (2015) 0.82
Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. J Cell Sci (2012) 0.82
SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner. Am J Physiol Cell Physiol (2014) 0.82
New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder. Adv Exp Med Biol (2009) 0.81
Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol (2015) 0.81
FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1. Circ Res (2015) 0.80
Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease. Cancer Res (2015) 0.79
Cell type-specific regulation of CCN2 protein expression by PI3K-AKT-FoxO signaling. J Cell Commun Signal (2009) 0.79
TGFbeta versatility: PI3K as a critical mediator of distinct cell type and context specific responses. Cell Cycle (2009) 0.78
Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One (2012) 0.78
Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. PLoS One (2014) 0.77
The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-β pathway. PLoS One (2015) 0.77
Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovasc Diabetol (2016) 0.77
An otx/nodal regulatory signature for posterior neural development in ascidians. PLoS Genet (2014) 0.77
Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. Oncogene (2016) 0.76
Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies. J Clin Med (2016) 0.75
Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut. Mediators Inflamm (2015) 0.75
Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway. Oncotarget (2017) 0.75
The Borg family of Cdc42 effector proteins Cdc42EP1-5. Biochem Soc Trans (2016) 0.75
SMAD transcription factors are altered in cell models of HD and regulate HTT expression. Cell Signal (2016) 0.75
C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation. PLoS Genet (2017) 0.75
Rapamycin enhances the antiproliferative effect of transforming growth factor-β on MCF-7 human breast cancer cells. Exp Ther Med (2017) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer (2002) 28.11
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
Smad transcription factors. Genes Dev (2005) 13.43
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
TGF-beta signaling in tumor suppression and cancer progression. Nat Genet (2001) 11.64
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell (2000) 11.10
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer (2003) 8.35
Predicting gene expression from sequence. Cell (2004) 8.12
Mechanism of activation of the TGF-beta receptor. Nature (1994) 8.10
FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene (2005) 7.50
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell (2004) 6.35
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 5.78
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev (1999) 5.13
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88
Transforming growth factor-beta in T-cell biology. Nat Rev Immunol (2002) 4.50
The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci U S A (2003) 4.41
Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A (2005) 4.20
Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat Genet (2004) 4.09
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell (2003) 3.57
Synexpression groups in eukaryotes. Nature (1999) 3.49
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell (2006) 3.31
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87
Connective tissue growth factor: what's in a name? Mol Genet Metab (2000) 2.82
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol (2005) 2.41
Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development (2004) 2.28
Nodal signalling in vertebrate development. Nature (2000) 2.20
Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol (1995) 2.08
Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem (2003) 1.97
Borg proteins control septin organization and are negatively regulated by Cdc42. Nat Cell Biol (2001) 1.76
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J (2004) 1.60
Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta. EMBO J (2002) 1.59
McBindall--a better name for CCAAT/enhancer binding proteins? Cell (2001) 1.55
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines. J Biol Chem (2005) 1.50
IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. EMBO J (2002) 1.26
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development (2005) 1.12
Global gene expression profiling and cluster analysis in Xenopus laevis. Mech Dev (2005) 1.10
Dpp-responsive silencers are bound by a trimeric Mad-Medea complex. J Biol Chem (2005) 1.07
Insulin's expanding control of forkheads. Proc Natl Acad Sci U S A (2003) 0.88
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85
Cancer metastasis: building a framework. Cell (2006) 19.67
A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
Smad transcription factors. Genes Dev (2005) 13.43
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer (2003) 8.35
Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23
Molecular basis of metastasis. N Engl J Med (2008) 8.19
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60
Epithelial-mesenchymal transitions: twist in development and metastasis. Cell (2004) 7.14
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med (2012) 6.93
Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66
Genetic determinants of cancer metastasis. Nat Rev Genet (2007) 6.38
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell (2004) 6.35
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (2002) 5.25
Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24
A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell (2005) 4.46
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell (2010) 4.37
Roles of TGFbeta in metastasis. Cell Res (2009) 4.35
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A (2005) 4.20
Frequent mutation of the PIK3CA gene in ovarian and breast cancers. Clin Cancer Res (2005) 4.14
Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell (2009) 3.76
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res (2008) 3.70
TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma. Cancer Cell (2010) 3.69
In vitro and in vivo two-photon luminescence imaging of single gold nanorods. Proc Natl Acad Sci U S A (2005) 3.66
Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res (2007) 3.63
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A (2003) 3.61
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell (2003) 3.57
Uniquely hominid features of adult human astrocytes. J Neurosci (2009) 3.49
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell (2009) 3.38
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell (2006) 3.31
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell (2007) 3.27
Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer Res (2010) 3.24
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23
Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell (2007) 3.23
Is cancer a disease of self-seeding? Nat Med (2006) 3.19
Control of rice grain-filling and yield by a gene with a potential signature of domestication. Nat Genet (2008) 3.09
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med (2012) 2.95
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87
ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A (2007) 2.85
The IFITM proteins inhibit HIV-1 infection. J Virol (2010) 2.80
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell (2011) 2.64
The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci (2007) 2.60
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol (2003) 2.51
Origins of metastatic traits. Cancer Cell (2013) 2.49
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45
Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell (2006) 2.41
Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5. Proc Natl Acad Sci U S A (2003) 2.25
Sorting out breast-cancer gene signatures. N Engl J Med (2007) 2.22
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05
Nucleocytoplasmic shuttling of signal transducers. Nat Rev Mol Cell Biol (2004) 2.04
Perspectives of gammadelta T cells in tumor immunology. Cancer Res (2007) 2.03
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J Biol Chem (2001) 1.99
Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest (2005) 1.98
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med (2012) 1.93
Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging. Langmuir (2008) 1.88
MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev (2011) 1.85
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways. Structure (2012) 1.77
Clinical implications of cancer self-seeding. Nat Rev Clin Oncol (2011) 1.77
Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo. Cereb Cortex (2008) 1.76
Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation. Cancer Res (2011) 1.73
Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proc Natl Acad Sci U S A (2004) 1.71
Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. J Biol Chem (2006) 1.63
A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev (2011) 1.60
Thrombolysis for ischemic stroke in the United States: data from National Hospital Discharge Survey 1999-2001. Neurosurgery (2005) 1.60
The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. J Clin Invest (2003) 1.58
Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res (2009) 1.58
Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol (2002) 1.54
Kv1.3 channels as a potential target for immunomodulation of CD4+ CD28null T cells in patients with acute coronary syndrome. Clin Immunol (2011) 1.53
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc Natl Acad Sci U S A (2006) 1.52
Clinical significance of IEX-1 expression in ovarian carcinoma. Ultrastruct Pathol (2011) 1.50
Modeling metastasis in the mouse. Curr Opin Pharmacol (2010) 1.46
Vascular endothelial growth factor-C associated with computed tomography used in the diagnosis of lymph node metastasis of bladder carcinoma. Arch Med Res (2010) 1.45
alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol Biol Cell (2002) 1.45