Published in Mol Cell on December 09, 2005
Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26
Target profiling of small molecules by chemical proteomics. Nat Chem Biol (2009) 3.20
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly. J Biol Chem (2010) 2.61
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. Cold Spring Harb Perspect Biol (2012) 2.19
XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol (2011) 1.89
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol (2007) 1.58
The biological and therapeutic relevance of mRNA translation in cancer. Nat Rev Clin Oncol (2011) 1.54
Selective pharmacological targeting of a DEAD box RNA helicase. PLoS One (2008) 1.49
Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. EMBO J (2007) 1.42
Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J (2009) 1.38
Stable formation of compositionally unique stress granules in virus-infected cells. J Virol (2010) 1.34
Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition. Nucleic Acids Res (2013) 1.31
Natural products as chemical probes. ACS Chem Biol (2010) 1.29
Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism. Mol Cell Biol (2008) 1.28
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science (2011) 1.27
Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol (2011) 1.26
Crystal structure of the eIF4A-PDCD4 complex. Proc Natl Acad Sci U S A (2009) 1.23
Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer. PLoS Genet (2009) 1.19
Stress granules, P-bodies and cancer. Biochim Biophys Acta (2014) 1.17
Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A. Mol Cancer Ther (2009) 1.10
Targeting translation dependence in cancer. Oncotarget (2011) 1.09
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A (2013) 1.09
A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. Oncogene (2006) 1.08
Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance. Mol Cell Biol (2008) 1.05
Emerging therapeutics targeting mRNA translation. Cold Spring Harb Perspect Biol (2012) 1.04
Plakophilin 1 stimulates translation by promoting eIF4A1 activity. J Cell Biol (2010) 1.04
Factors interacting with HIF-1alpha mRNA: novel therapeutic targets. Curr Pharm Des (2009) 0.99
Hydrogen peroxide induces stress granule formation independent of eIF2α phosphorylation. Biochem Biophys Res Commun (2012) 0.98
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide. J Natl Cancer Inst (2008) 0.98
Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem (2009) 0.96
The DEAD-box helicase eIF4A: paradigm or the odd one out? RNA Biol (2012) 0.95
Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide. Mar Drugs (2010) 0.93
DEAD-box helicases: posttranslational regulation and function. Biochem Biophys Res Commun (2010) 0.89
Identification and validation of protein targets of bioactive small molecules. Bioorg Med Chem (2011) 0.89
Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation. Mol Cancer Ther (2012) 0.87
Discovery of novel drug targets and their functions using phenotypic screening of natural products. J Ind Microbiol Biotechnol (2015) 0.86
Herpes simplex virus 2 infection impacts stress granule accumulation. J Virol (2012) 0.86
Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B. RNA (2011) 0.85
TGF-beta-dependent and -independent roles of STRAP in cancer. Front Biosci (Landmark Ed) (2011) 0.85
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents. Bioorg Med Chem (2013) 0.84
Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci U S A (2015) 0.83
Garbled messages and corrupted translations. Nat Chem Biol (2010) 0.82
Pateamine A-sensitive ribosome profiling reveals the scope of translation in mouse embryonic stem cells. BMC Genomics (2016) 0.82
Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. inhibit mitochondrial respiration and HIF-1 activation. J Nat Prod (2009) 0.82
Cytoplasmic hGle1A regulates stress granules by modulation of translation. Mol Biol Cell (2015) 0.79
Translational dysregulation by Pateamine A. Chem Biol (2007) 0.79
Key contribution of eIF4H-mediated translational control in tumor promotion. Oncotarget (2015) 0.78
Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity. Bioorg Med Chem Lett (2010) 0.78
Control of glutamate receptor 2 (GluR2) translational initiation by its alternative 3' untranslated regions. Mol Pharmacol (2009) 0.78
Recruitment, Duplex Unwinding and Protein-Mediated Inhibition of the Dead-Box RNA Helicase Dbp2 at Actively Transcribed Chromatin. J Mol Biol (2016) 0.77
eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. Oncotarget (2016) 0.77
Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography. Org Lett (2006) 0.76
Differential regulation of the melanoma proteome by eIF4A1 and eIF4E. Cancer Res (2016) 0.75
Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells. Bone Joint Res (2017) 0.75
Insights into the mechanisms of eukaryotic translation gained with ribosome profiling. Nucleic Acids Res (2016) 0.75
A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation. Nucleic Acids Res (2015) 0.75
Ribosomal Initiation Complex Assembly within the Wild-Strain of Coxsackievirus B3 and Live-Attenuated Sabin3-like IRESes during the Initiation of Translation. Int J Mol Sci (2013) 0.75
Therapeutic interventions to disrupt the protein synthetic machinery in melanoma. Pigment Cell Melanoma Res (2015) 0.75
Herpes Simplex Virus 2 Virion Host Shutoff Endoribonuclease Activity Is Required To Disrupt Stress Granule Formation. J Virol (2016) 0.75
Synthesis of a simplified triazole analogue of pateamine A. Org Biomol Chem (2016) 0.75
Translation inhibition and stress granules in the antiviral immune response. Nat Rev Immunol (2017) 0.75
Targeting RNA helicases in cancer: The translation trap. Biochim Biophys Acta (2017) 0.75
Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem Biol (2017) 0.75
In vitro-reduced translation efficiency of coxsackievirus B3 Sabin3-like strain is correlated to impaired binding of cellular initiation factors to viral IRES RNA. Curr Microbiol (2015) 0.75
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A (2008) 4.79
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 4.19
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol (2010) 3.44
The HBV drug entecavir - effects on HIV-1 replication and resistance. N Engl J Med (2007) 3.20
A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment. Cancer Discov (2011) 2.77
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest (2009) 2.75
A clinical drug library screen identifies astemizole as an antimalarial agent. Nat Chem Biol (2006) 2.72
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. J Natl Cancer Inst (2012) 2.47
mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol (2011) 2.41
eIF4A: the godfather of the DEAD box helicases. Prog Nucleic Acid Res Mol Biol (2002) 2.34
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci U S A (2009) 2.33
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. Genes Dev (2006) 2.18
Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. J Biol Chem (2006) 2.15
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem (2003) 2.06
Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol (2007) 2.00
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A (2009) 1.95
Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Res (2003) 1.91
XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol (2011) 1.89
The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation. J Biol Chem (2008) 1.83
Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell (2011) 1.80
Viral stress-inducible protein p56 inhibits translation by blocking the interaction of eIF3 with the ternary complex eIF2.GTP.Met-tRNAi. J Biol Chem (2003) 1.74
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proc Natl Acad Sci U S A (2002) 1.72
Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation. J Biol Chem (2004) 1.63
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem (2005) 1.61
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol (2007) 1.58
Reading dynamic kinase activity in living cells for high-throughput screening. ACS Chem Biol (2006) 1.54
Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci U S A (2010) 1.53
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control. Mol Cell (2007) 1.47
Natural-product synthesis: stitching together palau'amine. Nat Chem (2010) 1.46
Assembly of 48S translation initiation complexes from purified components with mRNAs that have some base pairing within their 5' untranslated regions. Mol Cell Biol (2003) 1.46
Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame. J Biol Chem (2001) 1.41
Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome. Biochem Biophys Res Commun (2005) 1.41
Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. J Mol Biol (2005) 1.38
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem (2007) 1.38
Distinct conformational states of nuclear receptor-bound CRSP-Med complexes. Nat Struct Mol Biol (2004) 1.35
Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology (2013) 1.34
Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5' untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated. Mol Cell Biol (2007) 1.33
Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Nature (2003) 1.32
Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem (2006) 1.31
Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics. J Am Chem Soc (2007) 1.29
GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. J Biol Chem (2010) 1.29
Asymmetric synthesis of bicyclic beta-lactones via the intramolecular, nucleophile-catalyzed aldol lactonization: improved efficiency and expanded scope. J Org Chem (2005) 1.28
Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids. Nat Prod Rep (2011) 1.28
Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase. J Org Chem (2006) 1.26
Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth. Prostate (2010) 1.25
Differential contribution of the m7G-cap to the 5' end-dependent translation initiation of mammalian mRNAs. Nucleic Acids Res (2009) 1.25
Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation. Mol Cell (2005) 1.24
Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. J Med Chem (2009) 1.23
Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity. Proc Natl Acad Sci U S A (2006) 1.23
Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst (2010) 1.22
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Nature (2007) 1.21
Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry (2005) 1.20
Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells. EMBO J (2003) 1.18
Characterization of mammalian eIF2A and identification of the yeast homolog. J Biol Chem (2002) 1.18
Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Res (2011) 1.18
A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae. J Biol Chem (2008) 1.17
Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proc Natl Acad Sci U S A (2011) 1.17
Enantioselective synthesis of (+)-monobromophakellin and (+)-phakellin: a concise phakellin annulation strategy applicable to Palau'amine. Angew Chem Int Ed Engl (2008) 1.16
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem (2010) 1.16
Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A (2006) 1.14
Bicyclic- and tricyclic-beta-lactones via organonucleophile-promoted bis-cyclizations of keto acids: Enantioselective synthesis of (+)-dihydroplakevulin. Org Lett (2006) 1.14
Facile synthesis of the trans-fused azabicyclo[3.3.0]octane core of the palau'amines and the tricyclic core of the axinellamines from a common intermediate. Org Lett (2008) 1.13
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation. J Antimicrob Chemother (2011) 1.13
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS One (2008) 1.12
Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway? Org Lett (2007) 1.11
Positive and negative effects of the major mammalian messenger ribonucleoprotein p50 on binding of 40 S ribosomal subunits to the initiation codon of beta-globin mRNA. J Biol Chem (2002) 1.11
Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. J Hum Genet (2003) 1.11
Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A. Mol Cancer Ther (2009) 1.10
The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. Biochem J (2012) 1.10
Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation. J Immunol (2008) 1.09
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A (2013) 1.09
Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A. J Biol Chem (2005) 1.08
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Biochemistry (2010) 1.08
Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica. Angew Chem Int Ed Engl (2012) 1.08
Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α. J Biol Chem (2014) 1.07
General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J (2008) 1.06
Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Res (2011) 1.06
Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer. J Thorac Oncol (2013) 1.05
Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity. Chem Biol (2007) 1.05