PubRank

Timothy J Mitchell

Author PubWeight™ 57.69‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Rapid pneumococcal evolution in response to clinical interventions. Science 2011 9.09
2 Pneumolysin: a double-edged sword during the host-pathogen interaction. Curr Mol Med 2008 1.61
3 The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol 2011 1.54
4 The biology of Gram-positive sortase enzymes. Trends Microbiol 2004 1.53
5 Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Crit Care Med 2009 1.46
6 Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states. J Bacteriol 2004 1.36
7 Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Eur J Immunol 2006 1.34
8 Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching. J Clin Microbiol 2004 1.29
9 Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis 2002 1.28
10 Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrob Agents Chemother 2003 1.25
11 Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Crit Care Med 2006 1.23
12 Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proc Natl Acad Sci U S A 2007 1.19
13 Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro. J Infect Dis 2002 1.17
14 Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. J Neuroimmunol 2004 1.16
15 Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infect Immun 2002 1.12
16 Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infect Immun 2011 1.11
17 The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O. Biophys J 2004 1.08
18 T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. J Infect Dis 2009 1.08
19 The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein. Microbiol Immunol 2004 1.04
20 A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathog 2011 1.02
21 Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog 2011 1.02
22 Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. FEMS Microbiol Lett 2005 1.01
23 Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol 2012 0.99
24 Pneumococcal pneumonia: mechanisms of infection and resolution. Chest 2012 0.97
25 Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infect Immun 2006 0.94
26 Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. Mol Microbiol 2008 0.92
27 Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone. PLoS One 2011 0.89
28 Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity. Toxins (Basel) 2011 0.89
29 Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin. J Mol Biol 2012 0.88
30 Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Mol Immunol 2009 0.88
31 Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathog 2012 0.88
32 Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4. Microbes Infect 2010 0.87
33 Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody. Infect Immun 2004 0.86
34 A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen. Vaccine 2009 0.84
35 Role of platelet-activating factor in pneumolysin-induced acute lung injury. Crit Care Med 2007 0.82
36 Purification, crystallization and preliminary X-ray diffraction analysis of RafE, a sugar-binding lipoprotein from Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.81
37 Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema. Glia 2011 0.81
38 Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage. PLoS Pathog 2013 0.81
39 Overexpression, purification and crystallization of a choline-binding protein CbpI from Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.79
40 IgG responses to Pneumococcal and Haemophilus influenzae protein antigens are not impaired in children with a history of recurrent acute otitis media. PLoS One 2012 0.79
41 Crystallization and preliminary crystallographic studies of the D59A mutant of MicA, a YycF response-regulator homologue from Streptococcus pneumoniae. Acta Crystallogr D Biol Crystallogr 2004 0.78
42 Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue. J Infect Dis 2011 0.78
43 Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea. Acta Otolaryngol 2004 0.77
44 Isolation and characterization of the promoter and partial enhancer region of the porcine inter-alpha-trypsin inhibitor heavy chain 4 gene. Clin Diagn Lab Immunol 2005 0.77
45 Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils. Infect Immun 2004 0.77
46 Cloning, overexpression, purification, crystallization and preliminary diffraction analysis of the receiver domain of MicA. Acta Crystallogr D Biol Crystallogr 2003 0.77
47 Expression, purification and X-ray characterization of residues 18-230 from the pneumococcal histidine triad protein A (PhtA) from Streptococcus pneumoniae. Acta Crystallogr D Biol Crystallogr 2004 0.77
48 Limited protection of TAT-Bcl-X(L) against pneumolysin-induced neuronal cell death. Neurosci Lett 2005 0.76
49 The use of microarray technology for the analysis of Streptococcus pneumoniae. Comp Funct Genomics 2002 0.75
50 Potential impact of conjugate vaccine on the incidence of invasive pneumococcal disease among children in Scotland. J Clin Microbiol 2006 0.75
51 Dissecting the components of the humoral immune response elicited by DNA vaccines. Vaccine 2005 0.75
52 Resting-State Blood Oxygen Level-Dependent Functional MRI: A Paradigm Shift in Preoperative Brain Mapping. Stereotact Funct Neurosurg 2016 0.75
53 Influence of subinhibitory concentrations of protein-synthesis-inhibiting antibiotics on production and release of the pneumococcal virulence factor pneumolysin in vitro. Chemotherapy 2007 0.75
54 Pneumococci causing invasive disease in children prior to the introduction of pneumococcal conjugate vaccine in Scotland. J Med Microbiol 2006 0.75
55 Purification, crystallization and preliminary X-ray analysis of the Enterococcus faecalis protein EF0377. Acta Crystallogr D Biol Crystallogr 2003 0.75