Published in Biochemistry on December 20, 2005
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc Natl Acad Sci U S A (2006) 2.35
Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. EMBO J (2006) 1.42
Bacterial lipids: metabolism and membrane homeostasis. Prog Lipid Res (2013) 1.42
Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase. Antimicrob Agents Chemother (2009) 1.41
Lipoic acid synthesis and attachment in yeast mitochondria. J Biol Chem (2009) 1.18
Scavenging of cytosolic octanoic acid by mutant LplA lipoate ligases allows growth of Escherichia coli strains lacking the LipB octanoyltransferase of lipoic acid synthesis. J Bacteriol (2009) 0.98
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis. Mol Microbiol (2011) 0.96
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases. Biochemistry (2010) 0.94
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. PLoS Pathog (2007) 0.92
Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation. Ecosal Plus (2014) 0.86
Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase. Biochemistry (2014) 0.85
Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism. J Biol Chem (2011) 0.84
Opening a new path to lipoic acid. J Bacteriol (2009) 0.84
Lipoic acid metabolism of Plasmodium--a suitable drug target. Curr Pharm Des (2012) 0.82
Chlamydia trachomatis serovar L2 can utilize exogenous lipoic acid through the action of the lipoic acid ligase LplA1. J Bacteriol (2010) 0.79
The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis. Yeast (2013) 0.79
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway. Microbiol Mol Biol Rev (2016) 0.78
Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria. J Biol Chem (2015) 0.78
Will the initiator of fatty acid synthesis in Pseudomonas aeruginosa please stand up? J Bacteriol (2012) 0.78
A new regulatory mechanism for bacterial lipoic acid synthesis. Microbiologyopen (2015) 0.76
Ralstonia solanacearum RSp0194 Encodes a Novel 3-Keto-Acyl Carrier Protein Synthase III. PLoS One (2015) 0.76
An NAD synthetic reaction bypasses the lipoate requirement for aerobic growth of Escherichia coli strains blocked in succinate catabolism. Mol Microbiol (2014) 0.75
Overproduction of α-Lipoic Acid by Gene Manipulated Escherichia coli. PLoS One (2017) 0.75
Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Chem Biol (2003) 2.11
The Enzyme Function Initiative. Biochemistry (2011) 1.87
Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis. Proc Natl Acad Sci U S A (2010) 1.82
Biotin synthase is catalytic in vivo, but catalysis engenders destruction of the protein. Chem Biol (2005) 1.73
The enigmatic Escherichia coli fadE gene is yafH. J Bacteriol (2002) 1.63
Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB. J Biol Chem (2009) 1.63
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches. ACS Chem Biol (2009) 1.60
Long-term and homogeneous regulation of the Escherichia coli araBAD promoter by use of a lactose transporter of relaxed specificity. Proc Natl Acad Sci U S A (2002) 1.57
Biotin synthesis begins by hijacking the fatty acid synthetic pathway. Nat Chem Biol (2010) 1.57
Vibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductase. J Biol Chem (2007) 1.46
Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature (2013) 1.46
Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase. Protein Sci (2008) 1.45
Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis. J Biol Chem (2003) 1.45
A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway. Mol Microbiol (2003) 1.42
Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase. Antimicrob Agents Chemother (2009) 1.41
The biotin repressor: modulation of allostery by corepressor analogs. J Mol Biol (2004) 1.39
The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family. Biochemistry (2006) 1.39
Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters. Mol Microbiol (2011) 1.29
Closing in on complete pathways of biotin biosynthesis. Mol Biosyst (2011) 1.26
The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities. Mol Microbiol (2012) 1.23
Promiscuous protein biotinylation by Escherichia coli biotin protein ligase. Protein Sci (2004) 1.22
A nucleosidase required for in vivo function of the S-adenosyl-L-methionine radical enzyme, biotin synthase. Chem Biol (2005) 1.22
Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids. Proc Natl Acad Sci U S A (2008) 1.20
A new member of the Escherichia coli fad regulon: transcriptional regulation of fadM (ybaW). J Bacteriol (2009) 1.19
The biotin carboxylase-biotin carboxyl carrier protein complex of Escherichia coli acetyl-CoA carboxylase. J Biol Chem (2003) 1.18
Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues. J Biol Chem (2004) 1.18
Unexpected functional diversity among FadR fatty acid transcriptional regulatory proteins. J Biol Chem (2005) 1.17
In vivo functional analyses of the type II acyl carrier proteins of fatty acid biosynthesis. J Biol Chem (2007) 1.16
Expression of Vibrio harveyi acyl-ACP synthetase allows efficient entry of exogenous fatty acids into the Escherichia coli fatty acid and lipid A synthetic pathways. Biochemistry (2010) 1.15
The beta-oxidation systems of Escherichia coli and Salmonella enterica are not functionally equivalent. J Bacteriol (2006) 1.13
Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA. J Bacteriol (2010) 1.13
The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase. J Bacteriol (2003) 1.11
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A (2006) 1.11
The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis. Mol Microbiol (2011) 1.10
Isolation and characterization of beta-ketoacyl-acyl carrier protein reductase (fabG) mutants of Escherichia coli and Salmonella enterica serovar Typhimurium. J Bacteriol (2004) 1.09
Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim. Proteins (2009) 1.07
The Thermoplasma acidophilum LplA-LplB complex defines a new class of bipartite lipoate-protein ligases. J Biol Chem (2009) 1.07
Expression of two Escherichia coli acetyl-CoA carboxylase subunits is autoregulated. J Biol Chem (2003) 1.06
Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis. Proc Natl Acad Sci U S A (2012) 1.03
Expression cloning and demonstration of Enterococcus faecalis lipoamidase (pyruvate dehydrogenase inactivase) as a Ser-Ser-Lys triad amidohydrolase. J Biol Chem (2004) 1.01
The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase. J Biol Chem (2004) 1.01
Scavenging of cytosolic octanoic acid by mutant LplA lipoate ligases allows growth of Escherichia coli strains lacking the LipB octanoyltransferase of lipoic acid synthesis. J Bacteriol (2009) 0.98
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis. Mol Microbiol (2011) 0.97
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis. Mol Microbiol (2011) 0.96
Roles of small laccases from Streptomyces in lignin degradation. Biochemistry (2014) 0.95
Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes. PLoS One (2012) 0.95
The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. J Biol Chem (2005) 0.95
Haemophilus influenzae Rd lacks a stringently conserved fatty acid biosynthetic enzyme and thermal control of membrane lipid composition. J Bacteriol (2003) 0.95
The Lactococcus lactis FabF fatty acid synthetic enzyme can functionally replace both the FabB and FabF proteins of Escherichia coli and the FabH protein of Lactococcus lactis. Arch Microbiol (2008) 0.95
Only one of the two annotated Lactococcus lactis fabG genes encodes a functional beta-ketoacyl-acyl carrier protein reductase. Biochemistry (2004) 0.94
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases. Biochemistry (2010) 0.94
Altered regulation of Escherichia coli biotin biosynthesis in BirA superrepressor mutant strains. J Bacteriol (2011) 0.94
Profligate biotin synthesis in α-proteobacteria - a developing or degenerating regulatory system? Mol Microbiol (2013) 0.94
Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis. Antimicrob Agents Chemother (2010) 0.94
Xanthomonas campestris RpfB is a fatty Acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase. Mol Microbiol (2014) 0.93
Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli. J Bacteriol (2006) 0.93
Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2010) 0.92
The switch regulating transcription of the Escherichia coli biotin operon does not require extensive protein-protein interactions. Chem Biol (2010) 0.91
The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance. MBio (2013) 0.91
Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. J Bacteriol (2006) 0.91
A Francisella virulence factor catalyses an essential reaction of biotin synthesis. Mol Microbiol (2013) 0.90
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis. J Biol Chem (2012) 0.90
Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis. BMC Microbiol (2009) 0.90
Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry (2015) 0.88
A genome rearrangement has orphaned the Escherichia coli K-12 AcpT phosphopantetheinyl transferase from its cognate Escherichia coli O157:H7 substrates. Mol Microbiol (2006) 0.86
Intein-mediated cyclization of bacterial acyl carrier protein stabilizes its folded conformation but does not abolish function. J Biol Chem (2010) 0.86
The wing of a winged helix-turn-helix transcription factor organizes the active site of BirA, a bifunctional repressor/ligase. J Biol Chem (2013) 0.85
Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism. J Biol Chem (2011) 0.84
Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo. J Bacteriol (2011) 0.84
Remarkable diversity in the enzymes catalyzing the last step in synthesis of the pimelate moiety of biotin. PLoS One (2012) 0.84
Dephospho-CoA kinase provides a rapid and sensitive radiochemical assay for coenzyme A and its thioesters. Anal Biochem (2007) 0.84
Genetic interaction between the Escherichia coli AcpT phosphopantetheinyl transferase and the YejM inner membrane protein. Genetics (2008) 0.83
Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation. ACS Chem Biol (2013) 0.83
Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family. Biochemistry (2007) 0.82
Chromosomal amplification of the Escherichia coli lipB region confers high-level resistance to selenolipoic acid. J Bacteriol (2002) 0.82
Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine. MBio (2014) 0.82
Only one of the five Ralstonia solanacearum long-chain 3-ketoacyl-acyl carrier protein synthase homologues functions in fatty acid synthesis. Appl Environ Microbiol (2011) 0.81
Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH. Protein Eng Des Sel (2012) 0.80
A complex lipoate utilization pathway in Listeria monocytogenes. J Biol Chem (2011) 0.80
FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle. Chem Biol (2013) 0.80
Stabilization of the biotinoyl domain of Escherichia coli acetyl-CoA carboxylase by interactions between the attached biotin and the protruding "thumb" structure. J Biol Chem (2002) 0.80
Two-Carbon Compounds and Fatty Acids as Carbon Sources. Ecosal Plus (2005) 0.79
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation. J Med Chem (2012) 0.79
The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis. Yeast (2013) 0.79
Remarkable structural variation within fatty acid megasynthases. Nat Chem Biol (2006) 0.79
Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors. J Med Chem (2015) 0.79
Tricarboxylic Acid Cycle and Glyoxylate Bypass. Ecosal Plus (2005) 0.77
Inefficient translation renders the Enterococcus faecalis fabK enoyl-acyl carrier protein reductase phenotypically cryptic. J Bacteriol (2013) 0.77
Biosynthesis of Membrane Lipids. Ecosal Plus (2008) 0.77
Never fat or gaunt. Dev Cell (2003) 0.77
In vivo resolution of conflicting in vitro results: synthesis of biotin from dethiobiotin does not require pyridoxal phosphate. Chem Biol (2007) 0.77
An NAD synthetic reaction bypasses the lipoate requirement for aerobic growth of Escherichia coli strains blocked in succinate catabolism. Mol Microbiol (2014) 0.75
Evaluation of pharmacokinetic/pharmacodynamic relationships of PD-0162819, a biotin carboxylase inhibitor representing a new class of antibacterial compounds, using in vitro infection models. Antimicrob Agents Chemother (2011) 0.75
Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation. Ecosal Plus (2008) 0.75
An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae. Biochemistry (2016) 0.75