Published in J Org Chem on December 23, 2005
Asymmetric [4 + 3] cycloadditions between vinylcarbenoids and dienes: application to the total synthesis of the natural product (-)-5-epi-vibsanin E. J Am Chem Soc (2009) 1.34
Torsional steering controls the stereoselectivity of epoxidation in the guanacastepene a synthesis. Org Lett (2006) 1.18
Enantioselective total synthesis of guanacastepene N using an uncommon 7-endo Heck cyclization as a pivotal step. J Am Chem Soc (2006) 0.97
Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B. Org Lett (2009) 0.86
An Approach to the Synthesis of Tricholomalide A: An Effective Means for Achieving Homo-Robinson Annulation. Tetrahedron Lett (2008) 0.86
Total synthesis and structural revision of (+/-)-tricholomalides A and B. J Am Chem Soc (2009) 0.80
Steric control of alpha- and beta-alkylation of azulenone intermediates in a guanacastepene a synthesis. J Org Chem (2010) 0.78
Torsional Control of Stereoselectivities in Electrophilic Additions and Cycloadditions to Alkenes. Chem Sci (2014) 0.75
A total synthesis of (-)-Hortonone C. Tetrahedron (2016) 0.75
Pattern recognition in retrosynthetic analysis: snapshots in total synthesis. J Org Chem (2007) 3.05
Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angew Chem Int Ed Engl (2007) 2.73
New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. J Am Chem Soc (2008) 2.61
Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol (2005) 2.55
Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature (2010) 2.41
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. J Org Chem (2006) 2.04
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proc Natl Acad Sci U S A (2005) 2.00
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. J Am Chem Soc (2008) 1.97
On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. J Am Chem Soc (2008) 1.96
A straightforward route to functionalized trans-Diels-Alder motifs. J Am Chem Soc (2010) 1.92
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. Curr Opin Chem Biol (2010) 1.91
Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm. J Am Chem Soc (2009) 1.86
Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. J Am Chem Soc (2004) 1.85
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. J Am Chem Soc (2004) 1.83
Syntheses of Isomerically Pure Reference Octalins and Hydrindanes. Tetrahedron Lett (2009) 1.75
Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes (2008) 1.72
Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way. Acc Chem Res (2006) 1.72
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. J Am Chem Soc (2004) 1.67
Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Angew Chem Int Ed Engl (2006) 1.53
Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. J Am Chem Soc (2006) 1.50
Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain. J Am Chem Soc (2009) 1.39
Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. J Am Chem Soc (2006) 1.37
Straightforward synthesis of panaxytriol: an active component of Red Ginseng. J Org Chem (2003) 1.36
Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis. Angew Chem Int Ed Engl (2008) 1.34
Gelsemine: a thought-provoking target for total synthesis. Angew Chem Int Ed Engl (2003) 1.34
The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms. Org Lett (2008) 1.32
Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem (2008) 1.29
Correspondence on microwave effects in organic synthesis. Angew Chem Int Ed Engl (2013) 1.28
On the remarkable antitumor properties of fludelone: how we got there. Angew Chem Int Ed Engl (2005) 1.28
Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate. J Am Chem Soc (2004) 1.28
Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Expert Rev Vaccines (2005) 1.27
Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles. Tetrahedron Lett (2009) 1.27
Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors. Proc Natl Acad Sci U S A (2004) 1.27
Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angew Chem Int Ed Engl (2007) 1.27
Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chem Biol (2007) 1.25
Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds. J Am Chem Soc (2009) 1.23
Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction. J Am Chem Soc (2005) 1.23
A Diels-Alder Route to Angularly Functionalized Bicyclic Structures. Tetrahedron (2010) 1.23
Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Curr Opin Chem Biol (2005) 1.22
Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages. Nat Protoc (2008) 1.21
The total synthesis of (+/-)-11-O-debenzoyltashironin. J Am Chem Soc (2006) 1.21
Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation. J Am Chem Soc (2009) 1.21
Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. J Am Chem Soc (2007) 1.19
Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorg Med Chem Lett (2008) 1.19
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. J Am Chem Soc (2010) 1.19
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc Natl Acad Sci U S A (2008) 1.18
Synthetic Studies towards Maoecrystal V. Tetrahedron Lett (2009) 1.18
Torsional steering controls the stereoselectivity of epoxidation in the guanacastepene a synthesis. Org Lett (2006) 1.18
The total synthesis of (+)-migrastatin. J Am Chem Soc (2003) 1.18
Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration. J Am Chem Soc (2006) 1.17
Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites. J Am Chem Soc (2009) 1.17
Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. J Am Chem Soc (2005) 1.17
A stereoselective route to guanacastepene A through a surprising epoxidation. Angew Chem Int Ed Engl (2002) 1.17
On the rearrangement of an azaspiroindolenine to a precursor to phalarine: mechanistic insights. Angew Chem Int Ed Engl (2007) 1.17
New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. J Am Chem Soc (2004) 1.15
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion. Nat Chem Biol (2012) 1.15
Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. J Am Chem Soc (2009) 1.15
An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions. Proc Natl Acad Sci U S A (2008) 1.15
In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence. Angew Chem Int Ed Engl (2004) 1.14
Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains. J Am Chem Soc (2002) 1.13
Chemical synthesis of normal and transformed PSA glycopeptides. J Am Chem Soc (2004) 1.13
A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core. Tetrahedron Lett (2008) 1.13
Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. J Am Chem Soc (2004) 1.13
Cyclobutenone as a highly reactive dienophile: expanding upon Diels-Alder paradigms. J Am Chem Soc (2010) 1.12
Total synthesis of garsubellin A. J Am Chem Soc (2006) 1.11
A concise synthesis of the cortistatin core. Tetrahedron Lett (2008) 1.10
Total synthesis of phalarine. Angew Chem Int Ed Engl (2007) 1.10
The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. J Org Chem (2005) 1.09
Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clin Cancer Res (2004) 1.09
Explorations in organic chemistry leading to the total synthesis of (+/-)-gelsemine. J Am Chem Soc (2002) 1.09
Diels-Alder routes to angularly halogenated cis-fused bicyclic ketones: Readily accessible cyclynone intermediates. Tetrahedron Lett (2010) 1.08
A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. Tetrahedron (2010) 1.08
Oxo-ester mediated native chemical ligation: concept and applications. J Am Chem Soc (2008) 1.08
On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory. Angew Chem Int Ed Engl (2010) 1.07
Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron (2009) 1.07
On the total synthesis and determination of the absolute configuration of rishirilide B: exploitation of subtle effects to control the sense of cycloaddition of o-quinodimethides. Chemistry (2003) 1.07
Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: new insights into glycal reactivity. Org Biomol Chem (2005) 1.07
Mix-and-heat benzylation of alcohols using a bench-stable pyridinium salt. J Org Chem (2006) 1.06
Total synthesis of (+/-)-aplykurodinone-1: traceless stereochemical guidance. J Am Chem Soc (2010) 1.06
An interesting issue of Diels-Alder selectivity discovered en route to 11-O-debenzoyltashironin. Org Lett (2006) 1.05
A direct route to fluostatin C by a fascinating Diels-Alder reaction. J Am Chem Soc (2008) 1.05
Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother (2004) 1.05
Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proc Natl Acad Sci U S A (2013) 1.05
Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under mild conditions. Tetrahedron Lett (2009) 1.04
Insights into the finer issues of native chemical ligation: an approach to cascade ligations. Angew Chem Int Ed Engl (2010) 1.04
Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. J Am Chem Soc (2010) 1.04
The Meyer-Schuster rearrangement for the synthesis of alpha,beta-unsaturated carbonyl compounds. Org Biomol Chem (2009) 1.04
Intramolecular Diels-Alder reactions of cycloalkenones: translation of high endo selectivity to trans junctions. J Am Chem Soc (2012) 1.03
Total synthesis of salinosporamide A. J Am Chem Soc (2005) 1.03
Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. Tetrahedron Lett (2006) 1.03
Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. J Am Chem Soc (2004) 1.03
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. J Am Chem Soc (2007) 1.02
Experimental Diels-Alder reactivities of cycloalkenones and cyclic dienes explained through transition-state distortion energies. Angew Chem Int Ed Engl (2011) 1.01
From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine. J Am Chem Soc (2009) 1.01
Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals. J Am Chem Soc (2011) 1.01
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience. Expert Rev Vaccines (2009) 1.01
Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route. Cancer Res (2005) 1.01