Published in Angew Chem Int Ed Engl on May 06, 2005
Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester. J Am Chem Soc (2011) 1.19
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. J Am Chem Soc (2010) 1.19
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc Natl Acad Sci U S A (2008) 1.18
(+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation. Tetrahedron (2007) 1.07
Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. Angew Chem Int Ed Engl (2013) 0.92
An "aprotic" Tamao oxidation/syn-selective tautomerization reaction for the efficient synthesis of the C1-C9 fragment of fludelone. Org Lett (2012) 0.89
The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last. Angew Chem Int Ed Engl (2013) 0.89
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance. Chem Soc Rev (2012) 0.84
Isolation and Reactivity of Trifluoromethyl Iodonium Salts. ACS Cent Sci (2016) 0.80
Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol. Proc Natl Acad Sci U S A (2011) 0.80
Synthetic studies toward (+)-cortistatin A. Tetrahedron (2011) 0.79
The enantioselective synthesis and biological evaluation of chimeric promysalin analogs facilitated by diverted total synthesis. J Antibiot (Tokyo) (2016) 0.79
Palladium-catalyzed transformations of salvinorin A, a neoclerodane diterpene from Salvia divinorum. Org Lett (2013) 0.78
Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Med Res Rev (2015) 0.78
Direct C-H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis. Beilstein J Org Chem (2014) 0.75
Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity. J Am Chem Soc (2016) 0.75
Nature's bounty - drug discovery from the sea. Expert Opin Drug Discov (2007) 0.75
Pattern recognition in retrosynthetic analysis: snapshots in total synthesis. J Org Chem (2007) 3.05
Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angew Chem Int Ed Engl (2007) 2.73
New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. J Am Chem Soc (2008) 2.61
Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma. Cancer Biol Ther (2006) 2.45
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. J Org Chem (2006) 2.04
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proc Natl Acad Sci U S A (2005) 2.00
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. J Am Chem Soc (2008) 1.97
On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. J Am Chem Soc (2008) 1.96
A straightforward route to functionalized trans-Diels-Alder motifs. J Am Chem Soc (2010) 1.92
Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm. J Am Chem Soc (2009) 1.86
Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. J Am Chem Soc (2004) 1.85
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. J Am Chem Soc (2004) 1.83
Syntheses of Isomerically Pure Reference Octalins and Hydrindanes. Tetrahedron Lett (2009) 1.75
Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way. Acc Chem Res (2006) 1.72
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. J Am Chem Soc (2004) 1.67
Total synthesis of guanacastepene a: a route to enantiomeric control. J Org Chem (2005) 1.56
Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Angew Chem Int Ed Engl (2006) 1.53
Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. J Am Chem Soc (2006) 1.50
Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro. Antimicrob Agents Chemother (2002) 1.49
Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain. J Am Chem Soc (2009) 1.39
Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. J Am Chem Soc (2006) 1.37
Straightforward synthesis of panaxytriol: an active component of Red Ginseng. J Org Chem (2003) 1.36
Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis. Angew Chem Int Ed Engl (2008) 1.34
Gelsemine: a thought-provoking target for total synthesis. Angew Chem Int Ed Engl (2003) 1.34
The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms. Org Lett (2008) 1.32
Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate. J Am Chem Soc (2004) 1.28
Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Expert Rev Vaccines (2005) 1.27
Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles. Tetrahedron Lett (2009) 1.27
Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors. Proc Natl Acad Sci U S A (2004) 1.27
Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angew Chem Int Ed Engl (2007) 1.27
Up-regulation of GADD34 mediates the synergistic anticancer activity of mitomycin C and a gamma134.5 deleted oncolytic herpes virus (G207). FASEB J (2004) 1.24
Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds. J Am Chem Soc (2009) 1.23
A Diels-Alder Route to Angularly Functionalized Bicyclic Structures. Tetrahedron (2010) 1.23
Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages. Nat Protoc (2008) 1.21
The total synthesis of (+/-)-11-O-debenzoyltashironin. J Am Chem Soc (2006) 1.21
Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation. J Am Chem Soc (2009) 1.21
Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. J Am Chem Soc (2007) 1.19
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. J Am Chem Soc (2010) 1.19
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc Natl Acad Sci U S A (2008) 1.18
Synthetic Studies towards Maoecrystal V. Tetrahedron Lett (2009) 1.18
The total synthesis of (+)-migrastatin. J Am Chem Soc (2003) 1.18
Torsional steering controls the stereoselectivity of epoxidation in the guanacastepene a synthesis. Org Lett (2006) 1.18
Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites. J Am Chem Soc (2009) 1.17
A stereoselective route to guanacastepene A through a surprising epoxidation. Angew Chem Int Ed Engl (2002) 1.17
Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. J Am Chem Soc (2005) 1.17
On the rearrangement of an azaspiroindolenine to a precursor to phalarine: mechanistic insights. Angew Chem Int Ed Engl (2007) 1.17
New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. J Am Chem Soc (2004) 1.15
Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. J Am Chem Soc (2009) 1.15
An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions. Proc Natl Acad Sci U S A (2008) 1.15
In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence. Angew Chem Int Ed Engl (2004) 1.14
Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains. J Am Chem Soc (2002) 1.13
A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core. Tetrahedron Lett (2008) 1.13
Chemical synthesis of normal and transformed PSA glycopeptides. J Am Chem Soc (2004) 1.13
Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. J Am Chem Soc (2004) 1.13
Cyclobutenone as a highly reactive dienophile: expanding upon Diels-Alder paradigms. J Am Chem Soc (2010) 1.12
Total synthesis of garsubellin A. J Am Chem Soc (2006) 1.11
Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma. Ann Surg Oncol (2006) 1.10
Total synthesis of phalarine. Angew Chem Int Ed Engl (2007) 1.10
A concise synthesis of the cortistatin core. Tetrahedron Lett (2008) 1.10
5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. J Gastrointest Surg (2005) 1.09
The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. J Org Chem (2005) 1.09
Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clin Cancer Res (2004) 1.09
Explorations in organic chemistry leading to the total synthesis of (+/-)-gelsemine. J Am Chem Soc (2002) 1.09
Diels-Alder routes to angularly halogenated cis-fused bicyclic ketones: Readily accessible cyclynone intermediates. Tetrahedron Lett (2010) 1.08
A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. Tetrahedron (2010) 1.08
Oxo-ester mediated native chemical ligation: concept and applications. J Am Chem Soc (2008) 1.08
On the total synthesis and determination of the absolute configuration of rishirilide B: exploitation of subtle effects to control the sense of cycloaddition of o-quinodimethides. Chemistry (2003) 1.07
On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory. Angew Chem Int Ed Engl (2010) 1.07
Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron (2009) 1.07
Total synthesis of (+/-)-aplykurodinone-1: traceless stereochemical guidance. J Am Chem Soc (2010) 1.06
An interesting issue of Diels-Alder selectivity discovered en route to 11-O-debenzoyltashironin. Org Lett (2006) 1.05
Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother (2004) 1.05
A direct route to fluostatin C by a fascinating Diels-Alder reaction. J Am Chem Soc (2008) 1.05
Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proc Natl Acad Sci U S A (2013) 1.05
Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. J Am Chem Soc (2010) 1.04
Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under mild conditions. Tetrahedron Lett (2009) 1.04
Insights into the finer issues of native chemical ligation: an approach to cascade ligations. Angew Chem Int Ed Engl (2010) 1.04
Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives. Eur J Med Chem (2003) 1.03
Intramolecular Diels-Alder reactions of cycloalkenones: translation of high endo selectivity to trans junctions. J Am Chem Soc (2012) 1.03
Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. Tetrahedron Lett (2006) 1.03
Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. J Am Chem Soc (2004) 1.03
Total synthesis of salinosporamide A. J Am Chem Soc (2005) 1.03
Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo. Cancer Res (2002) 1.02
Experimental Diels-Alder reactivities of cycloalkenones and cyclic dienes explained through transition-state distortion energies. Angew Chem Int Ed Engl (2011) 1.01
From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine. J Am Chem Soc (2009) 1.01
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience. Expert Rev Vaccines (2009) 1.01
Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route. Cancer Res (2005) 1.01
Total synthesis of cribrostatin IV: fine-tuning the character of an amide bond by remote control. J Am Chem Soc (2005) 1.01
Chemistry and biology in search of antimetastatic agents. ACS Chem Biol (2007) 1.01
Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angew Chem Int Ed Engl (2007) 1.01
On the power of chemical synthesis: immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines. Proc Natl Acad Sci U S A (2002) 0.99
In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments. Angew Chem Int Ed Engl (2004) 0.99
Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines. Vaccine (2002) 0.99
Novel synthetic approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene skeleton. Org Lett (2003) 0.99
Promising general solution to the problem of ligating peptides and glycopeptides. J Am Chem Soc (2010) 0.98
90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. Mol Pharmacol (2008) 0.98
Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin. Proc Natl Acad Sci U S A (2011) 0.97
Toward fully synthetic N-linked glycoproteins. Angew Chem Int Ed Engl (2003) 0.97
Total synthesis of the 2,6-sialylated immunoglobulin G glycopeptide fragment in homogeneous form. J Am Chem Soc (2009) 0.97