Published in J Am Chem Soc on June 14, 2006
Erythropoietin derived by chemical synthesis. Science (2013) 1.66
Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain. J Am Chem Soc (2009) 1.39
Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis. Angew Chem Int Ed Engl (2008) 1.34
Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. J Am Chem Soc (2009) 1.15
Oxo-ester mediated native chemical ligation: concept and applications. J Am Chem Soc (2008) 1.08
Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron (2009) 1.07
Native chemical ligation of thioamide-containing peptides: development and application to the synthesis of labeled α-synuclein for misfolding studies. J Am Chem Soc (2012) 1.04
Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. Tetrahedron Lett (2006) 1.03
At last: erythropoietin as a single glycoform. Angew Chem Int Ed Engl (2012) 0.97
Toward fully synthetic, homogeneous glycoproteins: advances in chemical ligation. Biopolymers (2010) 0.93
Protein chemical synthesis by serine and threonine ligation. Proc Natl Acad Sci U S A (2013) 0.92
An advance in proline ligation. J Am Chem Soc (2011) 0.90
The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last. Angew Chem Int Ed Engl (2013) 0.89
Sugar-assisted glycopeptide ligation with complex oligosaccharides: scope and limitations. J Am Chem Soc (2008) 0.80
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering. J Am Chem Soc (2007) 0.78
Biomimetic catalysis of intermodular aminoacyl transfer. J Am Chem Soc (2007) 0.78
Revisiting oxytocin through the medium of isonitriles. J Am Chem Soc (2012) 0.77
Shifting Native Chemical Ligation into Reverse through N→S Acyl Transfer. Isr J Chem (2011) 0.77
Biomimetic catalysis of diketopiperazine and dipeptide syntheses. Angew Chem Int Ed Engl (2008) 0.75
Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science (2011) 3.67
(E)-1-{4-[Bis(4-meth-oxy-phen-yl)meth-yl]piperazin-1-yl}-3-(4-fluoro-phen-yl)prop-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online (2011) 3.63
Pattern recognition in retrosynthetic analysis: snapshots in total synthesis. J Org Chem (2007) 3.05
Cyanine fluorophore derivatives with enhanced photostability. Nat Methods (2011) 2.85
Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angew Chem Int Ed Engl (2007) 2.73
New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. J Am Chem Soc (2008) 2.61
Single β-actin mRNA detection in neurons reveals a mechanism for regulating its translatability. Science (2014) 2.23
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. J Org Chem (2006) 2.04
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proc Natl Acad Sci U S A (2005) 2.00
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A (2011) 1.99
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. J Am Chem Soc (2008) 1.97
On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. J Am Chem Soc (2008) 1.96
An NMR approach to structural proteomics. Proc Natl Acad Sci U S A (2002) 1.95
A straightforward route to functionalized trans-Diels-Alder motifs. J Am Chem Soc (2010) 1.92
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Proc Natl Acad Sci U S A (2010) 1.89
Inhibitors selective for mycobacterial versus human proteasomes. Nature (2009) 1.89
Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm. J Am Chem Soc (2009) 1.86
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res (2008) 1.85
Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. J Am Chem Soc (2004) 1.85
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. J Am Chem Soc (2004) 1.83
Response of soil respiration to soil temperature and moisture in a 50-year-old oriental arborvitae plantation in China. PLoS One (2011) 1.80
Syntheses of Isomerically Pure Reference Octalins and Hydrindanes. Tetrahedron Lett (2009) 1.75
Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way. Acc Chem Res (2006) 1.72
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. Circ Res (2010) 1.70
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. J Am Chem Soc (2004) 1.67
Evaluation of the biocompatibility of a chitosan scaffold in mice. J Biomed Mater Res (2002) 1.62
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol Cell (2013) 1.57
Total synthesis of guanacastepene a: a route to enantiomeric control. J Org Chem (2005) 1.56
Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging. Biochemistry (2004) 1.56
Retroperitoneal laparoscopic anatrophic nephrolithotomy for large staghorn calculi. Int J Urol (2010) 1.53
Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Angew Chem Int Ed Engl (2006) 1.53
Cued spatial attention drives functionally relevant modulation of the mu rhythm in primary somatosensory cortex. J Neurosci (2010) 1.53
Xom interacts with and stimulates transcriptional activity of LEF1/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis. Cell Res (2007) 1.51
Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive protein. Hypertens Res (2011) 1.50
Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. J Am Chem Soc (2006) 1.50
Uniform hexagonal graphene flakes and films grown on liquid copper surface. Proc Natl Acad Sci U S A (2012) 1.49
Monomeric red fluorescent proteins with a large Stokes shift. Proc Natl Acad Sci U S A (2010) 1.47
(E)-1-(4-Benzhydrylpiperazin-1-yl)-3-(3,4-dieth-oxy-phen-yl)prop-2-en-1-one ethanol monosolvate. Acta Crystallogr Sect E Struct Rep Online (2011) 1.46
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest (2011) 1.43
PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation. Clin Cancer Res (2006) 1.43
Retracted Reanalysis of the gene expression profile in chronic pancreatitis via bioinformatics methods. Eur J Med Res (2014) 1.39
(E)-1-{4-[Bis(4-meth-oxy-phen-yl)meth-yl]piperazin-1-yl}-3-(3,4-dieth-oxy-phen-yl)prop-2-en-1-one ethanol disolvate. Acta Crystallogr Sect E Struct Rep Online (2012) 1.39
Second- versus first-generation azoles for antifungal prophylaxis in hematology patients: a systematic review and meta-analysis. Ann Hematol (2013) 1.39
Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain. J Am Chem Soc (2009) 1.39
Straightforward synthesis of panaxytriol: an active component of Red Ginseng. J Org Chem (2003) 1.36
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol (2013) 1.35
Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis. Angew Chem Int Ed Engl (2008) 1.34
Gelsemine: a thought-provoking target for total synthesis. Angew Chem Int Ed Engl (2003) 1.34
Visual disability, visual function, and myopia among rural chinese secondary school children: the Xichang Pediatric Refractive Error Study (X-PRES)--report 1. Invest Ophthalmol Vis Sci (2008) 1.34
Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments. Proc Natl Acad Sci U S A (2012) 1.33
Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat Struct Mol Biol (2008) 1.32
The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms. Org Lett (2008) 1.32
Dual-color photon-counting histogram. Biophys J (2004) 1.29
On the remarkable antitumor properties of fludelone: how we got there. Angew Chem Int Ed Engl (2005) 1.28
Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate. J Am Chem Soc (2004) 1.28
Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Expert Rev Vaccines (2005) 1.27
Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles. Tetrahedron Lett (2009) 1.27
Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors. Proc Natl Acad Sci U S A (2004) 1.27
Opsin is a phospholipid flippase. Curr Biol (2011) 1.27
Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angew Chem Int Ed Engl (2007) 1.27
Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. J Exp Bot (2012) 1.26
Total vs. proximal gastrectomy for proximal gastric cancer: a systematic review and meta-analysis. Hepatogastroenterology (2012) 1.24
Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds. J Am Chem Soc (2009) 1.23
A Diels-Alder Route to Angularly Functionalized Bicyclic Structures. Tetrahedron (2010) 1.23
The mechanics behind DNA sequence-dependent properties of the nucleosome. Nucleic Acids Res (2012) 1.23
Blind testing of routine, fully automated determination of protein structures from NMR data. Structure (2012) 1.23
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A (2012) 1.22
CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery. Clin Cancer Res (2009) 1.22
Isolation, antimicrobial resistance, and virulence genes of Pasteurella multocida strains from swine in China. J Clin Microbiol (2009) 1.22
Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages. Nat Protoc (2008) 1.21
The total synthesis of (+/-)-11-O-debenzoyltashironin. J Am Chem Soc (2006) 1.21
Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation. J Am Chem Soc (2009) 1.21
MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression. FEBS Lett (2012) 1.20
Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. J Am Chem Soc (2007) 1.19
(E)-1-{4-[Bis(4-bromo-phen-yl)meth-yl]piperazin-1-yl}-3-(4-eth-oxy-3-meth-oxy-phen-yl)prop-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online (2011) 1.19
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. J Am Chem Soc (2010) 1.19
Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc Natl Acad Sci U S A (2008) 1.18
Synthetic Studies towards Maoecrystal V. Tetrahedron Lett (2009) 1.18
Persistence of side population cells with high drug efflux capacity in pancreatic cancer. World J Gastroenterol (2008) 1.18
The total synthesis of (+)-migrastatin. J Am Chem Soc (2003) 1.18
Torsional steering controls the stereoselectivity of epoxidation in the guanacastepene a synthesis. Org Lett (2006) 1.18
Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites. J Am Chem Soc (2009) 1.17
A stereoselective route to guanacastepene A through a surprising epoxidation. Angew Chem Int Ed Engl (2002) 1.17
Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. J Am Chem Soc (2005) 1.17
(E)-1-{4-[Bis(4-meth-oxy-phen-yl)meth-yl]piperazin-1-yl}-3-(4-methyl-phen-yl)prop-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online (2011) 1.17
On the rearrangement of an azaspiroindolenine to a precursor to phalarine: mechanistic insights. Angew Chem Int Ed Engl (2007) 1.17
Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility. J Med Genet (2007) 1.16
New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. J Am Chem Soc (2004) 1.15
Characteristics of gastroesophageal reflux disease in Japan: increased prevalence in elderly women. J Gastroenterol (2003) 1.15
Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. J Am Chem Soc (2009) 1.15