3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.

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Published in J Biol Chem on December 21, 2005

Authors

Li-shar Huang1, Gang Sun, David Cobessi, Andy C Wang, John T Shen, Eric Y Tung, Vernon E Anderson, Edward A Berry

Author Affiliations

1: Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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