Published in Proc Natl Acad Sci U S A on December 22, 2005
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal (2011) 2.70
The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR. J Virol (2006) 2.00
Mechanism of PKR Activation by dsRNA. J Mol Biol (2008) 1.42
A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. Mol Biol Cell (2007) 1.32
Regulation of innate immunity through RNA structure and the protein kinase PKR. Curr Opin Struct Biol (2010) 1.29
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell (2010) 1.25
Sequence-non-specific effects of RNA interference triggers and microRNA regulators. Nucleic Acids Res (2009) 1.11
Unactivated PKR exists in an open conformation capable of binding nucleotides. Biochemistry (2006) 1.06
Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus. J Virol (2008) 1.05
West nile virus infections suppress early viral RNA synthesis and avoid inducing the cell stress granule response. J Virol (2012) 1.04
Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol (2006) 1.04
Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific. RNA Biol (2011) 0.94
Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2. EMBO Rep (2007) 0.92
West Nile virus infection does not induce PKR activation in rodent cells. Virology (2011) 0.92
Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis. Am J Physiol Endocrinol Metab (2014) 0.91
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. EMBO Rep (2010) 0.89
Cooperative roles of fish protein kinase containing Z-DNA binding domains and double-stranded RNA-dependent protein kinase in interferon-mediated antiviral response. J Virol (2011) 0.88
Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol (2010) 0.84
Bacterial RNA induces myocyte cellular dysfunction through the activation of PKR. J Thorac Dis (2012) 0.82
Analysis of monomeric and dimeric phosphorylated forms of protein kinase R. Biochemistry (2010) 0.80
JAK kinases are required for the bacterial RNA and poly I:C induced tyrosine phosphorylation of PKR. Int J Clin Exp Med (2012) 0.79
Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing. Mol Ther Nucleic Acids (2015) 0.76
Activation of the double-stranded RNA-dependent protein kinase PKR by small ubiquitin-like modifier (SUMO). J Biol Chem (2014) 0.76
The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development. FEBS J (2015) 0.76
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
The conformational plasticity of protein kinases. Cell (2002) 11.21
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol (1991) 9.39
Translational control in stress and apoptosis. Nat Rev Mol Cell Biol (2005) 8.91
Viruses and interferon: a fight for supremacy. Nat Rev Immunol (2002) 7.92
Gene-specific regulation by general translation factors. Cell (2002) 6.05
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J (1995) 4.63
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell (2005) 4.41
The double-stranded RNA-dependent protein kinase PKR: structure and function. J Interferon Cytokine Res (1997) 3.54
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell (1999) 3.47
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87
Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J (1998) 2.68
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system. Mol Cell Biol (1991) 2.55
Eph receptors and ephrin ligands: embryogenesis to tumorigenesis. Oncogene (2000) 2.45
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell (2001) 2.31
Tumor-suppressor genes: news about the interferon connection. Proc Natl Acad Sci U S A (1993) 1.76
A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR. EMBO J (2000) 1.68
Structural modes of stabilization of permissive phosphorylation sites in protein kinases: distinct strategies in Ser/Thr and Tyr kinases. J Mol Biol (2004) 1.61
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem (1991) 1.44
PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell (2005) 1.42
PKR, apoptosis and cancer. Int J Biochem Cell Biol (1999) 1.37
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J Biol Chem (2002) 1.28
Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation. Oncogene (2001) 1.22
The T-cell protein tyrosine phosphatase. Semin Immunol (2000) 1.17
Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR. J Biol Chem (2001) 1.16
The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. J Biol Chem (1999) 1.15
Modulation of protein translation by Nck-1. Proc Natl Acad Sci U S A (2002) 1.13
Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation. J Biol Chem (2003) 0.97
Critical role for Daxx in regulating Mdm2. Nat Cell Biol (2006) 2.96
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev (2004) 2.94
Mid-Mesozoic flea-like ectoparasites of feathered or haired vertebrates. Curr Biol (2012) 2.55
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell (2003) 2.50
HIV and syphilis prevalence among men who have sex with men: a cross-sectional survey of 61 cities in China. Clin Infect Dis (2013) 2.24
MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood (2009) 2.07
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (2011) 1.79
A gigantic feathered dinosaur from the lower cretaceous of China. Nature (2012) 1.72
Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells. Cell Cycle (2009) 1.52
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
PERK and PKR: old kinases learn new tricks. Cell Cycle (2008) 1.45
Distribution, translocation and accumulation of silver nanoparticles in rats. J Nanosci Nanotechnol (2009) 1.43
Color doppler hemodynamic study of the superficial temporal arteries in superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery for Moyamoya disease. World Neurosurg (2011) 1.43
Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Mol Cell Biol (2005) 1.35
Hind wings in Basal birds and the evolution of leg feathers. Science (2013) 1.34
A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. Mol Biol Cell (2007) 1.32
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J (2013) 1.32
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. J Biol Chem (2010) 1.28
PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation. J Biol Chem (2007) 1.28
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J Biol Chem (2002) 1.28
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. J Biol Chem (2007) 1.27
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell (2010) 1.25
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal (2011) 1.24
A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem (2013) 1.22
Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Shock (2011) 1.19
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol (2004) 1.18
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem (2005) 1.17
Noncontrast dynamic MRA in intracranial arteriovenous malformation (AVM), comparison with time of flight (TOF) and digital subtraction angiography (DSA). Magn Reson Imaging (2012) 1.16
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. J Virol (2004) 1.15
Isolation and characterization of a novel thermophilic Bacillus strain degrading long-chain n-alkanes. Extremophiles (2006) 1.15
Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. J Biol Chem (2007) 1.14
A rapid aflatoxin B1 ELISA: development and validation with reduced matrix effects for peanuts, corn, pistachio, and Soybeans. J Agric Food Chem (2004) 1.12
Toward sustainable and comprehensive control of schistosomiasis in China: lessons from Sichuan. PLoS Negl Trop Dis (2011) 1.12
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal (2009) 1.11
Upregulation of basal TGFbeta1 levels by EMF coincident with chondrogenesis--implications for skeletal repair and tissue engineering. J Orthop Res (2002) 1.11
Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer (2012) 1.10
Adrenal lymphangioma removed by a retroperitoneoscopic procedure. Oncol Lett (2012) 1.10
Hapten synthesis and enzyme-linked immunosorbent assay for phosmet residues: assay optimization and investigation of matrix effects from different food samples. Anal Bioanal Chem (2009) 1.08
Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α. J Biol Chem (2014) 1.07
PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone. J Virol (2002) 1.04
A chemokine receptor CXCR2 macromolecular complex regulates neutrophil functions in inflammatory diseases. J Biol Chem (2011) 1.04
The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J Biol Chem (2002) 1.03
The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation. Cell Cycle (2008) 1.02
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J Biol Chem (2006) 1.00
Hydrothermal synthesis of GSH-TGA co-capped CdTe quantum dots and their application in labeling colorectal cancer cells. Colloids Surf B Biointerfaces (2012) 1.00
Development of multianalyte flow-through and lateral-flow assays using gold particles and horseradish peroxidase as tracers for the rapid determination of carbaryl and endosulfan in agricultural products. J Agric Food Chem (2006) 1.00
The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells. Cell Cycle (2012) 0.99
Intraoperative contrast-enhanced ultrasound for brain tumors. Clin Imaging (2008) 0.99
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. J Hepatol (2007) 0.97
Study on RIZ1 gene promoter methylation status in human esophageal squamous cell carcinoma. World J Gastroenterol (2012) 0.96
Single-neuron correlates of atypical face processing in autism. Neuron (2013) 0.96
Clinical biophysics: the promotion of skeletal repair by physical forces. Ann N Y Acad Sci (2006) 0.95
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. PLoS One (2008) 0.95
Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival. Oncogene (2003) 0.95
Repeated Schistosoma japonicum infection following treatment in two cohorts: evidence for host susceptibility to helminthiasis? PLoS Negl Trop Dis (2013) 0.95
Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro. J Nanosci Nanotechnol (2010) 0.95
Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination. J Biol Chem (2007) 0.95
Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest. Resuscitation (2010) 0.94
Alkali-induced changes in functional properties and in vitro digestibility of wheat starch: the role of surface proteins and lipids. J Agric Food Chem (2014) 0.94
Addition of bevacizumab enhances antitumor activity of erlotinib against non-small cell lung cancer xenografts depending on VEGF expression. Cancer Chemother Pharmacol (2014) 0.93
Decreased expression of retinoblastoma protein-interacting zinc-finger gene 1 in human esophageal squamous cell cancer by DNA methylation. Clin Lab (2012) 0.93
Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes. PLoS One (2012) 0.93
Field evaluation of a PCR test for Schistosoma japonicum egg detection in low-prevalence regions of China. Am J Trop Med Hyg (2012) 0.93
eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}. Cancer Res (2010) 0.92
Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2. EMBO Rep (2007) 0.92
New transitional fleas from China highlighting diversity of Early Cretaceous ectoparasitic insects. Curr Biol (2013) 0.92
Applications and recent developments of multi-analyte simultaneous analysis by enzyme-linked immunosorbent assays. J Immunol Methods (2011) 0.92
Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem (2010) 0.92
Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. Neurol Med Chir (Tokyo) (2006) 0.91
Shen-Fu injection reduces impaired myocardial β-adrenergic receptor signaling after cardiopulmonary resuscitation. Chin Med J (Engl) (2013) 0.91
Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling. J Biol Chem (2009) 0.91
Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res (2013) 0.91
Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. Neurol Med Chir (Tokyo) (2011) 0.90
Fcgamma receptor regulation of Citrobacter rodentium infection. Infect Immun (2008) 0.90
Control of tumor suppressor p53 function by endoplasmic reticulum stress. Cell Cycle (2004) 0.90
Postoperatively administered vancomycin reaches therapeutic concentration in the cerebral spinal fluid of neurosurgical patients. Surg Neurol (2007) 0.89
Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget (2013) 0.89
Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae). J Ethnopharmacol (2012) 0.89
Ubiquitination and proteasome degradation of the E6 proteins of human papillomavirus types 11 and 18. J Gen Virol (2004) 0.89
Surgical treatment of giant intracranial arteriovenous malformations. Neurosurgery (2010) 0.89