Published in Mol Biol Cell on June 27, 2007
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J Immunol (2009) 1.44
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Sci Signal (2016) 1.30
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell (2010) 1.25
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal (2011) 1.24
PERK-dependent regulation of IAP translation during ER stress. Oncogene (2008) 1.23
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics (2009) 1.22
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death Differ (2010) 1.16
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal (2009) 1.11
Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α. J Biol Chem (2014) 1.07
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol Cell Biol (2012) 1.05
Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease. Antioxid Redox Signal (2011) 1.02
6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. PLoS One (2012) 1.00
SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep (2011) 0.99
The integrated stress response. EMBO Rep (2016) 0.96
Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. PLoS One (2012) 0.95
PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells. J Biol Chem (2008) 0.93
Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death. Cell Death Differ (2010) 0.93
Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress. Cell Death Dis (2015) 0.91
Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction. Autophagy (2012) 0.91
Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention. Nutrients (2013) 0.89
Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats. Metabolism (2013) 0.87
The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway. Open Biol (2015) 0.86
Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer. Breast Cancer Res (2013) 0.86
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. Mol Pharmacol (2008) 0.85
ChIP-Seq Data Mining: Remarkable Differences in NRSF/REST Target Genes between Human ESC and ESC-Derived Neurons. Bioinform Biol Insights (2013) 0.85
Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells. Oncotarget (2015) 0.85
Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB). J Biol Chem (2008) 0.84
The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells. PLoS One (2011) 0.84
eIF2α kinases control chalone production in Dictyostelium discoideum. Eukaryot Cell (2011) 0.83
A critical role for mTORC1 in erythropoiesis and anemia. Elife (2014) 0.82
The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther (2014) 0.80
High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice. J Nutr (2014) 0.79
The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development. FEBS J (2015) 0.76
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLoS Genet (2016) 0.75
Therapeutic interventions to disrupt the protein synthetic machinery in melanoma. Pigment Cell Melanoma Res (2015) 0.75
Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. J Neurosci (2016) 0.75
Neuronal human BACE1 knockin induces systemic diabetes in mice. Diabetologia (2016) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer (2002) 28.11
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 17.19
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem (1999) 14.59
Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol (2005) 11.57
Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell (2001) 11.21
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Gene-specific regulation by general translation factors. Cell (2002) 6.05
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem (2005) 5.62
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
PI3K/Akt and apoptosis: size matters. Oncogene (2003) 4.35
PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst) (2004) 3.85
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57
PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol (2004) 3.57
The double-stranded RNA-dependent protein kinase PKR: structure and function. J Interferon Cytokine Res (1997) 3.54
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A (1999) 3.10
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J (2003) 2.84
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol (2005) 2.47
Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett (2003) 2.22
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J Biol Chem (2002) 2.08
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem (2000) 1.83
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem (2001) 1.82
Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine Growth Factor Rev (2005) 1.80
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell (2002) 1.71
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J (1997) 1.49
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. EMBO J (2000) 1.41
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol (2002) 1.40
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem (2003) 1.36
Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR. EMBO J (2001) 1.35
The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. EMBO J (2004) 1.29
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J Biol Chem (2002) 1.28
SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci (2003) 1.27
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25
PKR protection against intranasal vesicular stomatitis virus infection is mouse strain dependent. Viral Immunol (2002) 1.23
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. Proc Natl Acad Sci U S A (2005) 1.20
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol (2004) 1.18
Regulation of constitutive expression of mouse PTEN by the 5'-untranslated region. Oncogene (2003) 1.16
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J Biol Chem (2006) 1.00
Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR. J Biol Chem (2001) 0.98
Ruk is ubiquitinated but not degraded by the proteasome. Eur J Biochem (2002) 0.89
Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells. Mol Cell Biol (2001) 0.87
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature (2004) 8.76
Short RNAs repress translation after initiation in mammalian cells. Mol Cell (2006) 6.70
Statistical practice in high-throughput screening data analysis. Nat Biotechnol (2006) 5.85
Antimicrobial drug discovery through bacteriophage genomics. Nat Biotechnol (2004) 4.17
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol (2006) 3.89
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proc Natl Acad Sci U S A (2005) 3.84
Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell (2007) 3.46
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev (2004) 2.94
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Mid-Mesozoic flea-like ectoparasites of feathered or haired vertebrates. Curr Biol (2012) 2.55
mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A (2008) 2.50
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell (2003) 2.50
Integrated endoplasmic reticulum stress responses in cancer. Cancer Res (2007) 2.43
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest (2008) 2.40
Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A (2009) 2.40
HIV and syphilis prevalence among men who have sex with men: a cross-sectional survey of 61 cities in China. Clin Infect Dis (2013) 2.24
Comparative genomic analysis of 18 Pseudomonas aeruginosa bacteriophages. J Bacteriol (2006) 2.18
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood (2009) 2.07
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00
Structural conservation of druggable hot spots in protein-protein interfaces. Proc Natl Acad Sci U S A (2011) 1.95
A tumour suppressor network relying on the polyamine-hypusine axis. Nature (2012) 1.85
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (2011) 1.79
A gigantic feathered dinosaur from the lower cretaceous of China. Nature (2012) 1.72
RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol (2006) 1.71
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (2008) 1.69
Altering chemosensitivity by modulating translation elongation. PLoS One (2009) 1.68
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Proc Natl Acad Sci U S A (2005) 1.65
Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen. Nucleic Acids Res (2004) 1.62
High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay. J Biomol Screen (2005) 1.61
Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev (2008) 1.60
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Res (2006) 1.60
Caliciviruses differ in their functional requirements for eIF4F components. J Biol Chem (2006) 1.60
Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells. Cell Cycle (2009) 1.52
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
Uncoupling stress granule assembly and translation initiation inhibition. Mol Biol Cell (2009) 1.49
Selective pharmacological targeting of a DEAD box RNA helicase. PLoS One (2008) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
PERK and PKR: old kinases learn new tricks. Cell Cycle (2008) 1.45
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med (2011) 1.45
Color doppler hemodynamic study of the superficial temporal arteries in superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery for Moyamoya disease. World Neurosurg (2011) 1.43
Distribution, translocation and accumulation of silver nanoparticles in rats. J Nanosci Nanotechnol (2009) 1.43
Dengue virus serotype infection specifies the activation of the unfolded protein response. Virol J (2007) 1.41
Repurposing CRISPR/Cas9 for in situ functional assays. Genes Dev (2013) 1.41
Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angew Chem Int Ed Engl (2007) 1.40
c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. Cancer Res (2008) 1.40
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. J Lipid Res (2008) 1.39
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res (2011) 1.35
Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta. Mol Cell Biol (2005) 1.35
Hind wings in Basal birds and the evolution of leg feathers. Science (2013) 1.34
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J (2013) 1.32
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. J Biol Chem (2011) 1.31
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A (2010) 1.30
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. J Biol Chem (2010) 1.28
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J Biol Chem (2002) 1.28
PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation. J Biol Chem (2007) 1.28
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. J Biol Chem (2007) 1.27
Inhibition of translation by RNA-small molecule interactions. RNA (2002) 1.27
Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell (2010) 1.25
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal (2011) 1.24
A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus. Bioorg Med Chem (2006) 1.23
A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem (2013) 1.22
Translation of nonSTOP mRNA is repressed post-initiation in mammalian cells. EMBO J (2007) 1.20
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. Proc Natl Acad Sci U S A (2005) 1.20
Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Shock (2011) 1.19
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol (2004) 1.18
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem (2005) 1.17
Noncontrast dynamic MRA in intracranial arteriovenous malformation (AVM), comparison with time of flight (TOF) and digital subtraction angiography (DSA). Magn Reson Imaging (2012) 1.16
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. J Virol (2004) 1.15
Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles. RNA (2004) 1.15
Isolation and characterization of a novel thermophilic Bacillus strain degrading long-chain n-alkanes. Extremophiles (2006) 1.15
Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. J Biol Chem (2007) 1.14
A cellular response linking eIF4AI activity to eIF4AII transcription. RNA (2012) 1.13
Toward sustainable and comprehensive control of schistosomiasis in China: lessons from Sichuan. PLoS Negl Trop Dis (2011) 1.12
Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. ACS Chem Biol (2013) 1.12
A rapid aflatoxin B1 ELISA: development and validation with reduced matrix effects for peanuts, corn, pistachio, and Soybeans. J Agric Food Chem (2004) 1.12
Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep (2012) 1.12
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal (2009) 1.11
Upregulation of basal TGFbeta1 levels by EMF coincident with chondrogenesis--implications for skeletal repair and tissue engineering. J Orthop Res (2002) 1.11
Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer (2012) 1.10
Adrenal lymphangioma removed by a retroperitoneoscopic procedure. Oncol Lett (2012) 1.10
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB J (2010) 1.10
Targeting translation dependence in cancer. Oncotarget (2011) 1.09
Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. Leuk Res (2009) 1.09
c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy. Cancer Res (2009) 1.08