Published in Ann N Y Acad Sci on November 01, 2005
Complement-targeted therapeutics. Nat Biotechnol (2007) 3.24
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol (2012) 0.86
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
Structural basis for complement factor H linked age-related macular degeneration. J Exp Med (2007) 2.02
The pluripotency rheostat Nanog functions as a dimer. Biochem J (2008) 1.97
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Natl Acad Sci U S A (2010) 1.91
A new map of glycosaminoglycan and C3b binding sites on factor H. J Immunol (2008) 1.89
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. J Immunol (2009) 1.70
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. J Immunol (2006) 1.63
Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A (2012) 1.62
Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure. J Biol Chem (2006) 1.48
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol (2012) 1.40
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology (2012) 1.39
An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Mol Cell (2004) 1.37
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. J Biol Chem (2007) 1.36
ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain. Plant Cell (2005) 1.33
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. J Mol Biol (2005) 1.31
Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes. J Biol Chem (2005) 1.27
Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell (2002) 1.25
Large-scale modelling as a route to multiple surface comparisons of the CCP module family. Protein Eng Des Sel (2005) 1.17
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. J Immunol (2009) 1.16
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. J Biol Chem (2008) 1.16
The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae. BMC Evol Biol (2008) 1.15
Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities. J Biol Chem (2011) 1.15
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13
NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett (2008) 1.11
Functional anatomy of complement factor H. Biochemistry (2013) 1.10
Production of biologically active complement factor H in therapeutically useful quantities. Protein Expr Purif (2010) 1.09
A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am J Hum Genet (2009) 1.08
Rational engineering of a minimized immune inhibitor with unique triple-targeting properties. J Immunol (2013) 1.07
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. J Immunol (2013) 1.06
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci (2011) 1.05
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood (2011) 1.02
DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00
Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation. PLoS One (2009) 0.97
Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin. Structure (2002) 0.97
Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases. J Biol Chem (2007) 0.97
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. Hum Mol Genet (2012) 0.97
The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol Biol (2009) 0.96
Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. J Biol Chem (2005) 0.96
NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'. Biomol Concepts (2013) 0.95
Solution structure of a functionally active fragment of decay-accelerating factor. Proc Natl Acad Sci U S A (2003) 0.94
Deciphering complement mechanisms: the contributions of structural biology. Mol Immunol (2007) 0.93
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci (2004) 0.92
Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells. J Biol Chem (2009) 0.92
Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core. Chembiochem (2003) 0.92
Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded. J Biol Chem (2004) 0.91
Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction. J Am Chem Soc (2010) 0.91
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking. Hum Mol Genet (2013) 0.91
The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut (2012) 0.91
The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function. J Biol Chem (2008) 0.90
Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas. BMC Genet (2007) 0.90
Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350. J Virol (2008) 0.89
Factor H autoantibodies in membranoproliferative glomerulonephritis. Mol Immunol (2012) 0.89
Complement factor h autoantibodies and age-related macular degeneration. Invest Ophthalmol Vis Sci (2010) 0.87
Atypical femoral fracture in osteoporosis pseudoglioma syndrome associated with two novel compound heterozygous mutations in LRP5. J Bone Miner Res (2015) 0.87
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. J Biol Chem (2013) 0.86
Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. PLoS One (2012) 0.86
The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro. Nucleic Acids Res (2009) 0.86
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol (2012) 0.86
MDM4 binds ligands via a mechanism in which disordered regions become structured. FEBS Lett (2010) 0.85
Functional insights from the structure of the multifunctional C345C domain of C5 of complement. J Biol Chem (2004) 0.85
Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus). Protein Sci (2011) 0.84
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution. J Biol Chem (2012) 0.84
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings. Biochemistry (2011) 0.83
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). PLoS One (2012) 0.83
Structural and functional characterization of the product of disease-related factor H gene conversion. Biochemistry (2012) 0.83
eEF1A2 and neuronal degeneration. Biochem Soc Trans (2009) 0.81
Vaccinia virus complement control protein is monomeric, and retains structural and functional integrity after exposure to adverse conditions. Biochim Biophys Acta (2002) 0.81
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. J Biol Chem (2009) 0.81
Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.80
Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation. Biol Direct (2013) 0.80