Published in Cell on March 22, 2002
Platelet activation leads to activation and propagation of the complement system. J Exp Med (2005) 1.76
Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome. Blood (2015) 1.58
Complement System Part I - Molecular Mechanisms of Activation and Regulation. Front Immunol (2015) 1.52
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. J Biol Chem (2008) 1.16
The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding. Proc Natl Acad Sci U S A (2002) 1.11
Production of biologically active complement factor H in therapeutically useful quantities. Protein Expr Purif (2010) 1.09
Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy. Proc Natl Acad Sci U S A (2011) 1.09
Concern Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation. Proc Natl Acad Sci U S A (2004) 1.00
Immunophysical properties and prediction of activities for vaccinia virus complement control protein and smallpox inhibitor of complement enzymes using molecular dynamics and electrostatics. Biophys J (2006) 0.94
Solution structure of a functionally active fragment of decay-accelerating factor. Proc Natl Acad Sci U S A (2003) 0.94
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci (2004) 0.92
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. J Biol Chem (2013) 0.86
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol (2012) 0.86
The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation. Acta Crystallogr D Biol Crystallogr (2009) 0.85
Structures of the rat complement regulator CrrY. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.84
Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion. Front Microbiol (2016) 0.80
Do follicular dendritic cells regulate lupus-specific B cells? Mol Immunol (2014) 0.80
Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology. Sci Rep (2016) 0.79
Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode. EMBO J (2016) 0.79
Identification of a complement receptor 1 peptide for inhibition of immune hemolysis. Biochem Biophys Res Commun (2006) 0.79
A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding. Mol Immunol (2007) 0.78
Prioritization of cancer-related genomic variants by SNP association network. Cancer Inform (2015) 0.77
Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins. Proc Natl Acad Sci U S A (2015) 0.76
Severity of malaria in relation to a complement receptor 1 polymorphism: a case-control study. Pathog Glob Health (2015) 0.75
Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor. J Biomol NMR (2002) 0.75
Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood (2006) 4.51
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 4.11
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood (2008) 3.10
New approaches to the treatment of dense deposit disease. J Am Soc Nephrol (2007) 3.02
Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. J Am Soc Nephrol (2006) 2.88
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature (2003) 2.83
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2003) 2.79
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood (2004) 2.58
Adenovirus type 11 uses CD46 as a cellular receptor. J Virol (2003) 2.52
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology (2005) 2.36
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet (2007) 2.35
Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32
T-cell regulation: with complements from innate immunity. Nat Rev Immunol (2006) 2.27
Immunology of age-related macular degeneration. Nat Rev Immunol (2013) 2.14
Structural basis for complement factor H linked age-related macular degeneration. J Exp Med (2007) 2.02
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly. J Immunol (2007) 2.00
The pluripotency rheostat Nanog functions as a dimer. Biochem J (2008) 1.97
Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog (2007) 1.97
West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc Natl Acad Sci U S A (2006) 1.96
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Natl Acad Sci U S A (2010) 1.91
A new map of glycosaminoglycan and C3b binding sites on factor H. J Immunol (2008) 1.89
Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci (2009) 1.86
Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.82
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol (2006) 1.81
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet (2013) 1.77
Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med (2010) 1.76
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. J Immunol (2009) 1.70
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol (2010) 1.67
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. J Immunol (2006) 1.63
Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun (2008) 1.57
Properdin: emerging roles of a pattern-recognition molecule. Annu Rev Immunol (2010) 1.55
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood (2007) 1.53
Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med (2011) 1.52
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol (2002) 1.51
Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure. J Biol Chem (2006) 1.48
Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J Immunol (2011) 1.45
Cerebrospinal fluid apolipoprotein E concentration decreases after seizure. Seizure (2010) 1.45
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Mol Immunol (2007) 1.42
Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol (2012) 1.40
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology (2012) 1.39
An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Mol Cell (2004) 1.37
CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7. J Virol (2005) 1.37
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. J Biol Chem (2007) 1.36
New roles for the major human 3'-5' exonuclease TREX1 in human disease. Cell Cycle (2008) 1.35
CD46: expanding beyond complement regulation. Trends Immunol (2004) 1.32
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. J Mol Biol (2005) 1.31
Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet (2010) 1.28
Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3. J Biol Chem (2008) 1.28
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood (2012) 1.28
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab (2011) 1.27
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb. J Biol Chem (2001) 1.22
Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation. J Immunol (2006) 1.21
Large-scale modelling as a route to multiple surface comparisons of the CCP module family. Protein Eng Des Sel (2005) 1.17
Two-dimensional universal conductance fluctuations and the electron-phonon interaction of surface states in Bi2Te2Se microflakes. Sci Rep (2012) 1.17
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. J Immunol (2009) 1.16
The role of the immune response in age-related macular degeneration. Int J Inflam (2013) 1.16
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. J Biol Chem (2008) 1.16
Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. J Biol Chem (2003) 1.16
Emerging roles and new functions of CD46. Springer Semin Immunopathol (2005) 1.16
Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities. J Biol Chem (2011) 1.15
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (2013) 1.14
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood (2010) 1.14
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J Cell Biol (2002) 1.14
Complete correction of hemophilia A with adeno-associated viral vectors containing a full-size expression cassette. Hum Gene Ther (2008) 1.13
Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation (2009) 1.13
Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol (2007) 1.12
Mapping QTL for multiple traits using Bayesian statistics. Genet Res (Camb) (2009) 1.10
Functional anatomy of complement factor H. Biochemistry (2013) 1.10
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood (2005) 1.10
Comparative study of SBP-box gene family in Arabidopsis and rice. Gene (2007) 1.09
In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
Production of biologically active complement factor H in therapeutically useful quantities. Protein Expr Purif (2010) 1.09
Localization of regions in CD46 that interact with adenovirus. J Virol (2005) 1.08
Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol (2004) 1.07
Rational engineering of a minimized immune inhibitor with unique triple-targeting properties. J Immunol (2013) 1.07
Surviving mousepox infection requires the complement system. PLoS Pathog (2008) 1.07
Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J Immunol (2005) 1.07
Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials (2009) 1.06
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther (2009) 1.05
Electron transport properties of atomic carbon nanowires between graphene electrodes. J Am Chem Soc (2010) 1.05
Advances in understanding of pathogenesis of aHUS and HELLP. Br J Haematol (2008) 1.05
Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China. J Antimicrob Chemother (2012) 1.05
The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors. J Biol Chem (2005) 1.05
Molecular evolution of the CPP-like gene family in plants: insights from comparative genomics of Arabidopsis and rice. J Mol Evol (2008) 1.04
Membrane protein Crry maintains homeostasis of the complement system. J Immunol (2008) 1.04
Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity. J Immunol (2009) 1.03
Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis. J Cell Mol Med (2014) 1.03
Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome. Mol Immunol (2006) 1.03
Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods. BMC Proc (2009) 1.03
The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene. Mol Ther (2007) 1.03
Mutations in CD46, a complement regulatory protein, predispose to atypical HUS. Trends Mol Med (2004) 1.02
Targeted and restricted complement activation on acrosome-reacted spermatozoa. J Clin Invest (2005) 1.02
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood (2011) 1.02