Published in Biomol Concepts on October 01, 2013
Mechanism and Regulation of Cytoplasmic Dynein. Annu Rev Cell Dev Biol (2015) 1.00
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages. Nat Commun (2016) 0.97
Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis. Blood (2014) 0.95
Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. Cell Rep (2015) 0.82
Dendrite arborization requires the dynein cofactor NudE. J Cell Sci (2015) 0.82
Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation. Biol Direct (2013) 0.80
Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia. PLoS One (2014) 0.78
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. J Cell Biol (2016) 0.76
The tumor suppressor FBW7 controls ciliary length. EMBO J (2015) 0.75
Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain. Neuroscience (2016) 0.75
Mechanisms of ciliogenesis suppression in dividing cells. Cell Mol Life Sci (2016) 0.75
Human NDE1 splicing and mammalian brain development. Sci Rep (2017) 0.75
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Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol (2011) 28.61
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Genome-wide association study identifies five new schizophrenia loci. Nat Genet (2011) 9.07
The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res (2004) 8.23
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence. Proteomics (2004) 7.76
Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet (2000) 7.16
Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet (2010) 5.78
A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet (2009) 5.01
Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. Nature (1993) 4.87
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies. Brain (2009) 3.96
Association within a family of a balanced autosomal translocation with major mental illness. Lancet (1990) 3.94
A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron (2000) 3.93
Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron (2004) 3.90
Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum Mutat (2007) 3.52
NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron (2000) 3.45
Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies. PLoS Genet (2010) 3.39
Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant. J Med Genet (2008) 3.35
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A (2002) 3.34
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron (2004) 3.33
Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci (2011) 2.89
LIS1 and NudE induce a persistent dynein force-producing state. Cell (2010) 2.88
LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron (2000) 2.78
Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching. Mol Cell Proteomics (2007) 2.78
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet (2010) 2.61
Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell (2012) 2.48
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet (2003) 2.39
Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry (2009) 2.29
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet (2003) 2.27
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol (2011) 2.15
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol (2004) 2.06
Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. Curr Biol (2007) 2.03
Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]. Am J Hum Genet (2011) 1.92
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J Cell Biol (2007) 1.85
DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci (2007) 1.84
The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J Cell Biol (2000) 1.82
Bioinformatic and experimental survey of 14-3-3-binding sites. Biochem J (2010) 1.73
Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol (2005) 1.71
The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am J Hum Genet (2011) 1.71
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol (2006) 1.69
Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci (2004) 1.62
Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol (2003) 1.61
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol Biol Cell (2005) 1.58
DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet (2006) 1.58
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron (2011) 1.57
Statistical analysis of protein kinase specificity determinants. FEBS Lett (1998) 1.53
Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. PLoS Biol (2011) 1.53
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron (2004) 1.51
Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. Am J Med Genet B Neuropsychiatr Genet (2008) 1.50
Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat Cell Biol (2009) 1.49
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J Cell Biol (2004) 1.47
Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning. J Cell Sci (2010) 1.47
Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun (2003) 1.47
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet (2005) 1.45
HZwint-1, a novel human kinetochore component that interacts with HZW10. J Cell Sci (2000) 1.44
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure (2007) 1.36
DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem Biophys Res Commun (2008) 1.34
Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci (2008) 1.32
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol (2009) 1.31
Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase. Mol Biol Cell (2007) 1.30
Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet (2006) 1.28
Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A (2010) 1.28
DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell (2008) 1.26
Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem (2011) 1.26
Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J Cell Biol (2008) 1.25
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet (2008) 1.23
Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders. PLoS One (2013) 1.23
Copy number variants of schizophrenia susceptibility loci are associated with a spectrum of speech and developmental delays and behavior problems. Genet Med (2011) 1.22
Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS. Dev Cell (2013) 1.20
Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. Hum Genet (2010) 1.20
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. J Cell Biol (2008) 1.17
Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE. FEBS Lett (2000) 1.17
Posttranslational regulation impacts the fate of duplicated genes. Proc Natl Acad Sci U S A (2009) 1.16
Systematic dissection of dynein regulators in mitosis. J Cell Biol (2013) 1.15
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13
16p13.11 duplication is a risk factor for a wide spectrum of neuropsychiatric disorders. J Hum Genet (2011) 1.12
NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett (2008) 1.11
A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. J Neurosci (2011) 1.10
Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice. J Neurosci (2009) 1.10
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J Cell Biol (2011) 1.07
Phenotypic manifestations of copy number variation in chromosome 16p13.11. Eur J Hum Genet (2010) 1.06
Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic (2009) 1.05
Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract. J Biol Chem (2010) 1.05
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci (2011) 1.05
Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. PLoS Biol (2009) 1.02
Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. Oncogene (2006) 1.02
NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. Mech Dev (2001) 1.01
Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. J Biol Chem (2008) 1.01
Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway. Proc Natl Acad Sci U S A (2005) 1.00
Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. EMBO J (2009) 1.00
Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci U S A (2005) 0.99
Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry (2009) 0.98
Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry (2005) 2.48
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A (2007) 2.04
ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain. Plant Cell (2005) 1.33
Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. Hum Mol Genet (2007) 1.28
Association of variants in DISC1 with psychosis-related traits in a large population cohort. Arch Gen Psychiatry (2009) 1.19
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. J Biol Chem (2008) 1.16
The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae. BMC Evol Biol (2008) 1.15
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13
NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett (2008) 1.11
A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am J Hum Genet (2009) 1.08
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci (2011) 1.05
The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. Schizophr Res (2007) 1.04
DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00
Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia. Biol Psychiatry (2009) 1.00
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort. PLoS One (2012) 0.98
Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry (2009) 0.98
Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases. J Biol Chem (2007) 0.97
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. Hum Mol Genet (2012) 0.97
The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol Biol (2009) 0.96
Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample. Biol Psychiatry (2008) 0.93
Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded. J Biol Chem (2004) 0.91
The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut (2012) 0.91
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking. Hum Mol Genet (2013) 0.91
Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas. BMC Genet (2007) 0.90
Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum Mol Genet (2012) 0.89
Atypical femoral fracture in osteoporosis pseudoglioma syndrome associated with two novel compound heterozygous mutations in LRP5. J Bone Miner Res (2015) 0.87
Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. Am J Med Genet B Neuropsychiatr Genet (2009) 0.86
The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro. Nucleic Acids Res (2009) 0.86
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol (2012) 0.86
Functional insights from the structure of the multifunctional C345C domain of C5 of complement. J Biol Chem (2004) 0.85
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia. Psychiatry Res (2011) 0.83
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). PLoS One (2012) 0.83
eEF1A2 and neuronal degeneration. Biochem Soc Trans (2009) 0.81
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. J Biol Chem (2009) 0.81
Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation. Biol Direct (2013) 0.80
Opportunities for new therapies based on the natural regulators of complement activation. Ann N Y Acad Sci (2005) 0.79
Disease-associated sequence variations in factor H: a structural biology approach. Adv Exp Med Biol (2006) 0.79
In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence. Physiol Genomics (2010) 0.76
Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists. Inorg Chem (2010) 0.75