Published in Crit Rev Eukaryot Gene Expr on January 01, 2005
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res (2007) 2.61
Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell (2012) 2.28
The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma (2010) 1.18
Insights from amphioxus into the evolution of vertebrate cartilage. PLoS One (2007) 1.16
Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA. Mol Endocrinol (2009) 1.06
Spatial and temporal regulation of gene expression in the mammalian growth plate. Bone (2010) 1.01
Evolution of a core gene network for skeletogenesis in chordates. PLoS Genet (2008) 1.00
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol (2008) 1.00
UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Dev Biol (2010) 0.94
Wnt signaling regulates pulp volume and dentin thickness. J Bone Miner Res (2014) 0.89
Inducible expression of Runx2 results in multiorgan abnormalities in mice. J Cell Biochem (2011) 0.84
Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol Cell Biol (2007) 0.84
A new mechanistic scenario for the origin and evolution of vertebrate cartilage. PLoS One (2011) 0.83
Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering. Genes Dis (2015) 0.80
Loss of osteoblast Runx3 produces severe congenital osteopenia. Mol Cell Biol (2015) 0.79
Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway. J Biol Chem (2012) 0.79
Runx3 negatively regulates Osterix expression in dental pulp cells. Biochem J (2007) 0.79
Making no bones about it: Transcription factors in vertebrate skeletogenesis and disease. Trends Dev Biol (2012) 0.78
Growth-plate cartilage in chronic renal failure. Pediatr Nephrol (2009) 0.78
Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. J Endocrinol (2011) 0.77
RUNX1 Plays an Important Role in Mediating BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Line C3H10T1/2, Murine Multi-Lineage Cells Lines C2C12 and MEFs. Int J Mol Sci (2017) 0.75
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev (2004) 3.33
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum (2006) 2.19
Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem (2005) 2.04
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol (2004) 1.99
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev (2005) 1.93
Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet (2002) 1.83
The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev Biol (2002) 1.68
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem (2004) 1.64
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn (2007) 1.56
Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol (2007) 1.49
Runx2 deficiency in chondrocytes causes adipogenic changes in vitro. J Cell Sci (2004) 1.44
MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genet (2013) 1.42
Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. Mol Cell Biol (2007) 1.25
BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol (2007) 1.21
Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol (2007) 1.21
Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J (2006) 1.20
Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development. Dev Dyn (2005) 1.12
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem (2004) 1.12
Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol (2006) 1.08
Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling. J Immunol (2010) 1.08
Inhibition of the terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice. Arch Histol Cytol (2008) 1.08
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice. Blood (2009) 1.03
Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol (2009) 1.03
Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem (2004) 1.03
Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res (2006) 1.01
Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PLoS One (2012) 0.99
Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J Biol Chem (2002) 0.99
Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo. Endocrinology (2006) 0.97
Delayed tooth eruption and suppressed osteoclast number in the eruption pathway of heterozygous Runx2/Cbfa1 knockout mice. Arch Oral Biol (2004) 0.96
Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia. Mod Pathol (2004) 0.95
Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. J Biol Chem (2008) 0.94
Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2. J Cell Biochem (2004) 0.92
Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice. J Anat (2007) 0.92
Aged mice require full transcription factor, Runx2/Cbfa1, gene dosage for cancellous bone regeneration after bone marrow ablation. J Bone Miner Res (2004) 0.92
Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PLoS One (2011) 0.92
Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone (2011) 0.92
Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. Biochem Biophys Res Commun (2004) 0.91
Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. J Biol Chem (2011) 0.91
SP7 inhibits osteoblast differentiation at a late stage in mice. PLoS One (2012) 0.89
Impaired vascular invasion of Cbfa1-deficient cartilage engrafted in the spleen. J Bone Miner Res (2002) 0.87
Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation. J Bone Miner Res (2011) 0.85
Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. Bone (2011) 0.85
Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. Histochem Cell Biol (2012) 0.84
Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. J Bone Miner Res (2012) 0.84
Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice. J Med Dent Sci (2004) 0.83
Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells. Bone (2012) 0.83
Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. J Cell Physiol (2005) 0.83
Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression. J Bone Miner Res (2014) 0.83
Cbfb regulates bone development by stabilizing Runx family proteins. J Bone Miner Res (2015) 0.83
In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues. Sci Rep (2012) 0.82
Immobilization-induced cartilage degeneration mediated through expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and chondromodulin-I. Connect Tissue Res (2009) 0.81
Novel sandwich ELISAs for rat DMP1: age-related decrease of circulatory DMP1 levels in male rats. Bone (2013) 0.80
Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation. J Bone Miner Metab (2010) 0.80
Pin1-mediated Runx2 modification is critical for skeletal development. J Cell Physiol (2013) 0.80
OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis. Dev Growth Differ (2012) 0.79
Comparative morphology of the osteocyte lacunocanalicular system in various vertebrates. J Bone Miner Metab (2011) 0.79
Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells. J Cell Physiol (2015) 0.78
Regulation of Rb family proteins by Cdk6/Ccnd1 in growth plates. Cell Cycle (2013) 0.78
Thrombospondin-1 is a putative target gene of Runx2 and Runx3. Int J Mol Sci (2013) 0.77
Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum Mol Genet (2014) 0.77
Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development: comparison of MR imaging and histological findings. Bone (2004) 0.76
Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix. J Bone Miner Metab (2012) 0.76
[Regulation of bone mass by osteocyte network]. Clin Calcium (2012) 0.75
[Glucocorticoid and Bone. The inhibition of osteoblast differentiation and induction of osteocyte apoptosis through the regulation of Bcl-2 by glucocorticoids]. Clin Calcium (2014) 0.75
Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely down-regulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. Cell Tissue Res (2015) 0.75
[Multifunctional roles of Runx2/Cbfa1 in skeletal development]. Nihon Rinsho (2004) 0.75
Medical open innovation initiative in Nagasaki University. Nihon Yakurigaku Zasshi (2015) 0.75
[Function of Osterix in osteoblasts]. Nihon Rinsho (2007) 0.75