Published in Genes Dev on April 15, 2004
MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells (2010) 3.16
Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med (2009) 2.81
Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci U S A (2006) 2.23
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol (2004) 1.99
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res (2008) 1.63
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Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev (2006) 1.52
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A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A (2006) 1.46
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Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol (2009) 1.36
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An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible. J Anat (2006) 1.17
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The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. J Cell Physiol (2013) 1.11
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An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat (2008) 1.00
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol (2008) 1.00
Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading. PLoS One (2012) 0.99
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Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis. BMC Evol Biol (2010) 0.98
MSX2 stimulates chondrocyte maturation by controlling Ihh expression. J Biol Chem (2008) 0.98
Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J Biol Chem (2012) 0.97
Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Ann N Y Acad Sci (2007) 0.97
Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner. J Cell Biol (2007) 0.96
Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer. Br J Cancer (2007) 0.96
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Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development. Cells Tissues Organs (2011) 0.95
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem (2012) 0.94
UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Dev Biol (2010) 0.94
Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. J Bone Miner Res (2014) 0.93
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation. Nat Commun (2016) 0.93
Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders. Biochim Biophys Acta (2013) 0.93
Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. Development (2011) 0.92
MicroRNAs involved in bone formation. Cell Mol Life Sci (2014) 0.92
Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. PLoS One (2011) 0.92
Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. J Biol Chem (2008) 0.92
Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing. J Bone Miner Res (2012) 0.91
Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model. PLoS One (2013) 0.91
Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies. Ann Rheum Dis (2014) 0.91
Impaired skin and hair follicle development in Runx2 deficient mice. Dev Biol (2008) 0.89
MicroRNAs in cartilage development, homeostasis, and disease. Curr Osteoporos Rep (2014) 0.89
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Dev Cell (2012) 0.88
Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One (2012) 0.88
MicroRNA-1 regulates chondrocyte phenotype by repressing histone deacetylase 4 during growth plate development. FASEB J (2014) 0.88
JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol (2015) 0.88
SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res (2015) 0.87
Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol (2014) 0.87
Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis Rheum (2011) 0.86
Retracted XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy. J Biol Chem (2012) 0.86
Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab (2010) 0.86
Nuclear receptors in bone physiology and diseases. Physiol Rev (2013) 0.86
NELL-1 promotes cartilage regeneration in an in vivo rabbit model. Tissue Eng Part A (2011) 0.85
Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits BMP2-induced osteogenic differentiation. PLoS One (2014) 0.85
Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol (2015) 0.84
Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One (2014) 0.83
Chondrocyte-specific knockout of Cbfβ reveals the indispensable function of Cbfβ in chondrocyte maturation, growth plate development and trabecular bone formation in mice. Int J Biol Sci (2014) 0.83
The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis. BMB Rep (2015) 0.82
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Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone. J Bone Miner Res (2009) 0.82
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Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. J Biol Chem (2014) 0.81
Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. Genetics (2014) 0.81
The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. Cell Cycle (2013) 0.81
The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo. J Cell Sci (2012) 0.81
Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4. J Biol Chem (2012) 0.81
Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation. J Bone Miner Metab (2010) 0.80
Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering. Genes Dis (2015) 0.80
delta-EF1 is a negative regulator of Ihh in the developing growth plate. J Cell Biol (2009) 0.80
Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions. Int J Mol Sci (2014) 0.80
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Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol (2005) 1.70
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RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol (2005) 1.64
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Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J Biol Chem (2009) 1.62
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol (2006) 1.60
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res (2006) 1.60
MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. Eur J Cancer (2010) 1.57
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn (2007) 1.56
Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS One (2012) 1.55
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol (2006) 1.54
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell (2008) 1.54
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell (2009) 1.53
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Runx2 deficiency in chondrocytes causes adipogenic changes in vitro. J Cell Sci (2004) 1.44