Published in J Immunol on February 08, 2010
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Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev (2004) 3.33
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Transcription-coupled events associating with immunoglobulin switch region chromatin. Science (2003) 2.50
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci (2002) 2.25
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum (2006) 2.19
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Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol (2004) 1.99
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Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. J Biol Chem (2008) 1.92
Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol (2008) 1.92
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A (2005) 1.87
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol (2004) 1.85
Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet (2002) 1.83
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol (2009) 1.82
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res (2005) 1.71
Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol (2002) 1.71
Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol (2005) 1.70
ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol (2010) 1.69
The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev Biol (2002) 1.68
Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. Am J Hum Genet (2002) 1.64
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem (2004) 1.64
RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol (2005) 1.64
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol (2006) 1.60
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res (2006) 1.60
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. Eur J Cancer (2010) 1.57
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Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn (2007) 1.56
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell (2008) 1.54
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell (2009) 1.53
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Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab (2005) 1.48
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Runx2 deficiency in chondrocytes causes adipogenic changes in vitro. J Cell Sci (2004) 1.44
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Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer. Biochem Biophys Res Commun (2004) 1.41
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Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease. J Atheroscler Thromb (2015) 1.38
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Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol (2002) 1.35
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RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors. Cancer Res (2005) 1.32
Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol (2004) 1.29
Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood (2003) 1.26
Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. Nucleic Acids Res (2006) 1.26
Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation (2004) 1.26
Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. Mol Cell Biol (2007) 1.25
Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms. EMBO Rep (2002) 1.25
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest (2005) 1.24
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood (2009) 1.23
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J Immunol (2010) 1.22
PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res (2006) 1.22
BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol (2007) 1.21
Method for hemoglobin A(1c) measurement based on peptide analysis by electrospray ionization mass spectrometry with deuterium-labeled synthetic peptides as internal standards. Clin Chem (2003) 1.21
Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol (2007) 1.21
Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J (2006) 1.20
RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression. Breast Cancer Res Treat (2008) 1.20
RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem (2005) 1.19
Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol Rep (2007) 1.19