Published in J Cell Sci on January 03, 2006
Methods in mammalian autophagy research. Cell (2010) 20.08
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet (2008) 4.93
The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol (2010) 4.15
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Can autophagy promote longevity? Nat Cell Biol (2010) 2.55
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A (2010) 2.53
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Autophagosome supports coxsackievirus B3 replication in host cells. J Virol (2008) 2.24
Autophagy in ischemic heart disease. Circ Res (2009) 2.20
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog (2011) 2.09
An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal (2013) 2.04
Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis. J Am Soc Nephrol (2009) 1.86
Autophagy and tumorigenesis. FEBS Lett (2009) 1.76
The cell biology of autophagy in metazoans: a developing story. Development (2008) 1.76
Human immunodeficiency virus type-1 infection inhibits autophagy. AIDS (2008) 1.65
Endosomal phosphoinositides and human diseases. Traffic (2008) 1.64
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochim Biophys Acta (2009) 1.56
Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol (2010) 1.53
Starving neurons show sex difference in autophagy. J Biol Chem (2008) 1.49
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat Commun (2012) 1.46
Bif-1/endophilin B1: a candidate for crescent driving force in autophagy. Cell Death Differ (2009) 1.46
An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol (2007) 1.44
Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res (2009) 1.40
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Mol Cancer Res (2008) 1.35
Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J Biol Chem (2008) 1.34
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J (2013) 1.32
Application and interpretation of current autophagy inhibitors and activators. Acta Pharmacol Sin (2013) 1.32
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One (2013) 1.28
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Am J Pathol (2009) 1.27
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy (2011) 1.26
Molecules and their functions in autophagy. Exp Mol Med (2012) 1.21
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner. J Neurosci (2011) 1.18
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling. J Virol (2012) 1.17
Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem (2008) 1.16
Autophagosome formation in mammalian cells. Semin Immunopathol (2010) 1.16
Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta (2012) 1.14
Manipulation of death pathways in desmin-related cardiomyopathy. Circ Res (2010) 1.11
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells. Mol Cancer (2011) 1.11
Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models. Autophagy (2013) 1.09
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PLoS One (2010) 1.06
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. J Immunol (2011) 1.05
Autophagy is increased in postmortem brains of persons with HIV-1-associated encephalitis. J Infect Dis (2011) 1.02
Functions of BCL-X L at the Interface between Cell Death and Metabolism. Int J Cell Biol (2013) 1.02
Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6. Mol Cancer Res (2010) 1.01
Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol (2011) 1.01
Autophagy: a core cellular process with emerging links to pulmonary disease. Am J Respir Crit Care Med (2011) 1.00
Cytotoxic autophagy in cancer therapy. Int J Mol Sci (2014) 0.99
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS Genet (2014) 0.99
Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent. Antimicrob Agents Chemother (2009) 0.98
Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction? Acta Neuropathol (2015) 0.97
Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability. Biochem J (2013) 0.97
Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations. Br J Pharmacol (2014) 0.96
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease. J Exp Med (2014) 0.96
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways. Cell Signal (2006) 0.95
Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway. Virology (2013) 0.95
Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis. PLoS One (2012) 0.95
Autophagy in dementias. Brain Pathol (2012) 0.95
S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p. J Cell Sci (2009) 0.93
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J Neurochem (2008) 0.93
Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. Neuroscience (2010) 0.92
The protective roles of autophagy in ischemic preconditioning. Acta Pharmacol Sin (2013) 0.92
The interplays between autophagy and apoptosis induced by enterovirus 71. PLoS One (2013) 0.92
The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. Cell Death Dis (2014) 0.89
Autophagy in the myocardium: Dying for survival? Exp Clin Cardiol (2006) 0.89
Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy (2015) 0.89
Autophagosomes contribute to intracellular lipid distribution in enterocytes. Mol Biol Cell (2013) 0.89
Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death Differ (2013) 0.88
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase. Cell Death Differ (2010) 0.87
Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. Asian J Androl (2010) 0.86
The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy (2012) 0.86
DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy (2014) 0.86
Cell death signalling mechanisms in heart failure. Exp Clin Cardiol (2011) 0.85
Atg6/UVRAG/Vps34-containing lipid kinase complex is required for receptor downregulation through endolysosomal degradation and epithelial polarity during Drosophila wing development. Biomed Res Int (2014) 0.84
Autophagy and mitophagy in the myocardium: therapeutic potential and concerns. Br J Pharmacol (2014) 0.84
The Interplay between Alpha-Synuclein Clearance and Spreading. Biomolecules (2015) 0.84
The pleiotropic roles of sphingolipid signaling in autophagy. Cell Death Dis (2014) 0.84
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
Tumor cells can evade dependence on autophagy through adaptation. Biochem Biophys Res Commun (2012) 0.82
Mitophagy and heart failure. J Mol Med (Berl) (2015) 0.82
Is autophagy rather than apoptosis the regression driver in imatinib-treated gastrointestinal stromal tumors? Transl Oncol (2008) 0.82
Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease. Curr Pathobiol Rep (2013) 0.82
Evaluation of autophagy using mouse models of brain injury. Biochim Biophys Acta (2009) 0.82
Neuroprotective effect of TAT-14-3-3ε fusion protein against cerebral ischemia/reperfusion injury in rats. PLoS One (2014) 0.81
Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus. Oncotarget (2014) 0.80
CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable. Biochem Biophys Res Commun (2013) 0.80
Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide. Mol Neurodegener (2013) 0.80
Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes. J Cell Sci (2006) 1.59
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Mol Cancer Res (2008) 1.35
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells. Mol Cancer (2011) 1.11
MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. Am J Pathol (2009) 1.08
Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6. Mol Cancer Res (2010) 1.01
Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death. J Med Chem (2012) 1.01
A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm Cancer (2011) 1.01
Death pathways triggered by activated Ras in cancer cells. Front Biosci (Landmark Ed) (2011) 1.00
Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells. Biochem Biophys Res Commun (2003) 0.98
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways. Cell Signal (2006) 0.95
Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. Neoplasia (2009) 0.78
Synthesis and biological evaluation of indolyl-pyridinyl-propenones having either methuosis or microtubule disruption activity. J Med Chem (2015) 0.78
Tyrosine phosphorylation of Rab proteins. Methods Enzymol (2005) 0.77