Autophagosome formation in mammalian cells.

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol (2011) 3.45

Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res (2011) 1.73

The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife (2013) 1.66

Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1. J Biol Chem (2012) 1.45

Regulation of autophagy by the Rab GTPase network. Cell Death Differ (2014) 1.37

Molecules and their functions in autophagy. Exp Mol Med (2012) 1.21

Autophagy proteins in macroendocytic engulfment. Trends Cell Biol (2012) 1.15

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. Elife (2014) 0.97

Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy (2013) 0.94

Autophagy and cancer. Cells (2012) 0.94

Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles. Nat Commun (2016) 0.92

Mucopolysaccharide diseases: a complex interplay between neuroinflammation, microglial activation and adaptive immunity. J Inherit Metab Dis (2013) 0.89

Inflammasomes in cardiovascular diseases. Am J Cardiovasc Dis (2011) 0.86

Cell death and autophagy in tuberculosis. Semin Immunol (2014) 0.85

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood (2015) 0.85

Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles. Autophagy (2014) 0.80

Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacol Sin (2013) 0.80

The relationship between LAPTM4B polymorphisms and cancer risk in Chinese Han population: a meta-analysis. Springerplus (2015) 0.79

Molecular characterization and expression of Rab7 from Clonorchis sinensis and its potential role in autophagy. Parasitol Res (2013) 0.77

Harnessing of Programmed Necrosis for Fighting against Cancers. Biomol Ther (Seoul) (2014) 0.76

Characterisation of the T cell and dendritic cell repertoire in a murine model of mucopolysaccharidosis I (MPS I). J Inherit Metab Dis (2012) 0.76

Hydroxychloroquine facilitates autophagosome formation but not degradation to suppress the proliferation of cervical cancer SiHa cells. Oncol Lett (2014) 0.76

Abnormal Processing of Autophagosomes in Transformed B Lymphocytes from SCARB2-Deficient Subjects. Biores Open Access (2013) 0.75

Crosstalk between mitochondria and peroxisomes. World J Biol Chem (2015) 0.75

Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages. PLoS One (2015) 0.75

Human bocavirus induces apoptosis and autophagy in human bronchial epithelial cells. Exp Ther Med (2017) 0.75

Local detection of PtdIns3P at autophagosome biogenesis membrane platforms. Autophagy (2017) 0.75

TOR signaling in growth and metabolism. Cell (2006) 35.29

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39

Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62

Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01

TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21

AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08

Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88

Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37

Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24

A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem (2000) 8.68

Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol (2009) 7.84

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol (2001) 7.68

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J (2000) 7.48

Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol (2007) 7.43

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol (1998) 7.41

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35

HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14

Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol (2005) 7.11

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell (2007) 7.09

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci (2006) 6.98

Ambra1 regulates autophagy and development of the nervous system. Nature (2007) 6.94

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69

The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem (2007) 6.28

Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells (2007) 6.14

The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem (1997) 6.09

The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol (2010) 5.95

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol (2008) 5.52

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem (2005) 5.22

Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res (1999) 4.79

Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nat Cell Biol (1999) 4.76

The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem (1999) 4.62

Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell (2008) 4.41

The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J (2008) 4.32

Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. J Cell Biol (1990) 4.20

3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy (2009) 4.17

The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol (2010) 4.15

The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13

The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02

Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell (2005) 4.02

Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell (1998) 4.01

Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci (2006) 3.83

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72

Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep (2009) 3.69

PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol (1999) 3.62

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J (1993) 3.49

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37

Autophagy and human disease. Cell Cycle (2007) 3.22

Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science (2010) 3.20

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab (2008) 2.96

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy (2010) 2.91

A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat Med (2006) 2.85

Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy (2009) 2.78

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J Biol Chem (1994) 2.66

Autophagy: a forty-year search for a missing membrane source. PLoS Biol (2006) 2.64

Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell (2006) 2.63

Human VPS34 is required for internal vesicle formation within multivesicular endosomes. J Cell Biol (2001) 2.63

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci (2008) 2.55

Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol Biol Cell (2004) 2.51

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy (2009) 2.43

A functional PtdIns(3)P-binding motif. Nature (1998) 2.38

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci (2002) 2.36

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35

A role for Rab5 in structuring the endoplasmic reticulum. J Cell Biol (2007) 2.34

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol (2005) 2.31

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J Biochem (2005) 2.28

Autophagosome supports coxsackievirus B3 replication in host cells. J Virol (2008) 2.24

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J (2009) 2.17

mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. Sci Signal (2009) 2.16

p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol (2006) 2.15

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J (2009) 2.08

Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy. EMBO J (2009) 2.07

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy (2009) 1.88

Human VPS34 and p150 are Rab7 interacting partners. Traffic (2003) 1.86

Regulation of the small GTPase Rheb by amino acids. Oncogene (2006) 1.85

Evolution of Atg1 function and regulation. Autophagy (2009) 1.83

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol (2010) 2.98

Phosphatidic acid- and phosphatidylserine-binding proteins. Biochim Biophys Acta (2006) 2.45

Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic (2010) 1.59

Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J Biol Chem (2004) 1.56

Isolation and identification of phosphatidic acid targets from plants. Plant J (2004) 1.36

Making autophagosomes: localized synthesis of phosphatidylinositol 3-phosphate holds the clue. Autophagy (2008) 1.35

Regulation of autophagy by phosphatidylinositol 3-phosphate. FEBS Lett (2010) 1.33

Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy (2011) 1.20

Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis. Traffic (2006) 1.19

Dynamic association of the ULK1 complex with omegasomes during autophagy induction. J Cell Sci (2013) 1.18

The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein. Self Nonself (2010) 0.93

Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors). Biochim Biophys Acta (2009) 0.88

Omegasomes: PI3P platforms that manufacture autophagosomes. Essays Biochem (2013) 0.86

Characteristics and requirements of basal autophagy in HEK 293 cells. Autophagy (2013) 0.86

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes. Org Biomol Chem (2009) 0.85

Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochim Biophys Acta (2009) 0.85

PA binding of phosphatidylinositol 4-phosphate 5-kinase. Adv Enzyme Regul (2007) 0.84

The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes. PLoS One (2013) 0.84

Effect of priming on activation and localization of phospholipase D-1 in human neutrophils. Eur J Biochem (2004) 0.82

Hierarchy of membrane-targeting signals of phospholipase D1 involving lipid modification of a pleckstrin homology domain. J Biol Chem (2002) 0.80

Live cell imaging of early autophagy events: omegasomes and beyond. J Vis Exp (2013) 0.78

Assembly of early machinery for autophagy induction: novel insights from high resolution microscopy. Oncotarget (2016) 0.75

Imaging autophagy. Curr Protoc Cytom (2014) 0.75