Published in Cell Stem Cell on January 21, 2010
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells (2010) 3.24
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol (2011) 2.52
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data. Nucleic Acids Res (2012) 2.11
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc Natl Acad Sci U S A (2011) 1.97
High resolution genome wide binding event finding and motif discovery reveals transcription factor spatial binding constraints. PLoS Comput Biol (2012) 1.76
Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res (2011) 1.69
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development (2010) 1.51
Induction of pluripotent stem cells from human third molar mesenchymal stromal cells. J Biol Chem (2010) 1.50
Canonical Wnt/β-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells (2010) 1.43
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev (2012) 1.34
Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell (2013) 1.25
Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Nucleic Acids Res (2014) 1.25
Large-scale quality analysis of published ChIP-seq data. G3 (Bethesda) (2014) 1.23
Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A (2011) 1.23
Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers. Stem Cell Reports (2013) 1.22
Molecular control of induced pluripotency. Cell Stem Cell (2014) 1.22
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. Genome Biol (2011) 1.19
A general approach for discriminative de novo motif discovery from high-throughput data. Nucleic Acids Res (2013) 1.18
Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell (2011) 1.17
A decade of transcription factor-mediated reprogramming to pluripotency. Nat Rev Mol Cell Biol (2016) 1.16
Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem (2013) 1.16
Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells (2013) 1.14
Role of Oct4 in maintaining and regaining stem cell pluripotency. Stem Cell Res Ther (2010) 1.12
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev (2011) 1.10
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem (2011) 1.08
Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network. PLoS One (2011) 1.06
Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc Natl Acad Sci U S A (2011) 1.06
Establishment of totipotency does not depend on Oct4A. Nat Cell Biol (2013) 1.05
Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate? PLoS One (2010) 1.02
Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary. J Ovarian Res (2012) 1.02
Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J (2013) 1.02
Emerging actions of the nuclear receptor LRH-1 in the gut. Biochim Biophys Acta (2010) 1.01
The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation. Genome Biol (2012) 1.00
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors. Nucleic Acids Res (2012) 1.00
MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs. PLoS One (2012) 0.99
An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding. PLoS Comput Biol (2014) 0.99
Do all roads lead to Oct4? the emerging concepts of induced pluripotency. Trends Cell Biol (2013) 0.98
Stem cell dynamics in Cnidaria: are there unifying principles? Dev Genes Evol (2012) 0.98
Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol (2012) 0.97
Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Mol Endocrinol (2010) 0.97
Experimental approaches for the generation of induced pluripotent stem cells. Stem Cell Res Ther (2010) 0.97
Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size. Integr Biol (Camb) (2012) 0.96
NR5A nuclear receptor Hr39 controls three-cell secretory unit formation in Drosophila female reproductive glands. Curr Biol (2012) 0.96
Role of Oct4 in the early embryo development. Cell Regen (Lond) (2014) 0.94
Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells. Nucleic Acids Res (2013) 0.93
Molecular features of cellular reprogramming and development. Nat Rev Mol Cell Biol (2016) 0.93
Mechanistic insights into reprogramming to induced pluripotency. J Cell Physiol (2011) 0.92
Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem (2012) 0.92
Transcription factor heterogeneity and epiblast pluripotency. Philos Trans R Soc Lond B Biol Sci (2011) 0.92
Sumoylation in gene regulation, human disease, and therapeutic action. F1000Prime Rep (2013) 0.92
The oncogene c-Jun impedes somatic cell reprogramming. Nat Cell Biol (2015) 0.91
Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A (2012) 0.91
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network. Cell Mol Life Sci (2015) 0.90
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development (2014) 0.90
Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol (2013) 0.90
microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming. Bioessays (2012) 0.89
SyStemCell: a database populated with multiple levels of experimental data from stem cell differentiation research. PLoS One (2012) 0.87
SNF5 is an essential executor of epigenetic regulation during differentiation. PLoS Genet (2013) 0.87
An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene (2013) 0.87
Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation. J Biol Chem (2013) 0.87
Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR. BMC Genomics (2012) 0.86
Epigenetic state network approach for describing cell phenotypic transitions. Interface Focus (2014) 0.86
The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation. PLoS One (2012) 0.85
Chemical approaches to cell reprogramming. Curr Opin Genet Dev (2014) 0.85
A virus-free poly-promoter vector induces pluripotency in quiescent bovine cells under chemically defined conditions of dual kinase inhibition. PLoS One (2011) 0.85
Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. J Assist Reprod Genet (2011) 0.85
Phospholipid--driven gene regulation. FEBS Lett (2013) 0.83
Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev (2013) 0.83
Mechanisms for enhancing cellular reprogramming. Curr Opin Genet Dev (2014) 0.82
Retinoic acid receptor γ (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons. J Biol Chem (2014) 0.82
The Role of the Leukemia Inhibitory Factor (LIF) - Pathway in Derivation and Maintenance of Murine Pluripotent Stem Cells. Genes (Basel) (2011) 0.82
Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research. Curr Neuropharmacol (2011) 0.82
Inhibition of transforming growth factor β (TGF-β) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotency. J Biol Chem (2014) 0.82
Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives. Stem Cells Cloning (2015) 0.82
Lineage specifiers: new players in the induction of pluripotency. Genomics Proteomics Bioinformatics (2013) 0.81
Decoding the genome with an integrative analysis tool: combinatorial CRM Decoder. Nucleic Acids Res (2011) 0.81
Pancreatic Cancer Genetics. Int J Biol Sci (2016) 0.81
Gene expression profiles in CHA3 and CHA4 human embryonic stem cells and embryoid bodies. Mol Cells (2011) 0.81
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors. J Biol Chem (2013) 0.81
Tissue engineering and cell-based therapy toward integrated strategy with artificial organs. J Artif Organs (2011) 0.80
Direct lineage conversion: induced neuronal cells and induced neural stem cells. Protein Cell (2012) 0.80
Nuclear receptors in stem cells and their therapeutic potential. Adv Drug Deliv Rev (2010) 0.80
Steroidogenic factor-1 (SF-1)-driven differentiation of murine embryonic stem (ES) cells into a gonadal lineage. Endocrinology (2011) 0.80
Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. PLoS Genet (2014) 0.80
Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis. Cell Reprogram (2013) 0.79
Overcoming barriers to the clinical utilization of iPSCs: reprogramming efficiency, safety and quality. Protein Cell (2012) 0.79
Molecular mechanisms of pluripotency and reprogramming. Stem Cell Res Ther (2010) 0.79
Mechanism and methods to induce pluripotency. Protein Cell (2011) 0.78
A role for polyamine regulators in ESC self-renewal. Cell Cycle (2012) 0.78
Induced pluripotent stem cells: origins, applications, and future perspectives. J Zhejiang Univ Sci B (2013) 0.78
Minireview: the diverse roles of nuclear receptors in the regulation of embryonic stem cell pluripotency. Mol Endocrinol (2013) 0.78
Culture environment-induced pluripotency of SACK-expanded tissue stem cells. J Biomed Biotechnol (2011) 0.78
TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability. Sci Rep (2015) 0.78
Transcriptomic analysis of pluripotent stem cells: insights into health and disease. Genome Med (2011) 0.78
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature (2008) 9.83
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science (2003) 8.79
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell (2010) 6.24
Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem (2005) 6.05
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
Subnetwork hierarchies of biochemical pathways. Bioinformatics (2003) 4.99
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. Genome Res (2011) 4.43
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Incidence of treated cardiac arrest in hospitalized patients in the United States. Crit Care Med (2011) 4.43
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell (2012) 3.92
A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell (2003) 3.90
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol (2008) 3.37
Specification of jaw subdivisions by Dlx genes. Science (2002) 3.33
Geographic variation in cardiovascular procedure use among Medicare fee-for-service vs Medicare Advantage beneficiaries. JAMA (2013) 3.30
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells (2005) 3.16
Influenza-associated hospitalization in a subtropical city. PLoS Med (2006) 3.07
Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell (2009) 3.02
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell (2011) 3.00
Retracted Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem (2002) 2.97
miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One (2009) 2.97
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell (2005) 2.95
Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature (2004) 2.90
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther (2007) 2.89
Coronary revascularization trends in the United States, 2001-2008. JAMA (2011) 2.81
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics (2013) 2.53
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev (2002) 2.48
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43
Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin Cancer Res (2003) 2.43
Third- and fourth-degree perineal lacerations: defining high-risk clinical clusters. Am J Obstet Gynecol (2011) 2.42
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells (2007) 2.40
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genet (2005) 2.32
Commuting and health in Cambridge: a study of a 'natural experiment' in the provision of new transport infrastructure. BMC Public Health (2010) 2.31
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell (2008) 2.28
Linking beta-catenin to androgen-signaling pathway. J Biol Chem (2002) 2.27
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions. Pharm Res (2012) 2.18
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18
Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res (2007) 2.15
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem (2004) 2.11
Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer. Nat Commun (2013) 2.11
Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells (2006) 2.11
Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril (2002) 2.10
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10