Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer.

PubWeight™: 1.43‹?› | Rank: Top 5%

🔗 View Article (PMID 16410826)

Published in Cancer Gene Ther on June 01, 2006

Authors

J Nemunaitis1, T Jahan, H Ross, D Sterman, D Richards, B Fox, D Jablons, J Aimi, A Lin, K Hege

Author Affiliations

1: Mary Crowley Medical Research Center, Baylor University Medical Center, Texas Oncology PA, Dallas, TX 75201, USA. jnemunaitis@mcmrc.com

Associated clinical trials:

Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas | NCT01258868

Articles citing this

Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity (2009) 3.21

Prostate cancer as a model for tumour immunotherapy. Nat Rev Immunol (2010) 2.28

Therapeutic cancer vaccines: are we there yet? Immunol Rev (2011) 1.86

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. Blood (2008) 1.80

Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs (2010) 1.57

Lung cancer patients' CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells. Cancer Immunol Immunother (2008) 1.45

Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. J Immunother (2009) 1.32

Gene therapy for cancer treatment: past, present and future. Clin Med Res (2006) 1.30

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting cellular immunotherapy in combination with autologous stem cell transplantation (ASCT) as postremission therapy for acute myeloid leukemia (AML). Blood (2009) 1.18

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor. Cancer Immunol Immunother (2011) 1.16

K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate. Clin Cancer Res (2010) 1.15

A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19. Immunol Rev (2014) 1.14

GM-CSF-secreting vaccines for solid tumors: moving forward. Discov Med (2010) 1.00

Active-specific immunotherapy for non-small cell lung cancer. J Thorac Dis (2011) 0.99

Strengths and weaknesses of immunotherapy for advanced non-small-cell lung cancer: a meta-analysis of 12 randomized controlled trials. PLoS One (2012) 0.95

Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients. Oncoimmunology (2013) 0.91

Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention. Clin Dev Immunol (2012) 0.89

Immunotherapy for lung cancer: advances and prospects. Am J Clin Exp Immunol (2016) 0.89

A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma. Cell Mol Immunol (2013) 0.89

Targeting the immune system in non-small-cell lung cancer: bridging the gap between promising concept and therapeutic reality. Clin Lung Cancer (2010) 0.88

Current status of immunotherapy for the treatment of lung cancer. J Thorac Dis (2010) 0.88

Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology (2012) 0.87

Allogeneic tumor cell vaccines: the promise and limitations in clinical trials. Hum Vaccin Immunother (2013) 0.87

Phase II trial of a GM-CSF-producing and CD40L-expressing bystander cell line combined with an allogeneic tumor cell-based vaccine for refractory lung adenocarcinoma. J Immunother (2013) 0.87

Whole Tumor Antigen Vaccines: Where Are We? Vaccines (Basel) (2015) 0.87

Induction of high-titer IgG antibodies against multiple leukemia-associated antigens in CML patients with clinical responses to K562/GVAX immunotherapy. Blood Cancer J (2013) 0.85

Adjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC: first clinical experience and evidence of an immune response. J Transl Med (2007) 0.85

Immunotherapy prospects in the treatment of lung cancer and mesothelioma. Transl Lung Cancer Res (2014) 0.85

Gene therapy for lung neoplasms. Clin Chest Med (2011) 0.84

Immune cell recruitment and cell-based system for cancer therapy. Pharm Res (2007) 0.83

Multiple vaccinations: friend or foe. Cancer J (2011) 0.83

Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells. Cancer Gene Ther (2015) 0.82

Lung cancer vaccines. Cancer J (2011) 0.82

MHC II lung cancer vaccines prime and boost tumor-specific CD4+ T cells that cross-react with multiple histologic subtypes of nonsmall cell lung cancer cells. Int J Cancer (2010) 0.80

Inoculation site from a cutaneous melanoma patient treated with an allogeneic therapeutic vaccine: a case report. Front Immunol (2015) 0.80

Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma. Clin Cancer Res (2016) 0.80

Chemotherapeutic Targeting of the Transforming Growth Factor-β Pathway in Breast Cancers. Breast Cancer Manag (2015) 0.79

A translational approach to lung cancer research: From EGFRs to Wnt and cancer stem cells. Ann Thorac Cardiovasc Surg (2009) 0.78

Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer. J Transl Med (2011) 0.78

Encapsulated cellular implants for recombinant protein delivery and therapeutic modulation of the immune system. Int J Mol Sci (2015) 0.78

Immunotherapy in non-small cell lung cancer: the clinical impact of immune response and targeting. Ann Transl Med (2016) 0.77

Immunotherapy for non-small cell lung cancer: current concepts and clinical trials. Eur J Cardiothorac Surg (2015) 0.77

Evaluation of tumour vaccine immunotherapy for the treatment of advanced non-small cell lung cancer: a systematic meta-analysis. BMJ Open (2015) 0.76

K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo. Clin Cancer Res (2015) 0.76

Wilms tumor 1 peptide vaccination after hematopoietic stem cell transplant in leukemia patients. Stem Cell Investig (2016) 0.75

Cancer targeting vaccines: surrogate measures of activity. Hum Vaccin Immunother (2013) 0.75

Respiratory Homeostasis and Exploitation of the Immune System for Lung Cancer Vaccines. US Oncol (2009) 0.75

Articles by these authors

(truncated to the top 100)

Proposed uniform nomenclature for mammalian ribosomal proteins. Mol Gen Genet (1979) 13.52

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev (1993) 10.01

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell (1995) 9.30

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A (1991) 6.42

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07

A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med (1992) 6.06

Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med (2000) 5.58

Inhibition of JNK activation through NF-kappaB target genes. Nature (2001) 5.03

A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet (1999) 4.96

Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med (2000) 3.74

F + , Hfr, and F' strains of Salmonella typhimurium and Salmonella abony. Bacteriol Rev (1972) 3.73

Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J Clin Oncol (2005) 3.62

Cigarette purchase patterns in four countries and the relationship with cessation: findings from the International Tobacco Control (ITC) Four Country Survey. Tob Control (2006) 3.23

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science (1999) 3.22

Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res (2001) 3.04

A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol (2005) 2.88

Revised clinical and laboratory criteria for subtypes of inherited epidermolysis bullosa. A consensus report by the Subcommittee on Diagnosis and Classification of the National Epidermolysis Bullosa Registry. J Am Acad Dermatol (1991) 2.79

Ozone revolution? Or emperor's new clothes? Br Dent J (2005) 2.78

Failed validation of a clinical decision rule for the use of radiography in acute ankle injury. N Z Med J (1994) 2.71

The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine (1998) 2.70

Incidence of traumatic spinal cord lesions. J Chronic Dis (1975) 2.64

Mixed infections with Opisthorchis viverrini and intestinal flukes in residents of Vientiane Municipality and Saravane Province in Laos. J Helminthol (2005) 2.62

A meta-analysis of randomized trials of behavioural treatment of depression. Psychol Med (2007) 2.58

Presumptive identification of streptococci with a new test system. J Clin Microbiol (1982) 2.55

Too many patients, too few cardiologists to care? Can J Cardiol (2006) 2.45

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol (1994) 2.41

Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett (1998) 2.40

Targeting and function in mRNA export of nuclear pore complex protein Nup153. J Cell Biol (1996) 2.38

Multisite pacing as a supplemental treatment of congestive heart failure: preliminary results of the Medtronic Inc. InSync Study. Pacing Clin Electrophysiol (1998) 2.38

Prevalent left ventricular hypertrophy in the predialysis population: identifying opportunities for intervention. Am J Kidney Dis (1996) 2.33

Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest (1999) 2.26

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J (1996) 2.22

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila. Nature (1999) 2.22

Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. Arch Dis Child (1971) 2.15

The role of tobacco control policies in reducing smoking and deaths in a middle income nation: results from the Thailand SimSmoke simulation model. Tob Control (2008) 2.07

Screening and management of renal disease in human immunodeficiency virus-infected patients in Australia. Intern Med J (2013) 2.01

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. J Neurosci (2001) 2.00

Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A (2001) 1.99

Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99

Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide. J Biol Chem (1982) 1.95

Parenchymal transection of the kidney inflicted by endocatch bag entrapment during a laparoscopic donor nephrectomy. Am J Transplant (2006) 1.95

Evidence-based practice. Br Dent J (1996) 1.93

Metabolic imaging of malignant pleural mesothelioma with fluorodeoxyglucose positron emission tomography. Chest (1998) 1.91

Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin. Clin Cancer Res (1999) 1.91

Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects. Diabetes Care (1999) 1.90

Prospective study of risk factors for early and persistent wheezing in childhood. Eur Respir J (1995) 1.88

Increased incidence of abnormal nasal cilia in patients with retinitis pigmentosa. Nature (1979) 1.87

Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J Biol Chem (1998) 1.87

The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. J Biol Chem (1999) 1.86

Recommendations for the diagnosis and management of Turner syndrome. J Clin Endocrinol Metab (2001) 1.84

Sequence of the amino-terminal region of rat liver ribosomal proteins S4, S6, S8, L6, L7a, L18, L27, L30, L37, L37a, and L39. J Supramol Struct (1979) 1.82

General commentary on access to cardiovascular care in Canada: universal access, but when? Treating the right patient at the right time. Can J Cardiol (2005) 1.81

The primary structure of rat ribosomal protein L7. The presence near the amino terminus of L7 of five tandem repeats of a sequence of 12 amino acids. J Biol Chem (1987) 1.81

Preventing cardiovascular disease in primary care. BMJ (2001) 1.80

Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study. Clin Cancer Res (2000) 1.74

Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage. Proc Natl Acad Sci U S A (1987) 1.74

A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology (2001) 1.70

Defined mutations in a small region of the brome mosaic virus 2 gene cause diverse temperature-sensitive RNA replication phenotypes. J Virol (1989) 1.69

Maternal cigarette smoking and child psychiatric morbidity: a longitudinal study. Pediatrics (1998) 1.68

Preferential expression of the T-cell receptor V beta 3 gene by Mlsc reactive T cells. Nature (1988) 1.68

The clinical and cost-effectiveness of self-help treatments for anxiety and depressive disorders in primary care: a systematic review. Br J Gen Pract (2001) 1.68

Prognostic value of FDG PET imaging in malignant pleural mesothelioma. J Nucl Med (1999) 1.67

Sequence specificity of mRNA N6-adenosine methyltransferase. J Biol Chem (1990) 1.67

Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer. Ann Oncol (2002) 1.67

The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell (2001) 1.66

Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial. Am J Transplant (2013) 1.65

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. Mol Cell Biol (1998) 1.65

Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol (1998) 1.63

Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. J Biol Chem (2000) 1.61

Improved survival among patients treated with adjuvant tamoxifen after mastectomy for early breast cancer. Lancet (1983) 1.61

The central issue? Visceral fat mass is a good marker of insulin resistance and metabolic disturbance in women with polycystic ovary syndrome. BJOG (2006) 1.60

Study of the aetiology of wheezing illness at age 16 in two national British birth cohorts. Thorax (1996) 1.59

Medical students in general practice: how do patients feel? Br J Gen Pract (1996) 1.59

Evidence for possible involvement of an elastolytic serine protease in aspergillosis. Infect Immun (1993) 1.58

A systematic review of the effectiveness of psychosocial interventions for carers of people with dementia. Aging Ment Health (2001) 1.57

The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein. J Biol Chem (1987) 1.57

Behavior of microbial aerosols in a -30 degrees C environment. Cryobiology (1970) 1.56

Pseudomonas cepacia: a new pathogen in patients with cystic fibrosis referred to a large centre in the United Kingdom. Arch Dis Child (1990) 1.55

Methods to identify postnatal depression in primary care: an integrated evidence synthesis and value of information analysis. Health Technol Assess (2009) 1.54

Effect of abdominal operation on glucose tolerance and serum levels of insulin, growth hormone, and hydrocortisone. Lancet (1966) 1.53

Effect of diluent and relative humidity on apparent viability of airborne Pasteurella pestis. Appl Microbiol (1966) 1.52

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. Neuropharmacology (2001) 1.51

Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. Carcinogenesis (2000) 1.51

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. J Biol Chem (2000) 1.50

Efficacy and safety of pegylated (40-kd) interferon alpha-2a compared with interferon alpha-2a in noncirrhotic patients with chronic hepatitis C. Hepatology (2001) 1.49

The 2002/3 Canadian Cardiovascular Society consensus guideline update for the diagnosis and management of heart failure. Can J Cardiol (2003) 1.49

The primary structure of rat ribosomal protein S8. Nucleic Acids Res (1987) 1.48

A brief spiritual beliefs inventory for use in quality of life research in life-threatening illness. Psychooncology (1999) 1.44

Biotransformation of polycyclic aromatic compounds by fungi. Xenobiotica (1986) 1.43

Mesenteric venous thrombosis: successful treatment by intraarterial lytic therapy. J Vasc Interv Radiol (1998) 1.42

Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. Cancer Res (1992) 1.42

Tracheobronchial stenting for management of bronchopleural fistula: a novel solution to an old problem. West Indian Med J (2006) 1.41

Insecticide-treated cattle for tsetse control: the power and the problems. Med Vet Entomol (2000) 1.39

Chronic eosinophilic pneumonia. Thorax (1980) 1.39

FasL is important in costimulation blockade-resistant skin graft rejection. Transplantation (2001) 1.39

The HLA-G 14 bp insertion/deletion polymorphism is a putative susceptible factor for active human cytomegalovirus infection in children. Tissue Antigens (2009) 1.39

What motivates dentists to work in prisons? A qualitative exploration. Br Dent J (2011) 1.38

Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J Biol Chem (1997) 1.36

The primary structure of the acidic phosphoprotein P2 from rat liver 60 S ribosomal subunits. Comparison with ribosomal 'A' proteins from other species. J Biol Chem (1982) 1.34

Cardiopulmonary exercise testing and prognosis in severe heart failure: 14 mL/kg/min revisited. Am Heart J (2000) 1.28