Published in Infect Immun on February 01, 2006
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest (2007) 2.44
Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J Virol (2006) 1.78
Rhinovirus disrupts the barrier function of polarized airway epithelial cells. Am J Respir Crit Care Med (2008) 1.43
Haemophilus influenzae outer membrane protein P5 is associated with inorganic polyphosphate and polyhydroxybutyrate. Biophys J (2006) 1.26
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell (2011) 1.08
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol (2012) 1.07
Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae. Cell Microbiol (2009) 1.07
PspK of Streptococcus pneumoniae increases adherence to epithelial cells and enhances nasopharyngeal colonization. Infect Immun (2012) 1.06
Non-typeable Haemophilus influenzae invasion and persistence in the human respiratory tract. Front Cell Infect Microbiol (2011) 1.05
A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin. Infect Immun (2007) 0.99
Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media. BMC Microbiol (2007) 0.93
Diminished ICAM-1 expression and impaired pulmonary clearance of nontypeable Haemophilus influenzae in a mouse model of chronic obstructive pulmonary disease/emphysema. Infect Immun (2008) 0.92
Serum intercellular adhesion molecule 1 variations in young children with acute otitis media. Clin Vaccine Immunol (2010) 0.91
Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes (2013) 0.89
Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells. Infect Immun (2007) 0.83
The Haemophilus influenzae Sap transporter mediates bacterium-epithelial cell homeostasis. Infect Immun (2012) 0.82
Phase variation and host immunity against high molecular weight (HMW) adhesins shape population dynamics of nontypeable Haemophilus influenzae within human hosts. J Theor Biol (2014) 0.81
Relative Contribution of P5 and Hap Surface Proteins to Nontypable Haemophilus influenzae Interplay with the Host Upper and Lower Airways. PLoS One (2015) 0.81
An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke. Int J Chron Obstruct Pulmon Dis (2016) 0.79
Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2009) 0.78
Increased biofilm formation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections. Appl Environ Microbiol (2014) 0.78
Immunization with Protein D from Non-Typeable Haemophilus influenzae (NTHi) Induced Cytokine Responses and Bioactive Antibody Production. Jundishapur J Microbiol (2016) 0.76
The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL). Respir Res (2017) 0.75
Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease? J Transl Med (2016) 0.75
Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae. Front Cell Infect Microbiol (2016) 0.75
Insights on Persistent Airway Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Pathog Dis (2017) 0.75
Characteristics of the molecular diversity of the outer membrane protein A gene of Haemophilus parasuis. Can J Vet Res (2010) 0.75
Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae. Cell Microbiol (2016) 0.75
Adhesion receptors of the immune system. Nature (1990) 28.86
A study of the genetic material determining an enzyme in Pneumococcus. Biochim Biophys Acta (1960) 16.02
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol (1986) 7.71
A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell (1989) 6.37
Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell (1988) 5.75
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell (1990) 4.83
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol (1990) 4.39
Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax (2002) 4.26
Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutinin of Bordetella pertussis. Infect Immun (1992) 3.22
High-molecular-weight proteins of nontypable Haemophilus influenzae mediate attachment to human epithelial cells. Proc Natl Acad Sci U S A (1993) 3.18
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature (1988) 3.12
Purification and partial characterization of outer membrane proteins P5 and P6 from Haemophilus influenzae type b. Infect Immun (1985) 2.99
Intercellular adhesion molecule-1. J Mol Med (Berl) (1996) 2.94
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med (1991) 2.76
Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol Microbiol (2000) 2.65
Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol (1999) 2.33
The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site. Cell (1992) 2.29
Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A. Infect Immun (1994) 2.25
A Haemophilus influenzae IgA protease-like protein promotes intimate interaction with human epithelial cells. Mol Microbiol (1994) 2.05
Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry. J Virol (1997) 1.88
The Haemophilus influenzae Hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein. Mol Cell (1998) 1.75
The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. Proc Natl Acad Sci U S A (1998) 1.73
Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol (1999) 1.64
Infectious etiology of acute exacerbations of chronic bronchitis. Chest (2000) 1.63
Changes in outer membrane proteins of nontypable Haemophilus influenzae in patients with chronic obstructive pulmonary disease. J Infect Dis (1988) 1.59
Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells. J Clin Invest (1997) 1.55
Expression, function and regulation of the intercellular adhesion molecule-1 (ICAM-1) on human intestinal epithelial cell lines. Eur J Immunol (1991) 1.49
Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas. J Clin Microbiol (2003) 1.46
IL-6 induces NF-kappa B activation in the intestinal epithelia. J Immunol (2003) 1.42
Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. J Exp Med (2004) 1.37
Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells. J Immunol (2000) 1.36
The variable P5 proteins of typeable and non-typeable Haemophilus influenzae target human CEACAM1. Mol Microbiol (2001) 1.36
The Haemophilus influenzae Hap autotransporter binds to fibronectin, laminin, and collagen IV. Infect Immun (2002) 1.32
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells. Infect Immun (2000) 1.31
Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin. Infect Immun (1996) 1.31
Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1. J Virol (2001) 1.27
Molecular variation in the major outer membrane protein P5 gene of nonencapsulated Haemophilus influenzae during chronic infections. Infect Immun (1997) 1.27
Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci U S A (2004) 1.25
Haemophilus influenzae pili are composite structures assembled via the HifB chaperone. Proc Natl Acad Sci U S A (1996) 1.20
Targeted inhibition of interferon-gamma-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1. J Biol Chem (1997) 1.19
Induction of proinflammatory cytokines from human respiratory epithelial cells after stimulation by nontypeable Haemophilus influenzae. Infect Immun (2000) 1.05
Pilus-mediated adherence of Haemophilus influenzae to human respiratory mucins. Infect Immun (2000) 1.04
Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae. Infect Immun (2000) 1.04
Role of alveolar epithelial cell intercellular adhesion molecule-1 in host defense against Klebsiella pneumoniae. Am J Physiol (1999) 1.04
Adhesion molecules in cell interactions. Curr Opin Immunol (1993) 1.04
Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1. Am J Physiol Lung Cell Mol Physiol (2004) 0.99
Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells: role for endogenous IFN-beta. Cytokine (1995) 0.94
Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Lung (1998) 0.88
Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20. J Bacteriol (2005) 2.31
Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein. J Bacteriol (2007) 2.14
Nontypeable Haemophilus influenzae as a pathogen in children. Pediatr Infect Dis J (2009) 2.12
A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae. Microbiology (2006) 1.92
Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy. AIDS (2010) 1.79
Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J Virol (2006) 1.78
Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo. J Virol (2007) 1.77
Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media. Infect Immun (2006) 1.71
Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. Infect Immun (2005) 1.65
Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media. Infect Immun (2003) 1.63
The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract. Mol Microbiol (2007) 1.53
The asymptomatic bacteriuria Escherichia coli strain 83972 outcompetes uropathogenic E. coli strains in human urine. Infect Immun (2006) 1.53
Safety and immunogenicity of live attenuated and inactivated influenza vaccines in children with cancer. J Infect Dis (2011) 1.49
Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas. J Clin Microbiol (2003) 1.46
Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: the taming of a pathogen. Infect Immun (2006) 1.45
A comparison of antibiotic susceptibility testing methods for cotrimoxazole with Burkholderia pseudomallei. Int J Antimicrob Agents (2002) 1.45
Microbial interactions in the respiratory tract. Pediatr Infect Dis J (2009) 1.37
A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media. Infect Immun (2005) 1.37
UpaG, a new member of the trimeric autotransporter family of adhesins in uropathogenic Escherichia coli. J Bacteriol (2008) 1.36
Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes. FEMS Microbiol Lett (2006) 1.34
The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway. PLoS One (2010) 1.26
Serotype III Streptococcus agalactiae from bovine milk and human neonatal infections. Emerg Infect Dis (2004) 1.25
Diversity of group B streptococcus serotypes causing urinary tract infection in adults. J Clin Microbiol (2009) 1.24
Limited genetic diversity of recent invasive isolates of non-serotype b encapsulated Haemophilus influenzae. J Clin Microbiol (2002) 1.23
Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A (2013) 1.23
Priming the immune system for heart disease: a perspective on group A streptococci. J Infect Dis (2010) 1.21
Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation. Infect Immun (2007) 1.21
Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media. Microb Pathog (2004) 1.19
Autotransporter proteins: novel targets at the bacterial cell surface. FEMS Microbiol Lett (2007) 1.19
Prevalence and distribution of adhesins in invasive non-type b encapsulated Haemophilus influenzae. Infect Immun (2003) 1.17
Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages. Immunobiology (2011) 1.17
The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition. Mol Microbiol (2006) 1.17
Identification of type 3 fimbriae in uropathogenic Escherichia coli reveals a role in biofilm formation. J Bacteriol (2007) 1.16
Virulence properties of asymptomatic bacteriuria Escherichia coli. Int J Med Microbiol (2008) 1.15
Correlation of phylogenetic lineages of group B Streptococci, identified by analysis of restriction-digestion patterns of genomic DNA, with infB alleles and mobile genetic elements. J Infect Dis (2002) 1.14
Role of L-ficolin/mannose-binding lectin-associated serine protease complexes in the opsonophagocytosis of type III group B streptococci. J Immunol (2005) 1.13
The OxyR regulon in nontypeable Haemophilus influenzae. J Bacteriol (2006) 1.13
Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates. Infect Immun (2004) 1.13
UpaH is a newly identified autotransporter protein that contributes to biofilm formation and bladder colonization by uropathogenic Escherichia coli CFT073. Infect Immun (2010) 1.13
Asymptomatic bacteriuria Escherichia coli strain 83972 carries mutations in the foc locus and is unable to express F1C fimbriae. Microbiology (2006) 1.12
Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer. Pediatr Infect Dis J (2011) 1.10
Long-range mapping of the Streptococcus agalactiae phylogenetic lineage restriction digest pattern type III-3 reveals clustering of virulence genes. Infect Immun (2002) 1.09
Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates. Vaccine (2009) 1.08
Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae. Cell Microbiol (2009) 1.07
Demonstration of a cell-mediated immune response in melioidosis. J Infect Dis (2002) 1.06
Genome-wide mapping of cystitis due to Streptococcus agalactiae and Escherichia coli in mice identifies a unique bladder transcriptome that signifies pathogen-specific antimicrobial defense against urinary tract infection. Infect Immun (2012) 1.04
Infections in children and young adults with bone malignancies undergoing limb-sparing surgery. Cancer (2005) 1.04
Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus. J Virol (2005) 1.03
Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention. Vaccine (2002) 1.02
Haemophilus influenzae and oxidative stress. Front Cell Infect Microbiol (2012) 1.02
The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant. Int J Med Microbiol (2009) 1.00
Beta-hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus. J Infect Dis (2003) 1.00
A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin. Infect Immun (2007) 0.99
Asymptomatic bacteriuria: prevalence rates of causal microorganisms, etiology of infection in different patient populations, and recent advances in molecular detection. FEMS Microbiol Lett (2013) 0.99
Prognostic value of semi-quantitative bacteruria counts in the diagnosis of group B streptococcus urinary tract infection: a 4-year retrospective study in adult patients. BMC Infect Dis (2012) 0.98
Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis. FEMS Immunol Med Microbiol (2012) 0.98
Molecular characterization of UpaB and UpaC, two new autotransporter proteins of uropathogenic Escherichia coli CFT073. Infect Immun (2011) 0.98
Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli. Infect Immun (2011) 0.98
Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. J Biol Chem (2004) 0.98
Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein. PLoS One (2013) 0.98
Mechanisms of group B streptococcal-induced apoptosis of murine macrophages. J Immunol (2005) 0.97
In vitro biofilm formation in an 8-well chamber slide. J Vis Exp (2011) 0.97
Equivalence of high-virulence clonotypes of serotype III group B Streptococcus agalactiae (GBS). J Med Microbiol (2004) 0.96
Biological roles of nontypeable Haemophilus influenzae type IV pilus proteins encoded by the pil and com operons. J Bacteriol (2012) 0.96
Nitric oxide is a key determinant of group B streptococcus-induced murine macrophage apoptosis. J Infect Dis (2005) 0.96
Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity. Curr Immunol Rev (2006) 0.96
Anatomy of the nasal cavity in the chinchilla. Cells Tissues Organs (2003) 0.95
Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function. J Bacteriol (2011) 0.95
Epithelial cell coculture models for studying infectious diseases: benefits and limitations. J Biomed Biotechnol (2011) 0.94
Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity. J Innate Immun (2012) 0.94
Vaccines for otitis media: proposals for overcoming obstacles to progress. Vaccine (2005) 0.94
Pgi genotyping is a surrogate for serotyping of encapsulated Haemophilus influenzae. J Clin Microbiol (2003) 0.93
Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein. J Med Microbiol (2007) 0.93
Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media. Infect Immun (2005) 0.93
L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway. Infect Immun (2007) 0.92
Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms. Mol Microbiol (2014) 0.92
Antiretroviral therapy corrects HIV-1-induced expansion of CD8+ CD45RA+ CD2-) CD11a(bright) activated T cells. J Allergy Clin Immunol (2008) 0.91
Trade-off between iron uptake and protection against oxidative stress: deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection. J Bacteriol (2008) 0.91
Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics. Ann Otol Rhinol Laryngol Suppl (2005) 0.90
Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis. J Cyst Fibros (2012) 0.90
Antibodies directed against integration host factor mediate biofilm clearance from Nasopore. Laryngoscope (2013) 0.89
A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Mol Immunol (2006) 0.89
Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media. Vaccine (2002) 0.89
UafB is a serine-rich repeat adhesin of Staphylococcus saprophyticus that mediates binding to fibronectin, fibrinogen and human uroepithelial cells. Microbiology (2011) 0.89
Recent advances in otitis media. 6. Vaccine. Ann Otol Rhinol Laryngol Suppl (2005) 0.88
Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes. JAKSTAT (2012) 0.88
Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media. PLoS One (2012) 0.87
The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope. J Immunol (2003) 0.87
Characterization of the pediatric acute-onset neuropsychiatric syndrome phenotype. J Child Adolesc Psychopharmacol (2014) 0.86