Published in Proc IEEE Comput Syst Bioinform Conf on January 01, 2004
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease. Infect Immun (2011) 1.15
GPS-CCD: a novel computational program for the prediction of calpain cleavage sites. PLoS One (2011) 1.04
Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate. Biosci Rep (2014) 0.76
MUSTANG: a multiple structural alignment algorithm. Proteins (2006) 4.69
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity (2003) 3.41
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol (2005) 2.52
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
An overview of the serpin superfamily. Genome Biol (2006) 2.14
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65. PLoS Pathog (2010) 2.03
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity (2009) 1.98
Corruption of innate immunity by bacterial proteases. J Innate Immun (2009) 1.96
A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol (2013) 1.85
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res (2005) 1.70
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J Exp Med (2013) 1.69
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A (2009) 1.63
The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (2003) 1.61
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol (2007) 1.56
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
Osteopontin and skeletal muscle myoblasts: association with muscle regeneration and regulation of myoblast function in vitro. Int J Biochem Cell Biol (2008) 1.50
Computational analysis of evolution and conservation in a protein superfamily. Methods (2004) 1.49
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep (2011) 1.37
Cascleave: towards more accurate prediction of caspase substrate cleavage sites. Bioinformatics (2010) 1.34
Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr (2008) 1.33
An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss. J Immunol (2005) 1.32
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem (2010) 1.32
Perforin: structure, function, and role in human immunopathology. Immunol Rev (2010) 1.30
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PLoS One (2012) 1.28
Automatic generation of protein structure cartoons with Pro-origami. Bioinformatics (2011) 1.28
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26
PoPS: a computational tool for modeling and predicting protease specificity. J Bioinform Comput Biol (2005) 1.23
The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol (2006) 1.23
Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol (2015) 1.23
The X-ray crystal structure of full-length human plasminogen. Cell Rep (2012) 1.22
Serpins in prokaryotes. Mol Biol Evol (2002) 1.22
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem Sci (2009) 1.21
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem (2005) 1.21
The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem (2005) 1.20
Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT. J Biol Chem (2003) 1.18
Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem (2002) 1.17
Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5. J Biol Chem (2003) 1.17
The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis. Future Microbiol (2009) 1.15
High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism. J Innate Immun (2008) 1.15
Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3. Biochem Biophys Res Commun (2004) 1.14
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A (2009) 1.14
Scabies mite inactivated serine protease paralogs inhibit the human complement system. J Immunol (2009) 1.11
COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes (2008) 1.11
The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism. J Mol Biol (2008) 1.11
X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A (2012) 1.11
The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates. PLoS Pathog (2010) 1.10
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol (2012) 1.09
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc Natl Acad Sci U S A (2010) 1.09
The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria. Mol Microbiol (2011) 1.07
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases. Proc Natl Acad Sci U S A (2011) 1.07
The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens. J Mol Biol (2002) 1.07
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol (2005) 1.04
Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem (2006) 1.03
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. J Immunol (2012) 1.03
Antithrombin: in control of coagulation. Int J Biochem Cell Biol (2004) 1.03
The initiating proteases of the complement system: controlling the cleavage. Biochimie (2007) 1.02
Novel scabies mite serpins inhibit the three pathways of the human complement system. PLoS One (2012) 1.02
The matrix refolded. Nat Methods (2005) 1.01
MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography. PLoS One (2010) 1.01
Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions? Biochim Biophys Acta (2011) 1.01
RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins. Genome Res (2007) 1.01
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PLoS One (2012) 1.00
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet (2012) 1.00
The evolution of enzyme specificity in Fasciola spp. J Mol Evol (2003) 0.99
Maspin (SERPINB5) is an obligate intracellular serpin. J Biol Chem (2010) 0.99
Subsite cooperativity in protease specificity. Biol Chem (2009) 0.99
REFOLD: an analytical database of protein refolding methods. Protein Expr Purif (2005) 0.99
Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS. PLoS Pathog (2013) 0.98
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. Biochemistry (2003) 0.98
Cathepsin B proteases of flukes: the key to facilitating parasite control? Trends Parasitol (2010) 0.98
Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni. Cell Mol Life Sci (2010) 0.98
Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Infect Immun (2003) 0.97
The N terminus of the serpin, tengpin, functions to trap the metastable native state. EMBO Rep (2007) 0.97
The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry (2002) 0.97
Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence. Mol Microbiol (2011) 0.96
The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori. J Biol Chem (2013) 0.96
Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases. Biochemistry (2002) 0.96