Published in J Biol Chem on May 24, 2010
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nat Rev Cancer (2013) 1.31
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem (2010) 1.14
Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders. Cold Spring Harb Perspect Biol (2011) 1.07
SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis. Br J Cancer (2014) 1.03
Identification and function of proteolysis regulators in seminal fluid. Mol Reprod Dev (2012) 1.02
Novel scabies mite serpins inhibit the three pathways of the human complement system. PLoS One (2012) 1.02
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog (2012) 0.98
Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor. J Biol Chem (2011) 0.92
Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm, Bombyx mori. PLoS One (2012) 0.89
SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I. Oncotarget (2014) 0.88
Kinetic intermediates en route to the final serpin-protease complex: studies of complexes of α1-protease inhibitor with trypsin. J Biol Chem (2013) 0.87
A blood meal-induced Ixodes scapularis tick saliva serpin inhibits trypsin and thrombin, and interferes with platelet aggregation and blood clotting. Int J Parasitol (2014) 0.87
Identification of immunity-related genes in Ostrinia furnacalis against entomopathogenic fungi by RNA-seq analysis. PLoS One (2014) 0.87
Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. PLoS One (2013) 0.84
Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. J Biol Chem (2014) 0.82
Novel treatment strategies for liver disease due to α1-antitrypsin deficiency. Clin Transl Sci (2012) 0.81
A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency. Hum Mol Genet (2014) 0.81
Characterization of a novel serine protease inhibitor gene from a marine metagenome. Mar Drugs (2011) 0.80
Viral serpin therapeutics from concept to clinic. Methods Enzymol (2011) 0.80
Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro. PLoS One (2012) 0.79
Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes. Proteins (2011) 0.79
93-kDa twin-domain serine protease inhibitor (Serpin) has a regulatory function on the beetle Toll proteolytic signaling cascade. J Biol Chem (2011) 0.78
Serpins in rice: protein sequence analysis, phylogeny and gene expression during development. BMC Genomics (2012) 0.78
A versatile monoclonal antibody specific to human SERPINB5. Hybridoma (Larchmt) (2012) 0.78
Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem (2015) 0.78
Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. PLoS One (2013) 0.77
Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin. PLoS One (2014) 0.76
1.45 Å resolution structure of SRPN18 from the malaria vector Anopheles gambiae. Acta Crystallogr F Struct Biol Commun (2016) 0.75
The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Genetics (2015) 0.75
The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K. Exp Biol Med (Maywood) (2015) 0.75
Serine protease SP105 activates prophenoloxidase in Asian corn borer melanization, and is regulated by serpin-3. Sci Rep (2017) 0.75
ANISERP: a new serpin from the parasite Anisakis simplex. Parasit Vectors (2015) 0.75
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry (2015) 0.75
A Novel Serpin Regulatory Mechanism: SerpinB9 IS REVERSIBLY INHIBITED BY VICINAL DISULFIDE BOND FORMATION IN THE REACTIVE CENTER LOOP. J Biol Chem (2015) 0.75
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition. BMC Biochem (2013) 0.75
Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity. Mol Vis (2017) 0.75
Resolving distinct molecular origins for copper effects on PAI-1. J Biol Inorg Chem (2017) 0.75
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Drosophila innate immunity: an evolutionary perspective. Nat Immunol (2002) 4.61
Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. Genome Res (2000) 3.55
Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science (1999) 2.95
Activation of Drosophila Toll during fungal infection by a blood serine protease. Science (2002) 2.31
Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. J Cell Biol (2000) 2.24
A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J (2002) 2.22
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest (1993) 2.20
An overview of the serpin superfamily. Genome Biol (2006) 2.14
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. J Clin Invest (1993) 2.08
An immune-responsive Serpin regulates the melanization cascade in Drosophila. Dev Cell (2002) 2.06
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell (2007) 1.56
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat Immunol (2008) 1.54
Molecular gymnastics: serpin structure, folding and misfolding. Curr Opin Struct Biol (2006) 1.47
Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis. Cell Mol Life Sci (2004) 1.46
The plasminogen activator system and cancer. Pathophysiol Haemost Thromb (2009) 1.45
The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases. Nat Rev Nephrol (2009) 1.38
A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci U S A (2009) 1.38
Shape-shifting serpins--advantages of a mobile mechanism. Trends Biochem Sci (2006) 1.37
The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol (2003) 1.32
Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9. J Mol Biol (2006) 1.29
Tip of another iceberg: Drosophila serpins. Trends Cell Biol (2005) 1.29
A serpin regulates dorsal-ventral axis formation in the Drosophila embryo. Curr Biol (2003) 1.28
Spatial regulation of developmental signaling by a serpin. Dev Cell (2003) 1.26
Exosite determinants of serpin specificity. J Biol Chem (2009) 1.23
A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem (1997) 1.23
Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin. Mol Cell Biol (2006) 1.22
A serpin that regulates immune melanization in the respiratory system of Drosophila. Dev Cell (2008) 1.20
Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circ Res (2006) 1.20
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem (2010) 1.14
Serpins in plants and green algae. Funct Integr Genomics (2007) 1.14
Maspin plays an essential role in early embryonic development. Development (2004) 1.13
Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1. Proc Natl Acad Sci U S A (2001) 1.12
Three pairs of protease-serpin complexes cooperatively regulate the insect innate immune responses. J Biol Chem (2009) 1.11
MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member. J Biol Chem (1999) 1.11
Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Dev Biol (2008) 1.08
Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia. Proc Natl Acad Sci U S A (2009) 1.04
PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration. Exp Eye Res (2008) 1.04
Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Genomics (2002) 1.03
Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins. Immunol Cell Biol (1999) 1.01
Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin. Mol Cell Biol (2006) 1.00
Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21). J Biol Chem (2010) 0.99
Control of granzymes by serpins. Cell Death Differ (2009) 0.98
X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J (2006) 0.94
Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development. Development (2007) 0.92
SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. J Biol Chem (2004) 0.92
Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Genomics (2004) 0.92
SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. J Biol Chem (2001) 0.89
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke. Mol Cell Biol (2004) 0.89
The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families. Biochem J (2007) 0.88
The multi-functional serpin, protein C inhibitor: beyond thrombosis and hemostasis. J Thromb Haemost (2008) 0.88
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic. Insect Biochem Mol Biol (2005) 0.88
Drosophila toll pathway: the new model. Sci Signal (2009) 0.88
Functional diversification of a protease inhibitor gene in the genus Drosophila and its molecular basis. Gene (2008) 0.87
SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. J Biol Chem (2007) 0.87
Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1. PLoS Genet (2009) 0.86
Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J Biol Chem (2008) 0.82
Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. BMC Genomics (2009) 0.82
Disruption of the murine alpha1-antitrypsin/PI2 gene. Exp Anim (2004) 0.80
The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases. Biochemistry (2006) 0.79
An inhibitor of serine proteases, neuroserpin, acts as a neuroprotective agent in a mouse model of neurodegenerative disease. J Neurosci (2006) 0.79
Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency. PLoS Genet (2005) 0.78
Absence of mutations in the PCI gene in subfertile men. Mol Hum Reprod (2004) 0.77
Immunity-related genes and gene families in Anopheles gambiae. Science (2002) 5.47
MUSTANG: a multiple structural alignment algorithm. Proteins (2006) 4.69
Drosophila innate immunity: an evolutionary perspective. Nat Immunol (2002) 4.61
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
A common fold mediates vertebrate defense and bacterial attack. Science (2007) 3.43
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity (2003) 3.41
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell (2005) 3.22
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature (2008) 2.88
Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell (2006) 2.66
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat Immunol (2005) 2.52
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol (2007) 2.36
Activation of Drosophila Toll during fungal infection by a blood serine protease. Science (2002) 2.31
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol (2004) 2.26
The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature (2010) 2.23
A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J (2002) 2.22
The MACPF/CDC family of pore-forming toxins. Cell Microbiol (2008) 2.15
An overview of the serpin superfamily. Genome Biol (2006) 2.14
Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proc Natl Acad Sci U S A (2002) 2.04
The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65. PLoS Pathog (2010) 2.03
The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity (2009) 1.98
Directing thrombin. Blood (2005) 1.85
A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol (2013) 1.85
How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. Nat Struct Biol (2003) 1.76
Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity (2011) 1.73
Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Res (2005) 1.70
The immune response of Drosophila melanogaster. Immunol Rev (2004) 1.69
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step. J Biol Chem (2006) 1.66
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A (2009) 1.63
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One (2010) 1.62
The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (2003) 1.61
Crystal structure of thrombin bound to heparin. J Biol Chem (2004) 1.61
Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. EMBO J (2006) 1.59
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol (2007) 1.56
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell (2007) 1.56
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat Immunol (2008) 1.54
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood (2013) 1.53
Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis. Blood (2013) 1.53
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway. FASEB J (2005) 1.51
Computational analysis of evolution and conservation in a protein superfamily. Methods (2004) 1.49
Sensing and signaling during infection in Drosophila. Curr Opin Immunol (2005) 1.49
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila. EMBO Rep (2006) 1.49
A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production. BMC Biotechnol (2006) 1.48
The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol (2006) 1.48
Molecular gymnastics: serpin structure, folding and misfolding. Curr Opin Struct Biol (2006) 1.47
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc Natl Acad Sci U S A (2002) 1.46
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity (2011) 1.45
Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J Exp Med (2004) 1.43
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor. Immunity (2009) 1.40
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem (2005) 1.39
Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983. J Immunol (2012) 1.38
NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation. Proc Natl Acad Sci U S A (2010) 1.38
Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies. Nucleic Acids Res (2003) 1.37
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer. EMBO Rep (2011) 1.37
Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell (2010) 1.36
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem (2009) 1.34
Cascleave: towards more accurate prediction of caspase substrate cleavage sites. Bioinformatics (2010) 1.34
Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr (2008) 1.33
The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol (2003) 1.32
A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe (2011) 1.31
Perforin: structure, function, and role in human immunopathology. Immunol Rev (2010) 1.30
Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein. J Mol Biol (2007) 1.29
PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites. PLoS One (2012) 1.28
A serpin regulates dorsal-ventral axis formation in the Drosophila embryo. Curr Biol (2003) 1.28
Automatic generation of protein structure cartoons with Pro-origami. Bioinformatics (2011) 1.28
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26
Thrombin-cofactor interactions: structural insights into regulatory mechanisms. Arterioscler Thromb Vasc Biol (2006) 1.24
Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6. Cancer Res (2004) 1.24
PoPS: a computational tool for modeling and predicting protease specificity. J Bioinform Comput Biol (2005) 1.23
Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol (2015) 1.23
The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol (2006) 1.23
The X-ray crystal structure of full-length human plasminogen. Cell Rep (2012) 1.22
Serpins in prokaryotes. Mol Biol Evol (2002) 1.22
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends Biochem Sci (2009) 1.21
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem (2005) 1.21
The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J Biol Chem (2005) 1.20
The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe (2013) 1.20
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein. J Biol Chem (2006) 1.18
Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT. J Biol Chem (2003) 1.18
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein. Biochemistry (2008) 1.18
Crystal structure of wild-type human thrombin in the Na+-free state. Biochem J (2005) 1.18
Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem (2002) 1.17
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. J Biol Chem (2004) 1.17
Enhancing the stability and solubility of TEV protease using in silico design. Protein Sci (2007) 1.17