Published in Anal Chem on February 01, 2006
Mass spectrometric imaging for biomedical tissue analysis. Chem Rev (2010) 2.51
Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses. Mass Spectrom Rev (2011) 2.39
Solvent-free matrix dry-coating for MALDI imaging of phospholipids. J Am Soc Mass Spectrom (2008) 1.86
Processing MALDI Mass Spectra to Improve Mass Spectral Direct Tissue Analysis. Int J Mass Spectrom (2007) 1.73
Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS). Biochim Biophys Acta (2011) 1.53
MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology. Histochem Cell Biol (2008) 1.53
Imaging mass spectrometry of neuropeptides in decapod crustacean neuronal tissues. J Proteome Res (2007) 1.52
Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J (2009) 1.39
MALDI imaging of lipid biochemistry in tissues by mass spectrometry. Chem Rev (2011) 1.29
Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts. Proc Natl Acad Sci U S A (2013) 1.26
Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells. Langmuir (2008) 1.25
Mass spectrometry imaging with high resolution in mass and space. Histochem Cell Biol (2013) 1.25
MALDI imaging mass spectrometry: state of the art technology in clinical proteomics. Mol Cell Proteomics (2009) 1.25
Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging. J Am Soc Mass Spectrom (2009) 1.23
Relationship between MALDI IMS intensity and measured quantity of selected phospholipids in rat brain sections. Anal Chem (2010) 1.18
Mass spectrometry imaging and profiling of single cells. J Proteomics (2012) 1.17
Visualization of spatiotemporal energy dynamics of hippocampal neurons by mass spectrometry during a kainate-induced seizure. PLoS One (2011) 1.16
Sphingolipid domains in the plasma membranes of fibroblasts are not enriched with cholesterol. J Biol Chem (2013) 1.14
Mass spectrometry imaging for drugs and metabolites. J Proteomics (2011) 1.05
Time of flight mass spectrometry imaging of samples fractured in situ with a spring-loaded trap system. Anal Chem (2010) 1.04
MALDI mass spectrometric imaging using the stretched sample method to reveal neuropeptide distributions in aplysia nervous tissue. Anal Chem (2009) 0.97
L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry. Mol Cell Proteomics (2011) 0.96
Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation. J Lipid Res (2013) 0.96
Nanotome cluster bombardment to recover spatial chemistry after preparation of biological samples for SIMS imaging. J Am Soc Mass Spectrom (2010) 0.95
Chapter 13: Imaging of cells and tissues with mass spectrometry: adding chemical information to imaging. Methods Cell Biol (2008) 0.95
Secondary ion mass spectrometry imaging of molecular distributions in cultured neurons and their processes: comparative analysis of sample preparation. J Am Soc Mass Spectrom (2012) 0.94
MALDI-guided SIMS: multiscale imaging of metabolites in bacterial biofilms. Anal Chem (2014) 0.93
Compositional mapping of the surface and interior of mammalian cells at submicrometer resolution. Anal Chem (2011) 0.91
Molecular mass spectrometry imaging in biomedical and life science research. Histochem Cell Biol (2010) 0.91
Analysis of cholesterol trafficking with fluorescent probes. Methods Cell Biol (2012) 0.91
Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution. Anal Chem (2009) 0.90
Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time-of-flight secondary ion mass spectrometry. Med Mol Morphol (2010) 0.89
Small molecule analysis and imaging of fatty acids in the zebra finch song system using time-of-flight-secondary ion mass spectrometry. J Neurochem (2011) 0.88
Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry. J Proteomics (2012) 0.88
From pixel to voxel: a deeper view of biological tissue by 3D mass spectral imaging. Bioanalysis (2011) 0.87
Applications of mass spectrometry for cellular lipid analysis. Mol Biosyst (2015) 0.85
An external matrix-assisted laser desorption ionization source for flexible FT-ICR Mass spectrometry imaging with internal calibration on adjacent samples. J Am Soc Mass Spectrom (2011) 0.85
Neuropeptide analysis with liquid chromatography-capillary electrophoresis-mass spectrometric imaging. J Sep Sci (2012) 0.84
Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry. J Phys Chem C Nanomater Interfaces (2009) 0.83
Hemagglutinin clusters in the plasma membrane are not enriched with cholesterol and sphingolipids. Biophys J (2015) 0.82
Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. J Am Soc Mass Spectrom (2015) 0.81
Sample Preparation for Mass Spectrometry Imaging of Plant Tissues: A Review. Front Plant Sci (2016) 0.81
In situ identification and mapping of neuropeptides from the stomatogastric nervous system of Cancer borealis. Rapid Commun Mass Spectrom (2014) 0.81
Characterization of sample preparation methods of NIH/3T3 fibroblasts for ToF-SIMS analysis. Biointerphases (2013) 0.81
Laserspray ionization imaging of multiply charged ions using a commercial vacuum MALDI ion source. Anal Chem (2012) 0.81
Metal-assisted polyatomic SIMS and laser desorption/ionization for enhanced small molecule imaging of bacterial biofilms. Biointerphases (2016) 0.80
Multi-dimensional TOF-SIMS analysis for effective profiling of disease-related ions from the tissue surface. Sci Rep (2015) 0.76
Intact lipid imaging of mouse brain samples: MALDI, nanoparticle-laser desorption ionization, and 40 keV argon cluster secondary ion mass spectrometry. Anal Bioanal Chem (2016) 0.76
Molecular mapping deep within a living human organ: analysis of microvessel function on the timescale of seconds and with sub-micrometre spatial resolution. Histochem Cell Biol (2009) 0.75
Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS. J Am Soc Mass Spectrom (2016) 0.75
Imaging mass spectrometry. Mass Spectrom Rev (2007) 3.79
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep (2004) 2.98
Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission. Biophys J (2004) 2.55
Mass spectrometric imaging for biomedical tissue analysis. Chem Rev (2010) 2.51
Bright cyan fluorescent protein variants identified by fluorescence lifetime screening. Nat Methods (2010) 2.43
A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example. PLoS One (2008) 2.23
TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J (2006) 2.20
PPIB mutations cause severe osteogenesis imperfecta. Am J Hum Genet (2009) 2.16
Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell (2004) 2.08
Integrins control motile strategy through a Rho-cofilin pathway. J Cell Biol (2005) 2.04
A concise review of mass spectrometry imaging. J Chromatogr A (2010) 2.01
Calcium signaling regulates translocation and activation of Rac. J Biol Chem (2003) 1.94
Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale. Mol Biol Cell (2002) 1.93
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity (2003) 1.89
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell (2007) 1.89
Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry. Nat Methods (2005) 1.79
Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog (2010) 1.76
On the beta-binomial model for analysis of spectral count data in label-free tandem mass spectrometry-based proteomics. Bioinformatics (2009) 1.74
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. Immunity (2005) 1.64
PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59
Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity (Silver Spring) (2011) 1.50
A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range. PLoS One (2011) 1.49
Direct molecular imaging of Lymnaea stagnalis nervous tissue at subcellular spatial resolution by mass spectrometry. Anal Chem (2005) 1.46
Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry. J Am Soc Mass Spectrom (2006) 1.42
imzML--a common data format for the flexible exchange and processing of mass spectrometry imaging data. J Proteomics (2012) 1.42
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem (2008) 1.32
Sample preparation issues for tissue imaging by imaging MS. Proteomics (2009) 1.29
Composition of the type VII secretion system membrane complex. Mol Microbiol (2012) 1.29
TRPM7 is required for breast tumor cell metastasis. Cancer Res (2012) 1.27
High-spatial resolution mass spectrometric imaging of peptide and protein distributions on a surface. Anal Chem (2004) 1.26
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. J Am Soc Nephrol (2009) 1.24
On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry. J Am Soc Mass Spectrom (2009) 1.23
Tandem mass spectrometry of intact GroEL-substrate complexes reveals substrate-specific conformational changes in the trans ring. J Am Chem Soc (2006) 1.22
Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard. Anal Chem (2012) 1.21
Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem (2006) 1.21
PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. EMBO J (2007) 1.19
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. BMC Biotechnol (2007) 1.19
WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy. Curr Biol (2013) 1.19
Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17
Subcellular imaging mass spectrometry of brain tissue. J Mass Spectrom (2005) 1.16
Subnuclear proteomics in colorectal cancer: identification of proteins enriched in the nuclear matrix fraction and regulation in adenoma to carcinoma progression. Mol Cell Proteomics (2010) 1.16
Imaging mass spectrometry at cellular length scales. Nat Protoc (2007) 1.15
Realistic modeling of ion cloud motion in a Fourier transform ion cyclotron resonance cell by use of a particle-in-cell approach. Rapid Commun Mass Spectrom (2007) 1.10
Effect of local matrix crystal variations in matrix-assisted ionization techniques for mass spectrometry. Anal Chem (2003) 1.09
Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior. J Neurosci (2007) 1.09
Branching of calyceal afferents during postnatal development in the rat auditory brainstem. J Comp Neurol (2006) 1.08
Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity. J Biol Chem (2003) 1.07
Difference in susceptibility to activity-based anorexia in two inbred strains of mice. Eur Neuropsychopharmacol (2006) 1.07
Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide. PLoS One (2011) 1.07
Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models. Cancer Res (2010) 1.06
Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems. Mol Cell Proteomics (2013) 1.05
Neurobiology of overeating and obesity: the role of melanocortins and beyond. Eur J Pharmacol (2011) 1.05
Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models. J Lipid Res (2012) 1.04
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease. Trends Pharmacol Sci (2005) 1.04
Specific chaperones for the type VII protein secretion pathway. J Biol Chem (2012) 1.03
Toward digital staining using imaging mass spectrometry and random forests. J Proteome Res (2009) 1.02
Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus. Hum Gene Ther (2010) 1.02
Emerging technologies in mass spectrometry imaging. J Proteomics (2012) 1.02
Neuropsychological weaknesses in anorexia nervosa: set-shifting, central coherence, and decision making in currently ill and recovered women. Int J Eat Disord (2012) 1.01
Perspectives for imaging mass spectrometry in the proteomics landscape. Proteomics (2009) 1.01
Electron capture dissociation at low temperatures reveals selective dissociations. J Am Soc Mass Spectrom (2004) 0.99
Tools and strategies for visualization of large image data sets in high-resolution imaging mass spectrometry. Rev Sci Instrum (2007) 0.99
Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1. Obesity (Silver Spring) (2012) 0.99
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol (2010) 0.98
Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression. BMC Neurosci (2009) 0.98
Electron capture dissociation as structural probe for noncovalent gas-phase protein assemblies. Anal Chem (2006) 0.98
The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons. Front Cell Neurosci (2013) 0.97
Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation. J Lipid Res (2013) 0.96
Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity. Eur Neuropsychopharmacol (2011) 0.96
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol (2006) 0.96
Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels. Exp Cell Res (2006) 0.96
Concise representation of mass spectrometry images by probabilistic latent semantic analysis. Anal Chem (2008) 0.95
Leptin treatment in activity-based anorexia. Biol Psychiatry (2005) 0.94
Fiducial markers for combined 3-dimensional mass spectrometric and optical tissue imaging. Anal Chem (2012) 0.94
Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event. J Mol Endocrinol (2005) 0.94
C60 secondary ion Fourier transform ion cyclotron resonance mass spectrometry. Anal Chem (2011) 0.94
Peptoid-peptide hybrids as potent novel melanocortin receptor ligands. J Med Chem (2005) 0.94
Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1. Mol Endocrinol (2009) 0.94
Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly. Mol Biol Cell (2012) 0.93
High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging. Anal Bioanal Chem (2013) 0.93
Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa. Eur Neuropsychopharmacol (2008) 0.93
Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models. Neoplasia (2012) 0.93
Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer. Mol Cell Proteomics (2012) 0.93
A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls. BMC Bioinformatics (2006) 0.92
Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution. Eur J Pharmacol (2008) 0.91
Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas. J Proteome Res (2010) 0.91
Ghrelin mediates anticipation to a palatable meal in rats. Obesity (Silver Spring) (2012) 0.91
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor. PLoS One (2011) 0.91
Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage. Arthritis Res Ther (2014) 0.91
Hyperactivity in anorexia nervosa: warming up not just burning-off calories. PLoS One (2012) 0.90
Identifying tissue-specific signal variation in MALDI mass spectrometric imaging by use of an internal standard. Anal Chem (2012) 0.90