Published in J Biol Chem on July 29, 2003
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26
Calcium flickers steer cell migration. Nature (2008) 3.01
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J (2005) 2.50
Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors. Proc Natl Acad Sci U S A (2004) 2.18
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
Guiding neuronal growth cones using Ca2+ signals. Trends Cell Biol (2004) 1.97
A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis. Mol Cell Biol (2009) 1.74
Oscillatory ROP GTPase activation leads the oscillatory polarized growth of pollen tubes. Mol Biol Cell (2005) 1.69
Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis. Mol Cell Biol (2006) 1.58
Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors. J Neurosci (2010) 1.37
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol (2009) 1.36
Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. J Exp Med (2004) 1.34
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. EMBO J (2007) 1.31
Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling. J Biol Chem (2008) 1.30
The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration. J Cell Biol (2005) 1.23
LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics. Mol Biol Cell (2007) 1.20
Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. EMBO J (2011) 1.19
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proc Natl Acad Sci U S A (2007) 1.19
Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol (2008) 1.15
Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. J Biol Chem (2009) 1.11
RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility. J Biol Chem (2012) 1.09
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs. Proc Natl Acad Sci U S A (2007) 1.07
Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Biol (2007) 1.07
Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Mol Cell Biol (2005) 1.02
Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway. Free Radic Biol Med (2010) 1.02
Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration. Mol Med (2011) 1.01
Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. J Biol Chem (2011) 1.00
Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization. Biochem J (2006) 1.00
Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding. Am J Physiol Cell Physiol (2008) 1.00
Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells. Hepatology (2010) 0.94
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Mol Biol Cell (2012) 0.94
Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood Cells Mol Dis (2010) 0.94
Cytoskeleton in mast cell signaling. Front Immunol (2012) 0.93
Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling. Small GTPases (2012) 0.88
Non-channel mechanosensors working at focal adhesion-stress fiber complex. Pflugers Arch (2014) 0.86
Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis (2013) 0.86
Activation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils. Biochem Pharmacol (2010) 0.85
Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth. BMC Biol (2011) 0.85
Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins. Cytoskeleton (Hoboken) (2015) 0.83
From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PLoS One (2014) 0.83
Rac1 modulates stimulus-evoked Ca(2+) release in neuronal growth cones via parallel effects on microtubule/endoplasmic reticulum dynamics and reactive oxygen species production. Mol Biol Cell (2009) 0.83
Regulation of serotonin-induced trafficking and migration of eosinophils. PLoS One (2013) 0.80
Rac1 participates in thermally induced alterations of the cytoskeleton, cell morphology and lipid rafts, and regulates the expression of heat shock proteins in B16F10 melanoma cells. PLoS One (2014) 0.78
RAC activity in keloid disease: comparative analysis of fibroblasts from margin of keloid to its surrounding normal skin. Eplasty (2008) 0.78
BIGH3 modulates adhesion and migration of hematopoietic stem and progenitor cells. Cell Adh Migr (2013) 0.77
RhoGTPases and p53 are involved in the morphological appearance and interferon-alpha response of hairy cells. Am J Pathol (2006) 0.77
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS One (2015) 0.76
Cholecystokinin-mediated RhoGDI phosphorylation via PKCα promotes both RhoA and Rac1 signaling. PLoS One (2013) 0.76
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation. PLoS One (2016) 0.75
Calcium Signaling Is Required for Erythroid Enucleation. PLoS One (2016) 0.75
Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep (2016) 0.75
Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis. Cell Death Dis (2016) 0.75
ERP44 inhibits human lung cancer cell migration mainly via IP3R2. Aging (Albany NY) (2016) 0.75
The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain. Front Cell Neurosci (2017) 0.75
Roles of the mitochondrial Na(+)-Ca(2+) exchanger, NCLX, in B lymphocyte chemotaxis. Sci Rep (2016) 0.75
Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol (2008) 3.05
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep (2004) 2.98
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature (2002) 2.79
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission. Biophys J (2004) 2.55
Bright cyan fluorescent protein variants identified by fluorescence lifetime screening. Nat Methods (2010) 2.43
VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. Am J Physiol Cell Physiol (2003) 2.37
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example. PLoS One (2008) 2.23
TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J (2006) 2.20
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell (2004) 2.08
Integrins control motile strategy through a Rho-cofilin pathway. J Cell Biol (2005) 2.04
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. J Cell Biol (2005) 2.03
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
Rap1 regulates E-cadherin-mediated cell-cell adhesion. J Biol Chem (2004) 1.98
The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol (2007) 1.98
Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale. Mol Biol Cell (2002) 1.93
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity (2003) 1.89
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell (2007) 1.89
Myosin II and mechanotransduction: a balancing act. Trends Cell Biol (2007) 1.85
Regulation of Tiam1-Rac signalling. FEBS Lett (2003) 1.83
Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci (2002) 1.72
Rap2A links intestinal cell polarity to brush border formation. Nat Cell Biol (2012) 1.71
Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry. Anal Chem (2006) 1.71
The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J Biol Chem (2004) 1.70
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. Immunity (2005) 1.64
P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium. Arterioscler Thromb Vasc Biol (2007) 1.63
PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59
Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. J Biol Chem (2002) 1.57
Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol (2008) 1.57
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol (2008) 1.56
Role of Rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol (2003) 1.53
A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range. PLoS One (2011) 1.49
The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem (2003) 1.45
Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation. J Biol Chem (2005) 1.45
Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. J Biol Chem (2003) 1.39
The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization. J Cell Biol (2007) 1.38
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem (2005) 1.33
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem (2008) 1.32
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. EMBO J (2007) 1.31
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci (2010) 1.31
Signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2004) 1.28
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28
TRPM7 is required for breast tumor cell metastasis. Cancer Res (2012) 1.27
Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol (2006) 1.26
The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. Blood (2009) 1.25
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. J Am Soc Nephrol (2009) 1.24
The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration. J Cell Biol (2005) 1.23
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes. J Immunol (2004) 1.23
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci (2011) 1.23
The role of ubiquitylation and degradation in RhoGTPase signalling. J Cell Sci (2010) 1.22
Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem (2006) 1.21
PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. EMBO J (2007) 1.19
WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy. Curr Biol (2013) 1.19
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. BMC Biotechnol (2007) 1.19
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol (2008) 1.17
Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J Biol Chem (2003) 1.17
Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17
Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukoc Biol (2006) 1.16
RhoA activation promotes transendothelial migration of monocytes via ROCK. J Leukoc Biol (2003) 1.16
Tiam1 takes PARt in cell polarity. Trends Cell Biol (2006) 1.15
The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci (2004) 1.14
The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci (2008) 1.13
Cell polarity proteins and cancer. Semin Cancer Biol (2012) 1.13
Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin. J Immunol (2002) 1.13
B plexins activate Rho through PDZ-RhoGEF. FEBS Lett (2002) 1.11
Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol (2003) 1.11
Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol (2012) 1.10
cAMP signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2007) 1.09
Filamin B mediates ICAM-1-driven leukocyte transendothelial migration. J Biol Chem (2008) 1.09
The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model. Oncogene (2005) 1.08
Endothelial signaling by Ig-like cell adhesion molecules. Arterioscler Thromb Vasc Biol (2007) 1.05
Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells. J Cell Sci (2007) 1.04
Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA. J Biol Chem (2003) 1.04
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease. Trends Pharmacol Sci (2005) 1.04
The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS One (2012) 1.03
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol (2012) 1.01
Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. J Biol Chem (2010) 1.00
Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization. Biochem J (2006) 1.00
Endothelial adapter proteins in leukocyte transmigration. Thromb Haemost (2009) 1.00
Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci (2010) 0.98
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol (2010) 0.98
Targeting and localized signalling by small GTPases. Biol Cell (2007) 0.98
The regulation of leucocyte transendothelial migration by endothelial signalling events. Cardiovasc Res (2010) 0.98
The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons. Front Cell Neurosci (2013) 0.97
Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. Blood (2003) 0.97
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol (2006) 0.96
Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels. Exp Cell Res (2006) 0.96
The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation. Mol Biol Cell (2012) 0.96
Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration. FEBS Lett (2012) 0.95
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Mol Biol Cell (2012) 0.94
Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1. Mol Endocrinol (2009) 0.94