Published in J Biol Chem on February 02, 2006
Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature (2008) 5.96
Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci U S A (2007) 2.11
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72
Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog (2009) 1.67
Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog (2007) 1.63
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites. EMBO Rep (2007) 1.62
Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A (2015) 1.58
Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum. Proc Natl Acad Sci U S A (2009) 1.54
Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern. PLoS Pathog (2011) 1.45
Variable switching rates of malaria virulence genes are associated with chromosomal position. Mol Microbiol (2007) 1.45
PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. Eukaryot Cell (2007) 1.31
Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum. Cell Microbiol (2013) 1.29
Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates. PLoS Pathog (2009) 1.24
Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol (2009) 1.20
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. Int J Parasitol (2008) 1.13
Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol Microbiol (2007) 1.12
Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter. PLoS Pathog (2011) 1.11
Genetics of antigenic variation in Plasmodium falciparum. Curr Genet (2009) 1.09
Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites. Malar J (2007) 1.08
Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance. PLoS Pathog (2008) 1.06
A regulatable transgene expression system for cultured Plasmodium falciparum parasites. Malar J (2008) 1.06
Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum. J Mol Biol (2008) 1.06
Default Pathway of var2csa switching and translational repression in Plasmodium falciparum. PLoS One (2008) 1.04
Clonally variant gene families in Plasmodium falciparum share a common activation factor. Mol Microbiol (2009) 1.02
Plasmodium falciparum: development of a transgenic line for screening antimalarials using firefly luciferase as the reporter. Exp Parasitol (2008) 0.98
Erasing the epigenetic memory and beginning to switch--the onset of antigenic switching of var genes in Plasmodium falciparum. PLoS One (2012) 0.97
Insulator-like pairing elements regulate silencing and mutually exclusive expression in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A (2012) 0.95
Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum. PLoS Pathog (2014) 0.90
Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell Microbiol (2012) 0.87
A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3' untranslated region and intronic cis-elements. Int J Parasitol (2009) 0.85
Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions. Eukaryot Cell (2011) 0.84
A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation and identifies H3K36me2 as a global mark of gene suppression. Epigenetics Chromatin (2015) 0.83
Use of peptide nucleic acids to manipulate gene expression in the malaria parasite Plasmodium falciparum. PLoS One (2014) 0.82
Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors. PLoS One (2014) 0.82
Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling. Mol Microbiol (2012) 0.82
Designing synthetic drugs against Plasmodium falciparum: a computational study of histone-lysine N-methyltransferase (PfHKMT). Syst Synth Biol (2014) 0.81
Plasmodium falciparum: hrp3 promoter region is associated with stage-specificity and episomal recombination. Exp Parasitol (2007) 0.78
Characterization of the unusual bidirectional ves promoters driving VESA1 expression and associated with antigenic variation in Babesia bovis. Eukaryot Cell (2012) 0.77
Sporozoite Route of Infection Influences In Vitro var Gene Transcription of Plasmodium falciparum Parasites From Controlled Human Infections. J Infect Dis (2016) 0.76
Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research. Front Microbiol (2015) 0.76
In Vitro Variant Surface Antigen Expression in Plasmodium falciparum Parasites from a Semi-Immune Individual Is Not Correlated with Var Gene Transcription. PLoS One (2016) 0.76
Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa. Cell Host Microbe (2016) 0.76
Antigenic variation in Plasmodium falciparum: moving beyond the laboratory strains. Wien Klin Wochenschr (2010) 0.75
Trans-acting GC-rich non-coding RNA at var expression site modulates gene counting in malaria parasite. Nucleic Acids Res (2016) 0.75
Punctuated chromatin states regulate Plasmodium falciparum antigenic variation at the intron and 2 kb upstream regions. BMC Genomics (2016) 0.75
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature (2005) 31.73
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell (1995) 10.35
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell (1995) 9.31
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell (1995) 9.31
Rapid switching to multiple antigenic and adhesive phenotypes in malaria. Nature (1992) 6.42
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Mol Microbiol (2003) 6.04
Malaria pathogenesis. Science (1994) 4.76
A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum. Science (1999) 4.75
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell (2005) 4.33
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell (2005) 4.26
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci U S A (1996) 3.86
Transfection of Plasmodium falciparum within human red blood cells. Proc Natl Acad Sci U S A (1995) 3.70
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. J Exp Med (2004) 3.63
Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Malar J (2003) 3.57
A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum. Mol Biochem Parasitol (2000) 3.12
Transformation of malaria parasites by the spontaneous uptake and expression of DNA from human erythrocytes. Nucleic Acids Res (2001) 3.06
Developmental selection of var gene expression in Plasmodium falciparum. Nature (1998) 2.96
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family. Mol Microbiol (2003) 2.92
Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum. Proc Natl Acad Sci U S A (1996) 2.75
Malaria. Cooperative silencing elements in var genes. Nature (2001) 2.62
A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A. EMBO Rep (2005) 2.53
A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum. Cell (1987) 2.53
Knob-positive and knob-negative Plasmodium falciparum differ in expression of a strain-specific malarial antigen on the surface of infected erythrocytes. J Exp Med (1984) 2.38
Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intron. J Biol Chem (2003) 2.16
A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern. Mol Microbiol (2003) 2.09
DNA replication-independent silencing in S. cerevisiae. Science (2001) 2.03
Variable var transition rates underlie antigenic variation in malaria. Proc Natl Acad Sci U S A (2004) 1.97
Establishment of transcriptional silencing in the absence of DNA replication. Science (2001) 1.93
Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations. Proc Natl Acad Sci U S A (2005) 1.85
A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J (2002) 1.69
The 3D7var5.2 (var COMMON) type var gene family is commonly expressed in non-placental Plasmodium falciparum malaria. Mol Biochem Parasitol (2003) 1.61
Cooperation at a distance between silencers and proto-silencers at the yeast HML locus. EMBO J (1996) 1.50
A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron. Eukaryot Cell (2005) 1.33
Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples. Exp Parasitol (1996) 1.25
Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum. Mol Biochem Parasitol (1999) 1.21
Topology and replication of a nuclear episomal plasmid in the rodent malaria Plasmodium berghei. Nucleic Acids Res (2002) 0.88
Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. PLoS Pathog (2006) 2.18
Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci U S A (2007) 2.11
Multiple roles for separase auto-cleavage during the G2/M transition. Nat Cell Biol (2005) 1.80
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites. EMBO Rep (2007) 1.62
Variable switching rates of malaria virulence genes are associated with chromosomal position. Mol Microbiol (2007) 1.45
Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J Cell Biol (2010) 1.44
Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies. J Exp Med (2013) 1.31
PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum. Int J Biochem Cell Biol (2008) 1.27
Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. Int J Parasitol (2006) 1.24
Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum. Proc Natl Acad Sci U S A (2012) 1.22
Dengue reporter virus particles for measuring neutralizing antibodies against each of the four dengue serotypes. PLoS One (2011) 1.20
Variant antigen gene expression in malaria. Cell Microbiol (2006) 1.20
Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One (2011) 1.20
Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg (2007) 1.15
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. Int J Parasitol (2008) 1.13
Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance. PLoS Pathog (2008) 1.06
Clonally variant gene families in Plasmodium falciparum share a common activation factor. Mol Microbiol (2009) 1.02
Var Gene promoter activation in clonal Plasmodium falciparum isolates follows a hierarchy and suggests a conserved switching program that is independent of genetic background. J Infect Dis (2011) 0.98
Erasing the epigenetic memory and beginning to switch--the onset of antigenic switching of var genes in Plasmodium falciparum. PLoS One (2012) 0.97
3D nuclear architecture reveals coupled cell cycle dynamics of chromatin and nuclear pores in the malaria parasite Plasmodium falciparum. Cell Microbiol (2011) 0.96
Insulator-like pairing elements regulate silencing and mutually exclusive expression in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A (2012) 0.95
PfSec13 is an unusual chromatin-associated nucleoporin of Plasmodium falciparum that is essential for parasite proliferation in human erythrocytes. J Cell Sci (2013) 0.86
Antigenic variation by protozoan parasites: insights from Babesia bovis. Mol Microbiol (2006) 0.85
The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol (2009) 0.84
Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions. Eukaryot Cell (2011) 0.84
Deciphering the export pathway of malaria surface proteins. Trends Parasitol (2006) 0.83
A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes. Nucleic Acids Res (2012) 0.81
3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. J Med Chem (2012) 0.81
Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine. Antimicrob Agents Chemother (2013) 0.78
High resolution 3D perspective of Plasmodium biology: advancing into a new era. Trends Parasitol (2011) 0.77
P. falciparum cpn20 is a bona fide co-chaperonin that can replace GroES in E. coli. PLoS One (2013) 0.77
Calling all antigens. Nat Med (2010) 0.75