Published in Gene Expr Patterns on February 02, 2006
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol (2011) 2.67
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol (2010) 2.47
Biology of claudins. Am J Physiol Renal Physiol (2008) 2.17
Alterations in intestinal permeability. Gut (2006) 2.17
Claudins and the modulation of tight junction permeability. Physiol Rev (2013) 2.05
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One (2012) 1.59
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol (2011) 1.58
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell (2008) 1.53
Inflammatory bowel disease: is it really just another break in the wall? Gut (2007) 1.46
Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol (2011) 1.38
Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene (2011) 1.29
Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol (2013) 1.20
Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol (2011) 1.18
Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins. Am J Physiol Renal Physiol (2006) 1.13
Tumour necrosis factor--induced loss of intestinal barrier function requires TNFR1 and TNFR2 signalling in a mouse model of total parenteral nutrition. J Physiol (2013) 1.12
Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J Comp Physiol B (2010) 1.09
Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A (2010) 1.08
Claudins in intestines: Distribution and functional significance in health and diseases. Tissue Barriers (2013) 1.07
Tight junctions in lung cancer and lung metastasis: a review. Int J Clin Exp Pathol (2012) 1.05
Claudins in lung diseases. Respir Res (2011) 1.05
Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Mol Pharmacol (2013) 1.03
Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol (2011) 1.01
Regulation of intestinal barrier function by signal transducer and activator of transcription 5b. Gut (2008) 0.99
Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin. Infect Immun (2009) 0.98
Salmonella infection upregulates the leaky protein claudin-2 in intestinal epithelial cells. PLoS One (2013) 0.98
Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo. Mol Cell Biol (2006) 0.97
Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo. Peptides (2008) 0.95
Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers. J Pharmacol Exp Ther (2015) 0.93
Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin. MBio (2013) 0.92
Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Mol Cell Biol (2013) 0.91
Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One (2014) 0.88
Specificity of interaction between clostridium perfringens enterotoxin and claudin-family tight junction proteins. Toxins (Basel) (2010) 0.88
Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil. PLoS One (2016) 0.87
Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. PLoS One (2015) 0.87
Claudins reign: The claudin/EMP/PMP22/γ channel protein family in C. elegans. Tissue Barriers (2013) 0.87
Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol (2014) 0.86
Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Mucosal Immunol (2014) 0.86
Claudins in teleost fishes. Tissue Barriers (2013) 0.85
Claudin-2-dependent paracellular channels are dynamically gated. Elife (2015) 0.85
Tight junction CLDN2 gene is a direct target of the vitamin D receptor. Sci Rep (2015) 0.85
Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. PLoS One (2013) 0.84
Epithelial junctions and polarity: complexes and kinases. Curr Opin Nephrol Hypertens (2008) 0.82
Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine. Gut Pathog (2013) 0.82
Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Expression patterns of claudin family of tight-junction proteins in the mouse prostate. Histochem Cell Biol (2007) 0.81
Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis. PLoS One (2010) 0.81
Vitamin D, Vitamin D Receptor, and Tissue Barriers. Tissue Barriers (2013) 0.81
Deoxynivalenol Impairs Weight Gain and Affects Markers of Gut Health after Low-Dose, Short-Term Exposure of Growing Pigs. Toxins (Basel) (2015) 0.81
Molecular aspects of tight junction barrier function. Curr Opin Pharmacol (2014) 0.81
Comparative characterization of mouse rectum CMT93-I and -II cells by expression of claudin isoforms and tight junction morphology and function. Histochem Cell Biol (2007) 0.79
Claudin-4 undergoes age-dependent change in cellular localization on pig jejunal villous epithelial cells, independent of bacterial colonization. Mediators Inflamm (2015) 0.78
HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation. Am J Pathol (2015) 0.78
Conceptual barriers to understanding physical barriers. Semin Cell Dev Biol (2015) 0.78
L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. PLoS One (2014) 0.78
CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice. Cell Mol Gastroenterol Hepatol (2017) 0.78
Emerging multifunctional roles of Claudin tight junction proteins in bone. Endocrinology (2014) 0.77
Claudins: vital partners in transcellular and paracellular transport coupling. Pflugers Arch (2016) 0.77
The tight junction protein claudin-1 influences cranial neural crest cell emigration. Mech Dev (2012) 0.77
Transcriptome analysis reveals regional and temporal differences in mucosal immune system development in the small intestine of neonatal calves. BMC Genomics (2016) 0.77
Urinary Claudin-2 Measurements as a Predictor of Necrotizing Enterocolitis: A Pilot Study. J Neonatal Surg (2015) 0.76
Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. Sci Rep (2015) 0.76
Claudin 7 is reduced in uterine epithelial cells during early pregnancy in the rat. Histochem Cell Biol (2012) 0.75
Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. PLoS One (2014) 0.75
Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin. MBio (2016) 0.75
Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets. J Anim Sci Biotechnol (2017) 0.75
Intestinal barrier analysis by assessment of mucins, tight junctions, and α-defensins in healthy C57BL/6J and BALB/cJ mice. Tissue Barriers (2016) 0.75
Intestinal absorption and renal reabsorption of calcium throughout postnatal development. Exp Biol Med (Maywood) (2017) 0.75
Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development. Sci Rep (2017) 0.75
Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. Lab Invest (2016) 0.75
Myrrh exerts barrier-stabilising and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells. Int J Colorectal Dis (2016) 0.75
Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation. Ann N Y Acad Sci (2017) 0.75
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe (2017) 0.75
Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets. Sci Rep (2017) 0.75
Claudins and epithelial paracellular transport. Annu Rev Physiol (2006) 4.79
Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol (2002) 3.59
First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med (2012) 3.56
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
The projected timing of climate departure from recent variability. Nature (2013) 3.00
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet (2003) 2.36
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol (2003) 2.31
Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials (2003) 2.27
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell (2009) 2.10
Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet (2006) 2.05
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci (2009) 1.96
Setting up a selective barrier at the apical junction complex. Curr Opin Cell Biol (2004) 1.93
Intestinal malrotation in children: a problem-solving approach to the upper gastrointestinal series. Radiographics (2006) 1.85
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol (2006) 1.84
Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol (2002) 1.70
SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. Proc Natl Acad Sci U S A (2009) 1.61
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell (2011) 1.60
The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction. J Biomed Mater Res A (2010) 1.48
Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells. J Biomed Mater Res A (2007) 1.47
Maternal circulating endothelial progenitor cells in normal singleton and twin pregnancy. Am J Obstet Gynecol (2008) 1.42
In vivo leukocyte cytokine mRNA responses to biomaterials are dependent on surface chemistry. J Biomed Mater Res A (2003) 1.42
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties. Mol Biol Cell (2006) 1.40
Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface. J Mol Biol (2005) 1.39
Palmitoylation of claudins is required for efficient tight-junction localization. J Cell Sci (2005) 1.36
Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci U S A (2002) 1.34
Characterization of topographical effects on macrophage behavior in a foreign body response model. Biomaterials (2010) 1.33
The attrition of young physician-scientists: problems and potential solutions. Gastroenterology (2007) 1.32
17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia. J Clin Invest (2008) 1.32
Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. J Biol Chem (2007) 1.32
Giant cell formation and function. Curr Opin Hematol (2009) 1.30
Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. Am J Physiol Gastrointest Liver Physiol (2007) 1.29
Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol (2011) 1.28
Occludin is required for cytokine-induced regulation of tight junction barriers. J Cell Sci (2010) 1.26
Dimerization of the scaffolding protein ZO-1 through the second PDZ domain. J Biol Chem (2006) 1.24
Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials. J Biomed Mater Res A (2008) 1.18
Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants. Cell Microbiol (2007) 1.17
Oxidative mechanisms of poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo and in vitro correlations. J Biomed Mater Res A (2004) 1.15
Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. J Biol Chem (2010) 1.10
Quantitative in vivo cytokine analysis at synthetic biomaterial implant sites. J Biomed Mater Res A (2009) 1.10
Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion. J Biomed Mater Res A (2005) 1.10
Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip. J Biomater Sci Polym Ed (2004) 1.09
Macrophage fusion and multinucleated giant cells of inflammation. Adv Exp Med Biol (2011) 1.09
Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation. J Biomed Mater Res A (2008) 1.09
Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J Clin Invest (2013) 1.09
Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exp Mol Pathol (2005) 1.08
Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1. J Cell Sci (2013) 1.07
Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods. J Biomed Mater Res A (2007) 1.05
alpha subunit partners to beta1 and beta2 integrins during IL-4-induced foreign body giant cell formation. J Biomed Mater Res A (2007) 1.04
The role of claudins in determining paracellular charge selectivity. Proc Am Thorac Soc (2004) 1.04
Student Research Award in the Undergraduate Degree Candidate category, 30th Annual Meeting of the Society for Biomaterials, Memphis, Tennessee, April 27-30, 2005. Monocyte/lymphocyte interactions and the foreign body response: in vitro effects of biomaterial surface chemistry. J Biomed Mater Res A (2005) 1.03
The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1. J Biol Chem (2011) 1.03
Lymphocyte/macrophage interactions: biomaterial surface-dependent cytokine, chemokine, and matrix protein production. J Biomed Mater Res A (2008) 1.03
Domain swapping within PDZ2 is responsible for dimerization of ZO proteins. J Biol Chem (2007) 1.02
Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes. J Cell Sci (2012) 1.02
Maternal arterial stiffness in pregnancies affected by preeclampsia. Am J Physiol Heart Circ Physiol (2009) 1.00
Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation. J Biomed Mater Res A (2006) 1.00
Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion. J Cell Sci (2013) 0.99
In vitro cytotoxicity evaluation of biomedical nanoparticles and their extracts. J Biomed Mater Res A (2010) 0.99
Modification of surface properties of biomaterials influences the ability of Candida albicans to form biofilms. Appl Environ Microbiol (2005) 0.99
Quality improvement initiative to reduce serious safety events and improve patient safety culture. Pediatrics (2012) 0.98
Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery. J Control Release (2002) 0.98
Combined radiofrequency ablation and doxorubicin-eluting polymer implants for liver cancer treatment. J Biomed Mater Res A (2007) 0.97
Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022. Am J Pathol (2003) 0.96
Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation. Biomaterials (2012) 0.96
A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells. Traffic (2008) 0.96
Poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo studies. J Biomed Mater Res A (2004) 0.96
Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages. J Lab Clin Med (2002) 0.96
Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem (2010) 0.95
S. epidermidis biofilm formation: effects of biomaterial surface chemistry and serum proteins. J Biomed Mater Res A (2007) 0.95
The foreign body reaction in T-cell-deficient mice. J Biomed Mater Res A (2009) 0.94
Effects of biomaterial surface chemistry on the adhesion and biofilm formation of Staphylococcus epidermidis in vitro. J Biomed Mater Res A (2006) 0.94
Paracrine and juxtacrine lymphocyte enhancement of adherent macrophage and foreign body giant cell activation. J Biomed Mater Res A (2009) 0.94
T cell subset distributions following primary and secondary implantation at subcutaneous biomaterial implant sites. J Biomed Mater Res A (2008) 0.94
Extracellular microbial synthesis of biocompatible CdTe quantum dots. Acta Biomater (2010) 0.93
Macroporous condensed poly(tetrafluoroethylene). I. In vivo inflammatory response and healing characteristics. J Biomed Mater Res A (2006) 0.93
Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing. Acta Biomater (2012) 0.92
Macrophage behavior on surface-modified polyurethanes. J Biomater Sci Polym Ed (2004) 0.92
Surface chemistry mediates adhesive structure, cytoskeletal organization, and fusion of macrophages. J Biomed Mater Res A (2004) 0.92
Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes/macrophages on biomaterials. J Mater Sci Mater Med (2003) 0.90
Confocal imaging of biofilm formation process using fluoroprobed Escherichia coli and fluoro-stained exopolysaccharide. J Biomed Mater Res A (2004) 0.89
Inhibition of macrophage development and foreign body giant cell formation by hydrophilic interpenetrating polymer network. J Biomed Mater Res A (2004) 0.89
Shear stress and material surface effects on adherent human monocyte apoptosis. J Biomed Mater Res (2002) 0.88
Adherent endotoxin mediates biological responses of titanium particles without stimulating their phagocytosis. J Orthop Res (2002) 0.88
Lymphocyte adhesion and interactions with biomaterial adherent macrophages and foreign body giant cells. J Biomed Mater Res A (2009) 0.88
Tight junctions. Curr Biol (2008) 0.88
Foreign body-type multinucleated giant cells induced by interleukin-4 express select lymphocyte co-stimulatory molecules and are phenotypically distinct from osteoclasts and dendritic cells. Exp Mol Pathol (2011) 0.88
Defective adenosine-stimulated cAMP production in cystic fibrosis airway epithelia: a novel role for CFTR in cell signaling. FASEB J (2011) 0.88
Effect of surgical wound classification on biologic graft performance in complex hernia repair: an experimental study. Surgery (2012) 0.87
Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. Exp Mol Pathol (2007) 0.86
Enzymatic degradation of poly(ether urethane) and poly(carbonate urethane) by cholesterol esterase. Biomaterials (2006) 0.86
Effect of strain and strain rate on fatigue-accelerated biodegradation of polyurethane. J Biomed Mater Res A (2003) 0.86
Instability of self-assembled monolayers as a model material system for macrophage/FBGC cellular behavior. J Biomed Mater Res A (2008) 0.85
Experimental versus predicted affinities for ligand binding to estrogen receptor: iterative selection and rescoring of docked poses systematically improves the correlation. J Comput Aided Mol Des (2013) 0.85