Published in J Mol Biol on September 09, 2005
The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol (2008) 2.42
Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet (2006) 2.05
Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol (2010) 1.87
Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. J Biol Chem (2009) 1.81
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol (2011) 1.58
Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem (2008) 1.55
Occludin: one protein, many forms. Mol Cell Biol (2011) 1.53
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties. Mol Biol Cell (2006) 1.40
Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol (2008) 1.38
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS (2011) 1.33
A33 antigen displays persistent surface expression. Cancer Immunol Immunother (2008) 1.26
Architecture of tight junctions and principles of molecular composition. Semin Cell Dev Biol (2014) 1.21
Tight junction proteins: from barrier to tumorigenesis. Cancer Lett (2013) 1.14
Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach. J Proteome Res (2009) 1.05
The role of molecular remodeling in differential regulation of tight junction permeability. Semin Cell Dev Biol (2014) 1.02
Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry. J Virol (2010) 1.00
Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell (2013) 0.98
Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem (2010) 0.95
The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability. Proc Natl Acad Sci U S A (2012) 0.93
Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J Biol Chem (2009) 0.90
Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain. Brain Res (2006) 0.90
Applying an empirical hydropathic forcefield in refinement may improve low-resolution protein X-ray crystal structures. PLoS One (2011) 0.87
Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. PLoS One (2015) 0.87
Breaking barriers. New insights into airway epithelial barrier function in health and disease. Am J Respir Cell Mol Biol (2014) 0.87
CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity. Cell Commun Signal (2013) 0.86
Occludin localizes to centrosomes and modifies mitotic entry. J Biol Chem (2011) 0.84
Endothelial Barrier and Its Abnormalities in Cardiovascular Disease. Front Physiol (2015) 0.83
Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction. J Mol Med (Berl) (2014) 0.83
Upregulation of the tight junction protein occludin: effects on ventilation-induced lung injury and mechanisms of action. BMC Pulm Med (2014) 0.82
Junctional proteins of the blood-brain barrier: New insights into function and dysfunction. Tissue Barriers (2016) 0.80
Real-time analysis of the effects of toxic, therapeutic and sub-therapeutic concentrations of digitoxin on lung cancer cells. Biosens Bioelectron (2014) 0.79
Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function. Exp Cell Res (2017) 0.76
ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. J Cell Sci (2016) 0.76
A complex affair: Attraction and repulsion make occludin and ZO-1 function! Tissue Barriers (2013) 0.76
A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells. Endocr Relat Cancer (2015) 0.75
Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nat Commun (2017) 0.75
Endothelial Cell Signaling and Ventilator-Induced Lung Injury (VILI): Molecular Mechanisms, Genomic Analyses & Therapeutic Targets. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation. FASEB J (2015) 0.75
Calcitonin Receptor-Zonula Occludens-1 Interaction Is Critical for Calcitonin-Stimulated Prostate Cancer Metastasis. PLoS One (2016) 0.75
Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability. J Cell Biochem (2015) 0.75
Claudins and epithelial paracellular transport. Annu Rev Physiol (2006) 4.79
First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med (2012) 3.56
The projected timing of climate departure from recent variability. Nature (2013) 3.00
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet (2003) 2.36
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol (2003) 2.31
Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials (2003) 2.27
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell (2009) 2.10
Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet (2006) 2.05
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci (2009) 1.96
Setting up a selective barrier at the apical junction complex. Curr Opin Cell Biol (2004) 1.93
Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy. Mol Ther (2007) 1.91
Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr Patterns (2006) 1.86
Intestinal malrotation in children: a problem-solving approach to the upper gastrointestinal series. Radiographics (2006) 1.85
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol (2006) 1.84
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol (2003) 1.83
Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol (2004) 1.74
Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol (2002) 1.70
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell (2011) 1.60
Therapeutic target metabolism observed using hyperpolarized 15N choline. J Am Chem Soc (2008) 1.60
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med (2014) 1.49
The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction. J Biomed Mater Res A (2010) 1.48
Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells. J Biomed Mater Res A (2007) 1.47
Maternal circulating endothelial progenitor cells in normal singleton and twin pregnancy. Am J Obstet Gynecol (2008) 1.42
In vivo leukocyte cytokine mRNA responses to biomaterials are dependent on surface chemistry. J Biomed Mater Res A (2003) 1.42
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties. Mol Biol Cell (2006) 1.40
The TRAPP complex: insights into its architecture and function. Traffic (2008) 1.40
Palmitoylation of claudins is required for efficient tight-junction localization. J Cell Sci (2005) 1.36
Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci U S A (2002) 1.34
Characterization of topographical effects on macrophage behavior in a foreign body response model. Biomaterials (2010) 1.33
The attrition of young physician-scientists: problems and potential solutions. Gastroenterology (2007) 1.32
Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. J Biol Chem (2007) 1.32
Giant cell formation and function. Curr Opin Hematol (2009) 1.30
Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. Am J Physiol Gastrointest Liver Physiol (2007) 1.29
Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol (2011) 1.28
Occludin is required for cytokine-induced regulation of tight junction barriers. J Cell Sci (2010) 1.26
Dimerization of the scaffolding protein ZO-1 through the second PDZ domain. J Biol Chem (2006) 1.24
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides. J Med Chem (2007) 1.19
Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials. J Biomed Mater Res A (2008) 1.18
Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants. Cell Microbiol (2007) 1.17
Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol (2006) 1.17
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Res (2006) 1.15
Oxidative mechanisms of poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo and in vitro correlations. J Biomed Mater Res A (2004) 1.15
Binding of ATP to TK1-like enzymes is associated with a conformational change in the quaternary structure. J Mol Biol (2007) 1.12
Structural basis for substrate promiscuity of dCK. J Mol Biol (2008) 1.11
Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. J Biol Chem (2010) 1.10
Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. J Biol Chem (2011) 1.10
Quantitative in vivo cytokine analysis at synthetic biomaterial implant sites. J Biomed Mater Res A (2009) 1.10
Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion. J Biomed Mater Res A (2005) 1.10
Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation. J Biomed Mater Res A (2008) 1.09
Substrate-induced conformational changes in human UMP/CMP kinase. J Biol Chem (2004) 1.09
Macrophage fusion and multinucleated giant cells of inflammation. Adv Exp Med Biol (2011) 1.09
Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip. J Biomater Sci Polym Ed (2004) 1.09
Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J Clin Invest (2013) 1.09
Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exp Mol Pathol (2005) 1.08
Structural characterization of the closed conformation of mouse guanylate kinase. J Biol Chem (2002) 1.07
Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1. J Cell Sci (2013) 1.07
Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods. J Biomed Mater Res A (2007) 1.05
alpha subunit partners to beta1 and beta2 integrins during IL-4-induced foreign body giant cell formation. J Biomed Mater Res A (2007) 1.04
The role of claudins in determining paracellular charge selectivity. Proc Am Thorac Soc (2004) 1.04
Student Research Award in the Undergraduate Degree Candidate category, 30th Annual Meeting of the Society for Biomaterials, Memphis, Tennessee, April 27-30, 2005. Monocyte/lymphocyte interactions and the foreign body response: in vitro effects of biomaterial surface chemistry. J Biomed Mater Res A (2005) 1.03
The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1. J Biol Chem (2011) 1.03
Lymphocyte/macrophage interactions: biomaterial surface-dependent cytokine, chemokine, and matrix protein production. J Biomed Mater Res A (2008) 1.03
Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization. Biochemistry (2006) 1.02
Domain swapping within PDZ2 is responsible for dimerization of ZO proteins. J Biol Chem (2007) 1.02
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS Lett (2008) 1.02
Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes. J Cell Sci (2012) 1.02
Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates. J Biol Chem (2010) 1.01
Maternal arterial stiffness in pregnancies affected by preeclampsia. Am J Physiol Heart Circ Physiol (2009) 1.00
Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation. J Biomed Mater Res A (2006) 1.00
Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion. J Cell Sci (2013) 0.99
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry (2009) 0.99
Modification of surface properties of biomaterials influences the ability of Candida albicans to form biofilms. Appl Environ Microbiol (2005) 0.99
In vitro cytotoxicity evaluation of biomedical nanoparticles and their extracts. J Biomed Mater Res A (2010) 0.99
Quality improvement initiative to reduce serious safety events and improve patient safety culture. Pediatrics (2012) 0.98
The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol Cell Biol (2008) 0.98
Regulation of epithelial permeability by the actin cytoskeleton. Cytoskeleton (Hoboken) (2011) 0.98
Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery. J Control Release (2002) 0.98
Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance. J Neurosci (2010) 0.97
Combined radiofrequency ablation and doxorubicin-eluting polymer implants for liver cancer treatment. J Biomed Mater Res A (2007) 0.97
Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022. Am J Pathol (2003) 0.96
A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells. Traffic (2008) 0.96
Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation. Biomaterials (2012) 0.96
Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages. J Lab Clin Med (2002) 0.96
Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry (2010) 0.96
Poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo studies. J Biomed Mater Res A (2004) 0.96
ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions. J Cell Sci (2013) 0.96
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes. Structure (2007) 0.95
Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem (2010) 0.95