Published in Hum Mol Genet on August 15, 2003
A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol (2010) 3.09
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
Biology of claudins. Am J Physiol Renal Physiol (2008) 2.17
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest (2011) 2.17
Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol (2008) 2.13
Claudins and the modulation of tight junction permeability. Physiol Rev (2013) 2.05
Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet (2006) 2.05
The claudins. Genome Biol (2009) 1.76
Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. Nat Genet (2009) 1.73
Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia. J Cell Biol (2004) 1.47
Claudin-14 regulates renal Ca⁺⁺ transport in response to CaSR signalling via a novel microRNA pathway. EMBO J (2012) 1.40
Autosomal recessive nonsyndromic deafness genes: a review. Front Biosci (Landmark Ed) (2012) 1.39
A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Proc Natl Acad Sci U S A (2005) 1.34
Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. Am J Hum Genet (2010) 1.31
A claudin-9-based ion permeability barrier is essential for hearing. PLoS Genet (2009) 1.29
Regulation and roles for claudin-family tight junction proteins. IUBMB Life (2009) 1.26
Potassium ion movement in the inner ear: insights from genetic disease and mouse models. Physiology (Bethesda) (2009) 1.18
Tight junction proteins: from barrier to tumorigenesis. Cancer Lett (2013) 1.14
Claudins and the kidney. Annu Rev Physiol (2012) 1.11
Differential expression of claudin tight junction proteins in the human cortical nephron. Nephrol Dial Transplant (2010) 1.11
Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J Clin Invest (2013) 1.09
Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear. J Neurosci (2010) 1.08
Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development. J Assoc Res Otolaryngol (2006) 1.08
Double gene deletion reveals lack of cooperation between claudin 11 and claudin 14 tight junction proteins. Cell Tissue Res (2008) 1.07
The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Genetics (2010) 1.06
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2. J Membr Biol (2007) 1.05
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics (2006) 1.04
What's new in ion transports in the cochlea? Pflugers Arch (2006) 1.03
Inner ear supporting cells: rethinking the silent majority. Semin Cell Dev Biol (2013) 1.01
Hepatitis C Virus entry: the early steps in the viral replication cycle. Virol J (2009) 1.01
Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol (2007) 1.00
Claudins: control of barrier function and regulation in response to oxidant stress. Antioxid Redox Signal (2011) 1.00
A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1. Hum Genet (2004) 0.99
ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells. Hum Mol Genet (2014) 0.99
Human hereditary hearing impairment: mouse models can help to solve the puzzle. Hum Genet (2008) 0.96
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA. Mamm Genome (2010) 0.96
Activation of the Ca(2+)-sensing receptor increases renal claudin-14 expression and urinary Ca(2+) excretion. Am J Physiol Renal Physiol (2013) 0.95
Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor. J Neurosci (2015) 0.95
Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization. Mol Carcinog (2009) 0.95
Tight junction composition is altered in the epithelium of polycystic kidneys. J Pathol (2008) 0.95
New aspects of the molecular constituents of tissue barriers. J Neural Transm (Vienna) (2010) 0.93
Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. PLoS One (2012) 0.93
Function and regulation of claudins in the thick ascending limb of Henle. Pflugers Arch (2008) 0.92
Regulation of electromotility in the cochlear outer hair cell. J Physiol (2006) 0.92
Genetics of hearing and deafness. Anat Rec (Hoboken) (2012) 0.91
Changes in the adult vertebrate auditory sensory epithelium after trauma. Hear Res (2012) 0.91
Claudin-14 underlies Ca⁺⁺-sensing receptor-mediated Ca⁺⁺ metabolism via NFAT-microRNA-based mechanisms. J Am Soc Nephrol (2013) 0.90
Osteoblasts express claudins and tight junction-associated proteins. Histochem Cell Biol (2008) 0.90
Claudins in renal physiology and disease. Pediatr Nephrol (2011) 0.89
Novel CLDN14 mutations in Pakistani families with autosomal recessive non-syndromic hearing loss. Am J Med Genet A (2012) 0.88
TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signaling in HT-29/B6 cells. Mucosal Immunol (2013) 0.88
Breaking barriers. New insights into airway epithelial barrier function in health and disease. Am J Respir Cell Mol Biol (2014) 0.87
Mutations in CLDN14 are associated with different hearing thresholds. J Hum Genet (2010) 0.87
Possible involvement of tight junctions, extracellular matrix and nuclear receptors in epithelial differentiation. J Biomed Biotechnol (2011) 0.87
A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet (2011) 0.87
Epigenetic regulation of microRNAs controlling CLDN14 expression as a mechanism for renal calcium handling. J Am Soc Nephrol (2014) 0.86
Genetic analysis of genes related to tight junction function in the Korean population with non-syndromic hearing loss. PLoS One (2014) 0.86
Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells. Biol Open (2014) 0.86
Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol (2014) 0.85
Cadherins as targets for genetic diseases. Cold Spring Harb Perspect Biol (2010) 0.85
Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator. J Biol Chem (2011) 0.85
Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization. Mol Biol Cell (2015) 0.84
Regulation of claudins in blood-tissue barriers under physiological and pathological states. Tissue Barriers (2013) 0.84
Lecture: New light on the role of claudins in the kidney. Organogenesis (2012) 0.84
ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42. Biol Open (2015) 0.84
Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice. PLoS One (2015) 0.83
Critical role of tight junctions in drug delivery across epithelial and endothelial cell layers. J Membr Biol (2005) 0.82
Claudin family members exhibit unique temporal and spatial expression boundaries in the chick embryo. Tissue Barriers (2013) 0.82
Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation. J Bone Miner Res (2012) 0.82
Corticomedullary difference in the effects of dietary Ca(2+) on tight junction properties in thick ascending limbs of Henle's loop. Pflugers Arch (2015) 0.82
The yin and yang of claudin-14 function in human diseases. Ann N Y Acad Sci (2012) 0.81
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. Neural Regen Res (2014) 0.81
Cell-cell junctions: a target of acoustic overstimulation in the sensory epithelium of the cochlea. BMC Neurosci (2012) 0.81
Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth. PLoS One (2013) 0.80
Phenotypic variability of CLDN14 mutations causing DFNB29 hearing loss in the Pakistani population. J Hum Genet (2012) 0.80
Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells. Sci Rep (2015) 0.79
Genetics of auditory mechano-electrical transduction. Pflugers Arch (2014) 0.79
Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators. Mol Biol Rep (2009) 0.79
Altered transendothelial transport of hormones as a contributor to diabetes. Diabetes Metab J (2014) 0.78
DFNB86, a novel autosomal recessive non-syndromic deafness locus on chromosome 16p13.3. Clin Genet (2011) 0.78
Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss. Hum Genet (2015) 0.78
Progressive Hearing Loss in Mice Carrying a Mutation in Usp53. J Neurosci (2015) 0.78
Tricellular Tight Junctions in the Inner Ear. Biomed Res Int (2016) 0.77
Emerging multifunctional roles of Claudin tight junction proteins in bone. Endocrinology (2014) 0.77
The role of claudin in hypercalciuric nephrolithiasis. Curr Urol Rep (2013) 0.77
Claudins: vital partners in transcellular and paracellular transport coupling. Pflugers Arch (2016) 0.77
Mechanisms of otoconia and otolith development. Dev Dyn (2014) 0.77
A proposed route to independent measurements of tight junction conductance at discrete cell junctions. Tissue Barriers (2015) 0.77
A "Tric" to tighten cell-cell junctions in the cochlea for hearing. J Clin Invest (2013) 0.77
Do cell junction protein mutations cause an airway phenotype in mice or humans? Am J Respir Cell Mol Biol (2011) 0.77
Claudins in barrier and transport function-the kidney. Pflugers Arch (2016) 0.76
Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome. Clin Genet (2016) 0.75
QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice. J Assoc Res Otolaryngol (2016) 0.75
A common variant in CLDN14 causes precipitous, prelingual sensorineural hearing loss in multiple families due to founder effect. Hum Genet (2016) 0.75
Congenital sensorineural deafness in dalmatian dogs associated with quantitative trait loci. PLoS One (2013) 0.75
Common variants in CLDN14 are associated with differential excretion of magnesium over calcium in urine. Pflugers Arch (2016) 0.75
Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev Biol (2017) 0.75
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis (2006) 8.17
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med (2005) 5.17
Claudins and epithelial paracellular transport. Annu Rev Physiol (2006) 4.79
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol (2005) 4.79
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet (2005) 4.76
Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis (2010) 4.19
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol (2002) 3.59
First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med (2012) 3.56
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia. Nat Cell Biol (2005) 3.15
Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Nat Genet (2002) 3.10
Physiology and function of the tight junction. Cold Spring Harb Perspect Biol (2009) 3.06
Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A (2010) 3.05
The projected timing of climate departure from recent variability. Nature (2013) 3.00
Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Am J Hum Genet (2010) 2.95
Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response. Proc Natl Acad Sci U S A (2005) 2.84
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73
Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J Neurosci (2003) 2.67
Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development (2004) 2.54
Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet (2012) 2.43
The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15. J Neurosci (2006) 2.41
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol (2003) 2.31
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet (2002) 2.31
Rapid renewal of auditory hair bundles. Nature (2002) 2.28
Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials (2003) 2.27
SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice. PLoS One (2008) 2.27
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature (2003) 2.22
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest (2011) 2.21
Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis (2011) 2.19
PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23. Hum Mol Genet (2003) 2.14
A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation. J Infect Dis (2009) 2.12
Genetic insights into the morphogenesis of inner ear hair cells. Nat Rev Genet (2004) 2.11
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell (2009) 2.10
Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet (2006) 2.05
Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle. Proc Natl Acad Sci U S A (2003) 2.04
Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear. J Assoc Res Otolaryngol (2007) 2.03
Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci U S A (2002) 2.03
Frequency and distribution of GJB2 (connexin 26) and GJB6 (connexin 30) mutations in a large North American repository of deaf probands. Genet Med (2003) 2.00
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann N Y Acad Sci (2009) 1.96
Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell (2010) 1.94
Setting up a selective barrier at the apical junction complex. Curr Opin Cell Biol (2004) 1.93
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci (2004) 1.92
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. J Neurophysiol (2009) 1.89
Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr Patterns (2006) 1.86
Intestinal malrotation in children: a problem-solving approach to the upper gastrointestinal series. Radiographics (2006) 1.85
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol (2006) 1.84
Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development. Dev Biol (2005) 1.82
Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans. Nat Genet (2008) 1.78
Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells. PLoS Biol (2013) 1.77
To knockout in 129 or in C57BL/6: that is the question. Trends Genet (2004) 1.76
Gamma-actin is required for cytoskeletal maintenance but not development. Proc Natl Acad Sci U S A (2009) 1.74
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet (2004) 1.73
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J (2012) 1.71
Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol (2002) 1.70
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm Genome (2007) 1.68
Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem (2007) 1.66
Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract. Infect Immun (2010) 1.64
Nonsyndromic recessive deafness DFNB18 and Usher syndrome type IC are allelic mutations of USHIC. Hum Genet (2002) 1.62
Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell (2011) 1.60
Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm Genome (2007) 1.58
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell (2010) 1.57
Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport. J Cell Biol (2012) 1.57
Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Dev Dyn (2006) 1.54
Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection. Am J Pathol (2006) 1.53
Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses. J Neurosci (2008) 1.53
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A (2002) 1.52
Mutations of MYO6 are associated with recessive deafness, DFNB37. Am J Hum Genet (2003) 1.51
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol (2006) 1.51
The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction. J Biomed Mater Res A (2010) 1.48
Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci (2004) 1.48