Inflammation and neurodegenerative diseases.

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest (2007) 2.48

Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener (2009) 2.23

Regulation of inflammation by short chain fatty acids. Nutrients (2011) 2.15

Reimagining Alzheimer's disease--an age-based hypothesis. J Neurosci (2010) 2.12

Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev (2006) 1.94

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis (2009) 1.60

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol (2008) 1.55

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation (2008) 1.38

Age-related neuroinflammatory changes negatively impact on neuronal function. Front Aging Neurosci (2010) 1.31

Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol (2012) 1.26

Interleukin 18 in the CNS. J Neuroinflammation (2010) 1.26

Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging (2007) 1.26

Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease. J Neuroinflammation (2006) 1.20

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimers Res Ther (2010) 1.20

Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis. Am J Pathol (2008) 1.19

Cellular senescence, ageing and disease. Age (Dordr) (2008) 1.17

Telomere length regulates ISG15 expression in human cells. Aging (Albany NY) (2009) 1.13

A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Curr Alzheimer Res (2007) 1.10

Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death. J Neuroinflammation (2010) 1.10

Immunity and inflammation in neurodegenerative diseases. Am J Neurodegener Dis (2013) 1.08

The changing phenotype of microglia from homeostasis to disease. Transl Neurodegener (2012) 1.06

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J Neuroinflammation (2008) 1.06

Disease-modifying treatments for Alzheimer's disease. Ther Adv Neurol Disord (2011) 1.03

When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes. Front Immunol (2013) 1.03

Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. Brain Res Bull (2007) 1.00

Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions. Immunol Res (2011) 0.99

Oxidative stress and epilepsy: literature review. Oxid Med Cell Longev (2012) 0.98

miRNA-155 upregulation and complement factor H deficits in Down's syndrome. Neuroreport (2012) 0.98

Brain microglia express steroid-converting enzymes in the mouse. J Steroid Biochem Mol Biol (2008) 0.97

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice. J Neuroinflammation (2012) 0.97

ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation. Glia (2012) 0.94

Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behavior. PLoS One (2011) 0.93

Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain. Aging Dis (2010) 0.92

Impact of body mass index on neuronal fiber bundle lengths among healthy older adults. Brain Imaging Behav (2013) 0.91

Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration. Int J Clin Exp Med (2010) 0.91

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. J Biol Chem (2015) 0.91

High TNF-α levels in resting B cells negatively correlate with their response. Exp Gerontol (2014) 0.90

Progress in Alzheimer's disease. J Neurol (2011) 0.90

S100 proteins in cartilage: role in arthritis. Biochim Biophys Acta (2012) 0.90

Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease. Front Pharmacol (2014) 0.89

The inflammatory response to social defeat is increased in older mice. Physiol Behav (2007) 0.89

The effect of treadmill running on passive avoidance learning in animal model of Alzheimer disease. Int J Prev Med (2013) 0.87

Patterns of brain structural connectivity differentiate normal weight from overweight subjects. Neuroimage Clin (2015) 0.87

Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme. Psychopharmacology (Berl) (2008) 0.86

Effects of (-)Epicatechin on the Pathology of APP/PS1 Transgenic Mice. Front Neurol (2014) 0.85

Nucleotides released from Aβ₁₋₄₂ -treated microglial cells increase cell migration and Aβ₁₋₄₂ uptake through P2Y₂ receptor activation. J Neurochem (2012) 0.85

Raft aggregation with specific receptor recruitment is required for microglial phagocytosis of Abeta42. Glia (2009) 0.85

Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. J Neurochem (2009) 0.85

Neuroprotective roles of the P2Y(2) receptor. Purinergic Signal (2012) 0.84

Brain structure and cognitive correlates of body mass index in healthy older adults. Behav Brain Res (2014) 0.84

Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One (2013) 0.84

GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. J Neuroinflammation (2008) 0.84

Age-related neurodegeneration and memory loss in down syndrome. Curr Gerontol Geriatr Res (2012) 0.83

The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. Brain Res (2007) 0.83

Subtype and regional-specific neuroinflammation in sporadic creutzfeldt-jakob disease. Front Aging Neurosci (2014) 0.83

Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders? Clin Microbiol Rev (2015) 0.83

Parkinson's disease. Subcell Biochem (2012) 0.82

Raloxifene suppresses experimental autoimmune encephalomyelitis and NF-κB-dependent CCL20 expression in reactive astrocytes. PLoS One (2014) 0.81

Expression analysis of the TAB2 protein in adult mouse tissues. Inflamm Res (2007) 0.81

Phenotypic profile of alternative activation marker CD163 is different in Alzheimer's and Parkinson's disease. Acta Neuropathol Commun (2014) 0.81

A polymorphism in the upstream regulatory region of the interleukin-1α gene confers differential binding by transcription factors of the AP-1 family. Life Sci (2012) 0.80

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease. Mol Neurobiol (2016) 0.80

Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice. J Neuroinflammation (2016) 0.79

P2Y receptors in Alzheimer's disease. Biol Cell (2014) 0.79

Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells. Neuroimmunomodulation (2008) 0.79

Review: microglia in protein aggregation disorders: friend or foe? Neuropathol Appl Neurobiol (2013) 0.79

Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders. Aging Dis (2015) 0.78

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models. PLoS One (2016) 0.78

P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand. J Neuroinflammation (2012) 0.78

Progress in Alzheimer's disease research in the last year. J Neurol (2013) 0.78

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res (2016) 0.77

Obesity associated with increased brain age from midlife. Neurobiol Aging (2016) 0.76

Axonal Terminals Exposed to Amyloid-β May Not Lead to Pre-Synaptic Axonal Damage. J Alzheimers Dis (2015) 0.76

Systemic and localized extra-central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study. Alzheimers Dement (Amst) (2016) 0.75

Bacoside A: Role in Cigarette Smoking Induced Changes in Brain. Evid Based Complement Alternat Med (2015) 0.75

2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways. Heliyon (2016) 0.75

Cognitive dysfunction in Duchenne muscular dystrophy: a possible role for neuromodulatory immune molecules. J Neurophysiol (2016) 0.75

Active compound of Zingiber cassumunar Roxb. down-regulates the expression of genes involved in joint erosion in a human synovial fibroblast cell line. Afr J Tradit Complement Altern Med (2012) 0.75

An Association Study on IL16 Gene Polymorphisms with the Risk of Sporadic Alzheimer's Disease. Avicenna J Med Biotechnol (2015) 0.75