Caloric restriction and intermittent fasting: two potential diets for successful brain aging.

PubWeight™: 1.94‹?› | Rank: Top 2%

🔗 View Article (PMC 2622429)

Published in Ageing Res Rev on August 08, 2006

Authors

Bronwen Martin1, Mark P Mattson, Stuart Maudsley

Author Affiliations

1: Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. martinbro@grc.nia.nih.gov

Associated clinical trials:

Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness (OPTIMIZE) | NCT02681081

Articles citing this

Hormesis defined. Ageing Res Rev (2007) 3.00

"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell (2008) 2.32

Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A (2009) 2.22

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol (2008) 1.75

Dietary factors, hormesis and health. Ageing Res Rev (2007) 1.50

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci U S A (2006) 1.35

Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance. Am J Physiol Endocrinol Metab (2009) 1.30

Successful cognitive and emotional aging. World Psychiatry (2010) 1.26

Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. Curr Alzheimer Res (2012) 1.19

Optimal body weight for health and longevity: bridging basic, clinical, and population research. Aging Cell (2014) 1.16

Benefits of short-term dietary restriction in mammals. Exp Gerontol (2013) 1.16

Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats. Age (Dordr) (2011) 1.14

Imaging of brain dopamine pathways: implications for understanding obesity. J Addict Med (2009) 1.14

Will calorie restriction work in humans? Aging (Albany NY) (2013) 1.11

Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One (2010) 1.06

Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health. Ann N Y Acad Sci (2012) 1.05

Awareness of hormesis will enhance future research in basic and applied neuroscience. Crit Rev Toxicol (2008) 1.04

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Res (2010) 1.02

Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem (2009) 1.02

Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. Int J Alzheimers Dis (2010) 1.00

Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Histol Histopathol (2008) 0.99

Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease. Neurobiol Dis (2009) 0.97

Calorie restriction: what recent results suggest for the future of ageing research. Eur J Clin Invest (2010) 0.95

Bidirectional metabolic regulation of neurocognitive function. Neurobiol Learn Mem (2011) 0.95

Reduced energy intake: the secret to a long and healthy life? IBS J Sci (2007) 0.93

Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms? Biogerontology (2007) 0.93

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiol Aging (2009) 0.92

Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss. PLoS Genet (2012) 0.92

Caloric restriction: impact upon pituitary function and reproduction. Ageing Res Rev (2008) 0.91

Impact of ramadan intermittent fasting on oxidative stress measured by urinary 15-f(2t)-isoprostane. J Nutr Metab (2012) 0.90

Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose Response (2007) 0.89

Effects of diet on brain plasticity in animal and human studies: mind the gap. Neural Plast (2014) 0.89

Aging, Proteotoxicity, Mitochondria, Glycation, NAD and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox. Front Aging Neurosci (2010) 0.89

Autophagy promotes oligodendrocyte survival and function following dysmyelination in a long-lived myelin mutant. J Neurosci (2013) 0.88

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell (2013) 0.88

Central role of the EGF receptor in neurometabolic aging. Int J Endocrinol (2012) 0.88

Caloric restriction and heart function: is there a sensible link? Acta Pharmacol Sin (2010) 0.88

Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms. Exp Gerontol (2012) 0.87

Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. J Signal Transduct (2010) 0.86

Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. J Inflamm (Lond) (2011) 0.85

Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction. CNS Neurol Disord Drug Targets (2010) 0.85

GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats. PLoS One (2012) 0.85

Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment. Hippocampus (2010) 0.85

Impaired adaptive cellular responses to oxidative stress and the pathogenesis of Alzheimer's disease. Antioxid Redox Signal (2011) 0.85

Caloric restriction can improve learning ability in C57/BL mice via regulation of the insulin-PI3K/Akt signaling pathway. Neurol Sci (2014) 0.85

Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis. Am J Physiol Endocrinol Metab (2014) 0.84

Late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus. PLoS One (2012) 0.82

Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice. Toxicol Appl Pharmacol (2013) 0.82

Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Eur J Pharmacol (2013) 0.82

Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice. Physiol Rep (2015) 0.81

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators. J Gerontol A Biol Sci Med Sci (2013) 0.81

Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats. J Card Fail (2010) 0.81

Increasing Neuroplasticity to Bolster Chronic Pain Treatment: A Role for Intermittent Fasting and Glucose Administration? J Pain (2016) 0.81

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordr) (2009) 0.81

Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice. Exp Gerontol (2013) 0.80

Fasting Induces IL-1 Resistance and Free-Fatty Acid-Mediated Up-Regulation of IL-1R2 and IL-1RA. Front Immunol (2014) 0.80

Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. PLoS One (2014) 0.80

Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age. Age (Dordr) (2014) 0.79

Intermittent fasting results in tissue-specific changes in bioenergetics and redox state. PLoS One (2015) 0.79

Caloric restriction: beneficial effects on brain aging and Alzheimer's disease. Mamm Genome (2016) 0.78

Environment, leptin sensitivity, and hypothalamic plasticity. Neural Plast (2013) 0.78

Metabolic context regulates distinct hypothalamic transcriptional responses to antiaging interventions. Int J Endocrinol (2012) 0.77

The effect of fasting on indicators of muscle damage. Exp Gerontol (2012) 0.76

Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity. PLoS One (2015) 0.76

Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice. PLoS One (2016) 0.76

Effects of prolonged fasting on fatigue and quality of life in patients with multiple sclerosis. Neurol Sci (2016) 0.76

GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Front Endocrinol (Lausanne) (2016) 0.75

Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats. Biochem Biophys Res Commun (2011) 0.75

The Effects of Calorie Restriction in Depression and Potential Mechanisms. Curr Neuropharmacol (2015) 0.75

Eating less suppresses microRNA assassins in the brain. Aging (Albany NY) (2011) 0.75

Effects of chronic caloric restriction on kidney and heart redox status and antioxidant enzyme activities in Wistar rats. BMB Rep (2012) 0.75

A Single Bout of Fasting (24 h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats. Mediators Inflamm (2016) 0.75

Behavioral and Stereological Analysis of the Effects of Intermittent Feeding Diet on the Orally Administrated MDMA ("ecstasy") in Mice. Innov Clin Neurosci (2017) 0.75

β hydroxybutyrate levels in serum and cerebrospinal fluid under ketone body metabolism in rats. Exp Anim (2017) 0.75

Caloric Restriction and Formalin-Induced Inflammation: An Experimental Study in Rat Model. Iran Red Crescent Med J (2015) 0.75

Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases. Pharmaceuticals (Basel) (2009) 0.75

Intermittent fasting could ameliorate cognitive function against distress by regulation of inflammatory response pathway. J Adv Res (2017) 0.75

Differential Regulation of Hippocampal IGF-1-Associated Signaling Proteins by Dietary Restriction in Aging Mouse. Cell Mol Neurobiol (2016) 0.75

Articles cited by this

(truncated to the top 100)

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54

A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell (1998) 18.32

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

Live or let die: the cell's response to p53. Nat Rev Cancer (2002) 15.06

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature (2003) 14.49

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39

Oxidative stress, caloric restriction, and aging. Science (1996) 11.07

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev (1994) 10.44

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58

Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature (2001) 8.44

Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics (1987) 7.05

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition (1992) 6.77

Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol (2001) 5.81

Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem (2001) 5.74

Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell (2003) 5.39

Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev (2000) 5.36

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet (1999) 4.93

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest (2001) 4.93

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A (1999) 4.91

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80

Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science (2000) 4.72

Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (2004) 4.70

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell (2005) 4.64

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61

Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51

Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males. Proc Biol Sci (1996) 4.44

Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med (1997) 4.26

Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet (2005) 3.75

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39

Metabolic implications of body fat distribution. Diabetes Care (1991) 3.28

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem (2002) 3.27

Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol (2001) 3.05

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem (1993) 2.94

PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci U S A (2003) 2.89

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell (2003) 2.86

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82

Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol (1999) 2.81

Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem (2004) 2.76

The role of oxidative damage and stress in aging. Mech Ageing Dev (2004) 2.73

AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci (2001) 2.51

Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem (1997) 2.50

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol (1999) 2.42

Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes (2003) 2.40

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A (2003) 2.35

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res (1997) 2.34

The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem (2002) 2.28

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. J Clin Invest (2004) 2.24

Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23

Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology (2001) 2.19

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem J (2003) 2.17

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev (1994) 2.16

Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes (2003) 2.11

D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A (2000) 2.11

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol (1999) 1.95

Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res (1999) 1.94

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans. Exp Gerontol (2002) 1.94

Adiponectin: systemic contributor to insulin sensitivity. Curr Diab Rep (2003) 1.90

Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology (2004) 1.90

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86

FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J Biol Chem (2002) 1.76

Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J Biol Chem (1998) 1.76

Inflammation and neurodegenerative diseases. Am J Clin Nutr (2006) 1.76

Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem (1998) 1.76

Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. Am J Physiol (1995) 1.72

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J Neurosci Res (1999) 1.70

Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch Biochem Biophys (1996) 1.70

AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. Am J Physiol Endocrinol Metab (2001) 1.70

Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology (1997) 1.64

Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics (2004) 1.50

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43

Revisiting the role of fat mass in the life extension induced by caloric restriction. J Gerontol A Biol Sci Med Sci (1999) 1.43

Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res (1999) 1.42

Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev (2002) 1.41

Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int J Mol Med (2003) 1.41

Life history and bioeconomy of the house mouse. Biol Rev Camb Philos Soc (1992) 1.40

Articles by these authors

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A (2007) 3.91

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 3.61

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem (2002) 3.27

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci (2008) 3.25

AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci (2008) 3.11

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci (2004) 2.76

"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem (2002) 2.45

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus (2008) 2.44

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci U S A (2003) 2.35

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med (2006) 2.32

Calcium orchestrates apoptosis. Nat Cell Biol (2003) 2.27

A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16

Toll-like receptors in neurodegeneration. Brain Res Rev (2008) 2.15

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci (2002) 2.14

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2007) 2.08

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis. Proc Natl Acad Sci U S A (2010) 2.05

Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol (2007) 2.04

Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol (2008) 2.03

Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci (2011) 2.01

Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron (2004) 1.99

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem (2002) 1.99

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med (2011) 1.97

Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci (2003) 1.91

Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 1.89

Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. Ann Neurol (2004) 1.87

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86

p53 in neuronal apoptosis. Biochem Biophys Res Commun (2005) 1.85

Evidence for CALM in directing VAMP2 trafficking. Traffic (2007) 1.84

Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus (2009) 1.84

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med (2006) 1.82

Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77

Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77

Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem (2004) 1.73

When neurogenesis encounters aging and disease. Trends Neurosci (2010) 1.73

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem (2002) 1.71

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71

Age and energy intake interact to modify cell stress pathways and stroke outcome. Ann Neurol (2010) 1.68

A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing Res Rev (2004) 1.68

Inducible proteopathies. Trends Neurosci (2006) 1.67

Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med (2002) 1.63

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol (2002) 1.61

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol (2010) 1.61

Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.60

Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59

A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells (2009) 1.59

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol (2008) 1.58

Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines. BMC Dev Biol (2006) 1.58

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci (2004) 1.57

beta1 integrin maintains integrity of the embryonic neocortical stem cell niche. PLoS Biol (2009) 1.57

The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr (2013) 1.56

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim Biophys Acta (2010) 1.56

Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem (2008) 1.55

Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci (2008) 1.55

Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Ann Neurol (2005) 1.55

Cardioprotection by intermittent fasting in rats. Circulation (2005) 1.55

An overview of APP processing enzymes and products. Neuromolecular Med (2010) 1.54

Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol (2003) 1.53

Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med (2009) 1.53

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51

Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol (2007) 1.51

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther (2002) 1.51

Cell-extracellular matrix interactions regulate neural differentiation of human embryonic stem cells. BMC Dev Biol (2008) 1.49

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48

Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A (2007) 1.46

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res (2003) 1.45

Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem (2009) 1.45

miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol (2010) 1.43

Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes (2008) 1.42

Recruiting adaptive cellular stress responses for successful brain ageing. Nat Rev Neurosci (2012) 1.42

Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J Biol Chem (2007) 1.40

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia. J Neurochem (2009) 1.39

Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease. Pharmacol Rev (2011) 1.38

Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J (2006) 1.36

Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci (2010) 1.36

VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis. PLoS One (2012) 1.36

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis (2010) 1.36

Mitochondria and neuroplasticity. ASN Neuro (2010) 1.36

Involvement of notch signaling in wound healing. PLoS One (2007) 1.35